{"id":22348,"date":"2022-06-25T06:19:19","date_gmt":"2022-06-25T06:19:19","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22348"},"modified":"2022-06-25T09:35:54","modified_gmt":"2022-06-25T09:35:54","slug":"roactemra","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/roactemra\/","title":{"rendered":"RoActemra &#8211; Tocilizumab uses, dose and side effects"},"content":{"rendered":"\n<p>162 mg\u00a0solution for injection\u00a0in a pre-filled\u00a0pen\u00a0(ACTPen\u00ae)<br>Tocilizumab<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What RoActemra is and what it is used for<\/h2>\n\n\n\n<p>RoActemra contains the active substance tocilizumab, which is a\u00a0protein\u00a0produced from specific immune cells (monoclonal\u00a0antibody\u00a0) that inhibits the effect of a specific\u00a0protein\u00a0(\u00a0cytokine\u00a0) called\u00a0interleukin\u00a0-6.\u00a0This\u00a0protein\u00a0participates in inflammatory processes in the body and by\u00a0inhibiting the\u00a0protein,\u00a0inflammation\u00a0can be\u00a0reduced in your body.\u00a0RoActemra is used to treat:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>adults with moderate to severely<\/strong> active\u00a0rheumatoid arthritis\u00a0(RA or\u00a0rheumatoid arthritis\u00a0)\u00a0which is an\u00a0autoimmune\u00a0disease, if previous treatments have not worked well enough.<\/li><li>adults with severe, active,<strong> and progressive\u00a0rheumatoid arthritis\u00a0(RA)<\/strong>\u00a0who have not been treated with methotrexate before.<\/li><\/ul>\n\n\n\n<p>RoActemra helps to reduce symptoms such as pain and swelling in your joints and you can make it easier to perform your daily chores.&nbsp;RoActemra has been shown to slow down the damage to&nbsp;cartilage&nbsp;and bone in the joints caused by the disease, and can therefore improve the ability to perform normal daily activities.<\/p>\n\n\n\n<p>RoActemra is usually given in combination with another medicine used for RA called methotrexate.&nbsp;If your doctor thinks that methotrexate is not suitable for you, RoActemra can be given alone.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>adults who have a disease of the\u00a0arteries\u00a0called giant cell arteritis (GCA)<\/strong>\u00a0and which is caused by\u00a0inflammation of the largest\u00a0arteries\u00a0in the body, especially those that supply the head and neck with blood.\u00a0Symptoms include headache, fatigue, and jaw pain.\u00a0Effects may include\u00a0stroke\u00a0or blindness.<\/li><\/ul>\n\n\n\n<p>RoActemra can reduce pain and swelling in the\u00a0arteries\u00a0and veins in your head, neck, and arms.<\/p>\n\n\n\n<p>GCA is most often treated with a drug called\u00a0cortisone.\u00a0These are usually effective but can have\u00a0side effects\u00a0when used in high\u00a0doses\u00a0for a long time.\u00a0A reduction in\u00a0dose\u00a0one can also lead to a recurrence of GCA.\u00a0Adding RoActemra to the treatment means that\u00a0cortisone\u00a0can be used for a shorter time and the disease is still kept under control.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>children and adolescents, 12 years and older, with active&nbsp;<em>systemic&nbsp;juvenile idiopathic arthritis&nbsp;(sJIA)<\/em><\/strong>&nbsp;which is an&nbsp;inflammatory&nbsp;disease that causes pain and swelling in one or more joints as well as fever and rash.<br><br>RoActemra is used to improve the symptoms of sJIA and can be given in combination with methotrexate or alone.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>children and adolescents 12 years of age or older with active <\/strong>polyarticular\u00a0juvenile idiopathic arthritis\u00a0(DJIA).\u00a0DJIA is an\u00a0inflammatory\u00a0disease that causes pain and swelling in one or more joints.<br><br>RoActemra is used to improve the symptoms of DJIA and can be given in combination with methotrexate or alone<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using RoActemra<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use RoActemra<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you or the child you are caring for are allergic to tocilizumab or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you or the child you are caring for has an active, severe\u00a0infection.<\/li><\/ul>\n\n\n\n<p>If any of these apply to you, tell your doctor.&nbsp;Do not use RoActemra.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using RoActemra.