{"id":22062,"date":"2022-06-17T05:19:02","date_gmt":"2022-06-17T05:19:02","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22062"},"modified":"2022-06-18T12:24:26","modified_gmt":"2022-06-18T12:24:26","slug":"revolade","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/revolade\/","title":{"rendered":"Revolade &#8211; Eltrombopag uses, dose and side effects"},"content":{"rendered":"\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Revolade 12.5 mg film-coated tablets<\/strong><strong>Revolade 25 mg film-coated tablets<\/strong><strong>Revolade 50 mg film-coated tablets<\/strong><strong>Revolade 75 mg film-coated tablets<\/strong><\/td><\/tr><tr><td>eltrombopag<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">What Revolade is and what it is used for<\/h2>\n\n\n\n<p>Revolade contains eltrombopag, which belongs to a group of medicines called\u00a0<em>thrombopoietin receptor agonists<\/em>.\u00a0It is used to increase the number of\u00a0platelets\u00a0in your blood.\u00a0Platelets\u00a0are\u00a0blood cells\u00a0that help reduce or prevent bleeding.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Revolade is used to treat a bleeding disorder called\u00a0<em>immunological\u00a0(primary)\u00a0thrombocytopenia<\/em>\u00a0(ITP) in patients from 1 year of age who have already taken other medicines (\u00a0corticosteroids\u00a0or immunoglobulins) that have not worked.<br>ITP is caused by a low\u00a0platelet count\u00a0(\u00a0<em>thrombocytopenia<\/em>\u00a0).\u00a0People with ITP have an increased risk of bleeding.\u00a0Symptoms that patients with ITP may notice include\u00a0<em>petechiae<\/em>\u00a0(needle-sized, flat, round, red marks under the skin), bruising, nosebleeds, bleeding gums, and bleeding that does not stop if they cut or injure themselves.<\/li><li>Revolade can also be used to treat low\u00a0platelet counts\u00a0<em>(\u00a0thrombocytopenia\u00a0)<\/em>\u00a0in adults with\u00a0hepatitis\u00a0C\u00a0virus\u00a0(\u00a0HCV\u00a0)\u00a0infection\u00a0if they have had problems with the\u00a0side effects\u00a0of interferon therapy.\u00a0Many people with\u00a0hepatitis\u00a0C may have low\u00a0platelet counts, not only as a result of the disease but also because of some of the antiviral drugs used to treat it.\u00a0Taking Revolade may make it easier to complete an entire course of antiviral medicine (peginterferon and ribavirin).<\/li><li>Revolade can also be used to treat adult patients with low\u00a0blood cell counts\u00a0caused by severe\u00a0aplastic anemia\u00a0(SAA).\u00a0SAA is a disease in which the\u00a0bone marrow\u00a0is damaged, causing a lack of\u00a0red blood cells\u00a0(\u00a0anemia\u00a0),\u00a0white blood cells\u00a0(\u00a0leukopenia\u00a0), and\u00a0platelets\u00a0(\u00a0thrombocytopenia\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Revolade<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Revolade<\/h2>\n\n\n\n<p><strong>if you are allergic<\/strong>&nbsp;to eltrombopag or any of the other ingredients of this medicine (listed in section 6 under&nbsp;<strong><em>\u201c&nbsp;<\/em><\/strong><strong><em>Contents of contents\u201d<\/em><\/strong>&nbsp;).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Check with your doctor<\/strong>&nbsp;if you think this is true for you.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Revolade:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have\u00a0<strong>liver problems.\u00a0<\/strong>If you have a low number of\u00a0platelets\u00a0and at the same time an advanced\u00a0chronic\u00a0(long-term) liver disease, the risk of\u00a0side effects\u00a0is greater, including life-threatening liver damage and blood clots.\u00a0If your doctor considers that the benefits of taking Revolade outweigh the risks, you will be closely monitored during treatment.<\/li><li>if there is\u00a0<strong>a risk of getting a blood clot in your veins or\u00a0arteries\u00a0or if you<\/strong>\u00a0know that a clot is common in your family.<br>You may have\u00a0<strong>a higher risk of blood clots:<\/strong><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>as you get older<\/li><li>if you have had to lie in bed for a long time<\/li><li>if you have cancer<\/li><li>if you are taking&nbsp;birth control pills&nbsp;or hormone replacement therapy<\/li><li>if you have recently had surgery or been physically injured<\/li><li>if you are very overweight<\/li><li>if you smoke<\/li><li>if you have advanced&nbsp;chronic&nbsp;liver disease.<\/li><li>If any of these apply to you,&nbsp;<strong>tell your doctor<\/strong>&nbsp;before starting treatment.&nbsp;You should not take Revolade unless your doctor thinks that the expected benefits outweigh the risk of blood clots.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have\u00a0<strong>cataracts<\/strong>\u00a0(cloud of the lens of the eye)<\/li><li>if you have any other\u00a0<strong>blood disease<\/strong>, such as\u00a0<em>myelodysplastic syndrome\u00a0(MDS).\u00a0<\/em>Your doctor will perform tests to check that you do not have this blood disorder before starting Revolade.\u00a0If you have MDS and are taking Revolade, your MDS may worsen.<\/li><li>Tell your doctor if any of these apply to you.<\/li><\/ul>\n\n\n\n<p><strong>Eye examinations<\/strong><\/p>\n\n\n\n<p>Your doctor will recommend that you be checked for\u00a0cataracts.