{"id":22515,"date":"2022-06-30T07:47:36","date_gmt":"2022-06-30T07:47:36","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22515"},"modified":"2022-07-01T10:51:24","modified_gmt":"2022-07-01T10:51:24","slug":"ruconest","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ruconest\/","title":{"rendered":"Ruconest &#8211; Conestat alfa uses, dose and side effects"},"content":{"rendered":"\n<p>2100 units of powder and solvent for solution for injection\u00a0constat<br>alfa<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Ruconest is and what it is used for<\/h2>\n\n\n\n<p>Ruconest contains conestat alfa as an active substance.\u00a0Conestat alfa is a\u00a0recombinant\u00a0(not produced from blood) form of\u00a0human\u00a0C1 inhibitor (real-INH).<\/p>\n\n\n\n<p>Ruconest is for use in adults, adolescents, and children (2 years of age and older) with a rare hereditary problem of blood disease, hereditary\u00a0angioedema\u00a0(HAE).\u00a0HAE patients have a deficiency of C1 inhibitor protein in their blood.\u00a0This can lead to recurrent seizures with swelling, abdominal pain, difficulty breathing, and other symptoms.<\/p>\n\n\n\n<p>Ruconest is given to treat the C1 inhibitor deficiency and relieve the symptoms of acute hereditary&nbsp;angioedema&nbsp;(HAE).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Ruconest<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Ruconest<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are or think you may be allergic to rabbits.<\/li><li>if you are allergic to conestat alfa or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before using Ruconest.<\/p>\n\n\n\n<p>If you experience allergic reactions, e.g.\u00a0hives, rash,\u00a0itching, dizziness, wheezing, difficulty breathing or if the tongue swells up after receiving Ruconest, you should seek\u00a0emergency\u00a0care so that your allergic symptoms can be treated immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Ruconest should not be given to children under 2 years of age.&nbsp;Ruconest has not been studied in children younger than 5 years.&nbsp;Your doctor will decide if it is appropriate to treat your child with Ruconest.&nbsp;Additional monitoring of your child for symptoms of allergic reactions during and after&nbsp;administration&nbsp;is required.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Ruconest<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>If you are receiving tPA (tissue-type&nbsp;plasminogen activator&nbsp;) as&nbsp;an acute&nbsp;treatment for thrombosis, you should not be treated with Ruconest at the same time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Ruconest is not recommended during pregnancy and lactation.<\/p>\n\n\n\n<p>If you are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Do not drive or use any tools or machines if you feel dizzy or have a headache after taking Ruconest.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ruconest contains sodium (19.5 mg per vial)<\/h2>\n\n\n\n<p>This should be considered by patients on a low-sodium diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Ruconest<\/h2>\n\n\n\n<p>Ruconest treatment should be started by a doctor who specializes in the diagnosis and treatment of hereditary\u00a0angioedema.<\/p>\n\n\n\n<p>Ruconest must be given by a doctor or nurse until you or your carer have received adequate training in how to use Ruconest and can inject the medicine.<\/p>\n\n\n\n<p>Always use this medicine exactly as described in this leaflet or as directed by your doctor or nurse.&nbsp;If you are not sure, talk to your doctor or nurse.<\/p>\n\n\n\n<p>Ruconest is given to a friend for about 5 minutes.\u00a0Dose\u00a0one is calculated according to your body weight.<\/p>\n\n\n\n<p>One dose\u00a0is usually enough.\u00a0An additional\u00a0dose\u00a0may be administered if your symptoms do not improve after 120 minutes (for adults and adolescents) or after 60 minutes (for children).\u00a0A maximum of two\u00a0doses, calculated according to step 7, should be given within 24 hours.<\/p>\n\n\n\n<p>You or your healthcare provider must not inject Ruconest until your doctor or nurse has given you adequate instructions and appropriate training on how to use the medicine.<\/p>\n\n\n\n<p>Instructions for use<\/p>\n\n\n\n<p>Ruconest must not be mixed or given with other medicines or solutions.&nbsp;Below is a description of how the Ruconest solution is to be prepared and given.<\/p>\n\n\n\n<p>Before you begin<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Make sure the kit is complete and contains all the components listed in section 6 of this leaflet.<\/li><li>In addition to the kit, the following is needed:<ul><li>a constriction bandage<\/li><li>tape to attach the needle<\/li><\/ul><\/li><li>Inspect vials and other components.<ul><li>all vials must be sealed with plastic lids and aluminum lids and must not have visible damage, e.g.\u00a0cracks in the glass.<\/li><li>check the expiration date.\u00a0Never use kit components after the expiration date indicated on the large outer carton. Within the same kit box, different components can have different expiration dates.\u00a0The expiry date on the outer carton shows the date of the component with the shortest shelf life.