{"id":22018,"date":"2022-06-16T07:23:11","date_gmt":"2022-06-16T07:23:11","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22018"},"modified":"2022-06-16T09:47:26","modified_gmt":"2022-06-16T09:47:26","slug":"retsevmo","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/retsevmo\/","title":{"rendered":"Retsevmo &#8211; Selperkatinib uses, dose and side effects"},"content":{"rendered":"\n<p>40mg, 80 mg&nbsp;Hard capsules<br>selperkatinib<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Retsevmo is and what it is used for<\/h2>\n\n\n\n<p>Retsevmo is a cancer drug that contains the active substance selperkatinib.<\/p>\n\n\n\n<p>It is used to treat any of the following cancers that are caused by certain changes in the so-called RET gene and that have spread and\/or cannot be removed by surgery:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A type of lung cancer, so-called non-small cell lung cancer, in adults.<\/li><li>Thyroid cancer (all types) in adults.<\/li><li>A rare type of thyroid cancer called medullary thyroid cancer, in adults and adolescents from 12 years of age.<\/li><\/ul>\n\n\n\n<p>Retsevmo can be prescribed if previous treatments for lung or thyroid cancer have not worked.<\/p>\n\n\n\n<p>To be sure that Retsevmo is the right medicine for you, your doctor will perform a test to check that your cancer has a change in the RET gene.<\/p>\n\n\n\n<p><strong>How&nbsp;<\/strong><strong>Retsevmo works<\/strong><\/p>\n\n\n\n<p>If cancer has an altered RET gene, this gene change leads to the body producing an abnormal RET\u00a0protein.\u00a0It can lead to uncontrolled cell growth and cancer.\u00a0Retsevmo blocks the abnormal RET\u00a0protein\u00a0and can thus slow down or stop the growth of cancer.\u00a0It can also cause a\u00a0tumor\u00a0to shrink.<\/p>\n\n\n\n<p>If you have any questions about how Retsevmo works or why you have been given this medicine, ask your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Retsevmo<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Retsevmo<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to selperkatinib or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Retsevmo:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have high\u00a0blood pressure<\/li><li>if you have a heart rhythm disorder is seen on\u00a0ECG\u00a0(\u00a0electrocardiogram\u00a0), the so-called prolonged\u00a0QT interval<\/li><li>Retsevmo can affect the\u00a0fertility\u00a0of men and women and thus your ability to have children.\u00a0Talk to your doctor if this worries you.<\/li><li>if you have had major bleeding in the past.<\/li><\/ul>\n\n\n\n<p>Retsevmo can cause\u00a0hypersensitivity reactions\u00a0such as fever, rash, and pain.\u00a0Talk to a doctor if you get such a reaction.\u00a0After checking your symptoms, your doctor may ask you to take\u00a0corticosteroids\u00a0(\u00a0cortisone\u00a0) until your symptoms improve.<\/p>\n\n\n\n<p>Rapid degradation of cancer cells (tumor lysis syndrome, TLS) can occur when you take Retsevmo.\u00a0This can cause irregular heartbeat,\u00a0kidney failure,\u00a0or abnormal blood test results.\u00a0Talk to your doctor if you have previously had kidney problems or low\u00a0blood pressure\u00a0as this may increase the risks associated with TLS.<\/p>\n\n\n\n<p>See section 4 \u201cPossible side effects\u201d and talk to your doctor if you get any symptoms.<\/p>\n\n\n\n<p><strong>Medical examinations before and during treatment<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Retsevmo can affect\u00a0blood pressure.\u00a0Blood pressure\u00a0is measured before and during treatment with Retsevmo.<\/li><li>Retsevmo may affect liver function.\u00a0Tell your doctor immediately if you experience symptoms of hepatic effects such as jaundice (yellowing of the skin and eyes), decreased appetite, nausea or vomiting, or if you get pain in the upper right side of the abdomen.<\/li><li>Retsevmo can cause abnormal\u00a0ECG.\u00a0ECG\u00a0is taken both before and during treatment with Retsevmo.\u00a0Tell your doctor if you faint as it may be a symptom of an abnormal\u00a0ECG.<\/li><li>Before and during treatment with Retsevmo, blood samples are taken at regular intervals to check liver function and\u00a0electrolytes\u00a0(such as\u00a0sodium,\u00a0potassium,\u00a0magnesium,\u00a0and\u00a0calcium\u00a0) in the blood.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Retsevmo is not for use in patients under 18 years of age who have lung or thyroid cancer other than medullary thyroid cancer.&nbsp;Adolescents from the age of 12 who have medullary thyroid cancer can be treated with this drug.