{"id":22070,"date":"2022-06-17T05:22:47","date_gmt":"2022-06-17T05:22:47","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22070"},"modified":"2022-06-18T12:24:10","modified_gmt":"2022-06-18T12:24:10","slug":"rezolsta","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/rezolsta\/","title":{"rendered":"REZOLSTA &#8211; Darunavir \/ cobicistat uses, dose and side effects"},"content":{"rendered":"\n<p>800 mg \/ 150 mg\u00a0film-coated tablets<br>darunavir\/cobicistat<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What REZOLSTA is and what it is used for<\/h2>\n\n\n\n<p><strong>What is REZOLSTA?<\/strong><\/p>\n\n\n\n<p>REZOLSTA contains the active substances darunavir and cobicistat.<\/p>\n\n\n\n<p>Darunavir belongs to a group of&nbsp;HIV&nbsp;medicines called&nbsp;protease inhibitors&nbsp;that work by reducing the amount of&nbsp;HIV&nbsp;in the body to a very low level.&nbsp;It is given with cobicistat which increases the amount of darunavir in the blood.<\/p>\n\n\n\n<p>Treatment with REZOLSTA strengthens your immune system (your body&#8217;s natural defenses) and reduces the risk of developing diseases associated with\u00a0HIV\u00a0infection, but REZOLSTA is not a\u00a0cure\u00a0for\u00a0HIV\u00a0infection.<\/p>\n\n\n\n<p><strong>What is it used for?<\/strong><\/p>\n\n\n\n<p>REZOLSTA is used to treat adults and adolescents who are 12 years of age or older and weigh at least 40 kg, who are infected with&nbsp;HIV&nbsp;(see \u201cHow to take REZOLSTA\u201d).<\/p>\n\n\n\n<p>You must take REZOLSTA with other\u00a0HIV\u00a0medicines.\u00a0Your doctor will discuss with you which drug combination is best for you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking REZOLSTA<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take REZOLSTA<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are\u00a0<strong>allergic<\/strong>\u00a0to darunavir, cobicistat, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have\u00a0severe liver disease.\u00a0Talk to your doctor if you are unsure about the severity of your liver disease.\u00a0Additional tests may be necessary.<\/li><\/ul>\n\n\n\n<p>Tell your doctor about&nbsp;<strong>all<\/strong>&nbsp;medicines you take, including medicines you take by mouth, inhale, inject or lubricate your skin.<\/p>\n\n\n\n<p><strong>Do not combine REZOLSTA with any of the following medicines:<\/strong><\/p>\n\n\n\n<p>If you take any of these, ask your doctor if you can switch to another medicine<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Drug<\/strong><\/td><td><strong>Purpose of the drug<\/strong><\/td><\/tr><tr><td><em>Alfuzosin<\/em><\/td><td>for the treatment of enlarged&nbsp;prostate<\/td><\/tr><tr><td><em>Amiodarone&nbsp;, bepridil, dronedarone,&nbsp;<\/em><em>ivabradine&nbsp;,&nbsp;<\/em><em>&nbsp;quinidine, ranolazine<\/em><\/td><td>to treat certain heart diseases,<br>e.g.&nbsp;irregular heartbeat<\/td><\/tr><tr><td><em>Carbamazepine, phenobarbital and&nbsp;phenytoin<\/em><\/td><td>to treat seizures<\/td><\/tr><tr><td><em>Astemizole<\/em>&nbsp;or&nbsp;<em>terfenadine<\/em><\/td><td>to treat allergy symptoms<\/td><\/tr><tr><td><em>Colchicine<\/em>\u00a0(if you have kidney\/liver problems)<\/td><td>to treat&nbsp;gout&nbsp;or familial Mediterranean fever<\/td><\/tr><tr><td><em>Combination drugs with lopinavir \/ ritonavir<\/em><\/td><td>anti &#8211;&nbsp;HIV&nbsp;drugs<\/td><\/tr><tr><td><em>Rifampicin<\/em><\/td><td>to treat certain&nbsp;infections&nbsp;such as&nbsp;tuberculosis<\/td><\/tr><tr><td><em>Lurasidone, pimozide<\/em>&nbsp;,&nbsp;<em>quetiapine<\/em>&nbsp;or&nbsp;<em>sertindole<\/em><\/td><td>to treat psychiatric conditions<\/td><\/tr><tr><td><em>Ergotalkaloids<\/em>&nbsp;such