\u00a0If you do not go for routine eye examinations, your doctor should arrange regular examinations.\u00a0You can also be checked for the presence of bleeding in and around the retina (the photosensitive layer of cells in the back of the eye).<\/p>\n\n\n\n<p><strong>You need to take samples regularly<\/strong><\/p>\n\n\n\n<p>Before you start taking Revolade, your doctor will take blood samples to check your\u00a0blood cells, including platelets.\u00a0These tests are repeated at regular intervals while you are taking the medicine.<\/p>\n\n\n\n<p><strong>Blood tests to check liver function<\/strong><\/p>\n\n\n\n<p>Revolade may cause your liver tests to show signs of liver damage &#8211; and an increase in certain liver enzymes, especially\u00a0bilirubin\u00a0and alanine\/aspartate\u00a0transaminases.\u00a0Taking interferon-based medicines with Revolade to treat low\u00a0platelet counts\u00a0due to\u00a0hepatitis\u00a0C may make certain liver problems worse.<\/p>\n\n\n\n<p>You will be given blood tests to check your liver function before you start taking Revolade and at certain intervals while you are taking it.&nbsp;You may need to stop taking Revolade if the amount of these substances increases too much or if you get other signs of liver damage.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Read the information \u201cLiver problems\u201d in section 4 of this leaflet.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Blood tests to check the number of&nbsp;platelets<\/strong><\/p>\n\n\n\n<p>If you stop taking Revolade, you will likely get a low\u00a0platelet count\u00a0again after several days.\u00a0The\u00a0platelet count\u00a0will be checked and your doctor will discuss appropriate precautions with you.<\/p>\n\n\n\n<p>A very high number of\u00a0platelets\u00a0can increase the risk of blood clots.\u00a0However, blood clots can form even with normal or even low\u00a0platelet counts.\u00a0Your doctor will adjust your Revolade\u00a0dose\u00a0so that your platelet count does not become too high.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20150212000023#\" rel=\"noopener\"><\/a><\/td><td><strong>Seek medical attention immediately<\/strong>\u00a0if you have any of these signs of blood clots: swelling, pain\u00a0or tenderness in a leg sudden shortness of breath, especially with severe chest pain or rapid breathing abdominal pain, enlarged abdomen, blood in the stool<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Control of your&nbsp;bone marrow<\/strong><\/p>\n\n\n\n<p>In people with\u00a0bone marrow\u00a0problems, medicines such as Revolade can make the problems worse.\u00a0Signs of bone marrow changes may show abnormal results on your blood tests.\u00a0Your doctor may also perform tests to directly check your\u00a0bone marrow\u00a0during treatment with Revolade.<\/p>\n\n\n\n<p><strong>Controls for stomach bleeding<\/strong><\/p>\n\n\n\n<p>If you are taking interferon-based treatments with Revolade, you will be followed up for any signs of bleeding in the stomach or intestines after stopping Revolade.<\/p>\n\n\n\n<p><strong>Cardiac monitoring<\/strong><\/p>\n\n\n\n<p>Your doctor may consider it necessary to monitor your heart during treatment with Revolade and examine your heart with an&nbsp;ECG&nbsp;(&nbsp;electrocardiogram&nbsp;).<\/p>\n\n\n\n<p><strong>Elderly people (65 years and older)<\/strong><\/p>\n\n\n\n<p>There are limited data on the use of Revolade in patients 65 years of age and older.&nbsp;Caution should be exercised when using Revolade if you are 65 years of age or older.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Revolade is not recommended for children under 1 year who have ITP.\u00a0It is also not recommended for people under the age of 18 who have low\u00a0platelet counts\u00a0due to\u00a0hepatitis\u00a0C or severe\u00a0aplastic anemia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Revolade<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0This includes over-the-counter ones and\u00a0vitamins.<\/p>\n\n\n\n<p><strong>Some common medicines work with Revolade<\/strong>&nbsp;&#8211; these are prescription and over-the-counter medicines and minerals.&nbsp;These include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>antacids to treat\u00a0<strong>an upset stomach<\/strong>,\u00a0heartburn,\u00a0or\u00a0stomach ulcer\u00a0(see also\u00a0\u201c\u00a0When to take it\u00a0\u201d\u00a0in section 3)<\/li><li>drugs called statins, to\u00a0lower cholesterol<\/li><li>certain medicines\u00a0to treat\u00a0HIV\u00a0infection\u00a0such as\u00a0lopinavir and\/or ritonavir<\/li><li>ciclosporin is used in\u00a0transplants\u00a0or\u00a0immune diseases<\/li><li>minerals such as\u00a0iron,\u00a0calcium,\u00a0magnesium, aluminum, selenium, and zinc which may be present in\u00a0<strong>vitamin\u00a0and mineral supplements<\/strong>\u00a0(see also\u00a0<em>&#8221;\u00a0<strong>When to take it<\/strong>\u00a0&#8220;<\/em>\u00a0in section 3)<\/li><li>drugs such as\u00a0methotrexate and <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/topotecan-ebewe\/\">topotecan<\/a>, to treat\u00a0<strong>cancer<\/strong><\/li><li><strong>Tell your doctor<\/strong>\u00a0if you are taking any of these.\u00a0Some of them should not be taken with Revolade.