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Retsevmo<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>You must tell your doctor or pharmacist before taking Retsevmo if you are taking any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs that can increase the concentration of Retsevmo in the blood:<ul><li>clarithromycin (for the treatment of bacterial infections)<\/li><li>itraconazole,\u00a0ketoconazole\u00a0, posaconazole, voriconazole (used to treat fungal infections)<\/li><li>atazanavir, ritonavir, cobicistat (for the treatment of\u00a0HIV\u00a0infection \/ AIDS)<\/li><\/ul><\/li><li>drugs that can reduce the effect of Retsevmo:<ul><li>carbamazepine (for the treatment of\u00a0epilepsy, nerve pain, and\u00a0bipolar disorder\u00a0)<\/li><li>rifampicin (for the treatment of\u00a0tuberculosis\u00a0(TB) and other\u00a0infections\u00a0)<\/li><li>St. John&#8217;s wort\u00a0(a (traditional) herbal medicine for the treatment of mild depression and anxiety)<\/li><li>repaglinide (for the treatment of type 2\u00a0diabetes\u00a0and to control blood sugar)<\/li><li>dasabuvir (for the treatment of\u00a0hepatitis\u00a0C)<\/li><li>selexipag (for high\u00a0blood pressure\u00a0in the pulmonary arteries)<\/li><li>digoxin\u00a0(for the treatment of heart disease)<\/li><li>omeprazole, lansoprazole, or other\u00a0proton pump inhibitors\u00a0used for heartburn,\u00a0stomach ulcers,\u00a0and acid reflux;\u00a0If you are taking any of these medicines, take Retsevmo with a full meal.<\/li><li>ranitidine, famotidine, or other H2 blockers against\u00a0stomach ulcers\u00a0and acid reflux;\u00a0if you are taking any of these medicines, you must take them 2 hours after taking Retsevmo.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Pregnancy<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p>You should not use Retsevmo during pregnancy as it is not known how Retsevmo can affect the unborn baby.&nbsp;Women should avoid becoming pregnant and men should avoid getting a woman pregnant during treatment with Retsevmo, as the drug could harm the baby.&nbsp;If there is a possibility that you may become pregnant or can make a woman pregnant, you must use an effective contraceptive during treatment and for at least one week after the last&nbsp;dose&nbsp;of Retsevmo.<\/p>\n\n\n\n<p>Breast-feeding<\/p>\n\n\n\n<p>Do not breastfeed during treatment with Retsevmo.\u00a0Retsevmo could harm the breastfed baby.\u00a0It is not known if Retsevmo passes into breast milk.\u00a0Do not breastfeed for at least one week after the last\u00a0dose\u00a0of Retsevmo.<\/p>\n\n\n\n<p>Fertility<\/p>\n\n\n\n<p>Retsevmo can affect your chances of having children.&nbsp;Talk to your doctor about fertility preservation measures before treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Take special care when driving or using machines as you may feel tired or dizzy while taking Retsevmo.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Retsevmo contains excipients<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you, and in the&nbsp;dose&nbsp;prescribed.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Retsevmo is taken twice a day at about the same time each day, preferably in the morning and evening.<\/p>\n\n\n\n<p>If you get any&nbsp;side effects&nbsp;from Retsevmo, your doctor may reduce your&nbsp;dose&nbsp;or stop the treatment temporarily or permanently.<\/p>\n\n\n\n<p>You can take the capsules with or without food.\u00a0Swallow the capsule whole with a glass of water.\u00a0The capsules must not be chewed, crushed, or divided before swallowing.<\/p>\n\n\n\n<p>The jar is equipped with a screw cap:<\/p>\n\n\n\n<p>Push the screw cap downwards and at the same time turn it counterclockwise to open the jar, as shown in the picture.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20191224000014#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/b91731fd-91e0-40eb-acb1-dd275d9d1e8e\" alt=\"Push the screw cap downwards and at the same time turn it counterclockwise to open the jar.\" title=\"Push the screw cap downwards and at the same time turn it counterclockwise to open the jar.\"\/><\/a><\/figure>\n\n\n\n<p>To close the jar, turn the lid clockwise until it is firmly seated.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20191224000014#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/8c776f30-0918-4409-86ce-1e64e58e50e6\" alt=\"To close the jar, turn the lid clockwise until it is firmly seated\" title=\"To close the jar, turn the lid clockwise until it is firmly seated\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Retsevmo<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Retsevmo than you should&nbsp;<\/h2>\n\n\n\n<p>If you have taken too many capsules, or if another person has taken your medicine, contact your doctor or hospital for advice.&nbsp;Medical treatment may be necessary.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Retsevmo<\/h2>\n\n\n\n<p>If you vomit after taking a\u00a0dose\u00a0or have forgotten to take a\u00a0dose, take the next\u00a0dose\u00a0at the usual time.