as&nbsp;<em>ergotamine<\/em>&nbsp;,&nbsp;<em>dihydroergotamine<\/em>&nbsp;,&nbsp;<em>ergometry<\/em>&nbsp;and&nbsp;<em>methylergonovine<\/em><\/td><td>to treat migraine headaches<\/td><\/tr><tr><td><em>Cisapride<\/em><\/td><td>to treat certain stomach problems<\/td><\/tr><tr><td><em>St. John&#8217;s wort&nbsp;(Hypericum perforatum)<\/em><\/td><td>herbal medicine used for mild depression and mild anxiety<\/td><\/tr><tr><td><em>Elbasvir \/ grazoprevir<\/em><\/td><td>to treat&nbsp;hepatitis&nbsp;C&nbsp;infection<\/td><\/tr><tr><td><em>Lovastatin,&nbsp;<\/em><em>simvastatin&nbsp;and lomitapid<\/em><\/td><td>to lower cholesterol levels<\/td><\/tr><tr><td><em>Triazolam<\/em>&nbsp;or&nbsp;<em>orally<\/em>&nbsp;(taken orally)&nbsp;<em>midazolam<\/em><\/td><td>to help you sleep and\/or to relieve anxiety<\/td><\/tr><tr><td><em>Sildenafil<\/em><\/td><td>to treat a heart and lung disease called\u00a0pulmonary\u00a0arterial\u00a0hypertension.\u00a0Sildenafil has other uses.\u00a0See section \u201cOther medicines and REZOLSTA\u201d.<\/td><\/tr><tr><td><em>Avanafil<\/em><\/td><td>to treat erection problems<\/td><\/tr><tr><td><em>Dabigatran, tikagrelor<\/em><\/td><td>to prevent platelets from clotting in the treatment of patients who have had a heart attack<\/td><\/tr><tr><td><em>Naloxegol<\/em><\/td><td>to treat constipation caused&nbsp;by&nbsp;opioids<\/td><\/tr><tr><td><em>Dapoxetine<\/em><\/td><td>to treat premature ejaculation<\/td><\/tr><tr><td><em>Domperidone<\/em><\/td><td>to treat nausea and vomiting<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking REZOLSTA.<\/p>\n\n\n\n<p>You can still transmit&nbsp;HIV&nbsp;while taking this medicine, although the risk is reduced with effective&nbsp;antiretroviral&nbsp;therapy.&nbsp;Discuss with your doctor what precautions you need to take to avoid infecting others.<\/p>\n\n\n\n<p>People taking REZOLSTA may still develop\u00a0infections\u00a0or other illnesses associated with\u00a0HIV\u00a0infection.\u00a0You must have regular contact with a doctor.<\/p>\n\n\n\n<p>People taking REZOLSTA may get a skin rash.&nbsp;In rare cases, the rash can be severe or potentially life-threatening.&nbsp;Contact your doctor if you get a rash.<\/p>\n\n\n\n<p>Rash (usually mild or moderate) may occur more frequently in patients taking both REZOLSTA and raltegravir (in case of HIV&nbsp;infection&nbsp;) than in patients taking only one of these medicines.<\/p>\n\n\n\n<p>REZOLSTA has only been used in a limited number of patients aged 65 years or older.&nbsp;If you belong to this age group, discuss with your doctor if you can use REZOLSTA.<\/p>\n\n\n\n<p>Check the following points and tell your doctor if any of these apply to you.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you have a\u00a0<strong>history of liver problems<\/strong>, including\u00a0hepatitis\u00a0B or C\u00a0infection.\u00a0Your doctor can assess the severity of your liver disease before deciding if you can take REZOLSTA.<\/li><li>Tell your doctor if you have had\u00a0kidney problems\u00a0before.\u00a0Your doctor will carefully consider whether you should receive treatment with REZOLSTA.<\/li><li>Tell your doctor if you have\u00a0diabetes.\u00a0REZOLSTA may increase blood sugar levels.<\/li><li>Tell your doctor immediately if you notice any\u00a0symptoms of\u00a0infection\u00a0(such as enlarged\u00a0lymph nodes\u00a0or fever).\u00a0In some patients with advanced\u00a0HIV\u00a0infection\u00a0and who have previously had unusual\u00a0infections\u00a0due to a weakened immune system (\u00a0opportunistic infection\u00a0), signs and symptoms of\u00a0inflammation\u00a0from previous\u00a0infections\u00a0may appear shortly after starting treatment with\u00a0HIV\u00a0drugs.