\u00a0Dosage\u00a0may need to be adjusted or you may need to change the time you take them.\u00a0The doctor will review the medicines you are taking and suggest appropriate reimbursements if needed.<\/li><\/ul>\n\n\n\n<p>If you are also taking medicines that prevent blood clots, the risk of bleeding is greater.&nbsp;Your doctor will discuss this with you.<\/p>\n\n\n\n<p>If you are taking\u00a0<strong>corticosteroids<\/strong>, danazol,\u00a0and\/or\u00a0azathioprine, you may need to take lower\u00a0doses\u00a0or stop taking them while you are taking Revolade.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Revoluted with food and drink<\/h2>\n\n\n\n<p>Do not take Revolade with dairy products or milk drinks as the&nbsp;calcium&nbsp;found in dairy products affects the uptake of the medicine.&nbsp;For more information, see&nbsp;<em>&#8221;&nbsp;<strong>When to take it<\/strong>&nbsp;&#8220;<\/em>&nbsp;in section 3.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p><strong>Do not use Revolade if you are pregnant<\/strong>&nbsp;unless your doctor specifically recommends it.&nbsp;The effect of Revolade during pregnancy is unknown.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor if you are pregnant<\/strong>, think you may be pregnant, or are planning to have a baby.<\/li><li><strong>Use a reliable method of contraception<\/strong>\u00a0while taking Revolade to prevent pregnancy.<\/li><li><strong>If you become pregnant during treatment<\/strong>\u00a0with Revolade, tell your doctor.<\/li><\/ul>\n\n\n\n<p><strong>Do not breastfeed<\/strong> while taking Revolade.\u00a0It is not known if Revolade passes into breast milk.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are breastfeeding<\/strong>\u00a0or planning to breastfeed, tell your doctor.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Revolade can make you dizzy and cause other&nbsp;side effects&nbsp;that may make you less alert.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Do not drive or use machines<\/strong>&nbsp;unless you are sure you are unaffected.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Revolade contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Revolade<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.&nbsp;Do not change the&nbsp;dose&nbsp;or dosing schedule for taking Revolade unless your doctor or pharmacist recommends that you do so.&nbsp;While taking Revolade you will be under the supervision of a doctor with specialist knowledge in the treatment of your disease.<\/p>\n\n\n\n<p><strong>How much to take<\/strong><\/p>\n\n\n\n<p><strong>For ITP<\/strong><\/p>\n\n\n\n<p><b>For adults<\/b>\u00a0and\u00a0children\u00a0(6-17 years) &#8211; the usual starting dose for ITP is\u00a0one 50 mg tablet\u00a0of Revolade a day.\u00a0If you are of East \/ Southeast Asian descent, you may need to start with a\u00a0lower\u00a0dose\u00a0of 25 mg.<\/p>\n\n\n\n<p><strong>Children<\/strong>\u00a0(1-5 years) &#8211; the usual starting dose for ITP is\u00a0<strong>one 25\u00a0mg tablet<\/strong>\u00a0of Revolade a day.<\/p>\n\n\n\n<p><strong>For&nbsp;hepatitis&nbsp;C<\/strong><\/p>\n\n\n\n<p><strong>For adults<\/strong> &#8211;\u00a0the usual starting dose for\u00a0hepatitis\u00a0C is\u00a0one 25 mg tablet\u00a0of Revolade a day.\u00a0If you are of East \/ Southeast Asian descent, start with\u00a0the same\u00a025 mg\u00a0dose.<\/p>\n\n\n\n<p><strong>For SAA<\/strong><\/p>\n\n\n\n<p><strong>For adults<\/strong> &#8211;\u00a0the usual starting dose for SAA is\u00a0one 50 mg tablet\u00a0of Revolade a day.\u00a0If you are of East \/ Southeast Asian descent, you may need to start with a\u00a0lower\u00a0dose\u00a0of 25 mg.<\/p>\n\n\n\n<p>It may take 1 to 2 weeks for Revolade to start working.&nbsp;Depending on how you react to Revolade, your doctor may recommend that your daily&nbsp;dose&nbsp;be changed.<\/p>\n\n\n\n<p><strong>How to take the tablets<\/strong><\/p>\n\n\n\n<p>Swallow the tablet whole with a little water.<\/p>\n\n\n\n<p><strong>When to take it<\/strong><\/p>\n\n\n\n<p>Make sure you below<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>&nbsp;<strong>4 hours before<\/strong>&nbsp;taking Revolade<\/li><li>and&nbsp;<strong>2 hours after<\/strong>&nbsp;taking Revolade<\/li><\/ul>\n\n\n\n<p><strong>do not eat or drink<\/strong>&nbsp;any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>dairy products<\/strong>\u00a0such as\u00a0cheese, butter, yogurt, or ice cream<\/li><li>milk or milkshake, beverages containing milk, yogurt, or cream<\/li><li>antacids, a type of medicine for heartburn and heartburn<\/li><li>certain\u00a0mineral and vitamin supplements, e.g.\u00a0iron,\u00a0calcium,\u00a0magnesium, aluminum, selenium, and zinc.<\/li><\/ul>\n\n\n\n<p>If you do, the medicine will not be absorbed by the body properly.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20150212000023#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/d1333994-a6d2-46e2-ba57-d4f5e5c658b8\" alt=\"Ta Revolade\" title=\"Ta Revolade\"\/><\/a><\/figure>\n\n\n\n<p><strong>Talk to your doctor if you want more advice on proper food and drink.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Revolade than you should<\/h2>\n\n\n\n<p><strong>Contact a doctor or pharmacist immediately.