{"id":22014,"date":"2022-06-16T07:16:43","date_gmt":"2022-06-16T07:16:43","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22014"},"modified":"2022-06-16T09:47:37","modified_gmt":"2022-06-16T09:47:37","slug":"retacrit","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/retacrit\/","title":{"rendered":"Retacrit &#8211; Epoetin zeta uses, dose and side effects"},"content":{"rendered":"\n<p>1,000 IU \/ 0.3 ml; 2,000 IU \/ 0.6 ml; 3,000 IU \/ 0.9 ml; 4,000 IU \/ 0.4 ml; 5,000 IU \/ 0.5 ml; 6,000 IU \/ 0 .6 ml; 8,000 IU \/ 0.8 ml; 10,000 IU \/ 1.0 ml; 20,000 IU \/ 0.5 ml; 30,000 IU \/ 0.75 ml; 40,000 IU \/ 1.0&nbsp;solution&nbsp;for injection&nbsp;in pre-filled&nbsp;syringe<br>epoetin zeta<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Retacrit is and what it is used for<\/h2>\n\n\n\n<p>Retacrit contains the active substance epoetin zeta &#8211; a&nbsp;protein&nbsp;that stimulates the&nbsp;bone marrow&nbsp;to produce more&nbsp;red blood cells&nbsp;that contain&nbsp;hemoglobin&nbsp;(a substance that carries oxygen).&nbsp;Epoetin zeta is a copy of the human&nbsp;protein&nbsp;et erythropoetin and acts in the same way.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Retacrit is\u00a0used to treat\u00a0symptomatic\u00a0anemia\u00a0(\u00a0anemia\u00a0) caused by kidney disease<\/strong><ul><li>in children on\u00a0hemodialysis<\/li><li>in adults on\u00a0hemodialysis\u00a0or\u00a0peritoneal dialysis<\/li><li>in adults with severe\u00a0anemia, who have not yet undergone\u00a0dialysis.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>If you have kidney disease, you may have a lack of\u00a0red blood cells\u00a0if the kidneys do not produce enough erythropoietin (necessary for the production of\u00a0red blood cells\u00a0).\u00a0Retacrit is prescribed to stimulate the\u00a0bone marrow\u00a0to produce more\u00a0red blood cells.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Retacrit is used to treat\u00a0anemia\u00a0in adults who are receiving\u00a0chemotherapy\u00a0for solid\u00a0tumors<\/strong>,\u00a0malignant\u00a0lymphoma,\u00a0or multiple\u00a0myeloma\u00a0(bone marrow cancer) and who may need a\u00a0blood transfusion.\u00a0Retacrit may reduce the need for\u00a0blood transfusions\u00a0in these patients.<\/li><li>Retacrit is used in adults with moderate\u00a0anemia\u00a0who donate a certain amount of their blood before their operation\u00a0so that they can get it back during or after the operation.\u00a0Because Retacrit stimulates the production of\u00a0red blood cells, a larger volume of blood can be taken from these individuals.<\/li><li>Retacrit is used in adults with moderate\u00a0anemia\u00a0who need major\u00a0orthopedic\u00a0surgery\u00a0\u00a0(eg hip or knee surgery)\u00a0to reduce the need for\u00a0blood transfusions.<\/li><li>Retacrit is used to treat\u00a0anemia\u00a0in adults with a bone marrow disease that causes a serious disorder in the formation of\u00a0blood cells\u00a0(\u00a0myelodysplastic syndrome\u00a0).\u00a0Retacrit may reduce the need for\u00a0blood transfusions.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Retacrit<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Retacrit:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are allergic<\/strong>\u00a0to epoetin zeta or any of the other ingredients of this medicine (listed in section 6).<\/li><li><strong>If you have been diagnosed with\u00a0erythrocyte aplasia<\/strong>\u00a0(meaning that\u00a0your bone marrow\u00a0cannot produce enough\u00a0red blood cells\u00a0) after previous treatment with any drug that stimulates the formation of\u00a0red blood cells\u00a0(including Retacrit).\u00a0See section 4.<\/li><li>If you have high\u00a0blood pressure\u00a0that is not under control with the help of medication.<\/li><li>To stimulate the production of your\u00a0red blood cells\u00a0(so that the doctor can take a larger volume of blood from you)\u00a0if you can not get a\u00a0transfusion\u00a0with your <strong>blood<\/strong>\u00a0during or after surgery.<\/li><li><strong>If you are going to undergo a\u00a0major scheduled\u00a0<\/strong>orthopedic\u00a0<strong>surgery\u00a0(<\/strong>\u00a0eg hip or knee surgery), and you:<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>have severe heart disease<\/li><li>have severe disease of the veins&nbsp;or&nbsp;arteries<\/li><li>recently had a heart attack&nbsp;or&nbsp;stroke<\/li><li>can not take blood thinners.<\/li><\/ul>\n\n\n\n<p>Retacrit may be inappropriate for you.&nbsp;Discuss with your doctor.&nbsp;Some people taking Retacrit may also need medicines that reduce the risk of blood clots (blood-thinning medicines).&nbsp;<strong>If you can not take blood-thinning drugs, do not use Retacrit.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Retacrit.<\/p>\n\n\n\n<p><strong>Take special care with Retacrit<\/strong><\/p>\n\n\n\n<p><strong>Retacrit and other products that stimulate the formation of\u00a0red blood cells\u00a0may increase the risk of developing blood clots in all patients.\u00a0This risk may be higher if you have other risk factors<\/strong>\u00a0for developing blood clots\u00a0<em>(eg if you have had a blood clot before or if you are overweight, have\u00a0diabetes<\/em>, have heart disease,<em> or are in bed for a long time due to surgery or illness).\u00a0<\/em>Tell your doctor if you have any of these risk factors.\u00a0Your doctor will decide if Retacrit is right for you.<\/p>\n\n\n\n<p><strong>Talk to your doctor<\/strong>\u00a0if any of the following apply to you.