\u00a0It is believed that these symptoms are due to an improvement in the body&#8217;s\u00a0immune response, which enables the body to fight\u00a0infection. you who may have been present without giving clear symptoms.<\/li><li>In addition to opportunistic\u00a0infections,\u00a0autoimmune disorders\u00a0(conditions in which the immune system attacks healthy body tissue) can also occur after you start taking medication to treat your\u00a0HIV\u00a0infection.\u00a0Autoimmune disorders can occur several months after starting treatment.\u00a0If you notice any symptoms of\u00a0infection\u00a0or other symptoms such as muscle weakness, a weakness that starts in the hands or feet and moves to the torso, palpitations, tremors, or hyperactivity, inform your doctor immediately so that you can receive the necessary treatment.<\/li><li>Tell your doctor if you have\u00a0hemophilia.\u00a0REZOLSTA may increase the risk of bleeding.<\/li><li>Tell your doctor if you are\u00a0allergic to\u00a0sulphonamides\u00a0(such as those used to treat certain\u00a0infections\u00a0).<\/li><li>Tell your doctor if you notice\u00a0problems with muscles and bones.\u00a0Some patients taking combination\u00a0antiviral\u00a0therapy may develop a skeletal disease called\u00a0osteonecrosis\u00a0(dead bone tissue due to loss of blood supply to the skeleton).\u00a0This may be more likely with long-term treatment for\u00a0HIV, severe damage to the immune system, obesity, or the use of alcohol or other drugs called\u00a0corticosteroids.\u00a0Signs of\u00a0osteonecrosis\u00a0are stiff and aching joints (especially in the hip, knee, and shoulder) and difficulty moving.\u00a0If you notice any of these symptoms, talk to your doctor.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p><strong>REZOLSTA should not be used in children\u00a0younger than 12 years or weighing less than 40<\/strong>\u00a0kg<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and REZOLSTA<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines.<\/p>\n\n\n\n<p>There are certain medicines that&nbsp;<strong>you must not combine<\/strong>&nbsp;with REZOLSTA.&nbsp;These are listed above under the heading &#8220;Do not combine REZOLSTA with any of the following medicines&#8221;.<\/p>\n\n\n\n<p>REZOLSTA must not be used with another antiretroviral medicine that contains an enhancer or another antiretroviral medicine that requires amplification.&nbsp;In some cases, the&nbsp;dosage&nbsp;of one of the other medicines may need to be changed.&nbsp;Therefore, always tell your doctor if you are taking other medicines for&nbsp;HIV&nbsp;and carefully follow your doctor&#8217;s instructions on which medicines can be combined.<\/p>\n\n\n\n<p>The effects of REZOLSTA may be reduced if you take any of the following medicines.&nbsp;Tell your doctor if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tracleer\/\">bosentan<\/a><\/em>&nbsp;(to treat heart disease)<\/li><li><em><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toflacort\/\">dexamethasone<\/a><\/em>&nbsp;(for&nbsp;injection&nbsp;) (&nbsp;corticosteroid&nbsp;)<\/li><li><em>efavirenz, etravirine, nevirapine<\/em>&nbsp;(to treat&nbsp;HIV&nbsp;infection&nbsp;)<\/li><li><em>rifapentine, rifabutin<\/em>&nbsp;(to treat bacterial&nbsp;infections&nbsp;).<\/li><\/ul>\n\n\n\n<p>The effects of other medicines may be affected if you take REZOLSTA.&nbsp;Tell your doctor if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em>amlodipine, carvedilol,\u00a0diltiazem<\/em>,\u00a0disopyramide, felodipine,\u00a0flecainide,\u00a0lidocaine,\u00a0metoprolol, mexiletine, nicardipine,\u00a0nifedipine,\u00a0propafenone,\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/timosan\/\">timolol<\/a>, verapamil\u00a0(for heart disease) as the treatment effect or\u00a0side effects\u00a0of these medicines may be increased<\/li><li>apixaban, edoxaban, rivaroxaban,\u00a0warfarin, and clopidogrel\u00a0\u00a0(to reduce blood clotting) as the treatment effect or\u00a0side effects\u00a0may change.