{"id":22065,"date":"2022-06-17T05:20:22","date_gmt":"2022-06-17T05:20:22","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22065"},"modified":"2022-06-18T12:24:20","modified_gmt":"2022-06-18T12:24:20","slug":"reyataz","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/reyataz\/","title":{"rendered":"REYATAZ &#8211; Atazanavir uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg&nbsp;oral powder<br>of atazanavir<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What REYATAZ is and what it is used for<\/h2>\n\n\n\n<p><strong>REYATAZ is an\u00a0antiviral\u00a0(or\u00a0antiretroviral\u00a0) medicine.\u00a0<\/strong>It belongs to a group called\u00a0<em>protease inhibitors<\/em>,\u00a0which control human immunodeficiency virus (\u00a0HIV\u00a0)\u00a0infection\u00a0by blocking a\u00a0protein\u00a0that the\u00a0HIV\u00a0needs to multiply.\u00a0They work by reducing the number of\u00a0HIV\u00a0viruses\u00a0in\u00a0the blood and this, in turn, strengthens your immune system.\u00a0In this way, REYATAZ reduces the risk of developing HIV-related\u00a0diseases.<\/p>\n\n\n\n<p>REYATAZ oral powder can be used by children from 3 months of age and weighing at least 5 kg (see section 3 How to take REYATAZ).&nbsp;Your doctor has prescribed REYATAZ for you because you are infected with&nbsp;HIV&nbsp;which may cause Acquired Immune Deficiency Syndrome (&nbsp;AIDS&nbsp;).&nbsp;REYATAZ should always be used with a low&nbsp;dose&nbsp;of ritonavir and in combination with other anti-HIV medicines.&nbsp;Your doctor will discuss with you which combinations of these medicines together with REYATAZ are best for you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking REYATAZ<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take REYATAZ<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic (hypersensitive)<\/strong>\u00a0to atazanavir or any of the other ingredients of this medicine (listed in section 6).<\/li><li><strong>if you have moderate to severe liver problems.\u00a0<\/strong>Your doctor will assess the severity of your liver disease before deciding whether to take REYATAZ.<\/li><li><strong>if you are taking any of these medicines:<\/strong>\u00a0see also\u00a0<em>Using other medicines with REYATAZ<\/em><ul><li>rifampicin (an\u00a0antibiotic\u00a0used to treat\u00a0tuberculosis\u00a0)<\/li><li>astemizole or terfenadine (often used to treat allergic symptoms, these medications may be over-the-counter);\u00a0cisapride (used to treat acid reflux (heartburn));\u00a0pimozide (used to treat schizophrenia);\u00a0quinidine\u00a0or bepridil (used to correct heart rhythm);\u00a0ergotamine, dihydroergotamine, ergonovine, methylergonovine (used to treat headaches) and alfuzosin (used to treat prostate enlargement)<\/li><li>quetiapine (used to treat schizophrenia, bipolar disorder, and major depression);\u00a0lurasidone (used to treat schizophrenia)<\/li><li>medicines containing\u00a0St. John&#8217;s wort\u00a0(Hypericum perforatum, a herbal medicine)<\/li><li>triazolam and orally (taken orally) midazolam (used as a sleeping pill and\/or to reduce anxiety).<\/li><li>lomitapide,\u00a0simvastatin,\u00a0and lovastatin (used to lower blood cholesterol).<\/li><li>products containing grazoprevir, including a fixed-dose combination of elbasvir and grazoprevir, and a fixed-dose combination of glecaprevir and pibrentasvir (used to treat\u00a0chronic\u00a0hepatitis\u00a0C\u00a0infection\u00a0)<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Do not take sildenafil with REYATAZ when sildenafil is used to treat\u00a0pulmonary\u00a0arterial\u00a0hypertension.\u00a0Sildenafil is also used to treat\u00a0erectile dysfunction.\u00a0Tell your doctor if you are using sildenafil to treat\u00a0erectile dysfunction.<\/p>\n\n\n\n<p>Tell your doctor immediately if this applies to you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>REYATAZ\u00a0is not a cure for\u00a0HIV\u00a0infection<\/strong>.