{"id":22556,"date":"2022-07-01T11:46:35","date_gmt":"2022-07-01T11:46:35","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22556"},"modified":"2022-11-15T12:18:32","modified_gmt":"2022-11-15T12:18:32","slug":"ryeqo","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ryeqo\/","title":{"rendered":"Ryeqo &#8211; Relugolix \/ Estradiol \/ Norethisterone acetate Uses, Dose, And Side Effects"},"content":{"rendered":"\n<p>40 mg \/ 1 mg \/ 0.5 mg&nbsp;film-coated tablets<br>Regalix \/ estradiol\/norethisterone acetate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Ryeqo Is And What It Is Used For<\/h2>\n\n\n\n<p>Ryeqo contains the active substances relugolix, estradiol, and norethisterone acetate.&nbsp;It is used to treat moderate to severe symptoms of&nbsp;uterine&nbsp;fibroids, which is a benign&nbsp;tumor&nbsp;of the uterus.&nbsp;Ryeqo is used in adult women (over 18 years of age) who have not entered menopause.<\/p>\n\n\n\n<p>In some women,&nbsp;uterine&nbsp;fibroids can cause heavy menstrual bleeding and pelvic pain (pain below the navel).&nbsp;The drug is used to treat&nbsp;fibroids&nbsp;to stop or reduce bleeding and to reduce pain and discomfort in the pelvis associated with&nbsp;fibroids.<\/p>\n\n\n\n<p>This drug contains relugolix, a substance that blocks certain&nbsp;receptors&nbsp;in the brain which leads to reduced production of a&nbsp;hormone&nbsp;that normally stimulates the ovaries to produce estradiol and&nbsp;progesterone.&nbsp;When the&nbsp;receptors&nbsp;are blocked, the levels of&nbsp;estrogen&nbsp;and&nbsp;progesterone&nbsp;that circulate in the body decrease.&nbsp;<\/p>\n\n\n\n<p>This drug also contains two types of female hormones: estradiol which belongs to a group of drugs called&nbsp;estrogen&nbsp;er, and norethisterone which belongs to a group of drugs called&nbsp;progestin&nbsp;er.&nbsp;Taking these&nbsp;hormones has been included in Ryeqo maintains a hormonal state similar to that at the beginning of the menstrual cycle.&nbsp;In this way, the symptoms are relieved at the same time as the drug helps to keep the skeleton strong.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before Using Ryeqo<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Ryeqo<\/h2>\n\n\n\n<p>Do not use Ryeqo if you have any of the conditions listed below.<\/p>\n\n\n\n<p>If you have any of these conditions, tell your doctor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are&nbsp;<strong>allergic<\/strong>&nbsp;to relugolix, estradiol, norethisterone acetate, or any of the other ingredients of this medicine (listed in section 6)<\/li><li>If you have (or have had) a&nbsp;blood clot in a blood vessel&nbsp;in your legs (deep&nbsp;vein thrombosis, DVT), in your lungs (&nbsp;pulmonary embolism&nbsp;), heart (heart attack), brain (&nbsp;stroke&nbsp;), or other parts of your body<\/li><li>If you have or have ever had a disease caused by blood clots in the&nbsp;arteries, such as&nbsp;<ul><li>Heart attack,&nbsp;stroke,&nbsp;or&nbsp;angina<\/li><\/ul><\/li><li>If you have a&nbsp;coagulation disorder&nbsp;such as&nbsp;<ul><li>Protein&nbsp;C deficiency<\/li><li>Protein&nbsp;S deficiency<\/li><li>Antithrombin-III deficiency<\/li><li>Factor V Leiden&nbsp;mutation<\/li><\/ul><\/li><li>If you have&nbsp;osteoporosis<\/li><li>If you suffer from&nbsp;headaches&nbsp;with focal neurological symptoms, such as paralysis or impaired muscle control, or&nbsp;migraines&nbsp;with visual disturbances<\/li><li>If you have any type of&nbsp;cancer&nbsp;that may be aggravated by exposure to female sex hormones, such as&nbsp;breast or genital cancer<\/li><li>If you have or have ever had a&nbsp;tumor&nbsp;in your liver<\/li><li>If you have or have ever had a&nbsp;liver disease&nbsp;and your&nbsp;liver function values&nbsp;\u200b\u200bhave not returned to normal<\/li><li>If you are&nbsp;pregnant&nbsp;or if you think you&nbsp;may be pregnant&nbsp;or&nbsp;breast-feeding<\/li><li>If you have&nbsp;genital bleeding&nbsp;of unknown origin<\/li><li>If you are taking a&nbsp;hormonal contraceptive, such as&nbsp;the contraceptive pill, and do not want to stop using it<\/li><\/ul>\n\n\n\n<p>If any of the above conditions occur for the first time when you take Ryeqo, stop taking the medicine immediately and contact your doctor.