{"id":22024,"date":"2022-06-16T07:28:52","date_gmt":"2022-06-16T07:28:52","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22024"},"modified":"2022-06-16T09:47:07","modified_gmt":"2022-06-16T09:47:07","slug":"revatio","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/revatio\/","title":{"rendered":"Revatio &#8211; Sildenafil uses, dose and side effects"},"content":{"rendered":"\n<p>20 mg&nbsp;film-coated tablets<br>sildenafil<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Revatio is and what it is used for<\/h2>\n\n\n\n<p>Revatio contains the active substance sildenafil which belongs to a group of medicines called&nbsp;phosphodiesterase&nbsp;type 5 (PDE5) inhibitors.<\/p>\n\n\n\n<p>Revatio lowers&nbsp;blood pressure&nbsp;in the lungs by dilating the blood vessels in the lungs.<\/p>\n\n\n\n<p>Revatio is used to treat adults and children and adolescents from 1 to 17 years of age with high&nbsp;blood pressure&nbsp;in the blood vessels of the lungs (&nbsp;pulmonary&nbsp;arterial&nbsp;hypertension&nbsp;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Revatio<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Revatio<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to sildenafil or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are taking medicines that contain nitrates or nitric oxide donors such as amyl nitrite (&#8220;poppers&#8221;).\u00a0These medications are often given to relieve angina (or\u00a0angina pectoris\u00a0).\u00a0Revatio can cause a severe increase in the effect of these medicines.\u00a0Tell your doctor if you are taking any of these medicines.\u00a0If you are not sure, ask your doctor or pharmacist.<\/li><li>if you take riociguat.\u00a0This medicine is used to treat\u00a0pulmonary\u00a0arterial\u00a0hypertension\u00a0(ie high\u00a0blood pressure\u00a0in the lungs) and\u00a0chronic\u00a0thromboembolic\u00a0pulmonary\u00a0hypertension\u00a0(ie high\u00a0blood pressure\u00a0in the lungs due to blood clots).\u00a0PDE5 inhibitors, such as Revatio, have been shown to increase the antihypertensive effect of this medicine.\u00a0If you are taking riociguat or if you are not sure, talk to your doctor.<\/li><li>if you have recently had a\u00a0stroke, heart attack, severe liver disease, or very low\u00a0blood pressure\u00a0(&lt;90\/50 mmHg).<\/li><li>if you are taking medicines containing\u00a0ketoconazole\u00a0or itraconazole to treat fungal infections or medicines containing ritonavir (for\u00a0HIV\u00a0).<\/li><li>if you have ever before lost your sight due to a problem with the blood flow to the nerve in the eye called non-arteritic anterior ischemic optic infarction\/neuropathy (NAION).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Revatio if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have a disease that is due to a blocked or narrowed vein in the lung, rather than a blocked or narrowed\u00a0artery.<\/li><li>have severe heart problems.<\/li><li>have problems with the chambers of the heart.<\/li><li>have high\u00a0blood pressure\u00a0in the blood vessels of the lungs.<\/li><li>have low\u00a0blood pressure\u00a0at rest.<\/li><li>loses a large number of body fluids (\u00a0dehydration\u00a0) which can occur if you sweat a lot or do not drink enough fluid.\u00a0This can happen if you are sick with fever, vomiting, or diarrhea.<\/li><li>have a rare inherited eye disease (retinitis pigmentosa).<\/li><li>have abnormal\u00a0red blood cells\u00a0(sickle cell anemia), blood cell cancer (\u00a0leukemia\u00a0),\u00a0bone marrow\u00a0cancer (multiple\u00a0myeloma\u00a0), and any disease of the penis or deformed penis.<\/li><li>right now have\u00a0stomach ulcers\u00a0or a bleeding disorder (such as\u00a0hemophilia\u00a0) or problems with nosebleeds.<\/li><li>uses drugs for\u00a0erectile dysfunction.<\/li><\/ul>\n\n\n\n<p>When used to treat male\u00a0erectile dysfunction\u00a0(ED), the following\u00a0side effects\u00a0on vision have been reported with PDE5 inhibitors, including sildenafil, at an unknown frequency: partial, sudden, temporary, or permanent visual impairment or loss of vision in one or both eyes.<\/p>\n\n\n\n<p>If you experience sudden visual impairment or loss of vision,&nbsp;<strong>stop taking Revatio and contact your doctor immediately<\/strong>&nbsp;(see also section 4).<\/p>\n\n\n\n<p>Prolonged and sometimes painful&nbsp;erections&nbsp;have been reported in men after using sildenafil.