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you get an\u00a0<strong>allergic reaction<\/strong>\u00a0such as pressure over the chest, wheezing, severe dizziness or fainting, swollen lips, tongue, face or\u00a0itching\u00a0of the skin,\u00a0hives\u00a0or rash during or after\u00a0injection,\u00a0contact a doctor immediately.<\/li><li>If you have experienced symptoms of an\u00a0allergic reaction\u00a0after taking RoActemra, do not take the next\u00a0dose\u00a0until you have informed your doctor AND your doctor has told you to take the next\u00a0dose.<\/li><li>If you have any type of\u00a0infection, either short-term or long-term, or if you often suffer from\u00a0an infection.\u00a0<strong>Contact a doctor immediately<\/strong>\u00a0if you do not feel well.\u00a0RoActemra may reduce the body&#8217;s ability to handle\u00a0infections\u00a0and may aggravate an ongoing\u00a0infection\u00a0or increase the risk of a new\u00a0infection.<\/li><li>If you have had\u00a0tuberculosis, talk to your doctor.\u00a0Your doctor will check for any signs and symptoms of\u00a0tuberculosis\u00a0before starting treatment with RoActemra.\u00a0If symptoms of\u00a0tuberculosis\u00a0(persistent cough, weight loss, listlessness, mild fever) or any other\u00a0infection\u00a0occurs during or after treatment, contact your doctor immediately.<\/li><li>If you have a\u00a0history of intestinal ulcers\u00a0or\u00a0diverticulitis\u00a0(inflamed pockets on the intestines), talk to your doctor.\u00a0Symptoms may include abdominal pain and unexplained changes in bowel movements and fever.<\/li><li>If you have any\u00a0liver disease, talk to your doctor.\u00a0Before using RoActemra, your doctor may need to take a blood test to measure your liver function.<\/li><li>If you as a patient have recently been vaccinated, or are planning to be vaccinated, talk to your doctor.\u00a0It is recommended that all patients be immunized according to current vaccination guidelines before starting RoActemra treatment.\u00a0Certain types of vaccines should not be given during treatment with RoActemra.<\/li><li>If you have\u00a0cancer, talk to your doctor.\u00a0Your doctor will need to decide if you can then be treated with RoActemra.<\/li><li>If you have\u00a0risk factors for cardiovascular disease\u00a0such as high\u00a0blood pressure\u00a0or high cholesterol levels, talk to your doctor.\u00a0These factors need to be followed during your treatment with RoActemra.<\/li><li>If you have moderate to severe\u00a0problems with kidney function, your doctor will follow this up.<\/li><li>If you have\u00a0<strong>persistent headaches.<\/strong><\/li><\/ul>\n\n\n\n<p>Your doctor will take blood samples before you receive RoActemra, to determine that you do not have too few&nbsp;white blood cells&nbsp;or&nbsp;platelets&nbsp;or too high levels of liver enzymes in your blood.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>RoActemra pre-filled pen&nbsp;(ACTPen&nbsp;\u00ae&nbsp;<sup>)<\/sup>&nbsp;is not recommended for children under 12 years of age.&nbsp;RoActemra must not be given to children with sJIA weighing less than 10 kg.<\/p>\n\n\n\n<p>If a child has previously had&nbsp;<strong><em>macrophage activation syndrome<\/em><\/strong>&nbsp;(an activation and uncontrolled increase in specific blood cells), talk to your doctor.&nbsp;Your doctor must decide if they can then be treated with RoActemra.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and RoActemra<\/h2>\n\n\n\n<p>Tell your doctor if you are taking or have recently taken any other medicines.&nbsp;RoActemra may affect the way some medicines work and the&nbsp;dose&nbsp;of one of your medicines may need to be adjusted.&nbsp;<strong>Tell your doctor<\/strong>&nbsp;if you are taking medicines that contain any of the following active substances:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Methylprednisolone, and <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toflacort\/\">dexamethasone<\/a>, is used to reduce\u00a0inflammation<\/li><li>simvastatin\u00a0or atorvastatin is used to reduce cholesterol levels<\/li><li>calcium antagonist (eg amlodipine), is used to treat high\u00a0blood pressure<\/li><li>theophylline is used to treat\u00a0asthma<\/li><li>warfarin\u00a0or phenprocoumon, is used as a blood thinner<\/li><li>phenytoin\u00a0used to treat\u00a0epilepsy<\/li><li>ciclosporin is used to\u00a0inhibit\u00a0the immune system in connection with organ transplantation<\/li><li>benzodiazepines (eg temazepam), are used to relieve anxiety.<\/li><\/ul>\n\n\n\n<p>Due to the lack of clinical experience, the use of RoActemra in combination with other biologics for the treatment of RA, sJIA, DJIA, or GCA is not recommended.