<\/li><\/ul><\/li><li>Allow the number of vials of powder and liquid needed for step 1 to reach room temperature.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><\/ul>\n\n\n\n<p>Prepare solution<\/p>\n\n\n\n<p><strong>Step 1:<\/strong>&nbsp;Cleaning and other requirements<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Wash your hands thoroughly.<\/li><li>Place the vials of powder and liquid on a flat and clean surface.<ul><li>body weight 42 kg or less: 1&nbsp;vial&nbsp;of powder and 1 vial of liquid<\/li><li>body weight over 42 kg: 2 vials of powder and 2 vials of liquid<\/li><\/ul><\/li><li>Place the vial adapters on the work surface.&nbsp;Do not remove the adapter package.<ul><li>2 adapters if needed 1&nbsp;vial&nbsp;of powder and 1 vial of liquid<\/li><li>4 adapters if needed 2 vials of powder and 2 vials of liquid<\/li><\/ul><\/li><li>Place the syringe (s) on the work surface.&nbsp;Do not remove the syringe pack.<ul><li>1&nbsp;syringe&nbsp;if needed 1&nbsp;vial&nbsp;of powder and 1 vial of liquid<\/li><li>2 syringes if needed 2 vials of powder and 2 vials of liquid.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Step 2:&nbsp;<\/strong>Disinfect the stoppers&nbsp;on the vials<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Remove the plastic caps from the vials of powder and liquid.<\/li><li>Use an alcohol swab to&nbsp;disinfect&nbsp;the stoppers on the vials and wait at least 30 seconds until the stoppers have dried.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><li>After disinfection, do not touch the plugs with your fingers or anything else.<\/li><\/ul>\n\n\n\n<p><strong>Step 3:<\/strong>&nbsp;Mount the adapters on the vials<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take a packaged adapter in one hand and remove the lid.&nbsp;The adapter must remain in the plastic packaging.<\/li><li>Press the adapter onto a powder&nbsp;vial&nbsp;while penetrating the stopper until the adapter snaps onto the neck of the vial.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><li>Leave the package on the adapter until you connect the syringe in steps 4 and 5.<\/li><li>Repeat the above steps for mounting an adapter on the vial of liquid.&nbsp;All adapters that come with the kit are identical.<\/li><li>If you need to use another powder&nbsp;vial&nbsp;and one with liquid, repeat the above steps.<\/li><\/ul>\n\n\n\n<p><strong>Step 4:<\/strong>\u00a0Draw up the liquid<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take a\u00a0sterile\u00a0syringe\u00a0out of its package.<\/li><li>Remove the package from the adapter on the vial of liquid.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><li>Hold the adapter with one hand.\u00a0On the other hand, connect the syringe and secure it by turning it clockwise until it receives.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><li>Turn the entire device &#8211; the vial of liquid, the adapter, and the syringe &#8211; upside down.\u00a0Hold the device vertically while slowly drawing up 14 ml of liquid. If air bubbles are visible, minimize them as far as possible by tapping the syringe gently and applying a light pressure by pushing the plunger into the syringe.\u00a0Continue to fill the syringe with 14 ml of liquid.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><li>Release the syringe from the adapter by turning it counterclockwise.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><li>Leave the rest of the liquid in the vial and discard the vial. Place the syringe on the work surface but do not allow the tip of the syringe to touch the surface or any other object.<\/li><\/ul>\n\n\n\n<p><strong>Step 5:<\/strong>&nbsp;Add liquid to the powder and dissolve<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Remove the package from the adapter on the powder vial.<\/li><li>Take the syringe with the liquid that you prepared in step 4.<\/li><li>Hold the adapter with one hand and connect the syringe.\u00a0Secure the syringe by turning it clockwise until it receives.<\/li><li>To minimize foaming,\u00a0inject\u00a0the liquid slowly, in a single motion, into the powder vial.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><li>Leave the syringe on the adapter and gently swirl the vial for about half a minute.\u00a0Do not shake.\u00a0After spinning, leave the vial on the work surface for a few minutes until the solution is ready.\u00a0If there is still undissolved powder left, repeat the procedure.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><li>Repeat steps 4 and 5 if you need to prepare another solution.<\/li><\/ul>\n\n\n\n<p><strong>Step 6:<\/strong>&nbsp;Check ready-made solutions<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Check that the powder in the vial (s) is completely dissolved and that the plunger is completely depressed in the syringe.<\/li><li>When the powder is dissolved, the solution should be clear and colorless.<\/li><li>Do not use the reconstituted solution if it is cloudy, contains particles, or has changed color.\u00a0Inform healthcare professionals if this happens.\u00a0Small amounts of\u00a0foam\u00a0are acceptable.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><\/ul>\n\n\n\n<p><strong>Step 7:<\/strong>&nbsp;Draw up the prepared solution<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Calculate how many milliliters of the reconstituted solution is to be injected.