\u00a0You can continue to develop\u00a0infections\u00a0or diseases associated with\u00a0HIV.\u00a0You can still transmit\u00a0HIV\u00a0infection while taking this medicine, even though the risk of effective\u00a0antiviral\u00a0therapy is reduced.\u00a0Discuss with your doctor the necessary steps to avoid infecting others.<\/p>\n\n\n\n<p>For some people, special consideration may need to be given before or when taking REYATAZ.&nbsp;Talk to your doctor or pharmacist before taking REYATAZ and make sure your doctor knows the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have\u00a0hepatitis\u00a0B or C.<\/li><li>if you develop signs or symptoms of\u00a0gallstones\u00a0(pain on the right side of your stomach)<\/li><li>if you have\u00a0hemophilia\u00a0A or B<\/li><li>if you need\u00a0hemodialysis<\/li><\/ul>\n\n\n\n<p>REYATAZ can affect how well your kidneys work.<\/p>\n\n\n\n<p>Kidney stones&nbsp;have been reported in patients taking REYATAZ.&nbsp;Tell your doctor immediately if you develop signs and symptoms of&nbsp;kidney stones&nbsp;(pain in the side, blood in the urine, pain when urinating).<\/p>\n\n\n\n<p>In some patients with advanced\u00a0HIV\u00a0infection\u00a0(\u00a0AIDS\u00a0) and who have previously had opportunistic\u00a0infections\u00a0(\u00a0infections\u00a0that occur due to a weakened immune system), signs and symptoms of\u00a0inflammation\u00a0from\u00a0previous\u00a0infections\u00a0may occur shortly after treatment for\u00a0HIV.\u00a0started.\u00a0These symptoms are probably due to an improvement in the body&#8217;s\u00a0immune response, which enables the body to fight\u00a0infections\u00a0that may have been present without any obvious symptoms.\u00a0Tell your doctor immediately if you notice any symptoms of\u00a0infection.<\/p>\n\n\n\n<p>In addition to opportunistic\u00a0infections, autoimmune disorders (conditions in which the immune system attacks healthy body tissues) can also occur after you start taking medicines to treat\u00a0your\u00a0HIV\u00a0infection.\u00a0Autoimmune disorders can occur several months after starting treatment.\u00a0If you notice any symptoms of\u00a0infection\u00a0or other symptoms such as muscle weakness, a weakness that starts in the hands or feet and moves to the torso, palpitations, tremors, or hyperactivity, informs your doctor immediately for the necessary treatment.<\/p>\n\n\n\n<p>Some patients receiving combination\u00a0antiretroviral\u00a0therapy may develop a bone disease called\u00a0osteonecrosis\u00a0(bone tissue dies due to lost blood supply to the bone).\u00a0Some of the many risk factors for developing the disease are long-term\u00a0antiretroviral\u00a0combination therapy, use of\u00a0corticosteroids, alcohol consumption, a severe weakening of the immune system, and a higher body mass index.\u00a0Signs of\u00a0osteonecrosis\u00a0are stiffness in the joints and pain (especially in the hip, knee, and shoulders) and difficulty moving.\u00a0Tell your doctor if you experience any of these symptoms.<\/p>\n\n\n\n<p>Increased levels of bile dye in the blood (hyperbilirubinemia) have occurred in patients receiving REYATAZ.&nbsp;Signs of this may be a mild yellowing of the skin or eyes.&nbsp;Tell your doctor if you experience any of these symptoms.<\/p>\n\n\n\n<p>Severe rash including&nbsp;Stevens-Johnson&nbsp;syndrome has been reported in patients taking REYATAZ.&nbsp;Tell your doctor immediately if you develop a rash.<\/p>\n\n\n\n<p>If you notice that your heart is beating differently (changes in your heart rhythm), tell your doctor.<\/p>\n\n\n\n<p>Children receiving REYATAZ may need to have their hearts monitored.\u00a0This is determined by your child&#8217;s doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p><strong>Do not give this medicine to children<\/strong>&nbsp;younger than 3 months and weighing less than 5 kg.