<\/p>\n\n\n\n<p>If you are not sure about any of the above, talk to your doctor before taking Ryeqo.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Ryeqo.<\/p>\n\n\n\n<p>You should know that most women have less or no menstrual bleeding at all during treatment and for a few weeks afterward.<\/p>\n\n\n\n<p>Your doctor will talk to you about your medical history and family history.&nbsp;Your doctor will also need to check your&nbsp;blood pressure&nbsp;and check if you are pregnant.&nbsp;You may also need to undergo a physical examination and additional checks that are specific to your medical needs and\/or problems, such as a breast examination and an examination to measure how strong your legs are.<\/p>\n\n\n\n<p><strong>Stop taking Ryeqo and contact a doctor immediately if you:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Experience any of the conditions mentioned in the section &#8220;Do not use Ryeqo&#8221;<\/li><li>Gets signs of&nbsp;<strong>liver disease<\/strong>&nbsp;:<ul><li>Yellowed skin or yellow whites of the eyes (jaundice)<\/li><li>Nausea or vomiting<\/li><li>Fever<\/li><li>Severe fatigue<\/li><li>Dark urine<\/li><li>Itching<\/li><li>Pain in the upper abdomen<\/li><\/ul><\/li><li>Gets severely elevated&nbsp;blood pressure. Symptoms may include <ul><li>Headache<\/li><li>Fatigue<\/li><li>Dizziness<\/li><\/ul><\/li><li>Get&nbsp;migraines&nbsp;for the first time or unusually severe&nbsp;headaches&nbsp;that occur more often than before<\/li><li>Note any signs of a&nbsp;blood clot&nbsp;that could mean that you have a blood clot in a bone (ie deep&nbsp;vein thrombosis&nbsp;) or the lungs (ie&nbsp;pulmonary embolism&nbsp;), or that you have had a heart attack or&nbsp;stroke.&nbsp;Under &#8220;Ryeqo and the risk of blood clots&#8221; you will find a description of the symptoms of these serious conditions.<\/li><li>Getting&nbsp;<strong>pregnant.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor if any of the following apply to you:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You have one or more of the&nbsp;<strong>risk factors for developing a blood clot<\/strong>&nbsp;listed below.<\/li><li>You have&nbsp;<strong>high&nbsp;blood pressure<\/strong>.<\/li><li>You have&nbsp;osteoporosis.<\/li><li>You suffer from&nbsp;migraines.<\/li><li>You think you may be&nbsp;pregnant.&nbsp;Ryeqo treatment usually results in a significant reduction or even absence of menstrual bleeding, which makes it difficult to detect a possible pregnancy.<\/li><li>If you have or have had&nbsp;depression&nbsp;before.<\/li><li>If you have&nbsp;kidney disease.<\/li><\/ul>\n\n\n\n<p><strong>Ryeqo and risk of blood clots<\/strong><\/p>\n\n\n\n<p>The use of other drugs that contain&nbsp;estrogen&nbsp;and&nbsp;progestogens&nbsp;increases the risk of blood clots.&nbsp;The risk of blood clots with Ryeqo has not been established.&nbsp;Ryeqo reduces estrogen levels to a level similar to that at the beginning of your normal menstrual cycle.<\/p>\n\n\n\n<p>Factors that may increase the risk of blood clots in veins and\/or arteries:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rising&nbsp;<strong>age<\/strong>&nbsp;(especially if you are over 35 years old).<\/li><li>If you are overweight (body mass index or&nbsp;BMI&nbsp;over&nbsp;<strong>30 kg \/ m&nbsp;<sup>2<\/sup><\/strong>&nbsp;).