{"id":22061,"date":"2022-06-17T05:17:18","date_gmt":"2022-06-17T05:17:18","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22061"},"modified":"2022-06-18T12:24:32","modified_gmt":"2022-06-18T12:24:32","slug":"revlimid","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/revlimid\/","title":{"rendered":"Revlimid &#8211; Lenalidomide uses, dose and side effects"},"content":{"rendered":"\n<p>2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg, 25 mg&nbsp;hard capsules<br>lenalidomide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Revlimid is and what it is used for<\/h2>\n\n\n\n<p><strong>What Revlimid is<\/strong><\/p>\n\n\n\n<p>Revlimid contains the active substance &#8220;lenalidomide&#8221; and belongs to a group of medicines that affect the function of the immune system.<\/p>\n\n\n\n<p><strong>What Revlimid is used for<\/strong><\/p>\n\n\n\n<p>Revlimid is used in adults for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Multiple&nbsp;myeloma<\/li><li>Myelodysplastic syndrome<\/li><li>Mantle cell lymphoma<\/li><li>Follicular&nbsp;lymphoma<\/li><\/ul>\n\n\n\n<p><strong>Multiple&nbsp;myeloma<\/strong><\/p>\n\n\n\n<p>Multiple\u00a0myeloma\u00a0is a form of cancer that affects a certain type of\u00a0white blood cell, called plasma cells.\u00a0These cells are found in the\u00a0bone marrow\u00a0and multiply uncontrollably.\u00a0This can damage the skeleton and kidneys.<\/p>\n\n\n\n<p>Multiple&nbsp;myeloma&nbsp;can generally not be cured.&nbsp;However, signs and symptoms can be greatly reduced and occasionally disappear.&nbsp;This is called a &#8220;treatment response&#8221; or just a &#8220;response&#8221;.<\/p>\n\n\n\n<p>Newly diagnosed multiple&nbsp;myeloma&nbsp;&#8211; in patients who have undergone a bone marrow transplant<\/p>\n\n\n\n<p>Revlimid is used alone as a maintenance treatment after the patient has recovered sufficiently after the bone marrow transplant.<\/p>\n\n\n\n<p>Newly diagnosed multiple&nbsp;myeloma&nbsp;&#8211; in patients who cannot be treated with bone marrow transplantation<\/p>\n\n\n\n<p>Revlimid is taken with other medicines.&nbsp;These may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a cytostatic drug (also called&nbsp;cytotoxic drug&nbsp;) called &#8216;bortezomib&#8217;<\/li><li>an anti-inflammatory drug called <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toflacort\/\">dexamethasone<\/a><\/li><li>a chemotherapy drug called melphalan and<\/li><li>an immunosuppressive drug called prednisone.<\/li><\/ul>\n\n\n\n<p>You take these other medicines at the beginning of treatment and then continue to take Revlimid only.<\/p>\n\n\n\n<p>If you are 75 years of age or older or have moderate to severe kidney problems, your doctor should check carefully before starting treatment.<\/p>\n\n\n\n<p>Multiple&nbsp;myeloma&nbsp;&#8211; in patients who have undergone treatment before<\/p>\n\n\n\n<p>Revlimid is taken with an anti-inflammatory drug called dexamethasone.<\/p>\n\n\n\n<p>Revlimid may prevent the signs and symptoms of multiple&nbsp;myeloma&nbsp;from getting worse.&nbsp;Revlimid has also been shown to delay the recurrence of multiple&nbsp;myeloma&nbsp;after treatment.<\/p>\n\n\n\n<p><strong>Myelodysplastic syndrome&nbsp;(MDS)<\/strong><\/p>\n\n\n\n<p>MDS is a collective name for several different diseases of the blood and\u00a0bone marrow.\u00a0The blood cells\u00a0become abnormal and do not work properly.\u00a0Patients may experience several different signs and symptoms, e.g.\u00a0a low number of\u00a0red blood cells\u00a0(\u00a0anemia\u00a0), need for\u00a0blood transfusions,\u00a0and are at risk of\u00a0infection.<\/p>\n\n\n\n<p>Revlimid is used alone to treat adult patients who have been diagnosed with MDS when all of the following points apply:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you need regular\u00a0blood transfusions\u00a0to treat low levels of\u00a0red blood cells\u00a0(&#8220;transfusion-dependent anemia&#8221;)<\/li><li>you have abnormal cells in the\u00a0bone marrow\u00a0which is called an &#8220;isolated part (5q) cytogenetic abnormality&#8221;.\u00a0This means that your body does not produce enough healthy\u00a0blood\u00a0cells<\/li><li>other treatments that have been used in the past, are inappropriate or do not work well enough.<\/li><\/ul>\n\n\n\n<p>Revlimid can increase the number of healthy&nbsp;red blood cells&nbsp;that the body produces by reducing the number of abnormal cells:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>this can reduce the number of&nbsp;blood transfusions&nbsp;you need.&nbsp;No transfusion may&nbsp;be needed&nbsp;at all.<\/li><\/ul>\n\n\n\n<p><strong>Mantle cell lymphoma (MCL)<\/strong><\/p>\n\n\n\n<p>MCL is a cancer of a part of the immune system (lymph tissue).\u00a0It occurs in a type of\u00a0white blood cell\u00a0called\u00a0B lymphocytes\u00a0or\u00a0B cells\u00a0and causes them to grow in an uncontrolled manner and accumulate in the lymph tissue,\u00a0bone marrow,\u00a0or blood.