{"id":22597,"date":"2022-07-04T07:37:45","date_gmt":"2022-07-04T07:37:45","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22597"},"modified":"2022-07-04T11:50:53","modified_gmt":"2022-07-04T11:50:53","slug":"salazopyrin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/salazopyrin\/","title":{"rendered":"Salazopyrin &#8211; Sulfasalazine uses, dose and side effects"},"content":{"rendered":"\n<p>500 mg&nbsp;sulfasalazine&nbsp;tablets<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Salazopyrin is and what it is used for<\/h2>\n\n\n\n<p>Salazopyrin has\u00a0anti-inflammatory\u00a0and\u00a0antibacterial\u00a0effects and inhibits\u00a0inflammation, especially in the intestinal\u00a0mucosa.<\/p>\n\n\n\n<p>Salazopyrin is used to treat inflammatory bowel disease (\u00a0ulcerative colitis,\u00a0Crohn&#8217;s disease\u00a0).\u00a0Salazopyrin is also used in the treatment of the skin disease\u00a0pyoderma gangrenous, which is sometimes seen in patients with\u00a0ulcerative colitis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Salazopyrin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Salazopyrin<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to sulfasalazine, its\u00a0metabolites, sulfa (\u00a0sulfonamides\u00a0) or\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiplo-citrus\/\">acetylsalicylic acid<\/a>\u00a0(included in some medicines for fever and pain), or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have\u00a0acute\u00a0intermittent\u00a0porphyria\u00a0(liver porphyria, increased presence of certain blood dyes caused by enzyme deficiency).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Salazopyrin.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you\u00a0have a recurrent or\u00a0chronic\u00a0infection<\/li><li>if you have impaired kidney or liver function<\/li><li>if you have severe\u00a0allergies\u00a0or\u00a0asthma<\/li><li>if you have\u00a0glucose\u00a0-6-\u00a0phosphate\u00a0-dehydrogenase deficiency, you should inform your doctor before starting treatment.<\/li><li>if you are a man trying to have children because Salazopyrin may reduce sperm production (normalizes if medication is stopped)<\/li><li>if you are taking or have recently taken Salazopyrin or any other medicines that contain sulfasalazine, as they may affect your blood and urine test results.<\/li><\/ul>\n\n\n\n<p>Contact your doctor immediately if you develop a new&nbsp;infection&nbsp;during your treatment with Salazopyrin.&nbsp;Your doctor may stop treatment.<\/p>\n\n\n\n<p>Blood count and renal and hepatic function should be checked before starting treatment and at the beginning of treatment.\u00a0Thereafter, the treating physician should be contacted for regular check-ups.<\/p>\n\n\n\n<p>Contact your doctor immediately if you experience symptoms such as sore throat, fever, paleness, or reddish or yellowish skin color.\u00a0This may indicate liver problems, as well as blood count changes, and treatment may need to be stopped.<\/p>\n\n\n\n<p>Skin reactions, which may be life-threatening (\u00a0Stevens-Johnson syndrome\u00a0and\u00a0toxic epidermal necrolysis\u00a0), have been reported with sulfasalazine.\u00a0It can start as red-violet target-like or round spots with blistering in the middle, often symmetrically spread, on the torso.\u00a0Additional signs to be aware of are sores in the mouth, throat, nose, genitals, or eye inflammation (red and swollen eyes).\u00a0The skin reactions, which can be life-threatening, are often followed by\u00a0flu-like symptoms.\u00a0The rash can develop into blisters over large areas of skin detachment.\u00a0The risk of serious skin reactions is greatest during the first weeks of treatment.\u00a0If you suffer from\u00a0Stevens-Johnson\u00a0syndrome or\u00a0toxic epidermal necrolysisWhen you have used sulfasalazine in Salazopyrin, you should never use medicines containing sulfasalazine again.\u00a0If you get a rash or signs of these skin reactions, stop taking Salazopyrin immediately, contact your doctor immediately and tell them that you are taking this medicine.<\/p>\n\n\n\n<p>Hypersensitivity reactions, which may be life-threatening (such as drug-induced skin rash (DRESS)), have been reported with the use of sulfasalazine.\u00a0Early signs of hypersensitivity may be rash, fever, or swollen\u00a0lymph nodes.\u00a0If you get symptoms of a\u00a0hypersensitivity reaction, contact your doctor immediately and tell them you are taking this medicine.<\/p>\n\n\n\n<p>During treatment with sulfasalazine, it is important to drink properly to prevent the formation of crystals in the urine and\u00a0kidney stones.