<\/li><li>If you need to have an&nbsp;<strong>operation<\/strong>&nbsp;or stay in&nbsp;bed&nbsp;for a long period due to injury or illness (eg with a plastered leg)<\/li><li>If you have&nbsp;given birth recently<\/li><li>If someone in your family has had a&nbsp;blood clot in their bones, lungs, or another organ, or has had a&nbsp;heart attack&nbsp;or&nbsp;stroke&nbsp;at a young age&nbsp;(eg before the age of 50)<\/li><li>If you&nbsp;smoke.<\/li><li>If you have heart problems (&nbsp;valve disease, a heart rhythm disorder called&nbsp;atrial fibrillation&nbsp;).<\/li><li>If you have&nbsp;diabetes.<\/li><li>If you have certain diseases such as&nbsp;systemic lupus erythematosus&nbsp;(&nbsp;SLE&nbsp;&#8211; a disease that affects the natural defense system),&nbsp;sickle cell disease&nbsp;(a hereditary disease of the red&nbsp;blood cells&nbsp;),&nbsp;Crohn&#8217;s disease&nbsp;or&nbsp;ulcerative colitis&nbsp;(&nbsp;chronic&nbsp;inflammatory&nbsp;bowel disease), or&nbsp;cancer.<\/li><\/ul>\n\n\n\n<p>The more conditions you have, the greater the risk of developing a blood clot.<\/p>\n\n\n\n<p>The symptoms of a blood clot depend on where the blood clot is located.<\/p>\n\n\n\n<p><em>Symptoms of a <\/em>blood clot in the leg (&nbsp;deep&nbsp;vein thrombosis<em><strong>, DVT<\/strong>&nbsp;)<\/em><\/p>\n\n\n\n<p>The symptoms of a blood clot in a bone, so-called deep&nbsp;vein thrombosis&nbsp;(DVT), can include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling of the legs and\/or feet or along a vein in the leg<\/li><li>Pain or tenderness in the leg that is only felt when standing or walking<\/li><li>Increasing heat in the affected bone with red discoloration or discoloration of the bone<\/li><\/ul>\n\n\n\n<p><em>Symptoms of blood clots in the lungs (&nbsp;<strong>pulmonary embolism<\/strong>&nbsp;)<\/em><\/p>\n\n\n\n<p>Symptoms of a blood clot in the lungs, called&nbsp;pulmonary embolism&nbsp;(PE), may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sudden onset of unexplained shortness of breath or rapid breathing<\/li><li>Sudden cough that may be associated with severe chest pain<\/li><li>Bloody vomiting<\/li><li>Severe instability or dizziness<\/li><li>Fast or irregular heartbeat<\/li><\/ul>\n\n\n\n<p><em>Symptoms of&nbsp;<strong>heart attack<\/strong><\/em><\/p>\n\n\n\n<p>Symptoms of myocardial infarction may be temporary and may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Pain<\/li><li>Discomfort<\/li><li>Pressure<\/li><li>Heaviness<\/li><li>Pressure, or fullness in the chest, arm, or below the sternum<\/li><li>Discomfort that radiates to the back, jaw, neck, arm, abdomen<\/li><li>Feeling full, indigestion or suffocation<\/li><li>Sweating<\/li><li>Nausea<\/li><li>Vomiting, or dizziness<\/li><li>Extreme weakness<\/li><li>Anxiety, or shortness of breath<\/li><li>Fast or irregular heartbeat<\/li><\/ul>\n\n\n\n<p><em>Symptoms of&nbsp;<strong>stroke<\/strong><\/em><\/p>\n\n\n\n<p>Symptoms of&nbsp;a stroke&nbsp;may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sudden numbness or weakness in the face, arms, or legs, especially on one side of the body<\/li><li>Sudden difficulty walking<\/li><li>Dizziness<\/li><li>Loss of balance or coordination<\/li><li>Sudden confusion<\/li><li>Difficulty speaking or understanding<\/li><li>Sudden vision problems in one or both eyes<\/li><li>Sudden, severe, or prolonged headache without a known cause<\/li><li>Unconsciousness or fainting with or without seizures<\/li><\/ul>\n\n\n\n<p><strong>Operation<\/strong><\/p>\n\n\n\n<p>If you are going to have surgery, you must tell&nbsp;the surgeon&nbsp;that you are taking Ryeqo.<\/p>\n\n\n\n<p><strong>Liver tumors or liver disease<\/strong><\/p>\n\n\n\n<p>In rare cases, liver tumors or liver disease have been reported in women taking&nbsp;estrogen&nbsp;and&nbsp;progestogens.&nbsp;If you get any symptoms of jaundice, contact your doctor for further medical advice.