\u00a0Your doctor may need to take blood samples<\/li><li>of clonazepam\u00a0(to prevent seizures).<\/li><li>estrogen-based hormonal contraceptives or hormonal replacement therapy.\u00a0REZOLSTA may reduce their effect.\u00a0If these are used as a method of contraception, alternative non-hormonal methods of contraception are recommended<\/li><li>Ethinyl estradiol\/drospirenone.\u00a0REZOLSTA may increase the risk of increased potassium levels caused by drospirenone.<\/li><li>atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin\u00a0(to lower cholesterol levels).\u00a0The risk of muscle damage may be increased.\u00a0Your doctor will evaluate which cholesterol-lowering treatment best suits your specific situation.<\/li><li>ciclosporin, everolimus, tacrolimus, and sirolimus\u00a0(to suppress the immune system) as the treatment effect or\u00a0side effects\u00a0of these medicines may be increased.\u00a0Your doctor may want to do some additional tests.<\/li><li>Corticosteroids\u00a0include betamethasone, budesonide,\u00a0fluticasone, mometasone, prednisone, and triamcinolone.\u00a0These drugs are used to treat\u00a0allergies,\u00a0asthma, inflammatory bowel diseases,\u00a0inflammation\u00a0of the skin, eyes, joints, and muscles, and other inflammatory conditions.\u00a0These medicines are usually taken by mouth, inhaled, injected, or applied to the skin.\u00a0If alternative medicines can not be used, these medicines should only be used after a medical evaluation and under the close supervision of your doctor about\u00a0the side effects\u00a0of\u00a0corticosteroids.<\/li><li>buprenorphine\/naloxone,\u00a0methadone\u00a0(a drug to treat opioid dependence)<\/li><li>salmeterol\u00a0(medicine to treat\u00a0asthma\u00a0)<\/li><li>artemether \/ lumefantrine\u00a0(a combination drug for\u00a0malaria\u00a0)<\/li><li>dasatinib,\u00a0irinotecan,\u00a0nilotinib, vinblastine, vincristine\u00a0(medicines used to treat cancer)<\/li><li>perfenazine,\u00a0risperidone, thioridazine\u00a0(psychiatric drugs)<\/li><li>clorazepate,\u00a0diazepam<em>, estazolam, flurazepam<\/em>\u00a0(medicines used to treat sleep disorders or anxiety)<\/li><li><em>sildenafil, tadalafil, vardenafil<\/em>\u00a0(for erection problems or to treat a heart and lung disease called\u00a0pulmonary\u00a0arterial\u00a0hypertension\u00a0)<\/li><li><em>glekaprevir \/ pibrentasvir<\/em>\u00a0(to treat\u00a0hepatitis\u00a0C\u00a0infection\u00a0)<\/li><li><em>fesoterodine, solifenacin<\/em>\u00a0(to treat urinary tract problems).<\/li><\/ul>\n\n\n\n<p>The dosage\u00a0of one of the other medicines may need to be changed as the treatment effect or\u00a0side effects\u00a0of either the other medicine or Rezolsta may be affected if they are combined.\u00a0<\/p>\n\n\n\n<p>Tell your doctor if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em>alfentanil<\/em>\u00a0(powerful and short-acting injectable painkiller used in surgery)<\/li><li><em>digoxin\u00a0<\/em>(to treat certain heart diseases)<\/li><li><em>clarithromycin<\/em>\u00a0(\u00a0antibiotic\u00a0)<\/li><li><em>clotrimazole,\u00a0fluconazole<\/em>,\u00a0\u00a0itraconazole,\u00a0\u00a0isavuconazole, and posaconazole\u00a0(for fungal infections).