intravenously\u00a0via a plastic tube (\u00a0catheter\u00a0), that is usually inserted in the neck, chest, or groin area.<\/li><\/ul>\n\n\n\nIn both cases, Remodulin is pushed through the tube using a portable pump that is placed outside your body (external).<\/p>\n\n\n\n
Before leaving the hospital or clinic, your doctor will tell you how to prepare Remodulin and at what rate the pump will give you Remodulin.<\/p>\n\n\n\n
Flushing the infusion line while it is connected may cause an accidental overdose.<\/p>\n\n\n\n
Alternatively, Remodulin can be administered intravenously via an implantable infusion pump that is usually operated on under the skin of the stomach (abdomen). In this case, the pump and the tube are both completely inside your body (internal) and you must visit the hospital regularly (eg every four weeks) to have the internal container filled.<\/p>\n\n\n\n
Regardless of how you receive Remodulin, you should get information on how to use the pump correctly and what to do if it stops working. You should also receive information about who to contact in an emergency.<\/p>\n\n\n\n
Remodulin is diluted only when given intravenously as a continuous intravenous infusion:<\/p>\n\n\n\n
For\u00a0<\/em>intravenous<\/em>\u00a0infusion\u00a0with an <\/strong>external portable pump only: the Remodulin\u00a0solution\u00a0should only be diluted with sterile water for injections or with 9 mg\/ml sodium chloride solution for injection (given by your doctor).<\/p>\n\n\n\nFor\u00a0intravenous\u00a0infusion\u00a0with an <\/em>implantable infusion pump:\u00a0You must visit the hospital regularly (eg every four weeks).\u00a0During the visit, the caregiver should dilute your Remodulin solution with 9 mg\/ml sodium chloride solution for injections and refill the internal container.<\/p>\n\n\n\nAdult patients<\/em><\/p>\n\n\n\nRemodulin is available as 1 mg \/ ml, 2.5 mg \/ ml, 5 mg \/ ml or 10 mg \/ ml solution for infusion . Your doctor will determine the infusion rate and infusion dose appropriate for your condition.<\/p>\n\n\n\n
Obese patients<\/em><\/p>\n\n\n\nIf you are overweight (weighing 30% or more than your ideal body weight), your doctor will determine the first and following doses based on your ideal body weight. See also section 2, \u201cWarnings and Precautions\u201d.<\/p>\n\n\n\n
Elderly<\/em><\/p>\n\n\n\nYour doctor will determine the infusion rate and infusion dose appropriate for your condition.<\/p>\n\n\n\n
Children and young people<\/em><\/p>\n\n\n\nThere are limited data for children and adolescents.<\/p>\n\n\n\n
Dose adjustment<\/em><\/p>\n\n\n\nThe infusion rate can be lowered or increased individually only under medical supervision.<\/strong><\/p>\n\n\n\nThe goal of adjusting the infusion rate is to establish an effective maintenance rate that improves the symptoms of\u00a0pulmonary\u00a0arterial\u00a0hypertension\u00a0while minimizing\u00a0any\u00a0side effects.<\/p>\n\n\n\n
If your symptoms increase or if you need complete rest, or are confined to the bed or chair, or if any physical activity causes discomfort and your symptoms occur at rest, do not increase the dose without a doctor’s prescription. Remodulin may no longer be sufficient to treat your illness and other treatment may be needed.<\/p>\n\n\n\n
How can your bloodstream\u00a0infection\u00a0be prevented during treatment with Remodulin given\u00a0intravenously?<\/strong><\/p>\n\n\n\nAs with any long-term intravenous treatment, there is a risk of infection in your bloodstream. Your doctor will instruct you on how to avoid this.<\/p>\n\n\n\n
If you use more Remodulin than you should<\/h2>\n\n\n\n
If you accidentally overdose on Remodulin, you may experience nausea, vomiting, diarrhea, low\u00a0blood pressure\u00a0(dizziness, intoxication, or fainting), reddening of the skin, and\/or headache.<\/p>\n\n\n\n
If any of these effects become severe, contact your doctor or hospital immediately. Your doctor may reduce the dose one or discontinue the infusion one until the symptoms have disappeared. Treatment with Remodulin infusion solution is restarted at a dose recommended by your doctor.<\/p>\n\n\n\n
If you have ingested too much medicine or if e.g.\u00a0a child ingested the medicine accidentally contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n
If you stop using Remodulin<\/h2>\n\n\n\n
Always use Remodulin exactly as your doctor or hospital specialist has told you. Do not stop using Remodulin unless your doctor tells you to.<\/p>\n\n\n\n
Sudden interruption or sudden dose reductions of Remodulin may cause recurrent\u00a0pulmonary\u00a0arterial\u00a0hypertension, with the risk of rapid and severe deterioration of your condition.<\/p>\n\n\n\n
If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n
Very common <\/strong>side effects (<\/strong> may affect more than 1 user in 10)<\/p>\n\n\n\n- dilated blood vessels with reddening of the skin<\/li>
- pain or redness at the infusion site<\/li>
- discoloration of the skin or bruising at the infusion site<\/li>
- headache<\/li>
- rash<\/li>
- nausea<\/li>
- diarrhea<\/li>
- pain in the jaws<\/li><\/ul>\n\n\n\n
Common <\/strong>side effects<\/strong> (<\/strong> may affect up to 1 in 10 people)<\/em><\/strong><\/p>\n\n\n\n- dizziness<\/li>
- vomiting<\/li>
- feeling drunk or fainting due to low\u00a0blood pressure<\/li>
- itching\u00a0or redness of the skin<\/li>