<\/p>\n\n\n\n<p><strong>Impaired renal function<\/strong><\/p>\n\n\n\n<p>If you experience that urine production decreases or you notice possible&nbsp;fluid retention&nbsp;(accumulation of fluid in the body) that causes swelling in the legs, ankles, or feet, you should contact a doctor for further medical advice.<\/p>\n\n\n\n<p><strong>Altered bleeding pattern during menstruation<\/strong><\/p>\n\n\n\n<p>Treatment with Ryeqo usually results in a significant reduction or even absence of menstrual bleeding (your period) during the first 30 days of treatment.&nbsp;However, if you continue to have heavy bleeding, tell your doctor.<\/p>\n\n\n\n<p><strong>Depression<\/strong><\/p>\n\n\n\n<p>If you feel that your mood has changed or you are experiencing symptoms of depression, you should contact your doctor for further medical advice.<\/p>\n\n\n\n<p><strong>High&nbsp;blood pressure<\/strong><\/p>\n\n\n\n<p>In rare cases, treatment with Ryeqo may lead to a slight increase in&nbsp;blood pressure.&nbsp;If you get symptoms of high&nbsp;blood pressure, contact your doctor for further medical advice.<\/p>\n\n\n\n<p><strong>Prolapse&nbsp;or expulsion of&nbsp;fibroids<\/strong><\/p>\n\n\n\n<p>Myoma&nbsp;can develop anywhere in the uterine wall, including the submucosa, a thin layer of tissue in the uterus.&nbsp;In some women,&nbsp;fibroids&nbsp;can protrude or slide through the cervix and into the vagina, leading to significantly more severe uterine bleeding or pain.&nbsp;If you recover from severe bleeding after your symptoms have improved with treatment with Ryeqo, you should contact your doctor for medical advice.<\/p>\n\n\n\n<p><strong>Diseases of the gallbladder<\/strong><\/p>\n\n\n\n<p>Some women taking&nbsp;estrogen&nbsp;and progestogen hormones, including Ryeqo, have reported gallbladder problems (&nbsp;gallstones&nbsp;or gallbladder&nbsp;inflammation&nbsp;).&nbsp;If you experience unusually severe pain under the chest or in the upper abdomen, consult a doctor for medical advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children And Young People<\/h2>\n\n\n\n<p>Ryeqo should not be taken by children under 18 years of age as the safety and efficacy of Ryeqo have not been established in this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Ryeqo<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Talk to your doctor if you are taking any of the following medicines.&nbsp;These medicines can affect Ryeqo or be affected by Ryeqo:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Some medicines are used to treat&nbsp;epilepsy&nbsp;eg <ul><li>Carbamazepine<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/topiramate-1a-pharma\/\">Topiramate<\/a><\/li><li>Phenytoin<\/li><li>Phenobarbital<\/li><li>Primidone<\/li><li>Oxcarbazepine<\/li><li>Felbamate<\/li><\/ul><\/li><li>Some medicines are used to treat&nbsp;HIV \/ AIDS&nbsp;(human immunodeficiency virus \/ acquired immunodeficiency syndrome) eg <ul><li>Ritonavir<\/li><li>Efavirenz<\/li><\/ul><\/li><li>Some medicines used to treat&nbsp;hepatitis&nbsp;C&nbsp;virus&nbsp;(&nbsp;HCV&nbsp;)&nbsp;eg <ul><li>Boceprevir<\/li><li>Sofosbuvir<\/li><li>Velpatasvir<\/li><li>Voxilaprevir<\/li><li>Telaprevir<\/li><li>Glekaprevir<\/li><\/ul><\/li><li>Some medicines used to treat&nbsp;fungal infections&nbsp;eg&nbsp;<ul><li>Ketoconazole<\/li><li>Itraconazole<\/li><li>Fluconazole&nbsp;<\/li><li>Griseofulvin<\/li><\/ul><\/li><li>Some medicines are used to treat&nbsp;bacterial infections&nbsp;eg <ul><li>Rifampicin<\/li><li>Rifabutin<\/li><li>Clarithromycin<\/li><li>Erythromycin<\/li><li>Gentamicin<\/li><li>Tetracycline<\/li><li>Griseofulvin<\/li><\/ul><\/li><li>Some medicines are used to treat&nbsp;high&nbsp;blood pressure&nbsp;in the&nbsp;arteries&nbsp;of the lungs&nbsp;(eg&nbsp;bosentan&nbsp;).