\u00a0You may still be able to use Retacrit, but first, discuss this with your doctor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you know you\u00a0are suffering from<\/strong>\u00a0or have suffered from:<\/li><li><strong>high\u00a0blood pressure<\/strong><\/li><li><strong>epileptic seizures or seizures<\/strong><\/li><li><strong>liver disease<\/strong><\/li><li><strong>anemia\u00a0of other causes<\/strong><\/li><li><strong>porphyria\u00a0(a rare blood disease).<\/strong><\/li><li><strong>If you are a patient with\u00a0chronic\u00a0kidney failure<\/strong>,\u00a0and especially if you do not respond adequately to Retacrit, your doctor will check your\u00a0dose\u00a0of Retacrit, as repeated dose increases of Retacrit if you do not respond to treatment may increase the risk of heart or blood vessel problems and may increase the risk of heart attack,\u00a0stroke,\u00a0and death.<\/li><li>If you are a cancer patient, you should be aware that products that stimulate the formation of\u00a0red blood cells\u00a0such as Retacrit can act as a growth factor and could therefore theoretically affect the development of your cancer.\u00a0Depending on your condition, a\u00a0blood transfusion\u00a0may be preferable.\u00a0Discuss this with your doctor.<\/li><li>If you are a cancer patient, you should be aware that the use of Retacrit may be associated with shorter survival and higher mortality in head and neck cancer as well as metastatic breast cancer in patients treated with\u00a0chemotherapy.<\/li><li>Severe skin reactions\u00a0such as\u00a0Stevens-Johnson syndrome\u00a0and\u00a0toxic epidermal necrolysis\u00a0have been reported during treatment with epoetin.<br>Stevens-Johnson syndrome\u00a0and\u00a0toxic epidermal necrolysis\u00a0can begin as reddish-purple target-like spots or round spots on the torso, often with blisters in the middle.\u00a0Sores in the mouth, throat, nose, genitals, and eyes (red and swollen eyes) may also occur.\u00a0These severe skin reactions are often preceded by fever and\/or\u00a0flu-like symptoms.\u00a0The rash can develop into widespread areas with scaly skin and life-threatening complications.<br>If you get a severe rash or any of these skin symptoms, stop taking Retacrit and contact a doctor or hospital immediately.<\/li><\/ul>\n\n\n\n<p><strong>Take special care with other drugs that stimulate the formation of red blood cells:<\/strong><\/p>\n\n\n\n<p>Retacrit belongs to a group of medicines that stimulate the formation of\u00a0red blood cells, as does the human\u00a0protein\u00a0erythropoietin.\u00a0Your healthcare professional will always document exactly which medicine you are using.<\/p>\n\n\n\n<p>If you get any product in this group other than Retacrit during your treatment, talk to your doctor or pharmacist before using it.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Retacrit<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p><strong>If you are taking the drug ciclosporin<\/strong>&nbsp;(used, for example, after a kidney transplant), your doctor may&nbsp;prescribe&nbsp;blood tests to check your ciclosporin levels while you are taking Retacrit.<\/p>\n\n\n\n<p><strong>Iron supplements and other blood-stimulating drugs<\/strong>&nbsp;may increase the effect of Retacrit.&nbsp;Your doctor will decide if you should take such or not.<\/p>\n\n\n\n<p><strong>If you are visiting a hospital<\/strong> or going to your clinic or GP, tell them that you are being treated with Retacrit.\u00a0It may affect other treatments or test results.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><strong>You must tell your doctor<\/strong>\u00a0if any of the following apply to you.\u00a0You may still be able to take Retacrit but talk to your doctor first.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/li><li>If you are breastfeeding.<\/li><\/ul>\n\n\n\n<p>There are no data available on the effect of epoetin zeta on\u00a0fertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Retacrit has no or negligible effect on the ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Retacrit contains phenylalanine<\/h2>\n\n\n\n<p>This medicine contains 0.5 mg phenylalanine per ml.<\/p>\n\n\n\n<p>Phenylalanine can be harmful if you have phenylketonuria (PKU), a rare, inherited disease that leads to the accumulation of high levels of phenylalanine in your body.<\/p>\n\n\n\n<p><strong>Retacrit contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per\u00a0dose, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Retacrit<\/h2>\n\n\n\n<p><strong>Always use this medicine exactly as your doctor has told you<\/strong>.\u00a0Consult a doctor if you are unsure.<\/p>\n\n\n\n<p><strong>Your doctor has taken blood samples<\/strong>&nbsp;and decided that you need Retacrit.<\/p>\n\n\n\n<p>Retacrit can be given as an injection:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>either<\/strong>&nbsp;in a vein or in a tube that enters a vein (&nbsp;intravenously&nbsp;)<\/li><li><strong>or<\/strong>&nbsp;under the skin (&nbsp;subcutaneously&nbsp;).<\/li><\/ul>\n\n\n\n<p>Your doctor will decide how to inject Retacrit.\u00a0You will usually receive injections\u00a0from a doctor, nurse, or other healthcare professional.\u00a0Depending on why they need treatment with Retacrit, some people may later learn to inject themselves under the skin: see\u00a0How to inject Retacrit yourself.