\u00a0Voriconazole\u00a0should only be taken after a medical evaluation<\/li><li>rifabutin\u00a0(against bacterial infections)<\/li><li>tadalafil, sildenafil, vardenafil\u00a0(for erection problems or high\u00a0blood pressure\u00a0in the blood vessels in the lungs)<\/li><li>amitriptyline, desipramine, imipramine, nortriptyline,\u00a0paroxetine,\u00a0sertraline, trazodone\u00a0(for treating depression and anxiety)<\/li><li>maraviroc\u00a0(to\u00a0treat\u00a0HIV\u00a0infection\u00a0)<\/li><li>colchicine\u00a0(to treat\u00a0gout\u00a0or familial Mediterranean fever).\u00a0If you have impaired kidney and\/or liver function, see section \u201cDo not combine REZOLSTA with any of the following medicines\u201d.<\/li><li>bosentan\u00a0(to treat high\u00a0blood pressure\u00a0in the blood vessels of the lungs)<\/li><li>buspirone, clorazepate,\u00a0diazepam, estazolam, flurazepam,\u00a0\u00a0zolpidem, and midazolam when taken as an\u00a0injection\u00a0(medicines to treat sleep problems and\/or anxiety)<\/li><li>metformin\u00a0(to treat type 2\u00a0diabetes\u00a0)<\/li><li>fentanyl<em>, oxycodone, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tramadol-retard-krka\/\">tramadol<\/a><\/em>\u00a0(to treat pain)<\/li><\/ul>\n\n\n\n<p>This is&nbsp;<strong>not<\/strong>&nbsp;a complete list of medicines.&nbsp;Inform your healthcare provider about&nbsp;<strong><em>all<\/em><\/strong>&nbsp;medicines you are taking.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Tell your doctor immediately if you are pregnant, planning to become pregnant, or breastfeeding.\u00a0Pregnant or breastfeeding mothers should not take REZOLSTA.<\/p>\n\n\n\n<p>HIV\u00a0-infected women should not breastfeed their infants because there is both a risk of the baby becoming infected with\u00a0HIV\u00a0through breast milk and because it is not known how the medicine affects the baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Do not drive or use machines if you feel dizzy after taking REZOLSTA.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">REZOLSTA contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take REZOLSTA<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor, pharmacist or nurse has told you.\u00a0If you are not sure, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<p>You must take REZOLSTA every day and always with food.&nbsp;REZOLSTA does not work properly without food.&nbsp;You must eat a meal or snack at least 30 minutes before taking REZOLSTA.&nbsp;The type of food is not important.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swallow the tablet whole with a drink, e.g.\u00a0water or milk.\u00a0Tell your doctor if you have difficulty swallowing REZOLSTA.\u00a0The tablet can be shared with a tablet divider.\u00a0Once you have divided the tablet, take the whole\u00a0dose\u00a0(both halves) immediately with a drink, e.g.\u00a0water or milk.<\/li><li>Take the other\u00a0HIV\u00a0medicines you use in combination with REZOLSTA according to your doctor&#8217;s recommendation<\/li><\/ul>\n\n\n\n<p><strong>Open the childproof cover.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20131031000074#\" rel=\"noopener\"><\/a><\/td><td>The plastic jar has a childproof lid and should be opened as follows: Press the plastic cap down while turning it counterclockwise. Remove the lid.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more REZOLSTA than you should<\/h2>\n\n\n\n<p>Contact a doctor, pharmacist, or nurse immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take REZOLSTA<\/h2>\n\n\n\n<p>If you notice this\u00a0<strong>within 12 hours<\/strong>, take the tablets immediately.\u00a0Always take the tablets with food.\u00a0If you notice it\u00a0later than 12 hours\u00a0after the missed\u00a0dose, skip the tablets and take the next\u00a0dose\u00a0as usual.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you vomit after taking REZOLSTA<\/h2>\n\n\n\n<p>If you vomit&nbsp;<strong>within 4 hours<\/strong>&nbsp;of taking the medicine, you should take another&nbsp;dose&nbsp;of REZOLSTA with food as soon as possible.