<\/li><li>Some medicines are used to treat&nbsp;high&nbsp;blood pressure&nbsp;eg&nbsp;<ul><li>Diltiazem<\/li><li>Carvedilol<\/li><li>Verapamil<\/li><\/ul><\/li><li>Some medicines are used to treat&nbsp;irregular heartbeats&nbsp;eg&nbsp;<ul><li>Amiodarone<\/li><li>Dronedarone<\/li><li>Propafenone<\/li><li>Quinidine<\/li><li>Verapamil<\/li><\/ul><\/li><li>Some medicines are used to treat&nbsp;angina&nbsp;eg <ul><li>Ranolazine<\/li><li>Carvedilol<\/li><li>Verapamil<\/li><\/ul><\/li><li>Some medicines prevent organ&nbsp;rejection after transplantation&nbsp;(eg cyclosporine).<\/li><li>Herbal medicines contain St. John&#8217;s&nbsp;<strong>wort<\/strong>&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy And Breastfeeding<\/h2>\n\n\n\n<p>Do not take Ryeqo if you are pregnant or breastfeeding.&nbsp;If you think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.&nbsp;If you become pregnant, stop taking Ryeqo and consult a doctor.<\/p>\n\n\n\n<p>Ryeqo stops ovulation and it is therefore unlikely that you will become pregnant while using Ryeqo if you use the medicine according to the instructions.&nbsp;Ovulation and menstrual bleeding return quickly after stopping treatment with Ryeqo and alternative contraceptive methods are recommended immediately after stopping Ryeqo.<\/p>\n\n\n\n<p>Depending on when in your cycle you start taking Ryeqo, it may take time to achieve completely inhibited ovulation with Ryeqo.&nbsp;Therefore, you should use non-hormonal contraceptives (eg condoms) for the first month after you start taking Ryeqo.<\/p>\n\n\n\n<p>If you miss your&nbsp;dose&nbsp;for two consecutive days or more, use non-hormonal contraceptives (eg condoms) for the next 7 days of treatment.<\/p>\n\n\n\n<p><strong>Laboratory samples<\/strong><\/p>\n\n\n\n<p>If you need to take a blood or urine sample, tell your doctor or laboratory staff that you are taking Ryeqo as this medicine may affect<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>Ryeqo has no known effect on the ability to drive and use machines<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ryeqo Contains Lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Take Ryeqo<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/li><li>The recommended&nbsp;dose&nbsp;is one tablet per day.<\/li><li>The tablet must be taken by mouth every day at about the same time, with or without food with a little liquid.<\/li><\/ul>\n\n\n\n<p>It is recommended that you start taking Ryeqo one of the first five days after the start of your period.&nbsp;If you start at another time in the menstrual cycle, you may initially experience bleeding that is irregular or heavier.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Take More Ryeqo Than You Should<\/h2>\n\n\n\n<p>No serious adverse effects have been reported from multiple&nbsp;doses&nbsp;of this medicine.&nbsp;Large&nbsp;doses&nbsp;of&nbsp;estrogen&nbsp;can cause nausea and vomiting and bleeding from the vagina.&nbsp;If you have taken too many Ryeqo tablets, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Take Ryeqo Tablets<\/h2>\n\n\n\n<p>If you have missed a&nbsp;dose, take it as soon as you remember, and then continue to take your tablet the next day as usual.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Stop Taking Ryeqo<\/h2>\n\n\n\n<p>Talk to your doctor first if you want to stop taking Ryeqo tablets.&nbsp;Your doctor will explain the effects of stopping treatment and discuss other options with you.<\/p>\n\n\n\n<p>If you have any further questions about the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible Ryeqo Side Effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;of Ryeqo have been reported and are listed below according to how common they are.