\u00a0Do not take a double\u00a0dose\u00a0to make up for a\u00a0forgotten or vomited dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Retsevmo<\/h2>\n\n\n\n<p>Do not stop taking Retsevmo unless your doctor tells you to.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0Contact your doctor immediately if you get any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Liver problems (may affect more than 1 in 10 people and may cause abnormal liver values \u200b\u200bin blood tests, such as increased liver enzymes), such as yellowing of the skin and eyes (jaundice), dark-colored urine, decreased appetite, nausea or vomiting, or pain in the upper right part of the abdomen.<\/li><li>Allergic reaction\u00a0with fever, muscle and joint pain, accompanied by a rash (may affect up to 1 in 10 people).<\/li><li>High\u00a0blood pressure\u00a0(may affect more than 1 user in 10).<\/li><li>Bleeding with symptoms such as bloody cough.<\/li><\/ul>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you get any of the following side effects:<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 user in 10)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dry mouth<\/li><li>Diarrhea<\/li><li>Fatigue or tiredness<\/li><li>Constipation<\/li><li>Headache<\/li><li>Nausea, abdominal pain, vomiting<\/li><li>Reduced appetite<\/li><li>Accumulation of fluid that can cause swollen hands or ankles (\u00a0edema\u00a0)<\/li><li>The increased amount of\u00a0creatinine\u00a0in the blood, which may indicate that the kidneys are not working properly (kidney disease)<\/li><li>Abnormal\u00a0ECG<\/li><li>Decreased\u00a0platelet count, which may lead to bleeding and\/or bruising<\/li><li>Symptoms of bleeding<\/li><li>Fever<\/li><li>Rash<\/li><li>Dizziness<\/li><li>Decreased\u00a0white blood cell count<\/li><li>Low magnesium levels in the blood<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Retsevmo<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the can or blister card and the carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Do not use this medicine if the inner seal is broken or shows signs of tampering.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is selperkatinib.&nbsp;Each hard capsule contains 40 mg or 80 mg of selperkatinib.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Capsule content:\u00a0colloidal\u00a0anhydrous silica, microcrystalline cellulose.<\/li><li>Capsule shell 40 mg: gelatin, titanium dioxide (E171), and iron oxide (E172).<\/li><li>Capsule shell 80 mg: gelatin, titanium dioxide (E171), and brilliant blue FCF (E133).<\/li><li>Black ink: shellac,\u00a0ethanol\u00a0(96%), isopropyl alcohol, butanol, propylene glycol, purified water, concentrated ammonia, potassium hydroxide, black iron oxide.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Retsevmo 40 mg is a gray, opaque hard gelatin capsule, marked with \u201cLilly\u201d, \u201c3977\u201d and \u201c40 mg\u201d in black.<\/p>\n\n\n\n<p>Retsevmo 80 mg is a blue, opaque hard gelatin capsule, marked with \u201cLilly\u201d, \u201c2980\u201d and \u201c80 mg\u201d in black.<\/p>\n\n\n\n<p>Retsevmo is supplied in white opaque plastic jars with a plastic screw cap, which contains either 60 hard 40 mg capsules or 60 or 120 hard 80 mg capsules.&nbsp;Each carton contains a jar.<\/p>\n\n\n\n<p>Retsevmo is available in blister packs of 14, 42, 56, or 168 hard 40 mg capsules and 14, 28, 56, or 112 80 mg capsules.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Eli Lilly Nederland BV, Papendorpseweg 83, 3528BJ Utrecht, The Netherlands.<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Lilly SA, Avda.&nbsp;de la Industria 30, 28108 Alcobendas, Madrid, Spain<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder if you would like to know more about this medicine: Eli Lilly Sweden AB Tel: + 46- (0) 8 7378800<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Retsevmo is a cancer drug that contains the active substance selperkatinib.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[22844,22847,22848,22839,22842,22843,22845,22840,22846,22841],"class_list":["post-22018","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-retsevmo","tag-retsevmo-capsule","tag-retsevmo-side-effects","tag-selperkatinib","tag-selperkatinib-capsule","tag-selperkatinib-side-effects","tag-what-is-retsevmo","tag-what-is-selperkatinib","tag-what-retsevmo-is-used-for","tag-what-selperkatinib-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22018","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22018"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22018\/revisions"}],"predecessor-version":[{"id":22050,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22018\/revisions\/22050"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22018"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22018"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22018"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}