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Salazopyrin<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.&nbsp;The treatment effect may be affected if Salazopyrin is taken at the same time as certain other medicines.&nbsp;If you are taking any of the following medicines, the&nbsp;dose&nbsp;of Salazopyrin or the other medicine may need to be changed or other precautions may need to be taken.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Digoxin&nbsp;for heart disease<\/li><li>Folic acid&nbsp;for&nbsp;anemia<\/li><li>Rifampicin for&nbsp;tuberculosis<\/li><li>Mercaptopurine or azathioprine for&nbsp;leukopenia&nbsp;or transplantation and immunological diseases<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Salazopyrin with food, drink, and alcohol<\/h2>\n\n\n\n<p>The tablets should be taken with a meal and distributed as evenly as possible during the day.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Salazopyrin treatment may lead to <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triobe\/\">folic acid<\/a> deficiency<\/p>\n\n\n\n<p>The concentration of the drug can be expected to be the same in the mother and the fetus and thus there is a risk of&nbsp;side effects&nbsp;in the fetus as well.&nbsp;However, animal studies do not indicate any risk of birth defects, but risks associated with use during pregnancy can not be completely ruled out.&nbsp;During pregnancy, Salazopyrin should be given only after special medical consideration.<\/p>\n\n\n\n<p>Sulfasalazine passes into breast milk in small amounts.\u00a0Bloody stools and diarrhea have been reported in infants where the breastfeeding woman has been treated with sulfasalazine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>No effects were observed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Salazopyrin<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Consult a doctor if you are unsure.&nbsp;Dose&nbsp;one is individually tailored for you.&nbsp;Carefully follow the&nbsp;dosage&nbsp;stated on the pharmacy label!<\/p>\n\n\n\n<p>The usual\u00a0dose, adults: 2-4 tablets 2-4 times daily.<\/p>\n\n\n\n<p>The usual\u00a0dose, children:\u00a0dose\u00a0one depends on the weight of the child.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Salazopyrin than you should &nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine &#8211; or if e.g.\u00a0a child ingested the medicine by mistake, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Salazopyrin<\/h2>\n\n\n\n<p>Do not compensate (eg with a double\u00a0dose\u00a0) for a missed\u00a0dose.\u00a0Medication should be continued for as long as your doctor prescribes, otherwise the disease may worsen and return.\u00a0As a rule, Salazopyrin should be taken for a long time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0In rare cases,\u00a0hypersensitivity reactions\u00a0may occur.<\/p>\n\n\n\n<p>During treatment with Salazopyrin, any&nbsp;side effects&nbsp;usually occur during the first 3 months of treatment.<\/p>\n\n\n\n<p>Common (affects more than 1 user in 100):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased&nbsp;leukocyte&nbsp;count (&nbsp;white blood cells&nbsp;)<\/li><li>loss of appetite<\/li><li>headache, dizziness, taste changes<\/li><li>tinnitus<\/li><li>cough<\/li><li>nausea, abdominal pain, bloating, diarrhea, vomiting<\/li><li>hives<\/li><li>itching<\/li><li>purple discoloration of the skin<\/li><li>joint pain<\/li><li>protein&nbsp;in the urine<\/li><li>reduced sperm production (&nbsp;reversible&nbsp;)<\/li><li>fever<\/li><li>transient increase in liver enzymes<\/li><\/ul>\n\n\n\n<p>Uncommon (affects less than 1 user in 100):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased&nbsp;platelet count&nbsp;(&nbsp;platelets&nbsp;)<\/li><li>swelling of the face<\/li><li>Depression<\/li><li>breathing difficulties<\/li><li>hair loss<\/li><\/ul>\n\n\n\n<p>Rare (affects less than 1 user in 1,000):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nail changes, skin reactions that can be life-threatening (&nbsp;epidermal&nbsp;necrolysis&nbsp;and&nbsp;Stevens-Johnson syndrome&nbsp;)<\/li><li>jaundice<\/li><\/ul>\n\n\n\n<p>Has been reported (occurs in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pseudomembranous\u00a0colitis\u00a0(intestinal inflammation)<\/li><li>mononucleosis-like syndrome (false glandular fever)<\/li><li>effects on the blood picture with, for example, severe\u00a0white blood cell deficiency\u00a0(\u00a0agranulocytosis\u00a0) and