&nbsp;<\/strong>Show them the package or this leaflet if possible.<\/p>\n\n\n\n<p>You will be monitored for any signs or symptoms of&nbsp;side effects&nbsp;and receive appropriate treatment immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Revolade<\/h2>\n\n\n\n<p>Take the next&nbsp;dose&nbsp;at the usual time.&nbsp;Do not take more than one&nbsp;dose&nbsp;of Revolade in one day.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Revolade<\/h2>\n\n\n\n<p>Do not stop taking Revolade without talking to your doctor.&nbsp;If your doctor advises you to stop treatment, your&nbsp;platelets&nbsp;will be checked weekly for four weeks.&nbsp;See also \u201c&nbsp;<strong><em>Bleeding or bruising after stopping treatment<\/em><\/strong>&nbsp;\u201d in section 4.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Symptoms that need treatment: see a doctor<\/strong><\/p>\n\n\n\n<p>People taking Revolade for either ITP or low platelet counts due to\u00a0hepatitis\u00a0C may experience signs of potentially serious\u00a0side effects.\u00a0You must tell<strong> your doctor if you develop such symptoms.<\/strong><\/p>\n\n\n\n<p><strong>Higher risk of blood clots<\/strong><\/p>\n\n\n\n<p>Some people may have a higher risk of blood clots and medications like Revolade can make the problem worse.\u00a0Sudden blockage of a blood vessel due to a blood clot is an uncommon\u00a0side effect\u00a0and can occur in up to 1 in 100 people.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20150212000023#\" rel=\"noopener\"><\/a><\/td><td><strong>Seek medical attention immediately if you get any signs or symptoms of a blood clot, such as:<\/strong><\/td><\/tr><tr><td>&nbsp;<\/td><td><strong>swelling<\/strong>, pain, heat,\u00a0redness,\u00a0or tenderness\u00a0in a leg sudden\u00a0shortness of breath, especially with severe chest pain or rapid breathing abdominal pain, enlarged abdomen, and blood in the stool.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Liver problem<\/strong><\/p>\n\n\n\n<p>Revolt can cause changes that show up in blood tests and can be a sign of liver damage.&nbsp;Liver problems (elevated enzyme levels in blood samples) are common and may affect up to 1 in 10 people.&nbsp;Other liver problems are less common and can affect up to 1 in 100 people.<\/p>\n\n\n\n<p>If you have any of the following signs of liver problems:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>yellowing of the skin or whites of the eyes (jaundice)<\/li><li>unusually dark-colored urine<\/li><li><strong>Tell your doctor immediately if<\/strong>&nbsp;you get any of these symptoms.<\/li><\/ul>\n\n\n\n<p><strong>Bleeding or bruising after stopping treatment<\/strong><\/p>\n\n\n\n<p>Within two weeks of stopping Revolade, your platelet count usually returns to what it was before you started taking Revolade.&nbsp;The lower platelet count may increase the risk of bleeding and bruising.&nbsp;Your doctor will check your platelet count for at least 4 weeks after you stop taking Revolade.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor<\/strong>&nbsp;if you experience bleeding or bruising after stopping Revolade.<\/li><\/ul>\n\n\n\n<p>Some people may have problems with\u00a0<strong>bleeding in the digestive system<\/strong>\u00a0when they have stopped taking peginterferon, ribavirin, and Revolade.\u00a0The symptoms are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>black tar-like stools (discolored stools are a less common&nbsp;side effect&nbsp;that can occur in up to 1 in 100 people)<\/li><li>blood in the stool<\/li><li>vomiting or vomiting that looks like coffee grounds.<\/li><li><strong>Tell&nbsp;<\/strong><strong>your doctor immediately if<\/strong>&nbsp;you get any of these symptoms.<\/li><\/ul>\n\n\n\n<p><strong>The following&nbsp;adverse reactions&nbsp;have been reported to be associated with Revolade treatment in adult patients with ITP:<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>more than 1 in 10<\/strong>&nbsp;people:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cold<\/li><li>nausea<\/li><li>diarrhea<\/li><li>cough<\/li><li>infection\u00a0of the nose, sinuses, throat, and upper respiratory tract (upper respiratory tract infection)<\/li><li>back pain<\/li><\/ul>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;that may appear on blood tests:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>elevated liver enzymes (&nbsp;alanine aminotransferase&nbsp;(&nbsp;ALT&nbsp;))<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 10<\/strong>&nbsp;people:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>muscle pain, muscle spasm, muscle weakness<\/li><li>skeletal pain<\/li><li>heavy menstrual bleeding or prolonged menstruation<\/li><li>sore throat and discomfort when swallowing<\/li><li>eye problems include an abnormal vision tests, dry eyes, eye pain, and blurred vision<\/li><li>vomiting<\/li><li>influenza<\/li><li>cold sores<\/li><li>pneumonia<\/li><li>irritation and\u00a0inflammation\u00a0(swelling) of the sinuses<\/li><li>inflammation\u00a0(swelling) and\u00a0infection\u00a0of\u00a0the\u00a0tonsils<\/li><li>infection\u00a0of the lungs, sinuses, nose, and throat<\/li><li>gingivitis<\/li><li>loss of appetite<\/li><li>tingling or numbness in the hands or feet<\/li><li>decreased skin sensitivity<\/li><li>drowsiness<\/li><li>ear