&nbsp;The use of REYATAZ in children less than 3 months of age weighing less than 5 kg has not been studied due to the risk of serious complications.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and REYATAZ<\/h2>\n\n\n\n<p><strong>You must not take REYATAZ with certain medicines.&nbsp;<\/strong>These are listed under Do not take REYATAZ, at the beginning of section 2.<\/p>\n\n\n\n<p>Other medicines may not be taken with REYATAZ.\u00a0Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0It is especially important to mention these:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>other medicines to treat\u00a0HIV\u00a0infection\u00a0(eg indinavir, nevirapine, and efavirenz)<\/li><li>Sofosbuvir \/ velpatasvir \/ voxilaprevir (used to treat\u00a0hepatitis\u00a0C)<\/li><li>sildenafil, vardenafil, or tadalafil (used by men to treat\u00a0impotence\u00a0(\u00a0erectile dysfunction\u00a0))<\/li><li>if you are taking contraceptives\u00a0(\u00a0contraceptive pills\u00a0)\u00a0with REYATAZ to prevent pregnancy, take it exactly according to the instructions given to you by your doctor, and do not miss a\u00a0dose<\/li><li>medicines used to treat diseases related to the acid in the stomach (eg antacids to be taken 1 hour before or two hours after\u00a0administration\u00a0of REYATAZ, H\u00a02\u00a0blockers such as famotidine, and\u00a0proton pump inhibitors\u00a0such as omeprazole)<\/li><li>medicines that lower\u00a0blood pressure, decrease the heart rate, or affect the heart rhythm (\u00a0amiodarone,\u00a0diltiazem,\u00a0systemic\u00a0lidocaine, verapamil)<\/li><li>atorvastatin, pravastatin, and fluvastatin (used to lower blood cholesterol)<\/li><li>salmeterol\u00a0(used to treat\u00a0asthma\u00a0)<\/li><li>cyclosporine, tacrolimus, and sirolimus (medicines that reduce the effects of the body&#8217;s immune system)<\/li><li>certain\u00a0antibiotics\u00a0(rifabutin, clarithromycin)<\/li><li>ketoconazole\u00a0, itraconazole and voriconazole (antifungal)<\/li><li>apixaban, dabigatran, edoxaban, rivaroxaban and\u00a0warfarin\u00a0(\u00a0anticoagulants\u00a0, used to prevent blood clots)<\/li><li>carbamazepine,\u00a0phenytoin, phenobarbital, lamotrigine (used to treat\u00a0epilepsy\u00a0)<\/li><li>irinotecan (used to treat cancer)<\/li><li>sedatives (eg midazolam given as an\u00a0injection\u00a0)<\/li><li>buprenorphine (used to treat opioid abuse and pain).<\/li><\/ul>\n\n\n\n<p>Some medicines can be affected by ritonavir, a medicine taken with REYATAZ.&nbsp;It is important to tell your doctor if you are taking&nbsp;fluticasone&nbsp;or budesonide (given through the nose or inhaled to treat allergic symptoms or&nbsp;asthma&nbsp;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">REYATAZ with food and drink<\/h2>\n\n\n\n<p>See section 3 How to take REYATAZ.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.\u00a0Atazanavir, the active substance in REYATAZ, is excreted in human milk.\u00a0Patients should not breastfeed while taking REYATAZ.\u00a0Women infected with\u00a0HIV\u00a0are advised not to breastfeed as the\u00a0virus\u00a0can be transmitted through breast milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Do not drive or use machines if you feel dizzy or faint and contact your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">REYATAZ oral powder contains:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>63 mg aspartame per\u00a0sachet\u00a0.\u00a0Aspartame is a source of phenylalanine.\u00a0It can be harmful if you have phenylketonuria, a rare genetic disease where phenylalanine accumulates because the body can not\u00a0eliminate\u00a0it properly.<\/li><li>1.3 g sucrose per\u00a0sachet.\u00a0This must be considered in patients with\u00a0diabetes mellitus.\u00a0May be harmful to teeth.\u00a0If you have been told by your doctor that your child has an intolerance to some sugars, contact your doctor before giving this medicine to your child.