&nbsp;If you get an&nbsp;erection&nbsp;that lasts longer than 4 hours,&nbsp;<strong>stop taking Revatio and contact your doctor immediately<\/strong>&nbsp;(see also section 4).<\/p>\n\n\n\n<p><em>Especially to take into account patients with kidney or liver problems:<\/em><\/p>\n\n\n\n<p>You should tell your doctor if you have kidney or liver problems, as your&nbsp;dose&nbsp;may need to be adjusted.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Revatio should not be given to children under 1 year of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Revatio<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drugs containing nitrates, or nitric oxide donors such as amyl nitrite (&#8220;poppers&#8221;). These medicines are often given to relieve\u00a0angina pectoris\u00a0or angina (see section 2. What you need to know before taking Revatio).<\/li><li>Tell your doctor or pharmacist if you are already taking riociguat.<\/li><li>Treatment for\u00a0pulmonary\u00a0hypertension\u00a0(eg\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tracleer\/\">bosentan<\/a>, iloprost). Medicines containing\u00a0St. John&#8217;s wort (herbal medicine), rifampicin (used to treat bacterial infections), carbamazepine,\u00a0phenytoin,\u00a0and phenobarbital (used, among others, to treat\u00a0epilepsy\u00a0).<\/li><li>Blood-thinning drugs (eg\u00a0warfarin\u00a0) even if they do not show any side effects.<\/li><li>Medicines containing erythromycin, clarithromycin, telithromycin (\u00a0antibiotics\u00a0for the treatment of specific bacterial\u00a0infections\u00a0), saquinavir (for the treatment of\u00a0HIV\u00a0), or nefazodone (for depression), as your\u00a0dose\u00a0may need to be adjusted.<\/li><li>Alpha-receptor blockers (eg\u00a0doxazosin\u00a0) for the treatment of high\u00a0blood pressure\u00a0or prostate problems, as the combination of the two drugs, can cause symptoms that lead to a decrease in your\u00a0blood pressure\u00a0(eg dizziness and dizziness).<\/li><li>Medicines containing sacubitril \/ valsartan used to treat\u00a0heart failure.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Revatio with food and drink<\/h2>\n\n\n\n<p>You should not drink grapefruit juice while you are being treated with Revatio.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.\u00a0Revatio should be used during pregnancy only when needed.<\/p>\n\n\n\n<p>Revatio should not be given to women of&nbsp;childbearing potential&nbsp;unless appropriate contraception is used.<\/p>\n\n\n\n<p>Revatio passes into breast milk in very small amounts and is not expected to harm the baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Revatio can cause dizziness and affect vision.&nbsp;You should be aware of how you react to the medicine before driving or using machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Revatio contains sodium<\/h2>\n\n\n\n<p>Revatio 20 mg tablets contain less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Revatio<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>For adults, the recommended\u00a0dose\u00a0is 20 mg three times daily (taken at 6 to 8-hour intervals) with or without food.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>For children and adolescents between 1 year and 17 years of age, the recommended\u00a0dose\u00a0is either 10 mg three times daily for children and adolescents weighing 20 kg or less, or 20 mg three times daily for children and adolescents weighing more than 20 kg.\u00a0Taken with or without food.\u00a0Higher doses should not be used in children.\u00a0This medicine should only be used when\u00a0administering\u00a020 mg 3 times daily.\u00a0Other forms of medicine are more suitable for the treatment of patients weighing less than 20 kg, as well as for younger patients who can not swallow tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Revatio than you should &nbsp;<\/h2>\n\n\n\n<p>Do not take more medicines than your doctor tells you to do.\u00a0If you take more medicines than you have been told to take, contact your doctor immediately.\u00a0Taking more Revatio than you should increase the risk of known\u00a0side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Revatio<\/h2>\n\n\n\n<p>If you forget to take Revatio, take a\u00a0dose\u00a0as soon as you remember.\u00a0Then continue to take your medicine at the usual time.