pain<\/li><li>pain, swelling, and tenderness in one leg (usually the calf) with hot skin in the affected area (signs of a blood clot in a deep vein)<\/li><li>local, blood-filled swelling due to a ruptured blood vessel (hematoma)<\/li><li>hot flashes<\/li><li>mouth problems, including\u00a0dry mouth\u00a0or sores in the mouth, sensitive tongue, bleeding gums, cold sores<\/li><li>Runny nose<\/li><li>toothache<\/li><li>abdominal pain<\/li><li>abnormal liver function<\/li><li>skin changes, including heavy sweating, itchy raised rashes, red spots, altered appearance<\/li><li>hair loss<\/li><li>frothy, frothy urine or urine with visible bubbles (signs of\u00a0protein\u00a0in the urine)<\/li><li>fever, feeling hot<\/li><li>chest pain<\/li><li>feel weak<\/li><li>sleep problems, depression<\/li><li>migraine<\/li><li>impaired vision<\/li><li>fainting (dizziness)<\/li><li>indigestion \/ gas<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;that may show up in blood tests:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;)<\/li><li>decreased&nbsp;platelet count&nbsp;(&nbsp;thrombocytopenia&nbsp;)<\/li><li>decreased&nbsp;white blood cell count<\/li><li>decreased hemoglobin level<\/li><li>increased number&nbsp;of&nbsp;eosinophils<\/li><li>increased&nbsp;white blood cell count&nbsp;(&nbsp;leukocytosis&nbsp;)<\/li><li>increased levels of&nbsp;uric acid<\/li><li>decreased levels of&nbsp;potassium<\/li><li>increased levels of&nbsp;creatinine<\/li><li>increased levels of alkaline phosphatase<\/li><li>increase in liver enzymes (&nbsp;aspartate aminotransferase&nbsp;(&nbsp;ASAT&nbsp;))<\/li><li>increase in&nbsp;bilirubin&nbsp;(a substance produced in the liver) in the blood<\/li><li>increased levels of&nbsp;certain&nbsp;proteins<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 100<\/strong>&nbsp;people:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reaction<\/li><li>interrupted blood supply to a part of the heart<\/li><li>sudden shortness of breath, especially with concomitant severe pain in the chest and\/or rapid breathing, which may be a sign of a blood clot in the lungs (see \u201c\u00a0Higher risk of blood clots\u00a0\u201d earlier in section 4)<\/li><li>lost function in a part of the lung caused by a blockage in the pulmonary artery<\/li><li>possible pain, swelling, and\/or\u00a0redness\u00a0around a vein, which may be a sign of a blood clot in a vein<\/li><li>yellowing of the skin and\/or abdominal pain, which may be a sign of a blockage in the bile ducts, liver damage, or liver damage due to\u00a0inflammation\u00a0(see \u201c\u00a0Liver problems\u00a0\u201d earlier in section 4)<\/li><li>liver damage due to medication<\/li><li>rapid heartbeat, irregular\u00a0heartbeat, blue discoloration of the skin, and disturbances of heart rhythm (\u00a0QT\u00a0prolongation) which may be signs of disturbances related to the heart and blood vessels<\/li><li>blood clot<\/li><li>redness<\/li><li>painful, swollen joints caused by\u00a0uric acid\u00a0(\u00a0gout\u00a0)<\/li><li>lack of interest, mood swings, crying that is difficult to stop or occurs at unexpected times<\/li><li>problems with balance, speech and nerve function, tremors<\/li><li>painful and abnormal skin sensitivity<\/li><li>paralysis of one side of the body<\/li><li>migraine\u00a0with\u00a0aura<\/li><li>nerve damage<\/li><li>dilation or swelling of blood vessels causing headaches<\/li><li>eye problems including increased production of tears, the cloudy lens in the eye (cataracts), bleeding in the retina, dry eyes<\/li><li>problems with the nose, throat, and sinuses, breathing problems when sleeping<\/li><li>mouth and throat blisters\/sores<\/li><li>decreased appetite<\/li><li>problems with the digestive system, including frequent bowel movements, food poisoning, blood in the stool, vomiting of blood<\/li><li>bleeding from the rectum, change in color of stool, bloated stomach, constipation<\/li><li>problems with the mouth, including\u00a0dry mouth\u00a0or sores in the mouth, tongue pain, bleeding gums, discomfort in the mouth<\/li><li>sunburn<\/li><li>feel warm, feel anxious<\/li><li>redness\u00a0or swelling around wounds<\/li><li>bleeding in the skin around a\u00a0catheter\u00a0(if any)<\/li><li>the feeling of foreign objects in the body<\/li><li>kidney problems, including\u00a0inflammation\u00a0of the kidneys, increased need to urinate at night,\u00a0kidney failure,\u00a0white blood cells\u00a0in the urine<\/li><li>cold sweats<\/li><li>general malaise<\/li><li>skin infection<\/li><li>skin changes including skin discoloration, exfoliation (peeling),\u00a0redness,\u00a0itching,\u00a0and sweating<\/li><li>muscle weakness<\/li><li>cancer of the rectum and colon<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;that may show up in laboratory tests:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>changes in the form of\u00a0red blood cells<\/li><li>presence of developing\u00a0white blood cells\u00a0that may indicate certain diseases<\/li><li>increased\u00a0platelet count<\/li><li>decreased levels of\u00a0calcium<\/li><li>decreased number of\u00a0red blood cells\u00a0(\u00a0anemia\u00a0) caused by excessive destruction of\u00a0red blood cells\u00a0(\u00a0hemolytic anemia\u00a0)<\/li><li>increased number of myelocytes<\/li><li>increased number