<\/p>\n\n\n\n<p>Revlimid is used alone to treat adult patients who have been previously treated with other medicines.<\/p>\n\n\n\n<p><strong>Follicular&nbsp;lymphoma&nbsp;(FL)<\/strong><\/p>\n\n\n\n<p>FL is slow-growing cancer that affects the B\u2011\u00a0lymphocytes, a type of\u00a0white blood cell\u00a0that is involved in the body&#8217;s defense against\u00a0infection.\u00a0When you have FL, too many of these B\u2011\u00a0lymphocytes\u00a0can accumulate in the blood,\u00a0bone marrow, lymph nodes, or spleen.<\/p>\n\n\n\n<p>Revlimid is taken with another medicine called rituximab to treat adult patients with previously treated follicular\u00a0lymphoma.<\/p>\n\n\n\n<p><strong>How Revlimid works<\/strong><\/p>\n\n\n\n<p>Revlimid works by affecting the body&#8217;s immune system and directly attacking the cancerous tumor.\u00a0It works in several different ways:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>by&nbsp;inhibiting&nbsp;the development of cancer cells<\/li><li>by preventing blood vessels from growing in the cancerous tumor<\/li><li>by stimulating parts of the immune system to attack the cancer cells.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you take Revlimid<\/h2>\n\n\n\n<p><strong>You must read the package leaflets for all medicines to be taken in combination with Revlimid before starting treatment with Revlimid.<\/strong><\/p>\n\n\n\n<p><strong>Do not take Revlimid<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are pregnant, think you may be pregnant or are planning to have a baby,&nbsp;<strong>as Revlimid is expected to harm the fetus<\/strong>&nbsp;(see section 2, \u201cPregnancy, breast-feeding and contraception &#8211; information for women and men\u201d).<\/li><li>if you may become pregnant and do not take all the necessary measures to prevent getting pregnant (see section 2 &#8220;Pregnancy, breast-feeding and contraception &#8211; information for women and men&#8221;).&nbsp;If you could become pregnant, your doctor will note at each prescription that the necessary steps have been taken and give you this confirmation.<\/li><li>if you are allergic to lenalidomide or any of the other ingredients of this medicine (listed in section 6).&nbsp;If you think you may be allergic, ask your doctor for advice.<\/li><\/ul>\n\n\n\n<p>If any of these apply to you, do not take Revlimid.&nbsp;Talk to your doctor if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>Talk to your doctor, pharmacist, or nurse before taking Revlimid if:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have had blood clots before &#8211; you are at increased risk of getting blood clots in your veins and\u00a0arteries\u00a0during treatment<\/li><li>you have any signs of an\u00a0infection, e.g.\u00a0cough or fever<\/li><li>If you have kidney problems &#8211; your doctor may adjust the\u00a0dose\u00a0of Revlimid if necessary<\/li><li>you have or have had a viral infection, in particular:\u00a0hepatitis\u00a0B\u00a0infection, varicella-zoster, or\u00a0HIV.\u00a0Consult a doctor if you are unsure.\u00a0Treatment with Revlimid may reactivate the\u00a0virus\u00a0in patients who carry this\u00a0virus.\u00a0This leads to\u00a0a recurrence of\u00a0infection.\u00a0Your doctor will test you for\u00a0hepatitis\u00a0B\u00a0infection<\/li><li>you have had a heart attack, if you have ever had a blood clot or if you smoke, have high\u00a0blood pressure\u00a0or high cholesterol<\/li><li>you have had an\u00a0allergic reaction\u00a0such as skin rash,\u00a0itching, swelling, dizziness, or difficulty breathing after taking thalidomide (another medicine used to treat multiple\u00a0myeloma\u00a0)<\/li><li>you have previously experienced a combination of the following symptoms: widespread rash, red skin, high body temperature,\u00a0flu-like symptoms, elevated liver enzyme levels, abnormal blood counts (\u00a0eosinophilia\u00a0), enlarged\u00a0lymph nodes\u00a0&#8211; these are signs of a severe skin reaction called a drug reaction with\u00a0eosinophilia\u00a0and systemic also known as DRESS or drug hypersensitivity syndrome (see also section 4 \u201cPossible side effects\u201d).<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you, tell your doctor, pharmacist, or nurse before starting treatment.<\/p>\n\n\n\n<p>Always tell your doctor or nurse immediately if you get any of the following during or after treatment:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blurred vision, loss of vision or double vision, difficulty speaking, weakness in an arm or leg, change in gait or problems with balance, persistent numbness, decreased feeling or loss of feeling, memory loss or confusion.&nbsp;All of these symptoms can indicate a serious and potentially fatal brain disease called&nbsp;progressive&nbsp;multifocal&nbsp;leukoencephalopathy (PML).&nbsp;If you have had these symptoms before treatment with Revlimid, tell your doctor if the symptoms change in any way.