&nbsp;If you vomit&nbsp;<strong>more&nbsp;<\/strong><strong>than&nbsp;<\/strong><strong>4&nbsp;<\/strong><strong>hours<\/strong>&nbsp;after taking the medicine, you do not need to take any additional&nbsp;dose&nbsp;of REZOLSTA until your next regular dose.<\/p>\n\n\n\n<p>Contact a doctor\u00a0<strong>if you are not sure <\/strong>what to do if you miss a\u00a0dose\u00a0or if you vomit.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Do not stop taking REZOLSTA without first talking to your doctor<\/h2>\n\n\n\n<p>After starting treatment, do not stop it unless your doctor tells you to.<\/p>\n\n\n\n<p>Anti &#8211;&nbsp;HIV&nbsp;drugs can make you feel better.&nbsp;Even if you feel better, do not stop taking REZOLSTA.&nbsp;Talk to your doctor first.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>During&nbsp;HIV&nbsp;treatment, weight gain and increased levels of&nbsp;lipids&nbsp;and&nbsp;glucose&nbsp;in the blood may occur.&nbsp;This is partly related to restored health and lifestyle, but when it comes to blood lipids, there can sometimes be a connection with&nbsp;HIV&nbsp;drugs.&nbsp;The doctor will perform tests to find such changes.<\/p>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Tell your doctor if you experience any of the following&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p>Liver problems that can sometimes be serious have been reported.\u00a0Your doctor should take a blood sample before starting treatment with REZOLSTA.\u00a0If you have\u00a0chronic\u00a0hepatitis\u00a0B or C\u2011\u00a0infection, your doctor should take blood tests more often as you are at increased risk of developing liver problems.\u00a0Talk to your doctor about the signs and symptoms of liver problems.\u00a0These may include yellowing of the skin or whites of the eyes, dark (tea-colored) urine, pale stools (bowel movements), nausea, vomiting, loss of appetite, or pain, aches or pains, and discomfort on the right side below the ribs.<\/p>\n\n\n\n<p>A common side effect of REZOLSTA is skin rash (more often when used in combination with raltegravir),\u00a0and itching.\u00a0The rash is usually mild to moderate.\u00a0A skin rash can also be a symptom of a rare, serious situation.\u00a0It is therefore important that you talk to your doctor if you get a rash.\u00a0Your doctor will advise you on how to deal with your symptoms or if REZOLSTA needs to be stopped.<\/p>\n\n\n\n<p>Another serious\u00a0side effects\u00a0seen in up to 1 in 10 users were\u00a0diabetes.\u00a0Inflammation\u00a0of the pancreas (\u00a0pancreatitis\u00a0) has been reported in up to 1 in 100 users.<\/p>\n\n\n\n<p>Very common (may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>diarrhea, nausea.<\/li><\/ul>\n\n\n\n<p>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions such as&nbsp;itching<\/li><li>reduced appetite<\/li><li>abnormal dreams<\/li><li>vomiting, pain in or swelling of the abdomen, indigestion, flatulence<\/li><li>muscle pain<\/li><li>fatigue<\/li><li>abnormal blood test results, such as certain tests of the liver or kidneys.&nbsp;Your doctor will explain these to you<\/li><li>weakness.<\/li><\/ul>\n\n\n\n<p>Uncommon&nbsp;side effects&nbsp;(may affect 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>symptoms of\u00a0infection\u00a0or autoimmune disorders (immune reactivation syndrome)<\/li><li>osteonecrosis\u00a0(dead skeletal tissue due to decreased blood supply to the skeleton)<\/li><li>breast augmentation<\/li><li>abnormal blood test results, such as certain tests of the pancreas, high sugar levels, and abnormal levels of blood fats (lipids\u00a0).