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to take REYATAZ<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Consult a doctor if you are unsure.&nbsp;This way you can be sure that you get the full effect of the medicine and reduce the risk of the&nbsp;virus&nbsp;developing&nbsp;resistance&nbsp;to the treatment.<\/p>\n\n\n\n<p><strong>For children (from 3 months of age and weighing at least 5 kg), your child&#8217;s doctor will determine the correct\u00a0dose\u00a0based on the child&#8217;s weight<\/strong>.\u00a0The dose of a REYATAZ\u00a0oral powder for children is calculated based on body weight and is taken once daily with food and ritonavir as follows:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Body weight<\/strong><strong>(kg)<\/strong><\/td><td><strong>REYATAZ&nbsp;dose&nbsp;once daily (mg)<\/strong><\/td><td><strong>Ritonavir&nbsp;dose<\/strong><strong>&nbsp;*&nbsp;<\/strong><strong>once daily (mg)<\/strong><\/td><\/tr><tr><td>5 &#8211; less than 15<\/td><td>200 mg (4 sachets&nbsp;<sup>a<\/sup>&nbsp;)<\/td><td>80 mg&nbsp;<sup>b<\/sup><\/td><\/tr><tr><td>15 &#8211; less than 35<\/td><td>250 mg (5 sachets&nbsp;<sup>a<\/sup>&nbsp;)<\/td><td>80 mg&nbsp;<sup>b<\/sup><\/td><\/tr><tr><td>At least 35<\/td><td>300 mg (6 sachets&nbsp;<sup>a<\/sup>&nbsp;)<\/td><td>100 mg&nbsp;<sup>c<\/sup><\/td><\/tr><tr><td><sup>a<\/sup>&nbsp;Each&nbsp;sachet&nbsp;contains 50 mg REYATAZ<sup>b<\/sup>&nbsp;Ritonavir&nbsp;oral&nbsp;solution<sup>c<\/sup>&nbsp;Ritonavir&nbsp;oral&nbsp;solution or capsule \/ tablet<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>REYATAZ is also available as capsules for use in adults and children who are at least 6 years old and weigh at least 15 kg, and who can swallow capsules.&nbsp;Switching to REYATAZ capsules is encouraged as soon as the patient is inclined to swallow capsules.<\/p>\n\n\n\n<p>A dose change may be necessary when switching between oral powder and capsules.&nbsp;Your doctor will determine the correct&nbsp;dose&nbsp;based on your baby&#8217;s weight.<\/p>\n\n\n\n<p>There are no dosing recommendations for REYATAZ in children less than 3 months of age.<\/p>\n\n\n\n<p><strong>Instructions for REYATAZ oral powder:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For children who can drink from a cup, REYATAZ oral powder must be taken with food or drink.\u00a0If REYATAZ oral powder is mixed with water, food should also be taken at the same time.<\/li><li>For children who are unable to eat solid food or drink from a cup, REYATAZ oral powder must be mixed with infant formula and should be given using a dosing syringe in the mouth.\u00a0Ask your pharmacist for a dosing syringe.\u00a0Do not use a baby bottle to give REYATAZ mixed with infant formula.<\/li><li>See the &#8220;Instructions for Use&#8221; at the end of the package leaflet for how to prepare and give a\u00a0dose\u00a0of REYATAZ oral powder.<\/li><li>REYATAZ oral powder should be given within 60 minutes of\u00a0mixing.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more REYATAZ than you should<\/h2>\n\n\n\n<p>Yellowing of the skin and\/or eyes (jaundice) and irregular heartbeat (QTc prolongation) may occur if you or your child takes too much REYATAZ.<\/p>\n\n\n\n<p>If you accidentally take or give more REYATAZ oral powder than recommended, contact your&nbsp;HIV&nbsp;doctor immediately or contact your nearest hospital for advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take REYATAZ<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose\u00a0or if you forget to give your child a\u00a0dose, take or give the missed\u00a0dose\u00a0as soon as possible with food and then give or take the next\u00a0dose\u00a0at the usual time.\u00a0If it is almost time for your or your child&#8217;s next\u00a0dose, do not take or give the missed\u00a0dose\u00a0one.\u00a0Wait and take or give the next\u00a0dose\u00a0at the usual time.