of band neutrophils<\/li><li>increased level of blood urea<\/li><li>increased level of\u00a0protein\u00a0in the urine<\/li><li>increased levels of blood albumin<\/li><li>increased levels of total protein<\/li><li>decreased levels of blood albumin<\/li><li>increased\u00a0pH\u00a0in the urine<\/li><li>increased levels of\u00a0hemoglobin<\/li><\/ul>\n\n\n\n<p><strong>The following additional&nbsp;side effects&nbsp;have been reported to be associated with treatment with Revolade in children (aged 1 to 17 years) with ITP:<\/strong><\/p>\n\n\n\n<p>If these\u00a0side effects\u00a0become severe, consult your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>more than 1 in 10<\/strong>&nbsp;children<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection\u00a0of the nose, sinuses, throat, and upper respiratory tract, cold (upper respiratory tract infection)<\/li><li>diarrhea<\/li><li>abdominal pain<\/li><li>cough<\/li><li>fever<\/li><li>nausea<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 10<\/strong>&nbsp;children<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty sleeping (insomnia)<\/li><li>toothache<\/li><li>pain in the nose and throat<\/li><li>itchy, runny, or blocked nose<\/li><li>sore throat, runny nose, nasal congestion, and sneezing<\/li><li>mouth problems including dry mouth, sore mouth, sensitive tongue, bleeding gums, cold sores<\/li><\/ul>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;have been reported to be associated with treatment with Revolade in combination with peginterferon and ribavirin in patients with HCV:<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>more than 1 in 10<\/strong>&nbsp;people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>appetite<\/li><li>cough<\/li><li>nausea, diarrhea<\/li><li>muscle pain, muscle weakness<\/li><li>itching<\/li><li>feel tired<\/li><li>fever<\/li><li>unusual hair loss<\/li><li>feel weak<\/li><li>flu-like illness<\/li><li>swelling in hands or feet<\/li><li>overindulge<\/li><\/ul>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;that may show up in blood tests:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 10<\/strong>&nbsp;people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>urinary\u00a0tract infection<\/li><li>inflammation\u00a0of the nasal passages, throat, and mouth,\u00a0flu-like symptoms,\u00a0dry mouth, sores or inflamed mouth, toothache<\/li><li>weight loss<\/li><li>sleep disorders, abnormal sleepiness, depression, anxiety<\/li><li>dizziness, problems with attention and memory, change in mood<\/li><li>decreased brain function caused by liver damage<\/li><li>tingling or numbness in the hands or feet<\/li><li>fever, headache<\/li><li>eye problems, including cloudy lens in the eye (cataracts), dry eyes, small yellow deposits in the retina, yellowing of the whites of the eyes<\/li><li>bleeding in the retina<\/li><li>fainting (dizziness)<\/li><li>rapid or irregular heartbeat (palpitations), shortness of breath<\/li><li>cough leading to mucus, runny nose,\u00a0flu, cold sores, sore throat, and swallowing discomfort<\/li><li>gastrointestinal disorders, including vomiting, stomach pain, indigestion, constipation, bloating, taste disturbances,\u00a0hemorrhoids, discomfort\/stomach pain, swollen blood vessels, and bleeding esophagus<\/li><li>toothache<\/li><li>liver problems, including\u00a0tumors\u00a0in the liver, yellowing of the whites of the eyes or skin (jaundice), and liver damage due to medication (see\u00a0\u201cLiver problems\u201d\u00a0earlier in section 4)<\/li><li>skin changes, including rash, dry skin,\u00a0eczema, reddening of the skin,\u00a0itching, excessive sweating, unusual skin growths, hair loss<\/li><li>joint pain, back pain, skeletal pain, pain in the\u00a0extremities\u00a0(arms, legs, hands, or feet), muscle spasms<\/li><li>irritability, general nausea, skin reactions such as\u00a0redness\u00a0or swelling and pain at the injection site, chest pain, and discomfort, accumulation of fluid in the body or\u00a0extremity\u00a0causing swelling<\/li><li>infection\u00a0of the nose, sinuses, throat, and upper respiratory tract, cold (upper respiratory tract infection),\u00a0inflammation\u00a0of the mucous membranes of\u00a0the\u00a0bronchi<\/li><li>depression, anxiety, sleep problems, nervousness<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;that may show up in blood tests:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased level of blood sugar (&nbsp;glucose&nbsp;)<\/li><li>decreased&nbsp;white blood cell count<\/li><li>decreased&nbsp;number of&nbsp;neutrophils<\/li><li>decreased level of blood albumin<\/li><li>decreased level of&nbsp;hemoglobin<\/li><li>increased levels of&nbsp;bilirubin&nbsp;in the blood (a substance produced in the liver)<\/li><li>changes in&nbsp;enzymes&nbsp;that control blood coagulation<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 10<\/strong>&nbsp;people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>painful urination<\/li><li>heart rhythm disorders (\u00a0QT\u00a0prolongation)<\/li><li>gastric flu (\u00a0gastroenteritis\u00a0), sore throat<\/li><li>mouth blisters \/ &#8211; sores, gastritis<\/li><li>skin changes including discoloration, exfoliation,\u00a0redness,\u00a0itching, skin change, and night sweats<\/li><li>blood clots