<\/p>\n\n\n\n<p>Retacrit should not be used:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>after the expiry date which is stated on the label and the outer carton<\/li><li>if you know or believe that it may have been accidentally frozen, or<\/li><li>if the refrigerator has stopped working.<\/li><\/ul>\n\n\n\n<p>Retacrit&nbsp;dose&nbsp;is based on your body weight in kilograms.&nbsp;The cause of your&nbsp;anemia&nbsp;is also included as a factor when your doctor decides which&nbsp;dose&nbsp;is right for you.<\/p>\n\n\n\n<p><strong>Your doctor will monitor your&nbsp;blood pressure<\/strong>&nbsp;regularly while you are using Retacrit.<\/p>\n\n\n\n<p><strong>People with kidney disease<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will maintain a hemoglobin level of between 10 and 12 g \/ dl as a high hemoglobin level may increase the risk of blood clots and death.\u00a0In children, the hemoglobin level should be kept between 9.5 and 11 g \/ dl.<\/li><li><strong>The usual starting<\/strong>\u00a0dose of Retacrit for adults and children is 50 international units (IU) per kilogram (kg) body weight given three times a week.<\/li><li>For patients on\u00a0peritoneal dialysis, Retacrit can be given twice a week.<\/li><li>For adults and children, Retacrit is given as an\u00a0injection\u00a0either into a vein or into a tube that goes into a vein.\u00a0When this entry (via a vein or tube) is not easily accessible, your doctor may decide to inject Retacrit under the skin (\u00a0subcutaneously\u00a0).\u00a0This includes patients undergoing\u00a0dialysis\u00a0and patients not yet undergoing\u00a0dialysis.<\/li><li>Your doctor will\u00a0prescribe\u00a0regular blood tests to see how your\u00a0anemia\u00a0responds to treatment and may adjust\u00a0dose\u00a0one, usually no more often than every four weeks.\u00a0An increase in\u00a0hemoglobin\u00a0of more than 2 g \/ dl over four weeks should be avoided.<\/li><li>After your\u00a0anemia\u00a0has improved, your doctor will continue to check your blood regularly.\u00a0Your Retacrit\u00a0dose\u00a0and frequency of administration can be further adjusted to maintain your response to treatment.\u00a0Your doctor will use the lowest effective\u00a0dose\u00a0to keep the symptoms of your\u00a0anemia\u00a0under control.<\/li><li>If you do not respond well enough to Retacrit, your doctor will check your\u00a0dose\u00a0and tell you if you need to change the\u00a0dose\u00a0of Retacrit.<\/li><li>If you are on a longer dosing interval of Retacrit (less frequently than once a week), you may not be able to maintain adequate hemoglobin levels and you may need to increase your Retacrit\u00a0dose\u00a0or the frequency of administration.<\/li><li>You may be given iron supplements before and during your Retacrit treatment to make it more effective.<\/li><li>If you are undergoing dialysis treatment when you start treatment with Retacrit, your dialysis treatment may need to be adjusted.\u00a0Your doctor will decide this.<\/li><\/ul>\n\n\n\n<p><strong>Adults receiving&nbsp;chemotherapy<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor may start treatment with Retacrit if your hemoglobin level is 10 g \/ dl or lower.<\/li><li>Your doctor will keep your hemoglobin level between 10 and 12 g \/ dl, as a high hemoglobin level may increase the risk of blood clots and death.<\/li><li>The initial dose is&nbsp;<strong>either<\/strong>&nbsp;150 IU per kilogram of body weight three times a week or 450 IU per kilogram of body weight once a week.<\/li><li>Retacrit is given as an&nbsp;injection&nbsp;under the skin.<\/li><li>Your doctor will&nbsp;prescribe&nbsp;blood tests and may adjust&nbsp;dose&nbsp;one, depending on how your&nbsp;anemia&nbsp;responds to Retacrit treatment.<\/li><li>You may be given iron supplements before and during your Retacrit treatment to make it more effective.<\/li><li>You will usually continue your Retacrit treatment for one month after stopping the chemotherapy.<\/li><\/ul>\n\n\n\n<p><strong>Adults who donate their blood<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>The usual\u00a0dose<\/strong>\u00a0is 600 IU per kilogram of body weight twice a week<strong>.<\/strong><\/li><li>Immediately after you donate blood, Retacrit is given by\u00a0injection\u00a0into a vein for three weeks before your operation.<\/li><li>You may be given iron supplements before and during your Retacrit treatment to make it more effective.<\/li><\/ul>\n\n\n\n<p><strong>Adults undergoing major&nbsp;orthopedic&nbsp;surgery<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>The recommended\u00a0dose<\/strong>\u00a0is 600 IU per kilogram of body weight once a week.<\/li><li>Retacrit is given by\u00a0injection\u00a0under the skin every week for three weeks before the operation and on the day of the operation.<\/li><li>If there is a medical need to reduce the time until your surgery, you will receive a daily\u00a0dose\u00a0of 300 IU \/ kg for up to ten days before the operation, on the day of the operation, and for four days immediately thereafter.<\/li><li>If blood tests show that your\u00a0hemoglobin\u00a0is too high before the operation, treatment will be stopped.<\/li><li>You may be given iron supplements before and during your Retacrit treatment to make it more effective<strong>.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Adults with&nbsp;myelodysplastic syndrome<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor may start treatment with Retacrit if your hemoglobin value is 10 g \/ dl or lower.&nbsp;The goal of treatment is to maintain a hemoglobin level of between 10 and 12 g \/ dl as a higher hemoglobin value may increase the risk of blood clots and death.