\u00a0Do not take or give a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking REYATAZ<\/h2>\n\n\n\n<p>Do not stop taking REYATAZ before talking to your doctor.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, REYATAZ can cause\u00a0side effects, although not everybody gets them.\u00a0When treating\u00a0HIV\u00a0infection,\u00a0it is difficult to know which\u00a0side effects\u00a0are caused by REYATAZ, by the other medicines you are taking, or by the\u00a0HIV\u00a0infection\u00a0itself.\u00a0Tell your doctor if you notice anything unusual about your health.<\/p>\n\n\n\n<p>During&nbsp;HIV&nbsp;treatment, weight gain and increased levels of&nbsp;lipids&nbsp;and&nbsp;glucose&nbsp;in the blood may occur.&nbsp;This is partly related to restored health and lifestyle, but when it comes to blood lipids, there can sometimes be a connection with&nbsp;HIV&nbsp;drugs.&nbsp;The doctor will perform tests to find such changes.<\/p>\n\n\n\n<p>Talk to your doctor immediately if you develop any of the following serious side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Skin rash\u00a0and itching\u00a0that can sometimes be severe have been reported.\u00a0The rash usually disappears within 2 weeks without any change in your REYATAZ treatment.\u00a0The severe rash can develop along with other symptoms that can be severe.\u00a0Stop taking REYATAZ and talk to your doctor immediately if you get a severe rash or rash with flu-like symptoms, blisters, fever, cold sores, muscle or joint pain, swelling of the face,\u00a0inflammation\u00a0of the eye that causes\u00a0redness\u00a0(\u00a0conjunctivitis\u00a0), painful, hot, or red nodules (\u00a0nodules\u00a0).<\/li><li>Yellowing of the skin or the white part of your eyes caused by high levels of bilirubin in the blood has been reported as common.\u00a0This\u00a0side effect\u00a0is usually not dangerous in adults and children older than 3 months\u00a0but could be a symptom of a serious problem.\u00a0If your skin or the white part of your eyes turns yellow, talk to your doctor immediately.<\/li><li>Changes in how your heart beats (changes in heart rate) can sometimes occur.\u00a0Talk to your doctor immediately if you become dizzy, or if you suddenly faint.\u00a0These can be symptoms of a serious heart problem.<\/li><li>Liver problems are less common.\u00a0Your doctor should do blood tests before you start REYATAZ and during treatment.\u00a0If you have liver problems including\u00a0hepatitis\u00a0B or C\u00a0infection, you may experience a worsening of your liver problems.\u00a0Talk to your doctor immediately if you get dark (tea-colored) urine,\u00a0itching, yellowing of the skin or the white part of your eyes, pain around the abdomen, pale stools, or nausea.<\/li><li>Gallbladder problems are less common in people taking REYATAZ.\u00a0Symptoms of gallbladder problems may include pain in the right or middle of the upper abdomen, nausea, vomiting, fever, or yellowing of the skin or the white part of the eyes.<\/li><li>REYATAZ can affect how well your kidneys work.<\/li><li>Kidney stones\u00a0are less common in people taking REYATAZ.\u00a0Talk to your doctor immediately if you experience symptoms of\u00a0kidney stones\u00a0that may include pain in the lower back or lower abdomen, blood in the urine, or pain when urinating.<\/li><\/ul>\n\n\n\n<p>Other reported&nbsp;side effects&nbsp;in patients treated with REYATAZ:<\/p>\n\n\n\n<p>Common (may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>vomiting, diarrhea, stomach pain, nausea,&nbsp;dyspepsia&nbsp;(indigestion)<\/li><li>extreme fatigue<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>peripheral\u00a0neuropathy\u00a0(numbness, weakness, tingling, or pain in arms and legs)<\/li><li>hypersensitivity (\u00a0allergic reaction\u00a0)<\/li><li>asthenia\u00a0(unusual tiredness or weakness)<\/li><li>weight loss, weight gain,\u00a0anorexia\u00a0(loss of appetite), increase in appetite<\/li><li>depression, anxiety, sleep