<\/li><li>experiencing shortness of breath, fatigue, dizziness, chest pain, faster heartbeat, or swelling in the legs or ankles.&nbsp;These symptoms may indicate a serious condition called&nbsp;pulmonary&nbsp;hypertension&nbsp;(see section 4).&nbsp;<\/li><\/ul>\n\n\n\n<p><strong>Samples and controls<\/strong><\/p>\n\n\n\n<p>Before and after treatment with Revlimid, you will be given regular blood tests.\u00a0This is because Revlimid can reduce the number of\u00a0blood cells\u00a0that help fight\u00a0infections\u00a0(\u00a0white blood cells\u00a0) and help the blood to coagulate (\u00a0platelets\u00a0).\u00a0Your doctor will ask you to submit a blood test:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>before treatment<\/li><li>every week for the first 8 weeks of treatment<\/li><li>thereafter at least once a month.<\/li><\/ul>\n\n\n\n<p>You may be examined for signs of heart-lung problems before and during treatment with lenalidomide.<\/p>\n\n\n\n<p>For patients with MDS taking Revlimid<\/p>\n\n\n\n<p>If you have MDS, you may be more likely to get a more advanced condition called&nbsp;acute&nbsp;myeloid&nbsp;leukemia&nbsp;(AML).&nbsp;It is also not known how Revlimid affects your chances of getting AML.&nbsp;Your doctor may therefore take samples and check for signs that may better predict the likelihood of you getting AML during treatment with Revlimid.<\/p>\n\n\n\n<p>For patients with MCL taking Revlimid<\/p>\n\n\n\n<p>Your doctor will ask you to submit a blood test:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>before treatment<\/li><li>every week for the first 8 weeks of treatment (2 cycles)<\/li><li>since every other week during cycles 3 and 4 (see section &#8220;Treatment cycles&#8221; for more information)<\/li><li>then at the start of each cycle and<\/li><li>at least once a month.<\/li><\/ul>\n\n\n\n<p>For patients with FL taking Revlimid<\/p>\n\n\n\n<p>Your doctor will ask you to submit a blood test:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>before treatment<\/li><li>every week for the first 3 weeks of treatment (1 cycle)<\/li><li>since every other week during cycles 2 to 4 (see section 3 \u201cTreatment cycles\u201d for more information)<\/li><li>then at the start of each cycle and<\/li><li>at least once a month.<\/li><\/ul>\n\n\n\n<p>Your doctor can check if you have a high total tumor spread throughout your body including the\u00a0bone marrow.\u00a0This can lead to a condition where your\u00a0tumor\u00a0breaks down and can cause unusually high levels of chemicals in the blood.\u00a0This in turn can lead to\u00a0kidney failure\u00a0(&#8220;tumor light syndrome&#8221;).<\/p>\n\n\n\n<p>Your doctor may examine you to see if you have any skin changes, e.g.\u00a0red spots\/dots or rash.<\/p>\n\n\n\n<p>Your doctor may adjust the&nbsp;dose&nbsp;of Revlimid or discontinue treatment depending on the results of your blood tests and your general condition.&nbsp;If you have recently been diagnosed, your doctor may also decide what treatment to take based on your age and any other medical conditions you have.<\/p>\n\n\n\n<p><strong>Blood donation<\/strong><\/p>\n\n\n\n<p>You should not donate blood during treatment and until at least 7 days after the end of treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Revlimid is not recommended for use in children and adolescents under 18 years of age.<\/p>\n\n\n\n<p><strong>Elderly people and people with kidney problems<\/strong><\/p>\n\n\n\n<p>If you are 75 years of age or older or have moderate to severe kidney problems, your doctor should check carefully before starting treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Revlimid<\/h2>\n\n\n\n<p>Tell your doctor or nurse if you are taking, have recently taken, or might take any other medicines.\u00a0This is because Revlimid may affect the effectiveness of other medicines.\u00a0In addition, some other medicines may affect the way Revlimid works.<\/p>\n\n\n\n<p>In particular, tell your doctor or nurse if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>some contraceptives such as\u00a0birth control pills\u00a0may stop working.<\/li><li>certain heart medications such as\u00a0digoxin.<\/li><li>certain blood thinners such as\u00a0warfarin.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and contraception &#8211; information for women and men<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>For women taking Revlimid<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You must not take Revlimid if you are pregnant as it is expected to harm the fetus.<\/li><li>You must not become pregnant while taking Revlimid.\u00a0If you are a woman of\u00a0childbearing potential, you must therefore use a safe method of contraception.\u00a0(see &#8220;Contraceptives&#8221;).<\/li><li>If you become pregnant during treatment with Revlimid, you must stop treatment and inform your doctor immediately.