<\/li><li>Retacrit is given as an&nbsp;injection&nbsp;under the skin.<\/li><li>The starting dose is 450 IU per kilogram of body weight once a week.<\/li><li>Your doctor will order blood tests and may adjust the&nbsp;dose&nbsp;depending on how your&nbsp;anemia&nbsp;responds to Retacrit treatment.<\/li><\/ul>\n\n\n\n<p><strong>How to inject Retacrit yourself<\/strong><\/p>\n\n\n\n<p>When starting treatment, Retacrit is usually injected by a healthcare professional.\u00a0Later, your doctor may suggest that you or your caregiver learn how to inject Retacrit under the skin\u00a0<em>(\u00a0subcutaneously\u00a0)<\/em>.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Do not try to inject yourself without first being instructed by your doctor or nurse on how to do it.<\/strong><\/li><li><strong>Always use Retacrit exactly as your doctor or nurse has told you.<\/strong><\/li><li><strong>Only use this medicine if it has been stored correctly (see section 5,&nbsp;<em>How to store Retacrit<\/em>&nbsp;).<\/strong><\/li><li><strong>Take out the pre-filled syringe before using it and leave it until it has reached room temperature.&nbsp;It usually takes 15-30 minutes.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Take only one\u00a0dose\u00a0of Retacrit from each\u00a0syringe.<\/strong><\/p>\n\n\n\n<p>If Retacrit is injected under the skin (\u00a0subcutaneously\u00a0), the amount injected is usually no more than one milliliter (1 ml) in a single\u00a0injection.<\/p>\n\n\n\n<p>Retacrit is given alone and should not be mixed with other solutions for injection.<\/p>\n\n\n\n<p>Do not\u00a0<strong>shake the Retacrit syringes<\/strong>.\u00a0Prolonged, vigorous shaking can damage the product.\u00a0Do not use the product if it has been shaken vigorously.<\/p>\n\n\n\n<p><em>How to inject yourself with a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take the syringe out of the refrigerator.\u00a0Allow the liquid to reach room temperature.\u00a0Do not remove the dipstick while waiting for the syringe to reach room temperature.<\/li><li>Check the syringe to see that it contains the correct\u00a0dose, that the expiry date has not passed, that it is not damaged, and that the liquid is clear and not frozen.<\/li><li>Choose an injection site.\u00a0Good places are on the top of the thigh and around the abdomen (abdomen) but not near the navel.\u00a0Vary the injection site from day to day.<\/li><li>Wash your hands.\u00a0Use an\u00a0antiseptic\u00a0wipe at the injection site to\u00a0disinfect\u00a0it.<\/li><li>Hold the plastic cover that encloses the pre-filled syringe with the protected needle pointing upwards.<\/li><li>Do not touch any part of the plunger or the plug.<\/li><li>Never pull back the piston.<\/li><li>Do not remove the needle cover from the pre-filled syringe until you are ready to inject the medicine.<\/li><li>Remove the puncture guard from the syringe by holding the syringe and gently pulling off the cap without twisting it.\u00a0Do not press on the plunger, do not touch the needle, or shake the syringe.<\/li><li>Pinch a fold of skin between the thumb and forefinger.\u00a0Do not squeeze.<\/li><li>Push the needle down completely.\u00a0Your doctor or nurse may have shown you how to do this.<\/li><li>Press the plunger with your thumb as far as it will go to inject the entire amount of liquid.\u00a0Press it in slowly and evenly with a preserved grip on the skin fold.<\/li><li>When the plunger has been pushed in as far as it will go, remove the needle and release the skin.<\/li><li>When the needle is pulled out, there may be a small amount of bleeding at the injection site.\u00a0This is normal.\u00a0You can press an\u00a0antiseptic\u00a0wipe over the injection site for a few seconds after\u00a0injection\u00a0one.<\/li><li>Dispose of the used syringe in a safe container.\u00a0Do not try to put the stitch guard back on.<\/li><li>Never dispose of used syringes among the ordinary household waste.<\/li><\/ul>\n\n\n\n<p><em>How to inject yourself with a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>The pre-filled syringe can be fitted with automatic puncture protection to protect against puncture damage.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take the syringe out of the refrigerator.\u00a0Allow the liquid to reach room temperature.\u00a0Do not remove the dipstick while waiting for the syringe to reach room temperature.<\/li><li>Check the syringe to see that it contains the correct\u00a0dose, that the expiry date has not passed, that it is not damaged, and that the liquid is clear and not frozen.<\/li><li>Choose an injection site.\u00a0Good places are on the top of the thigh and around the abdomen (abdomen) but not near the navel.\u00a0Vary the injection site from day to day.<\/li><li>Wash your hands.\u00a0Use an\u00a0antiseptic\u00a0wipe at the injection site to\u00a0disinfect\u00a0it.<\/li><li>Hold the plastic cover that encloses the pre-filled syringe with the protected needle pointing upwards.<\/li><li>Do not touch any part of the plunger or the plug.<\/li><li>Never pull back the piston.<\/li><li>Do not remove the needle cover from the pre-filled syringe until you are ready to inject the medicine.<\/li><li>Remove the puncture guard from the syringe by holding the syringe and gently pulling off the cap without twisting it.\u00a0Do not press on the plunger, do not touch the needle, or shake the syringe.