in a vein in the liver (possible liver and\/or digestive system damage)<\/li><li>abnormal blood clot formation in small blood vessels with\u00a0renal failure<\/li><li>rash, bruising at the injection site, chest discomfort<\/li><li>decreased number of\u00a0red blood cells\u00a0(\u00a0anemia\u00a0) caused by excessive destruction of\u00a0red blood cells\u00a0(\u00a0hemolytic anemia\u00a0)<\/li><li>confusion,\u00a0agitation<\/li><li>liver failure<\/li><\/ul>\n\n\n\n<p><strong>The following&nbsp;adverse reactions&nbsp;have been reported to be associated with Revolade treatment in patients with severe&nbsp;aplastic anemia&nbsp;(SAA):<\/strong><\/p>\n\n\n\n<p>If these\u00a0side effects\u00a0become severe, consult your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>more than 1 in 10<\/strong>&nbsp;people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cough<\/li><li>headache<\/li><li>mouth and throat pain<\/li><li>diarrhea<\/li><li>feel sick, (nausea)<\/li><li>joint pain (\u00a0arthralgia\u00a0)<\/li><li>pain in the\u00a0extremities\u00a0(arms, legs, hands, and feet)<\/li><li>dizziness<\/li><li>feeling very tired<\/li><li>fever<\/li><li>overindulge<\/li><li>itchy eyes<\/li><li>blisters in the mouth<\/li><li>bleeding in the gums<\/li><li>abdominal pain<\/li><li>muscle twitching<\/li><\/ul>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;that may show up in blood tests:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal changes in the cells of the&nbsp;bone&nbsp;marrow<\/li><li>increased levels of liver enzymes (&nbsp;aspartate aminotransferase&nbsp;(&nbsp;ASAT&nbsp;))<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 10<\/strong>&nbsp;people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>anxiety<\/li><li>Depression<\/li><li>feel cold (freeze)<\/li><li>generally feel bad<\/li><li>eye problems, including vision problems, blurred vision, the cloudy lens in the eye (cataracts), spots or deposits in the\u00a0vitreous\u00a0of the eye (spots in the\u00a0field\u00a0of vision ), dry eyes, itchy eyes, yellowing of the whites of the eyes or skin<\/li><li>nosebleeds<\/li><li>bleeding gums<\/li><li>digestive problems, including difficulty swallowing, mouth pain, swollen tongue, vomiting, loss of appetite, stomach pain\/discomfort, bloating, gas, constipation, disturbances of bowel movements that can cause constipation, bloating, diarrhea, and\/or the above symptoms, change in color of stools<\/li><li>fainting<\/li><li>skin problems including small red or purple spots caused by bleeding in the skin (\u00a0petechiae\u00a0) rash,\u00a0itching, hives, skin damage<\/li><li>back pain<\/li><li>muscle pain<\/li><li>skeletal pain<\/li><li>weakness (\u00a0asthenia\u00a0)<\/li><li>swelling in the lower\u00a0extremity\u00a0is due to\u00a0the accumulation\u00a0of fluids<\/li><li>abnormally colored urine<\/li><li>interruption of blood supply to the\u00a0spleen\u00a0(splenic infarction)<\/li><li>Runny nose<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;that may show up in blood tests:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increase in\u00a0the enzyme\u00a0is due to muscle breakdown (creatine phosphokinase)<\/li><li>accumulation\u00a0of iron in the body (iron overload)<\/li><li>decrease in blood sugar levels (hypoglycemia)<\/li><li>increased levels of\u00a0bilirubin\u00a0(a substance produced in the liver) in the blood<\/li><li>decreased levels of\u00a0white blood cells<\/li><\/ul>\n\n\n\n<p><strong>Side effects&nbsp;are with unknown frequency<\/strong><\/p>\n\n\n\n<p>The frequency can not be calculated from the available data<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>discoloration of the skin<\/li><li>darker skin tone<\/li><li>liver damage due to medication<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Revolade<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance in Revolade is eltrombopag<\/p>\n\n\n\n<p><strong>12.5 mg film-coated tablets<\/strong><\/p>\n\n\n\n<p>One film-coated tablet contains eltrombopag olamine equivalent to 12.5 mg of eltrombopag.<\/p>\n\n\n\n<p><strong>25 mg film-coated tablets<\/strong><\/p>\n\n\n\n<p>One film-coated tablet contains eltrombopag olamine equivalent to 25 mg of eltrombopag.<\/p>\n\n\n\n<p><strong>50 mg film-coated tablets<\/strong><\/p>\n\n\n\n<p>One film-coated tablet contains eltrombopag olamine equivalent to 50 mg of eltrombopag.<\/p>\n\n\n\n<p><strong>75 mg film-coated tablets<\/strong><\/p>\n\n\n\n<p>One film-coated tablet contains eltrombopag olamine equivalent to 75 mg of eltrombopag.<\/p>\n\n\n\n<p>The other ingredients are hypromellose, macrogol 400, magnesium stearate, mannitol (E421), microcrystalline cellulose, povidone, sodium starch glycolate, and titanium dioxide (E171).<\/p>\n\n\n\n<p>Revolade 12.5 mg and 25 mg film-coated tablets also contain&nbsp;<strong>polysorbate<\/strong>&nbsp;80 (&nbsp;<strong>E433<\/strong>&nbsp;).<\/p>\n\n\n\n<p>Revolade 50 mg film-coated tablets also contain red iron oxide (E172) and yellow iron oxide (E172).<\/p>\n\n\n\n<p>Revolade 75 mg film-coated tablets also contain red iron oxide (E172) and black iron oxide (E172).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Revolte 12.5 mg film-coated tablets are round, biconvex, white, and punched with &#8220;GS MZ1&#8221; and &#8220;12.5&#8221; on one side.