<\/li><\/ul>\n\n\n\n<p>For men taking Revlimid<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If your partner becomes pregnant while you are taking Revlimid, tell your doctor immediately.&nbsp;It is recommended that your partner consult a doctor.<\/li><li>You must also use effective contraceptive methods (see &#8220;Contraceptives&#8221;).<\/li><\/ul>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>You must not breastfeed during treatment with Revlimid, as it is not known if Revlimid passes into breast milk.<\/p>\n\n\n\n<p><strong>Contraceptive<\/strong><\/p>\n\n\n\n<p>For women taking Revlimid<\/p>\n\n\n\n<p>Before starting treatment, ask your doctor if you could become pregnant, even if you think it is unlikely.<\/p>\n\n\n\n<p>If you can get pregnant<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you should undergo pregnancy tests under the supervision of your doctor (before each treatment, at least every 4 weeks during treatment, and at least once 4 weeks after the end of treatment), except in cases where it has been confirmed that the fallopian tubes have been cut off and blocked so that the eggs cannot reach the uterus (tube sterilization)<\/li><\/ul>\n\n\n\n<p>AND<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you must use effective contraception for at least 4 weeks before starting treatment, during treatment, and for at least 4 weeks after stopping treatment.\u00a0Your doctor will advise you on appropriate contraceptive methods.<\/li><\/ul>\n\n\n\n<p>For men taking Revlimid<\/p>\n\n\n\n<p>Revlimid passes into semen in humans.\u00a0If your partner is pregnant or may become pregnant, you must use a condom during the entire treatment period and for at least 7 days after the end of the treatment, even if you have undergone sterilization (vasectomy)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Do not drive or use machines if you feel dizzy, tired, sleepy, dizzy, or have blurred vision.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Revlimid contains lactose<\/h2>\n\n\n\n<p>Revlimid contains\u00a0lactose.\u00a0If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Revlimid<\/h2>\n\n\n\n<p>Only healthcare professionals with experience in the treatment of multiple\u00a0myeloma, MDS, MCL, or FL may give you Revlimid.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>When Revlimid is used for the treatment of multiple\u00a0myeloma\u00a0in patients who are not suitable for transplantation or who have received other treatments before, it is taken with other medicines (see section 1 \u201cWhat Revlimid is used for\u201d).<\/li><li>When Revlimid is used for the treatment of multiple\u00a0myeloma\u00a0in patients who have undergone a bone marrow transplant or for the treatment of patients with MDS or MCL, it is taken alone.<\/li><li>When Revlimid is used to treat follicular\u00a0lymphoma, it is taken together with another medicine called rituximab<\/li><\/ul>\n\n\n\n<p>Always take Revlimid exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>If you are taking Revlimid in combination with other medicines, read the package leaflets of these medicines for more information on their use and effects.<\/p>\n\n\n\n<p><strong>Treatment cycles<\/strong><\/p>\n\n\n\n<p>Revlimid is taken on certain days for 3 weeks (21 days).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Every 21 days is called a &#8220;treatment cycle&#8221;.<\/li><li>Depending on the day of the cycle, you should take one or more of the medicines.\u00a0But some days you should not take any of the medicines.<\/li><li>When each 21-day cycle is over, start a new &#8220;cycle&#8221; that lasts for the next 21 days.<\/li><\/ul>\n\n\n\n<p>OR<\/p>\n\n\n\n<p>Revlimid is taken on certain days for 4 weeks (28 days).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Every 28 days is called a &#8220;treatment cycle&#8221;.<\/li><li>Depending on the day of the cycle, you should take one or more of the medicines.\u00a0But some days you should not take any of the medicines.<\/li><li>At the end of each 28-day cycle, start a new cycle that will last for the next 28 days.<\/li><\/ul>\n\n\n\n<p><strong>How much Revlimid should you take?<\/strong><\/p>\n\n\n\n<p>Before starting treatment, tell your doctor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>how much Revlimid to take<\/li><li>how much of the other medicines you should take in combination with Revlimid (if you are taking any others)<\/li><li>on which days of the treatment cycle you should take each medicine.<\/li><\/ul>\n\n\n\n<p><strong>How and when to take Revlimid capsules<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swallow the\u00a0capsules\u00a0whole, preferably with water.<\/li><li>The capsules must not be crushed, opened, or chewed.\u00a0If powder from an opened capsule Revlimid comes in contact with the skin, wash the skin immediately with soap and water.<\/li><li>Healthcare professionals, carers, and family members should use disposable gloves when handling the blister or capsule.