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><strong>RoActemra should not be used during pregnancy<\/strong>\u00a0unless necessary.\u00a0Talk to your doctor if you are pregnant, possibly pregnant, or planning to become pregnant.<\/p>\n\n\n\n<p><strong>Women of&nbsp;childbearing potential&nbsp;must<\/strong>&nbsp;use effective contraception during and up to 3 months after treatment.<\/p>\n\n\n\n<p><strong>Stop breastfeeding<\/strong> if you are going to receive RoActemra, and talk to your doctor.\u00a0Take a break for at least 3 months after your last treatment before starting breastfeeding.\u00a0It is unknown whether RoActemra passes into breast milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>This medicine may cause dizziness.&nbsp;If you experience dizziness, do not drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use RoActemra<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor, pharmacist or nurse has told you.\u00a0If you are not sure, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<p>The treatment will be prescribed and started by healthcare professionals who have experience in the diagnosis and treatment of RA, sJIA, DJIA, or GCA.<\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;is one<\/strong><\/p>\n\n\n\n<p>The dose&nbsp;of RA or GCA for all adults is 162 mg (contained in 1 pre-filled&nbsp;pen&nbsp;) given once a week.<\/p>\n\n\n\n<p><strong>Children and adolescents with sJIA (12 years or older)<\/strong><\/p>\n\n\n\n<p><strong>The usual&nbsp;dose&nbsp;of RoActemra depends on the weight of the patient.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If the patient weighs\u00a0<strong>less than 30 kg<\/strong>, the dose is 162 mg (the contents of a pre-filled\u00a0pen\u00a0) once every two weeks.<\/li><li>If the patient weighs\u00a030 kg or more, the dose is 162 mg (the contents of a pre-filled\u00a0pen\u00a0) once a week.<\/li><\/ul>\n\n\n\n<p>The pre-filled pen should not be used to treat children under 12 years of age.<\/p>\n\n\n\n<p><strong>Children and adolescents with DJIA (12 years or older)<\/strong><\/p>\n\n\n\n<p><strong>The usual&nbsp;dose&nbsp;of RoActemra depends on the weight of the patient.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If the patient weighs\u00a0<strong>less than 30 kg<\/strong>, the dose is 162 mg (the contents of a pre-filled\u00a0pen\u00a0)\u00a0once every three weeks.<\/li><li>If the patient weighs\u00a030 kg or more, the dose is 162 mg (the contents of a pre-filled\u00a0pen\u00a0)<strong>, once every two weeks.<\/strong><\/li><\/ul>\n\n\n\n<p>The pre-filled pen should not be used to treat children under 12 years of age.<\/p>\n\n\n\n<p>RoActemra is given as an&nbsp;injection&nbsp;under the skin (&nbsp;subcutaneously&nbsp;).&nbsp;Initially, your doctor or nurse may inject RoActemra (ACTPen\u00ae).&nbsp;Your doctor may also decide that you can inject RoActemra yourself.&nbsp;In this case, you will learn to inject RoActemra yourself.&nbsp;Parents and caregivers receive training in how to inject RoActemra for patients who cannot inject themselves, such as children.<\/p>\n\n\n\n<p>Talk to your doctor if you have any questions about injecting RoActemra or a child you are taking care of yourself.&nbsp;You will find detailed instructions for&nbsp;injection&nbsp;at the end of this leaflet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more RoActemra than you should&nbsp;<\/h2>\n\n\n\n<p>Because RoActemra is given with a pre-filled\u00a0pen, it is unlikely that you will get too much.\u00a0If you are still worried, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use RoActemra<\/h2>\n\n\n\n<p><strong>If an adult patient with RA or GCA or a child or adolescent with sJIA misses or misses a&nbsp;dose<\/strong><\/p>\n\n\n\n<p>It is very important to use RoActemra exactly as your doctor has told you.\u00a0Keep track of when to take your next\u00a0dose.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have forgotten your weekly dose and it has not been more than 7 days, take your&nbsp;dose&nbsp;on the next scheduled day.<\/li><li>If you forget your&nbsp;dose&nbsp;that is taken every two weeks and it has not been more than 7 days, inject one&nbsp;dose&nbsp;as soon as you remember and take your next&nbsp;dose&nbsp;on your usual scheduled day.<\/li><li>If you have forgotten your weekly dose or&nbsp;dose&nbsp;taken every two weeks for more than 7 days or are not sure when to inject RoActemra, call your doctor or pharmacist.<\/li><\/ul>\n\n\n\n<p><strong>If a child or adolescent with pJIA misses or misses a&nbsp;dose<\/strong><\/p>\n\n\n\n<p>It is very important to use RoActemra exactly as your doctor has told you.