<\/p>\n\n\n\n<p><strong>Common&nbsp;<\/strong>Ryeqo side effects&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hot flashes<\/li><li>Very abundant, irregular, or prolonged bleeding from the uterus<\/li><li>Hair loss<\/li><li>Decreased sex drive<\/li><li>Irritability<\/li><li>Increased sweating<\/li><li>A lump in the breast tissue (breast cyst)<\/li><li>Indigestion<\/li><li>Night sweats<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;<\/strong>Ryeqo side effects&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rejection of&nbsp;myoma&nbsp;et (&nbsp;myoma&nbsp;et completely or partially penetrates through the vagina, usually with increased bleeding from the vagina).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How To Store Ryeqo<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Keep this medicine out of the sight and reach of children.<\/strong><\/li><li>Do not use this medicine after the expiry date which is stated on the outer carton and can after EXP.&nbsp;The expiration date is the last day of the specified month.<\/li><li>No special storage instructions.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;The hormonal active substances in the tablet can have harmful effects if they reach the aquatic environment.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Of The Packaging And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are relugolix, estradiol, and norethisterone acetate.&nbsp;One film-coated tablet contains 40 mg relugolix, 1 mg estradiol (in the form of hemihydrate), and 0.5 mg norethisterone acetate.<\/li><li>The other ingredients are&nbsp;lactose M<ul><li>Monohydrate<\/li><li>Mannitol (E421)<\/li><li>Sodium starch glycolate<\/li><li>Hydroxypropylcellulose (E463), magnesium stearate (E572)<\/li><li>Hypromellose type 2910 (E464)<\/li><li>Titanium dioxide (E171)<\/li><li>Triacetin (E1518)<\/li><li>Yellow iron oxide (E152)<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And The Contents Of The Pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Ryeqo is a light yellow to yellow, film-coated 8 mm round tablet, with \u201c415\u201d on one side and smooth on the other side.<\/li><li>Ryeqo tablets are available in jars containing 28 film-coated tablets.&nbsp;Each jar also contains a desiccant and is equipped with an induction-sealed childproof lid.<\/li><li>Pack sizes:<ul><li>One can (28 tablets)<\/li><li>Three cans (84 tablets)<\/li><li>Not all pack sizes may be marketed<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Gedeon Richter Plc.<\/p>\n\n\n\n<p>Gy\u00f6mr\u0151i out 19-21.<\/p>\n\n\n\n<p>1103 Budapest<\/p>\n\n\n\n<p>Hungary<\/p>\n\n\n\n<p><strong>Manufacturer (plants releasing batch)<\/strong><\/p>\n\n\n\n<p>Gedeon Richter Plc.<\/p>\n\n\n\n<p>Gy\u00f6mr\u0151i out 19-21.<\/p>\n\n\n\n<p>1103 Budapest<\/p>\n\n\n\n<p>Hungary<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ryeqo has the elements relugolix, estradiol and norethisterone acetate. It is used to the symptoms of uterine fibroids, which is a kind tumor of the uterus. <\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[3093,10344,3576,19194,23557,23560,23553,23556,10343,5414,19192,23558,23554,19193,23559,23555],"class_list":["post-22556","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-estradiol","tag-estradiol-tablet","tag-norethisterone-acetate","tag-norethisterone-acetate-tablet","tag-relugolix","tag-relugolix-tablet","tag-ryeqo","tag-ryeqo-tablet","tag-what-estradiol-is-used-for","tag-what-is-estradiol","tag-what-is-norethisterone-acetate","tag-what-is-relugolix","tag-what-is-ryeqo","tag-what-norethisterone-acetate-is-used-for","tag-what-relugolix-is-used-for","tag-what-ryeqo-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22556","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22556"}],"version-history":[{"count":50,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22556\/revisions"}],"predecessor-version":[{"id":32993,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22556\/revisions\/32993"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22556"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22556"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}