{"id":22094,"date":"2022-06-18T07:47:16","date_gmt":"2022-06-18T07:47:16","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22094"},"modified":"2022-06-18T12:23:49","modified_gmt":"2022-06-18T12:23:49","slug":"riamet","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/riamet\/","title":{"rendered":"Riamet | Artemeter and Lumefantrine uses, dose and side effects"},"content":{"rendered":"\n<p>20 mg \/ 120 mg&nbsp;tablets<br>artemeter and lumefantrine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Riamet is and what it is used for<\/h2>\n\n\n\n<p>Riamet is used only for the treatment of\u00a0acute, uncomplicated malaria infection caused by the parasite &#8220;Plasmodium falciparum&#8221;.\u00a0This parasite is a small\u00a0organism\u00a0that consists of a single cell and is found inside the red\u00a0blood cells.<\/p>\n\n\n\n<p>Riamet is used to treat adults, children, and infants weighing at least 5 kg.<\/p>\n\n\n\n<p>Riamet is not used to prevent\u00a0malaria\u00a0or to treat severe\u00a0malaria\u00a0(when the brain, lungs, or kidneys are affected).<\/p>\n\n\n\n<p>Riamet contains two substances, artemether, and lumefantrine.\u00a0They belong to a group of drugs called malaria drugs.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Riamet<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Riamet<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic (hypersensitive) to artemether and lumefantrine or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have a severe form of malaria infection affecting the brain, lungs, or kidneys<\/li><li>if you have heart problems, such as heart rhythm disorders, slow heartbeat, or severe heart disease<\/li><li>if a close relative (parents, siblings, grandparents) died suddenly due to heart problems or congenital heart defects<\/li><li>if your doctor has found that you have low levels of salts in your blood, such as\u00a0potassium\u00a0or\u00a0magnesium<\/li><li>if you are taking the following medicines:\u00a0flecainide,\u00a0metoprolol, imipramine, amitriptyline, clomipramine, certain\u00a0antibiotics\u00a0(\u00a0macrolides,\u00a0fluoroquinolones, imidazole), certain antifungal medicines (triazole derivatives), terfenadine, astemizole, cisapride (see also &#8220;Other medicines&#8221; and Riam) ).<\/li><li>if you are taking certain medicines (see also &#8220;Other medicines and Riamet&#8221;).<\/li><\/ul>\n\n\n\n<p>If any of the above applies to you, talk to a doctor and do not take Riamet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Riamet:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have severe liver or kidney disease<\/li><li>if you have heart problems such as\u00a0QT\u00a0prolongation (abnormal\u00a0ECG\u00a0)<\/li><li>if you are infected with both the parasite Plasmodium falciparum and Plasmodium vivax<\/li><li>if you have taken any other medicine to treat\u00a0malaria.\u00a0Some of these medicines should not be used at the same time as Riamet.<\/li><li>if you are pregnant in the first 3 months of pregnancy or intend to become pregnant.\u00a0Your doctor will give you another medicine as your first option.<\/li><li>if you feel worse or if you can not eat or drink.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you, talk to your doctor before taking Riamet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Riamet<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<p>Do not take Riamet and talk to a doctor if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs for the treatment of heart rhythm disorders such as\u00a0flecainide\u00a0or\u00a0metoprolol<\/li><li>drugs for the treatment of depression such as imipramine, amitriptyline, or clomipramine<\/li><li>drugs for the treatment of infections:<ul><li>rifampin is an\u00a0antibiotic\u00a0used to treat leprosy and\u00a0tuberculosis.<\/li><li>certain antibiotics:\u00a0macrolides,\u00a0fluoroquinolones\u00a0and imidazole<\/li><li>triazole derivatives, antifungal agents<\/li><\/ul><\/li><li>medicines to treat\u00a0allergies\u00a0or\u00a0inflammation\u00a0called &#8216;non-sedating antihistamines&#8217; such as terfenadine and astemizole<\/li><li>cisapride, a medicine for stomach upset.<\/li><li>certain drugs for the treatment of\u00a0epilepsy\u00a0(such as carbamazepine,\u00a0and phenytoin\u00a0).<\/li><li>St. John&#8217;s wort\u00a0(\u00a0<em>Hypericum perforatum<\/em>\u00a0) is a medicinal plant or extract of this medicinal plant that is used to treat, for example, depression.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>any other drug for the treatment of&nbsp;malaria<\/li><li>medicines to&nbsp;treat&nbsp;HIV&nbsp;infection&nbsp;or&nbsp;AIDS<\/li><li>a hormonal contraceptive (in this case, you should use another method of contraception).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Riamet with food and drink<\/h2>\n\n\n\n<p>Riamet should be taken with food or drink containing fats such as milk.