\u00a0The gloves should then be carefully removed to prevent contact with the skin, placed in a resealable plastic bag made of polyethylene, and disposed of by local regulations.\u00a0Then wash your hands thoroughly with soap and water.\u00a0Women who are pregnant or suspect they may be pregnant should not handle the blister or capsule.<\/li><li>The capsules can be taken with or without food.<\/li><li>You should take Revlimid at about the same time on the scheduled day.<\/li><\/ul>\n\n\n\n<p><strong>How to take this medicine<\/strong><\/p>\n\n\n\n<p>When removing the capsule from the blister:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you should only press one end of it so that it slides out through the foil<\/li><li>do not press in the middle of the capsule, as this may cause it to break.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20110106000102#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/5954abda-34ed-4b06-abe4-6f19f642277c\" alt=\"Remove the capsule from the blister by pressing on one end.  \" title=\"Remove the capsule from the blister by pressing on one end.  \"\/><\/a><\/figure>\n\n\n\n<p><strong>How long does the treatment with Revlimid lasts<\/strong><\/p>\n\n\n\n<p>Revlimid is taken during treatment cycles and each cycle is 21 or 28 days long (see \u201cTreatment cycle\u201d above).&nbsp;You should continue with the treatment cycles until your doctor tells you to stop the treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Revlimid than you should<\/h2>\n\n\n\n<p>If you have taken more Revlimid than you were told to, tell your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Revlimid<\/h2>\n\n\n\n<p>If you forget to take Revlimid at the usual time and:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>less than 12 hours have passed &#8211; take the capsule immediately.<\/li><li>more than 12 hours have passed &#8211; do not take the capsule.&nbsp;Take the next capsule at the usual time the next day.<\/li><\/ul>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Stop taking Revlimid and see a doctor immediately if you get any of the following serious&nbsp;side effects&nbsp;&#8211; you may need&nbsp;urgent&nbsp;medical attention:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hives, skin rash, swelling of the eyes, mouth, or face, difficulty breathing, or\u00a0itching, can be symptoms of severe types of allergic reactions called\u00a0angioedema\u00a0or\u00a0anaphylactic reaction.<\/li><li>A severe\u00a0allergic reaction\u00a0that can start as a rash on an area but spreads with extensive loss of skin throughout the body (\u00a0Stevens-Johnson syndrome\u00a0and\/or\u00a0toxic epidermal necrolysis\u00a0).<\/li><li>Widespread rash, high body temperature, elevated liver enzyme levels, abnormal blood levels (\u00a0eosinophilia\u00a0), enlarged\u00a0lymph nodes,\u00a0and effects on other organs in the body (drug reaction with\u00a0eosinophilia\u00a0and systemic symptoms also known as DRESS or drug hypersensitivity syndrome).\u00a0See also section 2.<\/li><\/ul>\n\n\n\n<p><strong>Tell&nbsp;<\/strong><strong>your doctor immediately if&nbsp;<\/strong><strong>you get any of the following serious side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fever, chills, sore throat, cough, cold sores, or any other symptoms of\u00a0infection\u00a0including\u00a0infection\u00a0in the blood (blood poisoning,\u00a0sepsis\u00a0)<\/li><li>Bleeding or bruising without injury<\/li><li>Pain in the chest or legs<\/li><li>Shortness of breath<\/li><li>Skeletal pain, muscle weakness, confusion, or fatigue may be due to high levels of\u00a0calcium\u00a0in the blood.<\/li><\/ul>\n\n\n\n<p>Revlimid can reduce the number of&nbsp;white blood cells&nbsp;that fight&nbsp;infection&nbsp;and also the&nbsp;blood cells&nbsp;that help the blood to coagulate (&nbsp;platelets&nbsp;) which can lead to bleeding problems such as nosebleeds and bruises.<\/p>\n\n\n\n<p>Revlimid can also cause blood clots in veins (&nbsp;thrombosis&nbsp;).<\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>It is important to note that a small proportion of patients develop other cancers and that treatment with Revlimid may increase this risk.&nbsp;Your doctor should therefore carefully evaluate the benefits and risks when you are prescribed Revlimid.