\u00a0Your doctor will explain these to you<\/li><li>allergic reactions such as\u00a0hives\u00a0(\u00a0urticaria\u00a0), severe swelling of the skin or other\u00a0tissues\u00a0(usually lips or eyes)<\/li><li>severe rash with blisters and flaky skin, especially around the mouth, nose, eyes, and genitals.<\/li><\/ul>\n\n\n\n<p>Rare&nbsp;side effects&nbsp;(may affect up to 1 in 1,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a reaction called DRESS [severe rash that may be followed by fever, fatigue, swelling of the face or\u00a0lymph nodes, increased\u00a0eosinophils\u00a0(type of\u00a0white blood cells\u00a0), effect on liver, kidney, or lung].<\/li><\/ul>\n\n\n\n<p>Has been reported (occurs in an unknown number of users): skin rash that can be severe or potentially life-threatening:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>skin rash with blisters and scaly skin on large parts of the body<\/li><li>red rashes are covered with small bumps that can spread over the body, sometimes with a fever.<\/li><\/ul>\n\n\n\n<p>Some&nbsp;side effects&nbsp;are typical of&nbsp;HIV&nbsp;medicines belonging to the same group as REZOLSTA.&nbsp;These are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>muscle aches, soreness, or weakness.\u00a0In rare cases, these muscle problems have been severe.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store REZOLSTA<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and can after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not use this medicine for more than 6 weeks after first opening the jar.<\/p>\n\n\n\n<p>REZOLSTA does not require any special storage instructions.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are darunavir and cobicistat.\u00a0One tablet contains 800 mg darunavir (as ethanolate) and 150 mg cobicistat.<\/li><li>The other ingredients are hypromellose, silicified microcrystalline cellulose, colloidal anhydrous silica, crospovidone, and magnesium stearate.\u00a0The film coating contains poly (vinyl alcohol) &#8211; partially hydrolyzed, titanium dioxide, polyethylene glycol (macrogol), talc, red iron oxide, and black iron oxide.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Film-coated, pink, oval tablet with TG embossed on one side and 800 on the other side.<\/p>\n\n\n\n<p>30 tablets in a plastic jar.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Janssen \u2011 Cilag International NV, 30 Turnhoutseweg, B-2340 Beerse, Belgium<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Janssen Cilag SpA, Via C. Janssen, Borgo San Michele, 04100 Latina, Italy<\/p>\n","protected":false},"excerpt":{"rendered":"<p>REZOLSTA contains the active substances darunavir and cobicistat.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[22927,6112,6115,22920,22924,22923,22926,21819,22925,6113,22921,22922],"class_list":["post-22070","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-cobicistat-tablet","tag-darunavir","tag-darunavir-tablet","tag-rezolsta","tag-rezolsta-side-effects","tag-rezolsta-tablet","tag-what-cobicistat-is-used-for","tag-what-darunavir-is-used-for","tag-what-is-cobicistat","tag-what-is-darunavir","tag-what-is-rezolsta","tag-what-rezolsta-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22070","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22070"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22070\/revisions"}],"predecessor-version":[{"id":22136,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22070\/revisions\/22136"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22070"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22070"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22070"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}