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Revatio<\/h2>\n\n\n\n<p>Sudden discontinuation of Revatio treatment may make your symptoms worse.&nbsp;Do not stop taking Revatio unless your doctor tells you to.&nbsp;Your doctor may ask you to reduce your&nbsp;dose&nbsp;for a few days before stopping completely.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Revatio can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If you experience any of the following\u00a0side effects, stop taking Revatio and contact your doctor immediately (see also section 2):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you experience a sudden deterioration or loss of vision (no known frequency).<\/li><li>if you have an&nbsp;erection&nbsp;that lasts longer than 4 hours.&nbsp;Prolonged and sometimes painful&nbsp;erections&nbsp;have been reported in men after taking sildenafil (no known frequency).<\/li><\/ul>\n\n\n\n<p><em>Adults<\/em><\/p>\n\n\n\n<p>The\u00a0side effects\u00a0that were reported as very common (may affect more than 1 in 10 people) were: headache, flushing, digestive problems, diarrhea, and pain in the arms and legs.<\/p>\n\n\n\n<p>Side effects\u00a0reported as common (may affect up to 1 in 10 people) were:\u00a0subcutaneous infection,\u00a0flu-like symptoms, sinusitis, decreased\u00a0red blood cell count\u00a0(\u00a0anemia\u00a0), fluid retention, difficulty sleeping, anxiety,\u00a0migraines, tremors, numbness and tingling, burning sensation, decreased sensitivity of the skin, bleeding in the back of the eye, effects on vision, blurred vision and light shading, effect on color vision, eye irritation, bloodshot eyes \/ red eyes, dizziness,\u00a0tracheal cataracts, nosebleeds, runny nose, cough, nasal congestion, stomach intestinal inflammation, heartburn,\u00a0hemorrhoids, distended abdomen,\u00a0dry mouth, hair loss, redness of the skin, night sweats, muscle aches, back pain, and increased body temperature.<\/p>\n\n\n\n<p>Side effects\u00a0that were reported as uncommon (may affect 1 in 100 people) were: decreased\u00a0visual acuity, double vision, abnormal sensation in the eyes, bleeding in the penis, the presence of blood in semen and\/or urine, and breast enlargement in men.<\/p>\n\n\n\n<p>Skin rash and sudden loss or loss of hearing and decreased&nbsp;blood pressure&nbsp;have also been reported with an unknown frequency (frequency can not be calculated from the available data).<\/p>\n\n\n\n<p><em>Children and young people<\/em><\/p>\n\n\n\n<p>The following serious\u00a0side effects\u00a0have been reported commonly (occurring in up to 1 user in 10):\u00a0pneumonia,\u00a0heart failure, right ventricular failure, heart-related\u00a0shock, high\u00a0blood pressure\u00a0in the lungs, chest pain, fainting, respiratory tract infection, tracheal inflammation, viral and intestinal viral\u00a0infection.<\/p>\n\n\n\n<p>The following serious\u00a0side effects\u00a0were considered treatment-related and have been reported as uncommon (occurring in up to 1 user in 100): allergic reactions (such as rash, swelling of the face, lips, and tongue, wheezing, difficulty breathing and swallowing), convulsions, irregular heartbeat, hearing loss, shortness of breath,\u00a0inflammation\u00a0of the stomach and intestines, wheezing due to obstructed airflow.<\/p>\n\n\n\n<p>Side effects\u00a0reported as very common (affects more than 1 user in 10) were: headache, vomiting, throat infection, fever, diarrhea,\u00a0flu,\u00a0and nosebleeds.<\/p>\n\n\n\n<p>Side effects\u00a0reported as common (affects up to 1 user in 10) include nausea, increased\u00a0erection,\u00a0pneumonia,\u00a0and runny nose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Revatio<\/h2>\n\n\n\n<p><strong>Keep this medicine out of the sight and reach of children.<\/strong><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.&nbsp;Store in the original package.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is sildenafil.&nbsp;Each tablet contains 20 mg of sildenafil (in the form of citrate).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Other ingredients are Tablet core: microcrystalline cellulose, anhydrous calcium phosphate, croscarmellose sodium (see section 2 \u201cRevatio contains sodium\u201d), and magnesium stearate. Film coating: hypromellose, titanium dioxide (E171),\u00a0lactose monohydrate\u00a0(see section 2 \u201cRevatio contains lactose\u201d), glycerol triacetate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Revatio film-coated tablets are white and round.