<\/p>\n\n\n\n<p><strong>Very common&nbsp;<\/strong>side effects&nbsp;(may affect more than 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A decrease in the number of\u00a0red blood cells\u00a0can cause\u00a0anemia\u00a0and lead to fatigue and weakness<\/li><li>Skin rash,\u00a0itching<\/li><li>Muscle cramps, muscle weakness, muscle pain, muscle aches, skeletal pain, joint pain, back pain, pain in arms and legs<\/li><li>General swelling including swelling of the arms and legs<\/li><li>Weakness, fatigue<\/li><li>Fever and\u00a0flu-like symptoms such\u00a0as fever, muscle aches, headache, earache, cough, and chills<\/li><li>Numbness, tingling or burning in the skin, pain in hands or feet, dizziness, trembling<\/li><li>Decreased appetite, altered sense of taste<\/li><li>Increased pain, tumor size, or\u00a0redness\u00a0around\u00a0tumor\u00a0one<\/li><li>Weight loss<\/li><li>Constipation, diarrhea, nausea, vomiting, abdominal pain, heartburn<\/li><li>Low levels of\u00a0potassium\u00a0or\u00a0calcium\u00a0and\/or\u00a0sodium\u00a0in the blood<\/li><li>Lower thyroid function than normal<\/li><li>Bone pain (which can be a symptom of a blood clot), chest pain, or shortness of breath (which can be a symptom of blood clots in the lungs, called\u00a0pulmonary embolism\u00a0)<\/li><li>Infections\u00a0of all kinds, including in the sinuses around the nose, in the lungs, and in the upper respiratory tract<\/li><li>Shortness of breath<\/li><li>Dimsyn<\/li><li>Clouding of the eye (cataracts)<\/li><li>Kidney problems, include the kidneys not functioning properly or being unable to maintain normal function<\/li><li>Abnormal liver values<\/li><li>Elevated liver values<\/li><li>Changes in a\u00a0protein\u00a0in the blood that can cause swelling of the arteries (\u00a0vasculitis\u00a0)<\/li><li>Elevated blood sugar level (\u00a0diabetes\u00a0)<\/li><li>Lowered blood sugar level<\/li><li>Headache<\/li><li>Nasal blood<\/li><li>Dry skin<\/li><li>Depression, mood swings, difficulty sleeping<\/li><li>Cough<\/li><li>Drop-in blood pressure<\/li><li>A vague feeling of discomfort in the body, a feeling of illness<\/li><li>Sore inflamed mouth,\u00a0dry mouth<\/li><li>Dehydration<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;<\/strong>side effects&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Degradation of\u00a0red blood cells\u00a0(hemolytic anemia\u00a0)<\/li><li>Certain types of skin tumors<\/li><li>Bleeding from gums, stomach, or intestines<\/li><li>High\u00a0blood pressure, slow, fast or irregular heartbeat<\/li><li>The increased amount of a substance that is the result of normal and abnormal degradation of red blood cells<\/li><li>The increased amount of a\u00a0protein\u00a0that indicates\u00a0inflammation\u00a0in the body<\/li><li>Darker skin, discolored skin due to bleeding under the skin, usually caused by bruising, swelling of the skin filled with blood;\u00a0bruise<\/li><li>The increased amount of\u00a0uric acid\u00a0in the blood<\/li><li>Skin rash,\u00a0reddened\u00a0skin, cracked, flaky or scaly skin,\u00a0hives<\/li><li>Increased sweating, night sweats<\/li><li>Difficulty swallowing, sore throat, poor voice quality, or voice changes<\/li><li>Suva<\/li><li>Production of much more or much less urine than usual or inability to control urine<\/li><li>Blood in the urine<\/li><li>Shortness of breath, especially in a supine position (which can be a symptom of\u00a0heart failure\u00a0)<\/li><li>Difficulty getting\u00a0an erection<\/li><li>Stroke, fainting, dizziness (problems in the inner ear that lead to a feeling that everything around is spinning), temporary unconsciousness<\/li><li>Chest pain radiating to the arms, neck, jaws, back or stomach, sweating and shortness of breath, nausea or vomiting.\u00a0All of these symptoms can be a sign of a heart attack<\/li><li>Muscle weakness, lack of energy<\/li><li>Neck pain, chest pain<\/li><li>Overindulge<\/li><li>Joint swelling<\/li><li>Slow or blocked bile flow from the liver<\/li><li>Low levels of\u00a0phosphate\u00a0or\u00a0magnesium\u00a0in the blood<\/li><li>Hard to talk<\/li><li>Liver damage<\/li><li>Impaired balance, difficult to move<\/li><li>Deafness, ringing in the ears (\u00a0tinnitus\u00a0)<\/li><li>Nerve pain, unpleasant abnormal sensation especially when touched<\/li><li>Excess iron in the body<\/li><li>Thirst<\/li><li>Confusion<\/li><li>Toothache<\/li><li>Cases that can lead to injuries<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;<\/strong>side effects&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bleeding inside the skull<\/li><li>Circulation problem<\/li><li>Loss of vision<\/li><li>Impaired\u00a0libido\u00a0_<\/li><li>Large urine output with skeletal pain and weakness, which may be a symptom of kidney disease (Fanconi&#8217;s syndrome)<\/li><li>Yellowing of the skin, mucous membranes or eyes (jaundice), light stools, dark urine,\u00a0itchy\u00a0skin, rash, stomach pain, or bloated stomach &#8211; these may be symptoms of liver damage (liver failure)<\/li><li>Stomach pain, bloating or diarrhea, may be symptoms of\u00a0inflammation\u00a0of the colon (\u00a0colitis\u00a0or appendicitis)<\/li><li>Damage to the kidney cells (called\u00a0renal\u00a0tubular\u00a0necrosis\u00a0)<\/li><li>Changes in skin color, sensitivity to sunlight<\/li><li>Tumor light syndrome &#8211; metabolic complications that can occur during treatment of cancer and sometimes even without treatment.