\u00a0Keep track of your next\u00a0dose.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If one\u00a0dose\u00a0is missed within 7 days of scheduled\u00a0dosing, inject one\u00a0dose\u00a0as soon as you remember and give the next\u00a0dose\u00a0as usual on the scheduled day.<\/li><li>If a\u00a0dose\u00a0is missed by more than 7 days after the scheduled\u00a0dose\u00a0or if you are not sure when to inject RoActemra, call your doctor or pharmacist.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using RoActemra<\/h2>\n\n\n\n<p>You should not stop using RoActemra without first discussing it with your doctor.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, RoActemra can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Side effects&nbsp;can occur up to at least 3 months after your last&nbsp;dose&nbsp;of RoActemra.<\/p>\n\n\n\n<p><strong>Possible serious side effects: Talk to a doctor immediately.<\/strong><br><em>These are common and may affect up to 1 in 10 users<\/em><\/p>\n\n\n\n<p><strong>Allergic reactions<\/strong>&nbsp;during or after the injection:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty breathing, pressure over the chest or dizziness<\/li><li>rash,\u00a0itching,\u00a0hives, swollen lips, tongue, or face.<\/li><\/ul>\n\n\n\n<p>If you experience any of these, talk to your doctor&nbsp;<strong>immediately.<\/strong><\/p>\n\n\n\n<p><strong>Signs of serious infections:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever and chills<\/li><li>blisters in the mouth or skin<\/li><li>magnet.<\/li><\/ul>\n\n\n\n<p><strong>Signs and symptoms of liver toxicity<\/strong><\/p>\n\n\n\n<p><em>It May affect up to 1 in 1,000 users<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fatigue<\/li><li>abdominal pain<\/li><li>jaundice (yellowish discoloration of skin and eyes)<\/li><\/ul>\n\n\n\n<p>If you experience any of these, talk to your doctor&nbsp;<strong>as soon as possible.<\/strong><\/p>\n\n\n\n<p><strong>Very common side effects:<\/strong><\/p>\n\n\n\n<p><em>It May affect more than 1 user in 10<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>upper respiratory tract infection with typical symptoms such as cough, nasal congestion, runny nose, sore throat, headache<\/li><li>high blood fat (\u00a0cholesterol\u00a0) levels.<\/li><li>injection site reactions.<\/li><\/ul>\n\n\n\n<p><strong>Common side effects:<\/strong><\/p>\n\n\n\n<p><em>It May affect up to 1 in 10 users<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pneumonia\u00a0_\u00a0_\u00a0_<\/li><li>shingles\u00a0(\u00a0herpes\u00a0zoster)<\/li><li>sores on the lips (cold sores), blisters<\/li><li>skin infection (\u00a0cellulite\u00a0) sometimes with fever and chills<\/li><li>rash and\u00a0itching,\u00a0hives<\/li><li>allergic (hypersensitivity) reactions<\/li><li>eye infection\u00a0(\u00a0conjunctivitis\u00a0)<\/li><li>headache, dizziness, high\u00a0blood pressure<\/li><li>cold sores, stomach pain<\/li><li>fluid retention (\u00a0edema\u00a0) in the lower legs, weight gain<\/li><li>cough, shortness of breath<\/li><li>low\u00a0white blood cell count\u00a0measured by blood tests (\u00a0neutropenia,\u00a0leukopenia\u00a0)<\/li><li>abnormal liver function values \u200b\u200b(elevated\u00a0transaminases\u00a0)<\/li><li>elevated\u00a0bilirubin\u00a0measured by blood tests<\/li><li>decreased levels of fibrinogen in the blood (a\u00a0protein\u00a0involved in blood coagulation).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon side effects:<\/strong><\/p>\n\n\n\n<p><em>It May affect up to 1 in 100 users<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diverticulitis\u00a0(inflamed pockets in the intestine that cause fever, nausea, diarrhea, constipation, abdominal pain)<\/li><li>red and swollen parts of the mouth<\/li><li>high blood fats (\u00a0triglycerides\u00a0)<\/li><li>gastric ulcer<\/li><li>kidney stone<\/li><li>hypothyroidism.\u00a0_<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p><em>It May affect up to 1 in 1,000 users<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stevens-Johnson syndrome&nbsp;(skin rash that can lead to severe blisters and skin loosening)<\/li><li>fatal allergic reactions (&nbsp;anaphylaxis&nbsp;[fatal])<\/li><li>inflammation&nbsp;of the liver (&nbsp;hepatitis&nbsp;), jaundice<\/li><\/ul>\n\n\n\n<p><strong>Very rare side effects:<\/strong><\/p>\n\n\n\n<p><em>It May affect up to 1 in 10,000 users<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low blood counts for\u00a0white blood cells,\u00a0red blood cells,\u00a0and\u00a0platelets\u00a0are shown by blood tests<\/li><li>liver failure<\/li><\/ul>\n\n\n\n<p><strong>Side effects\u00a0are in children and adolescents with sJIA or JPA<\/strong><\/p>\n\n\n\n<p>Side effects\u00a0in children and adolescents with sJIA or DJIA are generally similar to those in adults.