- swelling of the feet, ankles, and legs or fluid retention<\/li>
- bleeding such as nosebleeds, coughing up of blood, blood in the urine, bleeding in the gums, blood in the stool<\/li>
- joint pain<\/li>
- muscle pain<\/li>
- pain in legs and\/or arms<\/li><\/ul>\n\n\n\n
Other possible side effects (<\/strong> no known frequency (can not be calculated from the available data))<\/p>\n\n\n\n- infection at the infusion site<\/li>
- warping at the infusion site<\/li>
- decreased number of blood cells ( platelets ) that cause the blood to clot ( thrombocytopenia )<\/li>
- bleeding at the infusion site<\/li>
- skeletal pain<\/li>
- reddening of the skin with discoloration or raised lumps<\/li>
- tissue infection under the skin ( cellulite )<\/li>
- too much blood pumped from the heart leads to shortness of breath, fatigue, swelling of the legs and abdomen due to fluid retention, persistent cough<\/li><\/ul>\n\n\n\n
Additional side effects are associated with intravenous administration<\/strong><\/p>\n\n\n\n- inflammation of the vein<\/li>
- bacterial infection in the bloodstream (bacteremia) * (see section 3)<\/li>
- severe bacterial infection in the blood ( septicemia )<\/li><\/ul>\n\n\n\n
* life-threatening show larRemodulisho or fatal cases of bacterial infection in the bloodstream have been reported<\/p>\n\n\n\n
How to store Remodulin<\/h2>\n\n\n\n
Keep out of sight and reach of children.<\/strong><\/p>\n\n\n\nNo special storage instructions.<\/p>\n\n\n\n
Do not use this medicine after the expiry date which is stated on the carton and vial. The expiration date is the last day of the specified month.<\/p>\n\n\n\n
Do not use Remodulin if you notice any damage to the vial, discoloration, or other signs of deterioration.<\/p>\n\n\n\n
A\u00a0vial\u00a0of Remodulin must be used or discarded within 30 days of the first opening.<\/p>\n\n\n\n
For\u00a0continuous\u00a0subcutaneous\u00a0infusion, the reservoir (syringe) with undiluted Remodulin must be used within 72 hours.<\/p>\n\n\n\n
For continuous intravenous infusion with an external portable pump, the reservoir (syringe) with diluted Remodulin must be used within 24 hours.<\/p>\n\n\n\n
For continuous intravenous infusion with implantable infusion pumps, diluted Remodulin inserted into the container of the pump must be used within a maximum of 35 days. The healthcare staff at the hospital will inform you about the time interval for the next filling of the container.<\/p>\n\n\n\n
The diluted solution that may be left over must be discarded.<\/p>\n\n\n\n
For instructions on use, see section 3, \u201cHow to use Remodulin\u201d.<\/p>\n\n\n\n
Medicines should not be disposed of via wastewater or household waste.<\/p>\n\n\n\n
Ask your pharmacist how to dispose of medicines no longer required.<\/p>\n\n\n\n
These measures will help to protect the environment.<\/p>\n\n\n\n
Contents of the package and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\n
The active substance is treprostinil 1 mg \/ ml, 2.5 mg \/ ml, 5 mg \/ ml, 10 mg \/ ml.<\/p>\n\n\n\n
The other ingredients are sodium citrate, sodium chloride, sodium hydroxide,\u00a0hydrochloric acid, metacresol, and water for injections.<\/p>\n\n\n\n
What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
Remodulin is colorless to the slightly yellow solution, contained in a 20 ml clear glass\u00a0vial\u00a0sealed with a rubber stopper and a color-coded cap.<\/p>\n\n\n\n
- Remodulin 1 mg\/ml\u00a0solution for infusion\u00a0has a\u00a0yellow\u00a0rubber cap.<\/li>
- Remodulin 2.5 mg\/ml\u00a0solution for infusion\u00a0has a\u00a0blue\u00a0rubber cap.<\/li>
- Remodulin 5 mg\/ml\u00a0solution for infusion\u00a0has a\u00a0green\u00a0rubber cap.<\/li>
- Remodulin 10 mg\/ml\u00a0solution for infusion\u00a0has a\u00a0red<\/strong>\u00a0rubber cap.<\/li><\/ul>\n\n\n\n
Each carton contains one\u00a0vial.<\/p>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Marketing Authorisation Holder:<\/p>\n\n\n\n
Ferrer Internacional, SA<\/p>\n\n\n\n
Gran V\u00eda Carlos III, 94<\/p>\n\n\n\n
08028 – Barcelona<\/p>\n\n\n\n
Spain<\/p>\n\n\n\n
Manufacturer:<\/p>\n\n\n\n
Ferrer Internacional, SA<\/p>\n\n\n\n
Joan Buscall\u00e0, 1-9<\/p>\n\n\n\n
08173 – Sant Cugat del Vall\u00e8s (Barcelona)<\/p>\n\n\n\n
Spain<\/p>\n","protected":false},"excerpt":{"rendered":"
1 mg \/ ml, 2.5 mg \/ ml, 5 mg \/ ml and 10 mg \/ ml solution for infusion treprostinil What Remodulin is and what it is used for What Remodulin is The active substance in Remodulin is treprostinil. Treprostinil belongs to a group of medicines that work in almost the same way as naturally […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[22645,22640,22641,22644,22636,22639,22642,22637,22643,22638],"class_list":["post-21885","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-remodulin","tag-benefits-of-treprostinil","tag-remodulin","tag-remodulin-side-effects","tag-treprostinil","tag-treprostinil-side-effects","tag-what-is-remodulin","tag-what-is-treprostinil","tag-what-remodulin-is-used-for","tag-what-treprostinil-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21885","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21885"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21885\/revisions"}],"predecessor-version":[{"id":21903,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21885\/revisions\/21903"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}