\u00a0These complications are caused by the breakdown products of dying cancer cells and may include the following: changes in blood chemistry;\u00a0high levels of\u00a0potassium, phosphorus, and\u00a0uric acid\u00a0as well as low levels of\u00a0calcium\u00a0which leads to changes in kidney function and heart rhythm, seizures and sometimes death.<\/li><li>Elevated\u00a0blood pressure\u00a0in the blood vessels that supply the lungs with blood (\u00a0pulmonary\u00a0hypertension\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>No known frequency<\/strong>&nbsp;(can not be calculated from the available data):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sudden pain or mild pain that worsens in the upper abdomen and\/or back, which persists for a few days, possibly in combination with nausea, vomiting, fever, and rapid\u00a0pulse.\u00a0These symptoms may be due to\u00a0inflammation\u00a0of the pancreas.<\/li><li>Wheezing, shortness of breath, or dry cough, may be symptoms caused by\u00a0inflammation\u00a0of the lung tissue.<\/li><li>In rare cases, muscle breakdown (muscle pain, weakness, or swelling), which can lead to kidney problems (\u00a0rhabdomyolysis\u00a0), has been observed.\u00a0Some of the cases occurred when Revlimid was administered with a statin (a type of cholesterol-lowering drug).<\/li><li>A condition that affects the skin and is caused by\u00a0inflammation\u00a0of the small blood vessels, along with joint pain and fever (leukocytoclastic\u00a0vasculitis\u00a0).<\/li><li>Degradation of the stomach wall or intestinal wall.\u00a0This can lead to a very serious\u00a0infection.\u00a0Tell your doctor if you experience severe abdominal pain, fever, nausea, vomiting, blood in the stool, or changed bowel habits.<\/li><li>Viral infections, including\u00a0herpes\u00a0zoster (also known as\u00a0shingles, a viral disease that causes painful skin rashes with blisters) and recurrence of\u00a0hepatitis\u00a0B\u00a0infection\u00a0(which can lead to yellowing of the skin and whites of the eyes, dark brown urine, pain in the right side of the stomach, fever and nausea or vomiting).<\/li><li>Rejection of transplanted organs (eg kidney, heart).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Revlimid<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the blister and carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/li><li>No special storage instructions.<\/li><li>Do not use this medicine if the package is damaged or appears to have been tampered with.<\/li><li>Medicines should not be disposed of via wastewater or household waste.&nbsp;Leftover medicines must be returned to the pharmacy staff.&nbsp;These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>Revlimid 2.5 mg hard capsules:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is lenalidomide.\u00a0Each capsule contains 2.5 mg of lenalidomide.<\/li><li>Other ingredients are:<ul><li>Capsule content: anhydrous\u00a0lactose\u00a0(see section 2), microcrystalline cellulose, croscarmellose sodium, and magnesium stearate<\/li><li>Capsule shell: gelatin, titanium dioxide (E171), indigo carmine (E132), and yellow iron oxide (E172)<\/li><li>printing ink: shellac, propylene glycol (E1520), potassium hydroxide, and black iron oxide (E172).<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Revlimid 5 mg hard capsules:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is lenalidomide.\u00a0Each capsule contains 5 mg of lenalidomide.<\/li><li>Other ingredients are:<ul><li>Capsule content: anhydrous\u00a0lactose\u00a0(see section 2), microcrystalline cellulose, croscarmellose sodium, and magnesium stearate<\/li><li>Capsule shell: gelatin and titanium dioxide (E171)<\/li><li>printing ink: shellac, propylene glycol (E1520), potassium hydroxide, and black iron oxide (E172).<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Revlimid 7.5 mg hard capsules:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is lenalidomide.\u00a0Each capsule contains 7.5 mg of lenalidomide.<\/li><li>Other ingredients are:<ul><li>Capsule content: anhydrous\u00a0lactose\u00a0(see section 2), microcrystalline cellulose, croscarmellose sodium, and magnesium stearate<\/li><li>Capsule shell: gelatin, titanium dioxide (E171), and yellow iron oxide (E172)<\/li><li>printing ink: shellac, propylene glycol (E1520), potassium hydroxide, and black iron oxide (E172).<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Revlimid 10 mg hard capsules:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is lenalidomide.\u00a0Each capsule contains 10 mg of lenalidomide.<\/li><li>Other ingredients are:<ul><li>Capsule content: anhydrous\u00a0lactose\u00a0(see section 2), microcrystalline cellulose, croscarmellose sodium, and magnesium stearate<\/li><li>Capsule shell: gelatin, titanium dioxide (E171), indigo carmine (E132), and yellow iron oxide (E172)<\/li><li>printing ink: shellac, propylene glycol (E1520), potassium hydroxide, and black iron oxide (E172).<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Revlimid 15 mg hard capsules:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is lenalidomide.