disorders<\/li><li>disorientation, memory loss, dizziness, drowsiness, abnormal dreams<\/li><li>syncope\u00a0(fainting),\u00a0hypertension\u00a0(high\u00a0blood pressure\u00a0)<\/li><li>dyspnoea\u00a0(shortness of breath)<\/li><li>pancreatitis\u00a0(inflammation of the pancreas),\u00a0gastritis\u00a0(gastritis), aphthous\u00a0stomatitis\u00a0(cold sores and colds),\u00a0dysgeusia\u00a0(change of taste),\u00a0flatulence\u00a0(flatulence),\u00a0dry mouth, distended abdomen<\/li><li>angioedema\u00a0(severe swelling of the skin and other\u00a0tissues, usually your lips or eyes)<\/li><li>alopecia\u00a0(hair loss),\u00a0itching<\/li><li>muscle atrophy (muscle wasting),\u00a0arthralgia\u00a0(joint pain),\u00a0myalgia\u00a0(muscle pain)<\/li><li>interstitial nephritis (inflammation of the kidneys),\u00a0hematuria\u00a0(blood in the urine),\u00a0proteinuria\u00a0(increased amount of protein in the urine), pollakiuria (increased urination)<\/li><li>gynecomastia\u00a0(breast augmentation in men)<\/li><li>chest pain, malaise, fever<\/li><li>insomnia<\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal gait<\/li><li>edema&nbsp;(swelling)<\/li><li>hepatosplenomegaly&nbsp;(enlargement of the liver and spleen)<\/li><li>myopathy&nbsp;(muscle pain, muscle weakness, not caused by exercise)<\/li><li>kidney pain<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store REYATAZ<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton or sachet.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.&nbsp;Do not open the sachet until the oral powder is to be used.<\/p>\n\n\n\n<p>After mixing the oral powder with food or drink, the\u00a0mixture\u00a0can be stored at room temperature (maximum 30 \u00b0 C) for up to 1 hour.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is atazanavir.\u00a0Each\u00a0sachet\u00a0contains 50 mg of atazanavir (as sulphate).<\/li><li>The other ingredients are aspartame (E951), sucrose, and orange\/vanilla flavors.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Each&nbsp;dose of&nbsp;REYATAZ 50 mg oral powder contains 50 mg atazanavir.<\/p>\n\n\n\n<p>One pack size is available: 1 carton with 30 sachets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Bristol-Myers Squibb Pharma EEIG<br>Plaza 254<br>Blanchardstown Corporate Park 2<br>Dublin 15, D15 T867<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Swords Laboratories Unlimited Company T \/ A Lawrence Laboratories<\/p>\n\n\n\n<p>Unit 12 &amp; 15, Distribution Center<\/p>\n\n\n\n<p>Shannon Industrial Estate<\/p>\n\n\n\n<p>Shannon, Co.&nbsp;Clare, V14 DD39<br>Ireland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>REYATAZ is an antiviral (or antiretroviral ) medicine. It belongs to a group called protease inhibitors , which control human immunodeficiency virus ( HIV ) infection by blocking a protein that the HIV virus needs to multiply . They work by reducing the number of HIV viruses in the blood and this in turn strengthens your immune system. In this way, REYATAZ reduces the risk of developing HIV-related diseases .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[3367,3370,22928,22933,22929,22932,9919,9918,22930,22931],"class_list":["post-22065","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-atazanavir","tag-atazanavir-side-effects","tag-benefits-of-atazanavir","tag-benefits-of-reyataz","tag-reyataz","tag-reyataz-side-effects","tag-what-atazanavir-is-used-for","tag-what-is-atazanavir","tag-what-is-reyataz","tag-what-reyataz-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22065","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22065"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22065\/revisions"}],"predecessor-version":[{"id":22138,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22065\/revisions\/22138"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22065"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}