&nbsp;Be careful with grapefruit juice.&nbsp;Consult a doctor about suitable food or drink to take with Riamet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Riamet is not recommended during the first three months of pregnancy and if possible, your doctor will prescribe another medicine in the first instance.&nbsp;In the latter part of your pregnancy, you should use Riamet if your doctor thinks it is appropriate for you.<\/p>\n\n\n\n<p>Your doctor will explain the possible risks of taking Riamet during pregnancy.&nbsp;If you are taking hormonal contraceptives, you should also use another method of contraception for about a month.<\/p>\n\n\n\n<p>You should not breastfeed while taking Riamet.\u00a0After completing the Riamet treatment, you should wait a week before starting breastfeeding again.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Riamet can make you feel sleepy, dizzy, or generally weak.\u00a0If this applies to you, do not drive or use any tools or machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Riamet contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per tablet, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Riamet<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How to take Riamet<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>take the tablets with food or drink containing fat such as milk.\u00a0Consult a doctor about suitable food or drink to take with Riamet.<\/li><li>if you feel unwell or are too ill to eat and drink consult a doctor.<\/li><li>if you vomit within an hour of taking the tablets, you should take a new\u00a0dose.\u00a0If you are not sure, talk to a doctor.<\/li><\/ul>\n\n\n\n<p><strong>Use for children<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>when\u00a0dosing\u00a0small children or infants, the tablets may be crushed.<\/li><\/ul>\n\n\n\n<p>When treating children, you will receive a pack of 24 tablets.&nbsp;Follow your doctor&#8217;s instructions carefully and use only the amount of tablets needed.&nbsp;Return the remaining tablets to the pharmacy.<\/p>\n\n\n\n<p><strong>Dosage&nbsp;of Riamet<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Six\u00a0doses\u00a0should be taken over 3 days.<\/li><li>The first\u00a0dose\u00a0should be taken as soon as possible and the subsequent five\u00a0doses\u00a0should be taken 8, 24, 36, 48, and 60 hours after the first\u00a0dose\u00a0as described in the section below.<\/li><li>When you or your child has taken the first\u00a0dose, calculate the times for the subsequent\u00a0doses\u00a0and write them down.<\/li><li>All\u00a0doses\u00a0must be taken at the right time for the full effect of the medicine to be achieved.<\/li><\/ul>\n\n\n\n<p><strong>Adults and children weighing 35 kg or more<\/strong><\/p>\n\n\n\n<p>Take four tablets at each dose.<\/p>\n\n\n\n<p>You take as follows:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>4 tablets as soon as possible, thereafter<\/li><li>4 tablets 8 hours later, thereafter<\/li><li>4 tablets 24 hours after the first\u00a0dose\u00a0one, thereafter<\/li><li>4 tablets 36 hours after the first\u00a0dose\u00a0one, thereafter<\/li><li>4 tablets 48 hours after the first\u00a0dose\u00a0one and<\/li><li>finally 4 tablets 60 hours after the first\u00a0dose.<\/li><\/ul>\n\n\n\n<p>This means that you take a total of 24 tablets.<\/p>\n\n\n\n<p>No special precautions or dose adjustments are required for the treatment of the elderly.<\/p>\n\n\n\n<p><strong>Infants and children weighing between 5 and 35 kg<\/strong><\/p>\n\n\n\n<p>The number of tablets you need to give your child depends on the weight of the child:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For children weighing between 5 and 15 kg: give 1 tablet according to the above times.\u00a0This means that your child takes a total of 6 tablets.<\/li><li>For children weighing between 15 and 25 kg: give 2 tablets according to the above times.\u00a0This means that your child takes a total of 12 tablets.<\/li><li>For children weighing between 25 and 35 kg: give 3 tablets according to the above times.\u00a0This means that your child takes a total of 18 tablets.<\/li><\/ul>\n\n\n\n<p><strong>If the malaria infection returns<\/strong><\/p>\n\n\n\n<p>The second course of treatment with Riamet may be necessary if the malaria infection returns or if you become infected with \u201cPlasmodium falciparum\u201d again after recovering.\u00a0If this happens, consult a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Riamet than you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has accidentally ingested the medicine, contact a doctor or hospital for risk assessment and advice.\u00a0You may need medical attention.\u00a0Remember to take the medicine with you and show it to the healthcare staff.\u00a0If the tablets run out, bring the empty pack.