\u00a0Each capsule contains 15 mg of lenalidomide.<\/li><li>Other ingredients are:<ul><li>Capsule content: anhydrous\u00a0lactose\u00a0(see section 2), microcrystalline cellulose, croscarmellose sodium, and magnesium stearate<\/li><li>Capsule shell: gelatin, titanium dioxide (E171), and indigo carmine (E132)<\/li><li>printing ink: shellac, propylene glycol (E1520), potassium hydroxide, and black iron oxide (E172).<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Revlimid 20 mg hard capsules:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is lenalidomide.\u00a0Each capsule contains 20 mg of lenalidomide.<\/li><li>Other ingredients are:<ul><li>Capsule content: anhydrous\u00a0lactose\u00a0(see section 2), microcrystalline cellulose, croscarmellose sodium, and magnesium stearate<\/li><li>Capsule shell: gelatin and titanium dioxide (E171), indigo carmine (E132), and yellow iron oxide (E172)<\/li><li>printing ink: shellac, propylene glycol (E1520), potassium hydroxide, and black iron oxide (E172).<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Revlimid 25 mg hard capsules:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is lenalidomide.\u00a0Each capsule contains 25 mg of lenalidomide.<\/li><li>Other ingredients are:<ul><li>Capsule content: anhydrous\u00a0lactose\u00a0(see section 2), microcrystalline cellulose, croscarmellose sodium, and magnesium stearate<\/li><li>Capsule shell: gelatin and titanium dioxide (E171)<\/li><li>printing ink: shellac, propylene glycol (E1520), potassium hydroxide, and black iron oxide (E172).<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Revlimid 2.5 mg hard capsules are blue-green\/white and marked with \u201cREV 2.5 mg\u201d.<\/p>\n\n\n\n<p>The capsules are supplied in cartons.&nbsp;Each carton contains one or three blister cards, each with seven capsules.&nbsp;This gives a total of 7 or 21 capsules per pack.<\/p>\n\n\n\n<p>Revlimid 5 mg hard capsules are white and marked with \u201cREV 5 mg\u201d.<\/p>\n\n\n\n<p>The capsules are supplied in cartons.&nbsp;Each carton contains one or three blister cards, each with seven capsules.&nbsp;This gives a total of 7 or 21 capsules per pack.<\/p>\n\n\n\n<p>Revlimid 7.5 mg hard capsules are light yellow \/ white and marked with \u201cREV 7.5 mg\u201d.<\/p>\n\n\n\n<p>The capsules are supplied in cartons.&nbsp;Each carton contains one or three blister cards, each with seven capsules.&nbsp;This gives a total of 7 or 21 capsules per pack.<\/p>\n\n\n\n<p>Revlimid 10 mg hard capsules are blue-green\/light yellow and marked with \u201cREV 10 mg\u201d.<\/p>\n\n\n\n<p>The capsules are supplied in cartons.&nbsp;Each carton contains one or three blister cards, each with seven capsules.&nbsp;This gives a total of 7 or 21 capsules per pack.<\/p>\n\n\n\n<p>Revlimid 15 mg hard capsules are light blue \/ white and marked with \u201cREV 15 mg\u201d.<\/p>\n\n\n\n<p>The capsules are supplied in cartons.&nbsp;Each carton contains one or three blister cards, each with seven capsules.&nbsp;This gives a total of 7 or 21 capsules per pack.<\/p>\n\n\n\n<p>Revlimid 20 mg hard capsules are blue-green\/light blue and marked with \u201cREV 20 mg\u201d.<\/p>\n\n\n\n<p>The capsules are supplied in cartons.&nbsp;Each carton contains one or three blister cards, each with seven capsules.&nbsp;This gives a total of 7 or 21 capsules per pack.<\/p>\n\n\n\n<p>Revlimid 25 mg hard capsules are white and marked with \u201cREV 25 mg\u201d.<\/p>\n\n\n\n<p>The capsules are supplied in cartons.&nbsp;Each carton contains one or three blister cards, each with seven capsules.&nbsp;This gives a total of 7 or 21 capsules per pack.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Bristol \u2011 Myers Squibb Pharma EEIG<\/p>\n\n\n\n<p>Plaza 254<\/p>\n\n\n\n<p>Blanchardstown Corporate Park 2<\/p>\n\n\n\n<p>Dublin 15, D15 T867<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Celgene Distribution BV<\/p>\n\n\n\n<p>Orteliuslaan 1000<\/p>\n\n\n\n<p>3528 BD Utrecht<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Revlimid contains the active substance &#8220;lenalidomide&#8221; and belongs to a group of medicines that affect the function of the immune system.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[22948,22953,22944,22947,22949,22952,22945,22950,22946,22951],"class_list":["post-22061","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-lenalidomide","tag-benefits-of-revlimid","tag-lenalidomide","tag-lenalidomide-side-effects","tag-revlimid","tag-revlimid-side-effects","tag-what-is-lenalidomide","tag-what-is-revlimid","tag-what-lenalidomide-is-used-for","tag-what-revlimid-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22061","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22061"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22061\/revisions"}],"predecessor-version":[{"id":22140,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22061\/revisions\/22140"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}