<\/p>\n\n\n\n<p>Revolte 25 mg film-coated tablets are round, biconvex, white, and punched with &#8220;GS NX3&#8221; and &#8220;25&#8221; on one side.<\/p>\n\n\n\n<p>Revolte 50 mg film-coated tablets are round, biconvex, brown, and punched with &#8220;GS UFU&#8221; and &#8220;50&#8221; on one side.<\/p>\n\n\n\n<p>Related 75 mg film-coated tablets are round, biconvex, pink, and punched with &#8220;GS FFS&#8221; and &#8220;75&#8221; on one side.<\/p>\n\n\n\n<p>They are delivered in aluminum blisters in a carton containing 14 or 28 film-coated tablets and multiple packs containing 84 (3 packs of 28) film-coated tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Novartis Europharm Limited<\/p>\n\n\n\n<p>Vista Building<\/p>\n\n\n\n<p>Elm Park, Merrion Road<\/p>\n\n\n\n<p>Dublin 4<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Lek dd<\/p>\n\n\n\n<p>Verovskova Ulica 57<\/p>\n\n\n\n<p>Ljubljana 1526<\/p>\n\n\n\n<p>Slovenia<\/p>\n\n\n\n<p>Novartis Pharmac\u00e9utica SA<\/p>\n\n\n\n<p>Gran Via de les Corts Catalanes, 764<\/p>\n\n\n\n<p>08013 Barcelona<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p>Novartis Pharma GmbH<\/p>\n\n\n\n<p>Roonstra\u00dfe 25<\/p>\n\n\n\n<p>D-90429 Nuremberg<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Glaxo Wellcome SA<\/p>\n\n\n\n<p>Avenida de Extremadura, 3<\/p>\n\n\n\n<p>09400 Aranda de Duero<\/p>\n\n\n\n<p>Burgos<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Novartis Pharma NVTel: +32 2 246 16 11<\/td><td><strong>Lithuania<\/strong>SIA Novartis Baltics Lithuanian branchesTel: +370 5 269 16 50<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Novartis Bulgaria EOODTel: +359 2 489 98 28<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Novartis Pharma NVTel: +32 2 246 16 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Novartis sroTel: +420 225 775 111<\/td><td><strong>Hungary<\/strong>Novartis Hungary Kft.Tel .: +36 1 457 65 00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Novartis Healthcare A \/ STel: +45 39 16 84 00<\/td><td><strong>Malta<\/strong>Novartis Pharma Services Inc.Tel: +356 2122 2872<\/td><\/tr><tr><td><strong>Germany<\/strong>Novartis Pharma GmbHTel: +49 911 273 0<\/td><td><strong>The Netherlands<\/strong>Novartis Pharma BVTel: +31 88 04 52 555<\/td><\/tr><tr><td><strong>Eesti<\/strong>SIA Novartis Baltics Eesti subsidiaryTel: +372 66 30 810<\/td><td><strong>Norway<\/strong>Novartis Norge ASTel: +47 23 05 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Novartis (Hellas) AEBE:\u0397\u03bb: +30 210 281 17 12<\/td><td><strong>Austria<\/strong>Novartis&nbsp;Ph&nbsp;arma GmbHTel: +43 1 86 6570<\/td><\/tr><tr><td><strong>Spain<\/strong>Novartis Pharmac\u00e9utica, SATel: +34 93 306 42 00<\/td><td><strong>Poland<\/strong>Novartis Poland Sp.&nbsp;z ooTel .: +48 22 375 4888<\/td><\/tr><tr><td><strong>France<\/strong>Novartis Pharma SASTel: +33 1 55 47 66 00<\/td><td><strong>Portugal<\/strong>Novartis Farma &#8211; Pharmaceutical Products, SATel: +351 21 000 8600<\/td><\/tr><tr><td><strong>Croatia<\/strong>Novartis Hrvatska dooTel.&nbsp;+385 1 6274 220<\/td><td><strong>Romania<\/strong>Novartis Pharma Services Romania SRLTel: +40 21 31299 01<\/td><\/tr><tr><td><strong>Ireland<\/strong>Novartis Ireland LimitedTel: +353 1 260 12 55<\/td><td><strong>Slovenia<\/strong>Novartis Pharma Services Inc.Tel: +386 1 300 75 50<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovak Republic<\/strong>Novartis Slovakia sroTel: +421 2 5542 5439<\/td><\/tr><tr><td><strong>Italy<\/strong>Novartis Farma SpATel: +39 02 96 54 1<\/td><td><strong>Finland \/ Finland<\/strong>Novartis Finland OyPuh \/ Tel: +358 (0) 10 6133 200<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>Novartis Pharma Services Inc.:\u0397\u03bb: +357 22 690 690<\/td><td><strong>Sweden<\/strong>Novartis Sverige ABTel: +46 8 732 32 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Novartis BalticsTel: +371 67 887 070<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Novartis Ireland LimitedTel: +44 1276 698370<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Revolade contains eltrombopag, which belongs to a group of medicines called thrombopoietin receptor agonists . It is used to increase the number of platelets in your blood. Platelets are blood cells that help reduce or prevent bleeding.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[22934,22938,22937,22939,22943,22942,22936,22935,22940,22941],"class_list":["post-22062","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-eltrombopag","tag-eltrombopag-side-effects","tag-eltrombopag-tablet","tag-revolade","tag-revolade-side-effects","tag-revolade-tablet","tag-what-eltrombopag-is-used-for","tag-what-is-eltrombopag","tag-what-is-revolade","tag-what-revolade-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22062","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22062"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22062\/revisions"}],"predecessor-version":[{"id":22139,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22062\/revisions\/22139"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22062"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22062"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22062"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}