<\/li><li>Pinch a fold of skin between the thumb and forefinger.\u00a0Do not squeeze.<\/li><li>Push the needle down completely.\u00a0Your doctor or nurse may have shown you how to do this.<\/li><li>Press the plunger while holding the finger flange until the full\u00a0dose\u00a0has been given.\u00a0The puncture protection is NOT activated unless the ENTIRE\u00a0dose\u00a0has been given.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20070522000028#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/5989232c-5a93-4f6d-9315-581236f2977b\" alt=\"Injection with pre-filled syringe\" title=\"Injection with pre-filled syringe\"\/><\/a><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>When the plunger has been pushed in as far as it will go, remove the needle and release the skin.<\/li><li>Then release the plunger and allow the syringe to move upwards until the entire needle is protected and has clicked into place.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20070522000028#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/b87fc273-0cf2-4580-8e1e-24e2e76157a3\" alt=\"Release the piston\" title=\"Release the piston\"\/><\/a><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>When the needle is pulled out, there may be a small amount of bleeding at the injection site.&nbsp;This is normal.&nbsp;You can press an&nbsp;antiseptic&nbsp;wipe over the injection site for a few seconds after&nbsp;injection&nbsp;one.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Dispose of the used syringe in a safe container.\u00a0Do not try to put the stitch guard back on.<\/li><li>Never dispose of used syringes among the ordinary household waste.<\/li><\/ul>\n\n\n\n<p><em>How to inject yourself with a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>The pre-filled syringe is equipped with manual puncture protection specially designed to protect against accidental puncture injuries after proper\u00a0administration\u00a0of the injection.\u00a0It consists of plastic puncture protection that is firmly attached to the syringe label.\u00a0The puncture protection and the syringe label together constitute the puncture protection (safety) device.<\/p>\n\n\n\n<p>The user is required to perform special measures to &#8220;activate&#8221; the manual needle guard, which renders the needle harmless after the&nbsp;injection&nbsp;has been administered:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take the syringe out of the refrigerator.\u00a0Allow the liquid to reach room temperature.\u00a0Do not remove the dipstick while waiting for the syringe to reach room temperature.<\/li><li>Check the syringe to see that it contains the correct\u00a0dose, that the expiry date has not passed, that it is not damaged, and that the liquid is clear and not frozen.<\/li><li>Choose an injection site.\u00a0Good places are on the top of the thigh and around the abdomen (abdomen) but not near the navel.\u00a0Vary the injection site from day to day.<\/li><li>Wash your hands.\u00a0Use an\u00a0antiseptic\u00a0wipe at the injection site to\u00a0disinfect\u00a0it.<\/li><li>Hold the plastic cover that encloses the pre-filled syringe with the protected needle pointing upwards.<\/li><li>Do not touch any part of the plunger or the plug.<\/li><li>Never pull back the piston.<\/li><li>Grasp the tip of the colored needle guard and bend it away from the needle guard.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20070522000028#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/904451d6-bf52-4223-b36e-bcd29c5f401f\" alt=\"Remove the puncture protection\" title=\"Remove the puncture protection\"\/><\/a><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not remove the needle cover from the pre-filled syringe until you are ready to inject the medicine.<\/li><li>Remove the puncture guard from the syringe by holding the syringe and gently pulling off the cap without twisting it.\u00a0Do not press on the plunger, do not touch the needle, or shake the syringe.<\/li><li>Pinch a fold of skin between the thumb and forefinger.\u00a0Do not squeeze.<\/li><li>Push the needle down completely.\u00a0Your doctor or nurse may have shown you how to do this.<\/li><li>Press the plunger with your thumb as far as it will go to inject the entire amount of liquid.\u00a0Press it in slowly and evenly with a preserved grip on the skin fold.<\/li><li>When the plunger has been pushed in as far as it will go, remove the needle and release the skin.<\/li><li>Place the colored needle guard against a hard, stable surface, and turn the syringe with one hand upwards so that the needle is forced into the needle guard where it locks in place (a &#8220;click&#8221; is heard when the needle gets stuck in the needle guard).\u00a0Then bend the needle further until the syringe exceeds a 45 \u00b0 angle to the flat surface to make it permanently unusable.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20070522000028#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/ac4c13cf-92d0-45a2-bbd5-b50567904a8b\" alt=\"Make the syringe unusable\" title=\"Make the syringe unusable\"\/><\/a><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>When the needle is pulled out, there may be a small amount of bleeding at the injection site.&nbsp;This is normal.&nbsp;You can press an&nbsp;antiseptic&nbsp;wipe over the injection site for a few seconds after&nbsp;injection&nbsp;one.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Dispose of the used syringe in a safe container.\u00a0Do not try to put the stitch guard back on.