{"id":22398,"date":"2022-06-27T08:15:49","date_gmt":"2022-06-27T08:15:49","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22398"},"modified":"2022-06-27T10:19:09","modified_gmt":"2022-06-27T10:19:09","slug":"ronapreve","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ronapreve\/","title":{"rendered":"Ronapreve &#8211; Casirivimab and Imdevimab uses, dose and side effects"},"content":{"rendered":"\n<p>120 mg \/ ml + 120 mg \/ ml&nbsp;solution for injection \/ infusion<br>casirivimab and imdevimab<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Ronapreve is and what it is used for<\/h2>\n\n\n\n<p><strong>What Ronapreve is<\/strong><\/p>\n\n\n\n<p>Ronapreve consists of the active substances basiliximab and imdevimab.\u00a0Kasirivimab and imdevimab are a type of\u00a0protein\u00a0called monoclonal\u00a0antibodies.<\/p>\n\n\n\n<p><strong>What Ronapreve is used for<\/strong><\/p>\n\n\n\n<p>Ronapreve is used to treat adults and adolescents from 12 years of age who weigh at least 40 kg with covid-19 as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>do not need oxygen therapy to treat covid-19, and<\/li><li>have an increased risk of the disease becoming severe, according to the doctor&#8217;s assessment.<\/li><\/ul>\n\n\n\n<p>Ronapreve is used to prevent covid-19 in adults and adolescents from the age of 12 weighing at least 40 kg.<\/p>\n\n\n\n<p><strong>How Ronapreve works<\/strong><\/p>\n\n\n\n<p>Ronapreve attaches to a&nbsp;protein&nbsp;on the surface of the coronavirus called nail protein.&nbsp;In this way, the&nbsp;virus&nbsp;is prevented from entering your cells and from spreading between cells.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you get Ronapreve<\/h2>\n\n\n\n<p><strong>You should not receive Ronapreve<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to casirivimab, imdevimab, or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>Talk to your doctor or nurse as soon as possible if this applies to you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>This medicine may cause allergic reactions or reactions after&nbsp;infusion&nbsp;one or&nbsp;injection&nbsp;one.&nbsp;Signs of such reactions are listed in section 4. Tell your doctor immediately if you get any of these signs or symptoms.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this medicine to children under 12 years of age or adolescents weighing less than 40 kg.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Ronapreve<\/h2>\n\n\n\n<p><strong>Before<\/strong>&nbsp;you are given Ronapreve, you must tell your doctor or nurse who is giving you the medicine if you are taking any other medicines, or have recently taken any other medicines.<\/p>\n\n\n\n<p><strong>After<\/strong>&nbsp;receiving Ronapreve:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor, nurse, or pharmacist that you have been given this medicine to treat or prevent covid-19.<\/li><li>Tell your doctor, nurse, or pharmacist that you have been given this medicine if you are to receive a covid-19 vaccine.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Tell your doctor or nurse if you are pregnant or could be pregnant.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The reason for this is that there is not enough information on whether this medicine is safe to use during pregnancy.<\/li><li>This medicine is given only if the potential benefit of the treatment outweighs the potential risks to the mother and the unborn child.<\/li><\/ul>\n\n\n\n<p>Tell your doctor or nurse if you are breastfeeding.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The reason for this is that it is not yet known whether this drug passes into breast milk or whether it may affect the baby or milk production.<\/li><li>Your doctor will help you decide whether to continue breastfeeding or start treatment with this medicine.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>This medicine is not expected to have any effect on your ability to drive.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to get Ronapreve<\/h2>\n\n\n\n<p><strong>How much medicine do you give?<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for the treatment and prevention of covid-19 in adults and adolescents from 12 years of age weighing at least 40 kg is 600 mg casirivimab and 600 mg imdevimab.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0for the continued prevention of covid-19 in adults and adolescents from 12 years of age weighing at least 40 kg is 600 mg basiliximab and 600 mg imdevimab as the first\u00a0dose\u00a0and subsequent\u00a0dose\u00a0er is 300 mg basiliximab and 300 mg imdevimab once each fourth week.<\/p>\n\n\n\n<p><strong>How is this medicine given?<\/strong><\/p>\n\n\n\n<p>Kasirivimab and imdevimab can be given together as a single infusion (drip) into a vein for 20 to 30 minutes or as\u00a0injections\u00a0given directly one after the other under the skin in different parts of the body, should an\u00a0infusion\u00a0delay treatment.\u00a0Your doctor or nurse will decide how long you need to be monitored after receiving the medicine for any\u00a0side effects.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0The following\u00a0side effects\u00a0have been reported with Ronapreve.