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Riamet<\/h2>\n\n\n\n<p>Try to avoid forgetting any\u00a0dose.\u00a0If you still forget to take a dose of Riamet, take it as soon as you remember if it is not time for the next\u00a0dose.\u00a0In this case, take the next\u00a0dose\u00a0at the usual time.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.\u00a0Ask your doctor for advice if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Riamet<\/h2>\n\n\n\n<p>Do not stop treatment unless your doctor tells you to.&nbsp;Always follow your doctor&#8217;s instructions carefully and complete the treatment.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Most\u00a0side effects\u00a0are mild to moderate and usually, go away after a few days to a few weeks after stopping treatment.\u00a0Some\u00a0side effects\u00a0have been reported more frequently in children while others have been reported more often in adults.\u00a0In cases where this differs, a\u00a0side effect\u00a0has been reported with the most frequent frequency.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;can be serious and require immediate medical attention.<\/strong><\/p>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people)<\/p>\n\n\n\n<p>If you get a rash, swelling of the face, lips, tongue, or throat with difficulty swallowing or breathing, contact a doctor immediately.\u00a0This is a sign of an\u00a0allergic reaction.<\/p>\n\n\n\n<p><strong>Other side effects:<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people)<\/p>\n\n\n\n<p>Rapid\u00a0heart rate, headache, dizziness, cough, vomiting, abdominal pain, nausea, muscle, and joint pain, decreased appetite, general weakness\/fatigue, and difficulty sleeping.<\/p>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<p>Involuntary muscle contractions (sometimes as rapid\u00a0spasms\u00a0), cardiac arrhythmias (called prolonged\u00a0QT interval\u00a0), unexplained and persistent symptoms such as nausea, stomach upset, decreased appetite or unusual tiredness or weakness (signs of liver effects), diarrhea, abnormal gait *, tingling or tingling in hands and feet *, rash or\u00a0itching, insomnia.<\/p>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<p>Difficulty coordinating movements *decreased sensitivity of the skin *, drowsiness, itchy rash.<\/p>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurs in an unknown number of users)<\/p>\n\n\n\n<p>Anemia\u00a0is due to\u00a0red blood cell\u00a0degradation, which has been reported up to a few weeks after stopping treatment (delayed\u00a0hemolytic anemia\u00a0).<\/p>\n\n\n\n<p>*) These&nbsp;side effects&nbsp;have been reported in adults and adolescents over 12 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store the Riamet<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<\/p>\n\n\n\n<p>Do not use this medicine if the package is damaged or shows signs of tampering.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances in Riamet are artemether and lumefantrine.<\/li><li>The other ingredients are polysorbate 80, hypromellose, microcrystalline cellulose,\u00a0colloidal\u00a0silica, croscarmellose sodium, and magnesium stearate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Riamet tablets are light yellow, round, and imprinted with \u201cNC\u201d on one side and \u201cCG\u201d on the other.<\/p>\n\n\n\n<p>Riamet is supplied in blister packs containing 24 tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Novartis Sverige AB<\/p>\n\n\n\n<p>Box 1218&nbsp;<\/p>\n\n\n\n<p>164 28 Kista<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Riamet is used only for the treatment of acute , uncomplicated malaria infection caused by the parasite &#8220;Plasmodium falciparum&#8221;. This parasite is a small organism that consists of a single cell and is found inside the red blood cells .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[23010,23013,23014,23017,23005,23008,23009,23012,23011,23015,23006,23016,23007],"class_list":["post-22094","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-artemeter","tag-artemeter-tablet","tag-lumefantrine","tag-lumefantrine-tablet","tag-riamet","tag-riamet-side-effects","tag-riamet-tablet","tag-what-artemeter-is-used-for","tag-what-is-artemeter","tag-what-is-lumefantrine","tag-what-is-riamet","tag-what-lumefantrine-is-used-for","tag-what-riamet-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22094","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22094"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22094\/revisions"}],"predecessor-version":[{"id":22132,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22094\/revisions\/22132"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22094"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22094"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22094"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}