\u00a0Some\u00a0side effects\u00a0are more common in children and adolescents such as\u00a0inflammation\u00a0of the nose and throat, headache, nausea, and lower\u00a0white blood cell count.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store RoActemra<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the pre-filled pen label and carton (EXP or EXP).&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C).&nbsp;Do not freeze.&nbsp;The pre-filled pen can be stored for up to 2 weeks at a maximum of 30 \u00b0 C after being taken out of the refrigerator.<\/p>\n\n\n\n<p>Store the pre-filled pens in the outer carton.&nbsp;Sensitive to light.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Do not use this medicine if it is cloudy or contains particles, if the solution has a color other than clear to slightly yellowish or if any part of the pre-filled pen appears to be damaged.<\/p>\n\n\n\n<p>The pen must not be shaken.\u00a0After removing the cap, RoActemra must be injected within 3 minutes to prevent the drug from drying out and blocking the needle.\u00a0If the pre-filled pen is not used within 3 minutes after removing the cap, discard it in a non-stick container and use a new pre-filled\u00a0pen.<\/p>\n\n\n\n<p>If the purple indicator does not move after pressing the activation button, discard the pre-filled pen in a non-stick container.\u00a0<strong>Do not attempt<\/strong>\u00a0to reuse the pre-filled pen.\u00a0Do not repeat the injection with a new pre-filled\u00a0pen.\u00a0Contact your doctor for assistance.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">What RoActemra contains<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tocilizumab. Each pre-filled\u00a0pen\u00a0contains 162 mg of tocilizumab in 0.9 ml.<\/li><li>The other ingredients are L-histidine, L-histidine monohydrochloride monohydrate, L-arginine \/ L-arginine hydrochloride, L-methionine, Polysorbate 80, and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>RoActemra is a\u00a0solution for injection.\u00a0The solution is colorless to slightly yellowish.<\/p>\n\n\n\n<p>RoActemra is supplied as a 0.9 ml pre-filled\u00a0pen\u00a0containing 162 mg of tocilizumab\u00a0solution for injection.<\/p>\n\n\n\n<p>Each pack contains 4 pre-filled pens&nbsp;<strong>with a multi-pack containing 12 (3 packs of 4) pre-filled pens.&nbsp;Not all pack sizes may be marketed.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Roche Registration GmbH<\/p>\n\n\n\n<p>Emil-Barell-Strasse 1<\/p>\n\n\n\n<p>79639 Grenzach-Wyhlen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Roche Pharma AG<\/p>\n\n\n\n<p>Emil-Barell-Str.&nbsp;1<\/p>\n\n\n\n<p>79639 Grenzach-Wyhlen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>For any information about this medicine, please contact the local representative of the Marketing Authorization Holder:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Finland \/ Finland<\/strong>Roche OyPuh \/ Tel: +358 (0) 10 554 500<\/td><td><strong>Sweden<\/strong>Roche ABTel: +46 (0) 8 726 1200<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>RoActemra contains the active substance tocilizumab, which is a protein produced from specific immune cells (monoclonal antibody ) that inhibits the effect of a specific protein ( cytokine ) called interleukin -6. This protein participates in inflammatory processes in the body and by inhibiting the protein , inflammation can be reduced in your body. RoActemra is used to treat:<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[23290,23284,23285,23289,23280,23283,23286,23281,23288,23282],"class_list":["post-22348","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-roactemra","tag-benefits-of-tocilizumab","tag-roactemra","tag-roactemra-side-effects","tag-tocilizumab","tag-tocilizumab-side-effects","tag-what-is-roactemra","tag-what-is-tocilizumab","tag-what-roactemra-is-used-for","tag-what-tocilizumab-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22348"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22348\/revisions"}],"predecessor-version":[{"id":22385,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22348\/revisions\/22385"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22348"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22348"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}