<\/p>\n\n\n\n<p><strong>Reactions after&nbsp;infusion&nbsp;one<\/strong><\/p>\n\n\n\n<p>Tell your doctor immediately if you\u00a0get any of the signs of an\u00a0allergic reaction\u00a0or reaction listed below or after\u00a0an infusion.\u00a0Infusion\u00a0one may need to be given more slowly, discontinued, or stopped, and you may need other medicines to treat these symptoms.\u00a0Signs and symptoms of an\u00a0allergic reaction\u00a0or infusion-related reactions may be:<\/p>\n\n\n\n<p><strong>Uncommon<\/strong>: may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea<\/li><li>overindulge<\/li><li>dizziness<\/li><li>rash<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>: may affect up to 1 in 1,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe&nbsp;allergic reaction&nbsp;(&nbsp;anaphylaxis&nbsp;)<\/li><li>itchy rash<\/li><li>redness<\/li><\/ul>\n\n\n\n<p><strong>Reactions after&nbsp;injection&nbsp;subcutaneously (under the skin)<\/strong><\/p>\n\n\n\n<p>Tell your doctor immediately if you get any of these signs of a reaction after the\u00a0injections.<\/p>\n\n\n\n<p><strong>Common<\/strong>: may affect up to 1 in 10 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>redness,\u00a0itching, bruising, swelling, pain, or itchy rash at the injection site<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>: may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness<\/li><li>swollen&nbsp;lymph nodes&nbsp;near the injection site<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Ronapreve<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and bottle label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Ronapreve is stored by healthcare professionals at the hospital or clinic under the following conditions:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Before use<\/strong>, store unopened Ronapreve concentrate in the refrigerator until the day it is to be used.\u00a0Before dilution, the concentrated solution should have reached room temperature.<\/li><li>After dilution, Ronapreve should be used immediately.\u00a0If necessary, the diluted solution bags can be stored at 2 \u00b0 C to 8 \u00b0 C for up to 72 hours and at room temperature up to 25 \u00b0 C for up to 20 hours.\u00a0If the solution has been stored in a refrigerator, allow it to reach room temperature for about 30 minutes before\u00a0administration.<\/li><li>Filled syringes should be used immediately.\u00a0If necessary, pre-filled syringes can be stored at 2 \u00b0 C to 8 \u00b0 C for up to 72 hours, and at room temperature up to 25 \u00b0 C for up to 24 hours.\u00a0If they have been stored in a refrigerator, the syringes should be allowed to warm to room temperature for about 10-15 minutes before\u00a0administration.<\/li><\/ul>\n\n\n\n<p>Do not use this medicine if it contains particles or is discolored.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<p><strong>Table of Contents<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are casirivimab and imdevimab.\u00a0Each 20 ml multidose vial contains 1332 mg of casirivimab or 1332 mg of imdevimab.<\/li><li>The other ingredients are L-histidine, L-histidine monohydrochloride monohydrate, polysorbate 80, sucrose, and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Ronapreve is a solution for injection\/infusion.\u00a0It is a clear to slightly opalescent and colorless to pale yellow solution and is available in cartons with 2 vials in each pack, one\u00a0vial\u00a0for each active substance.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Roche Registration GmbH<\/p>\n\n\n\n<p>Emil-Barell-Strasse 1<\/p>\n\n\n\n<p>79639 Grenzach-Wyhlen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Roche Pharma AG<\/p>\n\n\n\n<p>Emil-Barell-Strasse 1<\/p>\n\n\n\n<p>79639 Grenzach-Wyhlen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Finland \/ Finland<\/strong><\/td><td><strong>Sweden<\/strong><\/td><\/tr><tr><td>Roche OyPuh \/ Tel: +358 (0) 10 554 500<\/td><td>Roche ABTel: +46 (0) 8 726 1200<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Ronapreve consists of the active substances kasirivimab and imdevimab. Kasirivimab and imdevimab are a type of protein called monoclonal antibodies .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[23343,23335,23338,23339,23342,23330,23334,23333,23337,23341,23336,23340,23331,23332],"class_list":["post-22398","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-imdevimab","tag-casirivimab","tag-casirivimab-side-effects","tag-imdevimab","tag-imdevimab-side-effects","tag-ronapreve","tag-ronapreve-side-effects","tag-ronapreve-tablet","tag-what-casirivimab-is-used-for","tag-what-imdevimab-is-used-for","tag-what-is-casirivimab","tag-what-is-imdevimab","tag-what-is-ronapreve","tag-what-ronapreve-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22398","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22398"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22398\/revisions"}],"predecessor-version":[{"id":22425,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22398\/revisions\/22425"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22398"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22398"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22398"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}