<\/li><li>Never dispose of used syringes among the ordinary household waste.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Retacrit than you should&nbsp;<\/h2>\n\n\n\n<p>Tell your doctor or nurse immediately if you think you have been given too much Retacrit.&nbsp;Side effects&nbsp;due to overdose of Retacrit are unlikely.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Retacrit<\/h2>\n\n\n\n<p>Take the next\u00a0injection\u00a0as soon as you remember.\u00a0If there is one day left or less until it is time for the next\u00a0injection, skip the missed\u00a0dose\u00a0and continue as usual.\u00a0Do not take double\u00a0injections\u00a0to compensate for a missed\u00a0dose.<\/p>\n\n\n\n<p><strong>If you have&nbsp;hepatitis&nbsp;C and are being treated with&nbsp;interferon&nbsp;and ribavirin<\/strong><\/p>\n\n\n\n<p>Talk to your doctor as concomitant treatment with epoetin alfa and\u00a0interferon\u00a0and ribavirin may lead to loss of efficacy and, in rare cases, the development of a condition called erythrocyte plasma (PRCA), a severe form of\u00a0anemia.\u00a0Retacrit is not approved for the treatment of\u00a0anemia\u00a0associated with\u00a0hepatitis\u00a0C.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, nurse, or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If any of the side effects gets serious, or if you notice any\u00a0side effects\u00a0not listed in this leaflet, please tell\u00a0<strong>your doctor or nurse.<\/strong><\/p>\n\n\n\n<p>Severe skin rashes such as\u00a0Stevens-Johnson syndrome\u00a0and\u00a0toxic epidermal necrolysis\u00a0have been reported during treatment with epoetin.\u00a0These conditions can cause symptoms such as reddish-purple target-like or round spots on the torso, often with blisters in the middle, scaly skin, sores in the mouth, throat, nose, genitals, and eyes and may be preceded by fever and\u00a0flu-like symptoms.\u00a0Stop taking Retacrit if you experience these symptoms and contact a doctor or hospital immediately.\u00a0See also section 2.<\/p>\n\n\n\n<p><em>Very common: may affect more than 1 in 10 people.<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Diarrhea<\/strong><\/li><li><strong>Nausea<\/strong><\/li><li><strong>Vomiting<\/strong><\/li><li><strong>Fever<\/strong><\/li><li><strong>Narrow airways<\/strong>\u00a0such as nasal congestion and sore throat have been reported in patients with kidney disease who have not yet undergone\u00a0dialysis.<\/li><\/ul>\n\n\n\n<p><em>Common: may affect up to 1 in 10 people.<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>High\u00a0blood pressure<\/strong>.\u00a0Headaches, especially sudden, stabbing migraine-like headaches, feelings of\u00a0confusion or seizures\u00a0can be signs of a sudden increase in\u00a0blood pressure.\u00a0This requires\u00a0urgent\u00a0treatment.\u00a0High\u00a0blood pressure\u00a0may require medication (or adjustment of the medications you are already taking for high\u00a0blood pressure\u00a0).<\/li><li>Blood clots\u00a0(including deep\u00a0vein thrombosis\u00a0and embolism) that may require\u00a0urgent\u00a0treatment.\u00a0You may experience\u00a0chest pain, shortness of breath, painful swelling, and\u00a0redness, usually in the leg, as symptoms.<\/li><li>Cough<\/li><li>Skin rash may be due to an\u00a0allergic reaction.<\/li><li>Skeletal or muscle pain<\/li><li>Influenza-like symptoms, such as headache, joint pain, pain, feeling weak, chills, fatigue, and dizziness.\u00a0These may be more common at the beginning of treatment.\u00a0If you get these symptoms by\u00a0intravenous\u00a0injection, they can be avoided in the future by giving\u00a0injection\u00a0more slowly.<\/li><li>Redness, burning, and pain at the injection site\u00a0<\/li><li>Swelling of the ankles, feet,<strong> and fingers\u00a0<\/strong><\/li><li><strong>Pain in arms or legs\u00a0<\/strong><\/li><\/ul>\n\n\n\n<p>Uncommon: may affect up to 1 in 100 people.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>High levels of\u00a0potassium\u00a0in the blood<\/strong>\u00a0can cause abnormal heart rhythms (this is a very common\u00a0side effect\u00a0in patients undergoing\u00a0dialysis\u00a0)<\/li><li><strong>Seizures<\/strong>\u00a0<\/li><li><strong>Nasal congestion or narrow airways<\/strong>\u00a0<\/li><li><strong>Allergic reaction<\/strong>\u00a0<\/li><li><strong>Hives<\/strong>\u00a0<\/li><\/ul>\n\n\n\n<p><em>Rare: may affect up to 1 in 1,000 people.<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Symptoms of erythrocyte plasma<\/strong> (PRCA)PRCA means the inability to produce enough\u00a0red blood cells\u00a0in the\u00a0bone marrow.\u00a0PRCA can lead to\u00a0sudden and severe\u00a0anemia<strong>.\u00a0The symptoms are:<\/strong><ul><li><strong>unusual fatigue,<\/strong><\/li><li><strong>dizziness,<\/strong><\/li><li><strong>respiratory distress.<\/strong><\/li><\/ul><\/li><\/ul>\n\n\n\n<p>PRCA has in very rare cases, mainly in patients with kidney disease, been reported after several months to years of treatment with Retacrit and other products that stimulate the formation of\u00a0red blood cells.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>An increase in the level of small\u00a0blood cells\u00a0(so-called\u00a0platelets\u00a0), which are normally involved in the formation of blood clots, can occur, especially at the beginning of treatment.