\u00a0They are marked \u201cPFIZER\u201d on one side and \u201cRVT 20\u201d on the other side.\u00a0The tablets are supplied in blister packs containing 90 tablets, 90 x 1 tablets in perforated unit dose blisters, and blister packs containing 300 tablets.\u00a0Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Marketing Authorisation Holder:<\/p>\n\n\n\n<p>Upjohn EESV, 142 Rivium Westlaan, 2909 LD Capelle aan den IJssel, The Netherlands<\/p>\n\n\n\n<p>Manufacturer:<\/p>\n\n\n\n<p>Fareva Amboise, Industrial Zone, 29 Route des Industries, 37530 Poc\u00e9-sur-Cisse, France<\/p>\n\n\n\n<p>Further information on this medicine can be obtained from the representative of the marketing authorization holder.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Pfizer SA \/ NVTel: +32 (0) 2 554 62 11<\/td><td><strong>Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaTel.&nbsp;+3705 2514000<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Pfizer Luxembourg SARE, Clone of BulgariaTel: +359 2 970 433<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Pfizer SATel: +32 (0) 2 554 62 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Pfizer sroTel: + 420-283-004-111<\/td><td><strong>Hungary<\/strong>Pfizer Kft.Tel .: + 36 1 488 37 00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Viatris ApSTel: +45 28 11 69 32<\/td><td><strong>Malta<\/strong>Vivian Corporation Ltd.Tel: +356 21344610<\/td><\/tr><tr><td><strong>Germany<\/strong>Pfizer OFG Germany GmbHTel: +49 (0) 800 5500634<\/td><td><strong>The Netherlands<\/strong>Pfizer bvTel: +31 (0) 10 406 43 01<\/td><\/tr><tr><td><strong>Eesti<\/strong>Pfizer Luxembourg SARL Eesti subsidiaryTel: +372 666 7500<\/td><td><strong>Norway<\/strong>Pfizer ASTel: +47 67 52 61 00<\/td><\/tr><tr><td><strong>Greece<\/strong>UPJOHN HELLAS \u0395\u03a0\u0395:\u0397\u03bb: +30 2100 100 002<\/td><td><strong>Austria<\/strong>Pfizer Corporation Austria Ges.mbHTel: +43 (0) 1 521 15-0<\/td><\/tr><tr><td><strong>Spain<\/strong>Viatris Pharmaceuticals, SLTel: +34 900 102 712<\/td><td><strong>Poland<\/strong>Pfizer Polska Sp.&nbsp;z ooTel .: +48 22 335 61 00<\/td><\/tr><tr><td><strong>France<\/strong>Viatris HealthTel: +33 (0) 4 37 25 75 00<\/td><td><strong>Portugal<\/strong>Pfizer Laboratories, Lda.Tel: +351 21 423 5500<\/td><\/tr><tr><td><strong>Croatia<\/strong>Mylan Hrvatska dooTel: +385 1 23 50 599<\/td><td><strong>Romania<\/strong>Pfizer Rom\u00e2nia SRLTel: +40 21 207 28 00<\/td><\/tr><tr><td><strong>Ireland<\/strong>Pfizer Healthcare IrelandTel: 1800 633 363 (toll free)+44 (0) 1304 616161<\/td><td><strong>Slovenia<\/strong>Pfizer Luxembourg SARLPfizer, a company in the field of pharmaceuticals, LjubljanaTel: + 386 (0) 1 52 11 400<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hf.Phone: + 354 540 8000<\/td><td><strong>Slovak Republic<\/strong>Pfizer Luxembourg SARL, organizerTel: + 421-2-3355 5500<\/td><\/tr><tr><td><strong>Italy<\/strong>Viatris Pharma SrlTel: +39 02 612 46921<\/td><td><strong>Finland \/ Finland<\/strong>Viatris OyPuh \/ Tel: +358 20 720 9555<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>GPA Pharmaceuticals Ltd:\u0397\u03bb: +357 22863100<\/td><td><strong>Sweden<\/strong>Viatris ABTel: + 46 (0) 8 630 19 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>Pfizer Luxembourg SARL subsidiary Latvij\u0101Tel: +371 670 35 775<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Pfizer LimitedTel: +44 (0) 1304 616161<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Revatio contains the active substance sildenafil which belongs to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[22823,22827,22826,9336,13284,9338,22824,9337,22825,13282],"class_list":["post-22024","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-revatio","tag-revatio-side-effects","tag-revatio-tablet","tag-sildenafil","tag-sildenafil-side-effects","tag-sildenafil-tablet","tag-what-is-revatio","tag-what-is-sildenafil","tag-what-revatio-is-used-for","tag-what-sildenafil-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22024"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22024\/revisions"}],"predecessor-version":[{"id":22047,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22024\/revisions\/22047"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}