severe\u00a0anemia<\/li><li>hypersensitivity reaction,\u00a0angioedema\u00a0(swelling of the lips, eyelids, face, tongue, and throat), serum sickness (delayed\u00a0allergic reaction\u00a0)<\/li><li>deficiency of\u00a0folic acid<\/li><li>effects on the nervous system,\u00a0meningitis,\u00a0encephalopathy\u00a0(brain disease), altered olfactory sensations, myocarditis<\/li><li>pericarditis, decreased oxygenation of the blood leading to bluish discoloration of the skin, lips, and mucous membranes (cyanosis) and pallor<\/li><li>different types of lung diseases (such as fibrous alveolitis), pain in the mouth and throat<\/li><li>pancreatitis, worsening of\u00a0ulcerative colitis<\/li><li>hepatitis sometimes sudden onset, hepatic failure, narrowing of the bile ducts in the liver, and slower flow of bile in the gallbladder<\/li><li>drug-induced rash (DRESS see also Warnings and precautions), skin rash, reddening of the skin, severe skin inflammation with dandruff (exfoliative\u00a0dermatitis\u00a0), skin reactions to sun exposure<\/li><li>SLE\u00a0syndrome (autoimmune disease)<\/li><li>kidney effects, blood in the urine, crystals in the urine,\u00a0kidney stones<\/li><li>yellowing of skin and body fluids (eg sweat, saliva, urine, and tear fluid) and thus also yellowing of soft contact lenses<\/li><li>formation of\u00a0antibodies\u00a0directed against the body&#8217;s\u00a0tissues\u00a0(so-called autoantibodies)<\/li><\/ul>\n\n\n\n<p>If you get an\u00a0infection\u00a0with symptoms such as fever with severe general deterioration or fever with local infection symptoms such as sore throat\/pharynx\/mouth or urination problems, you should see a doctor as soon as possible so that a lack of\u00a0white blood cells\u00a0(\u00a0agranulocytosis\u00a0) can be ruled out through blood tests.\u00a0.\u00a0It is important that you then information about your medication.<\/p>\n\n\n\n<p>Stop taking Salazopyrin and contact a doctor immediately if you get any of the following symptoms (&nbsp;angioedema&nbsp;)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, tongue, or throat<\/li><li>difficulty swallowing<\/li><li>hives\u00a0and difficulty breathing<\/li><\/ul>\n\n\n\n<p>Skin reactions, which may be life-threatening (&nbsp;Stevens-Johnson syndrome&nbsp;and&nbsp;toxic epidermal necrolysis&nbsp;) have been reported (see section Warnings and precautions).<\/p>\n\n\n\n<p>If you get\u00a0any side effects, talk to your doctor or pharmacist.\u00a0This also applies to any\u00a0side effects\u00a0not mentioned in this information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Salazopyrin<\/h2>\n\n\n\n<p>Keep out of sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is sulfasalazine.<\/li><li>The other ingredients are: pregelatinized corn starch, magnesium stearate, povidone, anhydrous&nbsp;colloidal&nbsp;silica<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Jar with screw caps made of HD polyethylene and polypropylene, 100 pcs and 300 pcs.&nbsp;The lid has a notch so that, for example, a pencil can simplify opening.<\/p>\n\n\n\n<p>The tablet is yellow, arched, with a notch, 13.5 mm with an engraved symbol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder:<\/strong><\/p>\n\n\n\n<p>Pfizer AB<\/p>\n\n\n\n<p>191 90 Sollentuna<\/p>\n\n\n\n<p>Tel: 08-550 520 00<\/p>\n\n\n\n<p>Email: eumedinfo@pfizer.com<\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Recipharm Uppsala AB<\/p>\n\n\n\n<p>Bj\u00f6rkgatan 30<\/p>\n\n\n\n<p>751 82 Uppsala<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Salazopyrin has anti-inflammatory and antibacterial effects and inhibits inflammation , especially in the intestinal mucosa .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[23630,23633,23634,23620,23624,23623,23631,23621,23632,23622],"class_list":["post-22597","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-salazopyrin","tag-salazopyrin-side-effects","tag-salazopyrin-tablet","tag-sulfasalazine","tag-sulfasalazine-side-effects","tag-sulfasalazine-tablet","tag-what-is-salazopyrin","tag-what-is-sulfasalazine","tag-what-salazopyrin-is-used-for","tag-what-sulfasalazine-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22597","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22597"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22597\/revisions"}],"predecessor-version":[{"id":22644,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22597\/revisions\/22644"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22597"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22597"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}