\u00a0Your doctor will check this<\/li><li>The severe\u00a0allergic reaction\u00a0may include:<ul><li>swelling of the face, lips, mouth, tongue, or throat<\/li><li>difficulty swallowing or breathing<\/li><li>itchy rash (\u00a0hives\u00a0)<\/li><\/ul><\/li><li>Problems with the blood that can cause pain, dark-colored urine, or increased sensitivity of the skin to sunlight (\u00a0porphyria\u00a0)<\/li><\/ul>\n\n\n\n<p><em>If you are undergoing hemodialysis:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Blood clots<\/strong>\u00a0(\u00a0thrombosis\u00a0) can form in your dialysis shunt.\u00a0There is a greater risk of this if you have low\u00a0blood pressure\u00a0or if there are complications with your\u00a0fistula.<\/li><li>Blood clots\u00a0can also form\u00a0in your hemodialysis system.\u00a0Your doctor can decide to increase your heparin dose during\u00a0dialysis.<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor or nurse immediately<\/strong>\u00a0if you notice any of these\u00a0side effects, or if you notice any other\u00a0side effects\u00a0while you are being treated with Retacrit.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Retacrit<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and the label after EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C-8 \u00b0 C).&nbsp;Retacrit can be taken out of the refrigerator and then stored at room temperature (maximum 25 \u00b0 C) for a maximum of 3 days.&nbsp;Once a&nbsp;syringe&nbsp;has been removed from the refrigerator and has reached room temperature (maximum 25 \u00b0 C), it must either be used within 3 days or discarded.<\/p>\n\n\n\n<p>Do not freeze or shake.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Do not use this medicine if you notice that the seal is broken or if the liquid is colored or if you see particles in it.&nbsp;If you see any of this, discard the medicine.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is epoetin zeta (produced by&nbsp;recombinant DNA&nbsp;technology in Chinese hamster ovary cells (CHO).<\/p>\n\n\n\n<p><em>Retacrit 1,000 IU \/ 0.3 ml&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>1 pre-filled&nbsp;syringe&nbsp;with 0.3 ml solution for injection contains 1,000 international units (IU) epoetin zeta (&nbsp;recombinant&nbsp;human erythropoietin).&nbsp;The solution contains 3,333 IU epoetin zeta per ml.<\/p>\n\n\n\n<p><em>Retacrit 2,000 IU \/ 0.6 ml&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>1 pre-filled&nbsp;syringe&nbsp;with 0.6 ml&nbsp;solution for injection&nbsp;contains 2,000 International Units (IU) epoetin zeta (&nbsp;recombinant&nbsp;human erythropoietin).&nbsp;The solution contains 3,333 IU epoetin zeta per ml.<\/p>\n\n\n\n<p><em>Retacrit 3,000 IU \/ 0.9 ml&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>1 pre-filled&nbsp;syringe&nbsp;with 0.9 ml&nbsp;solution for injection&nbsp;contains 3,000 international units (IU) epoetin zeta (&nbsp;recombinant&nbsp;human erythropoietin).&nbsp;The solution contains 3,333 IU epoetin zeta per ml.<\/p>\n\n\n\n<p><em>Retacrit 4,000 IU \/ 0.4 ml&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>1 pre-filled&nbsp;syringe&nbsp;with 0.4 ml&nbsp;solution for injection&nbsp;contains 4,000 international units (IU) epoetin zeta (&nbsp;recombinant&nbsp;human erythropoietin).&nbsp;The solution contains 10,000 IU epoetin zeta per ml.<\/p>\n\n\n\n<p><em>Retacrit 5,000 IU \/ 0.5 ml&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>1 pre-filled&nbsp;syringe&nbsp;with 0.5 ml&nbsp;solution for injection&nbsp;contains 5,000 international units (IU) epoetin zeta (&nbsp;recombinant&nbsp;human erythropoietin).&nbsp;The solution contains 10,000 IU epoetin zeta per ml.<\/p>\n\n\n\n<p><em>Retacrit 6,000 IU \/ 0.6 ml&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>1 pre-filled&nbsp;syringe&nbsp;with 0.6 ml&nbsp;solution for injection&nbsp;contains 6,000 international units (IU) epoetin zeta (&nbsp;recombinant&nbsp;human erythropoietin).&nbsp;The solution contains 10,000 IU epoetin zeta per ml.<\/p>\n\n\n\n<p><em>Retacrit 8,000 IU \/ 0.8 ml&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>1 pre-filled&nbsp;syringe&nbsp;with 0.8 ml&nbsp;solution for injection&nbsp;contains 8,000 international units (IU) epoetin zeta (&nbsp;recombinant&nbsp;human erythropoietin).&nbsp;The solution contains 10,000 IU epoetin zeta per ml.<\/p>\n\n\n\n<p><em>Retacrit 10,000 IU \/ 1 ml&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>1 pre-filled&nbsp;syringe&nbsp;with 1 ml&nbsp;solution for injection&nbsp;contains 10,000 international units (IU) epoetin zeta (&nbsp;recombinant&nbsp;human erythropoietin).&nbsp;The solution contains 10,000 IU epoetin zeta per ml.<\/p>\n\n\n\n<p><em>Retacrit 20,000 IU \/ 0.5 ml&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>1 pre-filled&nbsp;syringe&nbsp;with 0.5 ml&nbsp;solution for injection&nbsp;contains 20,000 international units (IU) epoetin zeta (&nbsp;recombinant&nbsp;human erythropoietin).&nbsp;The solution contains 40,000 IU epoetin zeta per ml.<\/p>\n\n\n\n<p><em>Retacrit 30,000 IU \/ 0.75 ml&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>1 pre-filled&nbsp;syringe&nbsp;with 0.75 ml&nbsp;solution for injection&nbsp;contains 30,000 international units (IU) epoetin zeta (&nbsp;recombinant&nbsp;human erythropoietin).&nbsp;The solution contains 40,000 IU epoetin zeta per ml.<\/p>\n\n\n\n<p><em>Retacrit 40,000 IU \/ 1 ml&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>1 pre-filled&nbsp;syringe&nbsp;with 1 ml&nbsp;solution for injection&nbsp;contains 40,000 international units (IU) epoetin zeta (&nbsp;recombinant&nbsp;human erythropoietin).