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><td>Body weight<\/td><td>Milliliters of reconstituted solution to be injected<\/td><\/tr><\/thead><tbody><tr><td>under 84 kg<\/td><td>Body weight in kg divided by three<\/td><\/tr><tr><td>84 kg or more<\/td><td>28 ml<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>Pull up the volume of the reconstituted solution while holding the syringe vertically.\u00a0If you have prepared:<ul><li>a\u00a0vial\u00a0of solution, draw up the calculated volume<\/li><li>two vials and your body weight is below 84 kg, pull up similarly:<ol><li>14 ml from the first vial<\/li><li>from the second vial, draw the difference between your estimated volume and the 14 milliliters from the second vial<\/li><\/ol><\/li><li>two vials and your body weight is 84 kg or more, draw 14 ml from each\u00a0vial\u00a0into each syringe. If air bubbles are visible, minimize them as far as possible by tapping the syringe gently and creating a light pressure by pushing the plunger into the syringe.\u00a0Continue to fill the syringe with the required volume.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><\/ul><\/li><li>Never exceed the volume of 14 ml per syringe.<\/li><li>Release the syringe (s) by turning it (them) counterclockwise and discarding the vial (s) together with the adapter.<\/li><li>Place the syringe (s) on the work surface, but do not allow the tip of the syringe to touch the surface or any other object.<\/li><\/ul>\n\n\n\n<p><strong>Step 8:<\/strong>&nbsp;Check ready-made syringes<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Check again that the volume of the syringe (s) you prepared in step 7 is correct.<\/li><\/ul>\n\n\n\n<p>Administration&nbsp;in a friend<\/p>\n\n\n\n<p>The reconstituted solution must be injected directly into a vein and not into an\u00a0artery\u00a0or surrounding\u00a0tissue.<\/p>\n\n\n\n<p>Inject the Ruconest solution immediately after\u00a0reconstitution, preferably while sitting.<\/p>\n\n\n\n<p><strong>Step 9:<\/strong>&nbsp;Required components<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Check that all required components are on the work surface:<ul><li>1 or 2 syringes with reconstituted solution<\/li><li>1 infusion set with 25 G-needle<\/li><li>1 alcohol compress<\/li><li>1 sterile nonwoven&nbsp;compress<\/li><li>1 patch<\/li><li>1 tightening bandage<\/li><li>1 piece of tape to attach the needle<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Step 10:<\/strong>&nbsp;Prepare the infusion set<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Remove the screw cap from the end of the infusion set.\u00a0It&#8217;s the end without a needle.<\/li><li>Hold this end with one hand, connect the end of the syringe tip and secure by turning clockwise until it receives.<\/li><li>Hold the syringe with the tip facing up.\u00a0Gently press the syringe plunger to fill the infusion set thoroughly with the reconstituted solution.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><li>Check that there is no air in the syringe, infusion line, or needle.<\/li><\/ul>\n\n\n\n<p><strong>Step 11:<\/strong>&nbsp;Prepare the injection site<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Place the lacing bandage above the injection site &#8211; preferably in the middle of the upper arm.&nbsp;Tighten to compress the vein.&nbsp;Reinforce this by tying your hand.<\/li><li>Feel with your other hand for a suitable vein.<\/li><li>Carefully disinfect the&nbsp;injection site with an alcohol swab and allow the skin to dry.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><\/ul>\n\n\n\n<p><strong>Step 12:&nbsp;<\/strong>Administer&nbsp;the reconstituted solution<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Remove the needle cover.<\/li><li>Carefully insert the needle on the infusion set, at as small an angle as possible, into the vein.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><li>Secure the needle with a piece of tape, about 7 cm long, over the wings of the needle.<\/li><li>Gently pull the plunger back slightly until you see blood drawn in the tubing to make sure the needle is in the vein.<\/li><li>Release the lacing bandage.<\/li><li>If there is no blood in the tubing, pull out the needle, repeat all steps from the beginning of step 11, and move the needle.<\/li><li>If there is blood, gently inject the solution into the vein, as shown in the picture.&nbsp;Inject for about 5 minutes.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><li>If you have prepared two syringes:<ul><li>fold the hose close to the coupling on the infusion set to prevent backflow.<\/li><li>unscrew the empty syringe from the infusion set and replace it immediately with the other syringe.<\/li><\/ul><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><li>fold back the tubing and gently inject this solution in the same way as the first syringe.<\/li><\/ul>\n\n\n\n<p><strong>Step 13:<\/strong>&nbsp;After&nbsp;administration<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Carefully remove the tape that secures the needle and pull the needle out of the vein.<\/li><li>Once you have pulled out the needle,&nbsp;<strong>press<\/strong>&nbsp;the sterile&nbsp;compress&nbsp;against the injection site for a few minutes to reduce bleeding.