&nbsp;The solution contains 40,000 IU epoetin zeta per ml.<\/p>\n\n\n\n<p>The other ingredients are disodium phosphate dihydrate, sodium dihydrogen phosphate dihydrate, sodium chloride (see section 2 &#8221; Retacrit\u00a0contains sodium&#8221;), calcium chloride dihydrate, polysorbate 20,\u00a0glycine, leucine, isoleucine, threonine, glutamic acid, see phenylalanine section (phenylalanine). , sodium hydroxide (for\u00a0pH\u00a0adjustment),\u00a0hydrochloric acid\u00a0(for\u00a0pH\u00a0adjustment).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Retacrit is a clear and colorless&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;syringe&nbsp;with a fixed injection needle.<\/p>\n\n\n\n<p>The pre-filled syringes contain between 0.3 and 1 ml of solution, depending on the amount of epoetin zeta (see &#8220;Contents of contents&#8221;).<\/p>\n\n\n\n<p>One package contains 1, 4, or 6 pre-filled syringes with or without automatic or manual puncture protection.<\/p>\n\n\n\n<p>The multipack contains 4 (4&#215;1) or 6 (6&#215;1) pre-filled syringes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Pfizer Europe MA EEIG<\/p>\n\n\n\n<p>Boulevard de la Plaine 17<\/p>\n\n\n\n<p>1050 Brussels<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>STADA Arzneimittel AG<\/p>\n\n\n\n<p>Stadastrasse 2-18<\/p>\n\n\n\n<p>D-61118 Bad Vilbel<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Hospira Zagreb doo<\/p>\n\n\n\n<p>Prudni\u010dka Cesta 60<\/p>\n\n\n\n<p>10291 Prigorje Brdove\u010dko<\/p>\n\n\n\n<p>Croatia<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong><strong>Luxembourg \/ Luxemburg<\/strong>Pfizer NV \/ SATel: +32 (0) 2 554 62 11<\/td><td><strong>Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaTel.&nbsp;+ 370 52 51 4000<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Pfizer Luxembourg SARE, Clone of BulgariaTel: +359 2 970 4333<\/td><td><strong>Hungary<\/strong>Pfizer Kft.Tel .: + 36 1 488 37 00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Pfizer, spol.&nbsp;s roTel: + 420-283-004-111<\/td><td><strong>Malta<\/strong>Drugsales LtdTel: + 356 21 419 070\/1\/2<\/td><\/tr><tr><td><strong>Denmark<\/strong>Pfizer ApSTel: + 45 44 20 11 00<\/td><td><strong>The Netherlands<\/strong>Pfizer bvTel: +31 (0) 10 406 43 01<\/td><\/tr><tr><td><strong>Germany<\/strong>PFIZER PHARMA GmbHTel: +49 (0) 30 550055-51000<\/td><td><strong>Norway<\/strong>Pfizer ASTel: +47 67 52 61 00<\/td><\/tr><tr><td><strong>Eesti<\/strong>Pfizer Luxembourg SARL Eesti subsidiaryTel: +372 666 7500<\/td><td><strong>Austria<\/strong>Pfizer Corporation Austria Ges.mbHTel: +43 (0) 1 521 15-0<\/td><\/tr><tr><td><strong>Greece<\/strong>Aenorasis SA:\u0397\u03bb: + 30 210 6136332<\/td><td><strong>Poland<\/strong>Pfizer Polska Sp.&nbsp;z ooTel .: +48 22 335 61 00<\/td><\/tr><tr><td><strong>Spain<\/strong>Pfizer, SLTel: +34 91 490 99 00<\/td><td><strong>Portugal<\/strong>Pfizer Laboratories, Lda.Tel: +351 21 423 55 00<\/td><\/tr><tr><td><strong>France<\/strong>PfizerTel: + 33 (0) 1 58 07 34 40<\/td><td><strong>Romania<\/strong>Pfizer Rom\u00e2nia SRLTel: +40 (0) 21 207 28 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>Pfizer Croatia dooTel: +385 1 3908 777<\/td><td><strong>Slovenia<\/strong>Pfizer Luxembourg SARLPfizer, a company in the field of pharmaceuticals, LjubljanaTel: +386 (0) 1 52 11 400<\/td><\/tr><tr><td><strong>Ireland<\/strong>Pfizer Healthcare IrelandTel: 1800 633 363 (toll free)+44 (0) 1304 616161<\/td><td><strong>Slovak Republic<\/strong>Pfizer Luxembourg SARL, organizerTel: + 421\u20132\u20133355 5500<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hf.Phone: +354 540 8000<\/td><td><strong>Finland \/ Finland<\/strong>Pfizer OyPuh \/ Tel: +358 (0) 9 430 040<\/td><\/tr><tr><td><strong>Italy<\/strong>Pfizer SrlTel: +39 06 33 18 21<\/td><td><strong>Sweden<\/strong>Pfizer ABTel: +46 (0) 8 550 520 00<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>Pfizer \u0395\u039b\u039b\u0391\u03a3 \u0391.\u0395.&nbsp;(Cyprus Branch):\u0397\u03bb: +357 22 817690<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Pfizer LimitedTel: +44 (0) 1304 616161<\/td><\/tr><tr><td><strong>Latvia<\/strong>Pfizer Luxembourg SARL subsidiary Latvij\u0101Tel .: + 371 670 35 775<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>1,000 IU \/ 0.3 ml; 2,000 IU \/ 0.6 ml; 3,000 IU \/ 0.9 ml; 4,000 IU \/ 0.4 ml; 5,000 IU \/ 0.5 ml; 6,000 IU \/ 0 .6 ml; 8,000 IU \/ 0.8 ml; 10,000 IU \/ 1.0 ml; 20,000 IU \/ 0.5 ml; 30,000 IU \/ 0.75 ml; 40,000 IU \/ 1.0&nbsp;solution&nbsp;for [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[22863,22868,22859,22862,22864,22867,22861,22860,22865,22866],"class_list":["post-22014","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-epoetin-zeta","tag-benefits-of-retacrit","tag-epoetin-zeta","tag-epoetin-zeta-side-effects","tag-retacrit","tag-retacrit-side-effects","tag-what-epoetin-zeta-is-usedfor","tag-what-is-epoetin-zeta","tag-what-is-retacrit","tag-what-retacrit-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22014","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22014"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22014\/revisions"}],"predecessor-version":[{"id":22052,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22014\/revisions\/22052"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22014"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22014"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22014"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}