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20160115000037#\" rel=\"noopener\"><\/a><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Then put&nbsp;patches&nbsp;on the injection site.<\/li><li>Fold the yellow protective cap over the needle.<\/li><li>Safely dispose of the used infusion set with needle, unused solution, syringe and empty vial in a suitable container for medical waste as these materials may harm others if not disposed of properly.&nbsp;Do not reuse equipment.<\/li><\/ul>\n\n\n\n<p><strong>Step 14:<\/strong>&nbsp;Document&nbsp;the&nbsp;administration<\/p>\n\n\n\n<p>Register (eg in your diary):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>date and time of administration<\/li><li>the batch number on the label on the powder vial.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Ruconest than you should<\/h2>\n\n\n\n<p>Contact a doctor or the nearest hospital if this happens.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If your symptoms worsen and\/or if you get a rash, tingling in the skin or difficulty breathing or if your face or tongue swells up, you should seek medical attention\u00a0immediately.\u00a0<strong>These symptoms may indicate that you have become allergic to Ruconest.<\/strong><\/p>\n\n\n\n<p>Ruconest can cause some side effects:<\/p>\n\n\n\n<p>Common: may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea<\/li><\/ul>\n\n\n\n<p>Uncommon: may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Abdominal pain, diarrhea<\/li><li>Irritating or stinging sensation or numbness in the mouth<\/li><li>Headache, dizziness<\/li><li>Decreased sensation in the skin or the arms or legs<\/li><li>Throat irritation<\/li><li>Hives<\/li><li>Swelling in the ears or the area around the ears<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Ruconest<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and the vial label after EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Keep the vial of powder in its carton.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Before Ruconest can be given, the powder must be dissolved in the liquid provided in the package (see section 3).<\/p>\n\n\n\n<p>After&nbsp;reconstitution&nbsp;of the drug, it should be used immediately.<\/p>\n\n\n\n<p>Do not use this medicine if you notice after dissolving the powder that the solution is discolored or contains particles.&nbsp;Small amounts of&nbsp;foam&nbsp;are acceptable.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>Powder vial&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is conestat alfa.\u00a0One powder\u00a0vial\u00a0contains 2100 units of conestat alfa, equivalent to 2100 units per 14 ml after\u00a0reconstitution\u00a0or a concentration of 150 units\/ml.<\/li><li>The other ingredients in the powder are sucrose, sodium citrate (E331), and citric acid.<\/li><\/ul>\n\n\n\n<p>Vial&nbsp;with liquid:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The ingredient in the liquid is water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Ruconest is supplied in a glass&nbsp;vial&nbsp;containing a white to off-white powder for solution for&nbsp;injection&nbsp;together with a glass&nbsp;vial&nbsp;containing a clear, colorless liquid to dissolve the powder.&nbsp;Once the powder has been dissolved in water for injections, the solution is clear and colorless.<\/p>\n\n\n\n<p>Ruconest is delivered as an administration kit in a box containing:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>1&nbsp;vial&nbsp;of 2,100 U powder<\/li><li>1&nbsp;vial&nbsp;with 20 ml liquid<\/li><li>2 vial adapters<\/li><li>1 syringe<\/li><li>1 infusion set with 35 cm tube and 25 G needle<\/li><li>2 alcohol compresses<\/li><li>1 sterile nonwoven&nbsp;compress<\/li><li>1 patch<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Marketing Authorisation Holder:<\/p>\n\n\n\n<p>Pharming Group NV<\/p>\n\n\n\n<p>Drawing 24<\/p>\n\n\n\n<p>2333 CR Leiden<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Manufacturer:<\/p>\n\n\n\n<p>Pharming Technologies BV<\/p>\n\n\n\n<p>Drawing 24<\/p>\n\n\n\n<p>2333 CR Leiden<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ruconest contains conestat alfa as active substance. Conestat alfa is a recombinant (not produced from blood) form of human C1 inhibitor (rhCl-INH).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[23474,23479,23470,23473,23475,23478,23472,23471,23476,23477],"class_list":["post-22515","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-conestat-alfa","tag-benefits-of-ruconest","tag-conestat-alfa","tag-conestat-alfa-side-effects","tag-ruconest","tag-ruconest-side-effects","tag-what-conestat-alfa-is-used-for","tag-what-is-conestat-alfa","tag-what-is-ruconest","tag-what-ruconest-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22515","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22515"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22515\/revisions"}],"predecessor-version":[{"id":22544,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22515\/revisions\/22544"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22515"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22515"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}