{"id":21876,"date":"2022-06-11T18:27:32","date_gmt":"2022-06-11T18:27:32","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21876"},"modified":"2022-06-14T07:35:54","modified_gmt":"2022-06-14T07:35:54","slug":"remicade","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/remicade\/","title":{"rendered":"Remicade &#8211; Infliximab uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg&nbsp;powder for concentrate for&nbsp;solution for&nbsp;infusion<br>infliximab<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Remicade is and what it is used for<\/h2>\n\n\n\n<p>Remicade contains the active substance infliximab.\u00a0Infliximab is a monoclonal\u00a0antibody\u00a0&#8211; a type of\u00a0protein\u00a0that binds to a specific target in the body called\u00a0TNF\u00a0alpha (\u00a0tumor necrosis factor-alpha).<\/p>\n\n\n\n<p>Remicade belongs to a group of medicines called &#8220;TNF inhibitors&#8221;.&nbsp;It is used in adults for the following inflammatory diseases:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rheumatoid arthritis<\/li><li>Psoriatic arthritis<\/li><li>Ankylosing spondylitis\u00a0(Bechterew&#8217;s disease)<\/li><li>Psoriasis.<\/li><\/ul>\n\n\n\n<p>Remicade is also used in adults and children, 6 years and older in:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Crohn&#8217;s disease<\/li><li>Ulcerative colitis.<\/li><\/ul>\n\n\n\n<p>Remicade works by specifically binding to TNF alpha and blocking its function.&nbsp;TNF&nbsp;alpha participates in inflammatory processes in the body and by blocking them,&nbsp;inflammation&nbsp;in your body can be reduced.<\/p>\n\n\n\n<p><strong>Rheumatoid arthritis<\/strong><\/p>\n\n\n\n<p>Rheumatoid arthritis\u00a0is an\u00a0inflammatory\u00a0disease that attacks the joints.\u00a0If you have active\u00a0rheumatoid arthritis, you will first be given other medicines.\u00a0If these medicines do not work well enough, you will be given Remicade, which you will need to take in combination with another medicine called methotrexate to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduce signs and symptoms of the disease<\/li><li>Reduce damage to the joints<\/li><li>Improve your physical function.<\/li><\/ul>\n\n\n\n<p><strong>Psoriatic arthritis<\/strong><\/p>\n\n\n\n<p>Psoriatic arthritis is an\u00a0inflammatory\u00a0disease of the joints, usually associated with\u00a0psoriasis.\u00a0If you have active psoriatic arthritis, you will first be given other medicines.\u00a0If these medicines do not work well enough, you will be given Remicade to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduce signs and symptoms of the disease<\/li><li>Reduce damage to the joints<\/li><li>Improve your physical function.<\/li><\/ul>\n\n\n\n<p><strong>Ankylosing spondylitis&nbsp;(Bechterew&#8217;s disease)<\/strong><\/p>\n\n\n\n<p>Ankylosing spondylitis\u00a0is an\u00a0inflammatory\u00a0disease of the spine.\u00a0If you have\u00a0ankylosing spondylitis, you will first be given other medicines.\u00a0If these medicines do not work well enough, you will be given Remicade to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduce signs and symptoms of the disease<\/li><li>Improve your physical function.<\/li><\/ul>\n\n\n\n<p><strong>Psoriasis<\/strong><\/p>\n\n\n\n<p>Psoriasis&nbsp;is an&nbsp;inflammatory&nbsp;disease of the skin.&nbsp;If you have moderate or severe plaque psoriasis, you will first be given other medicines or treatments such as light therapy.&nbsp;If these medicines or treatments do not work well enough, you will be given Remicade to reduce the signs and symptoms of the disease.<\/p>\n\n\n\n<p><strong>Ulcerative colitis<\/strong><\/p>\n\n\n\n<p>Ulcerative colitis\u00a0is an\u00a0inflammatory\u00a0disease of the intestine.\u00a0If you have\u00a0ulcerative colitis, you will first be given other medicines.\u00a0If these medicines do not work well enough, you will be given Remicade to treat the disease.<\/p>\n\n\n\n<p><strong>Crohn&#8217;s disease<\/strong><\/p>\n\n\n\n<p>Crohn&#8217;s disease\u00a0is an\u00a0inflammatory\u00a0disease of the intestine.\u00a0If you have\u00a0Crohn&#8217;s disease, you will first be given other medicines.\u00a0If these medicines do not work well enough, you will be given Remicade to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Treat active Crohn&#8217;s disease<\/li><li>Reduce the number of abnormal passages (\u00a0fistulas\u00a0) through the skin from the intestine that has not been controlled with other drugs or\u00a0surgery.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Remicade<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You will not receive Remicade if:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>You are allergic to infliximab or any of the other ingredients of Remicade (listed in section 6)<\/li><li>You are allergic (hypersensitive) to&nbsp;protein&nbsp;that comes from mice<\/li><li>You have&nbsp;tuberculosis&nbsp;(TB) or any other serious&nbsp;infection&nbsp;such as&nbsp;pneumonia&nbsp;or sepsis<\/li><li>You have&nbsp;heart failure&nbsp;that is moderate or severe.<\/li><\/ul>\n\n\n\n<p>Do not use Remicade if any of the above apply to you.&nbsp;If you are not sure, talk to your doctor before taking Remicade.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before or during treatment with Remicade if you have:<\/p>\n\n\n\n<p><br>Received treatment with Remicade before<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you have previously received Remicade and are now starting treatment with Remicade again.<\/li><\/ul>\n\n\n\n<p>If you have had a break in your Remicade treatment for more than 16 weeks, there is an increased risk of allergic reactions when you start treatment again.<\/p>\n\n\n\n<p>Infection&nbsp;is<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor before receiving Remicade if you have an\u00a0infection, even if it is a very mild one.<\/li><li>Tell your doctor before receiving Remicade if you have ever lived in or traveled to areas where\u00a0infection\u00a0called\u00a0histoplasmosis,\u00a0coccidioidomycosis\u00a0or\u00a0blastomycosis\u00a0is common.\u00a0These\u00a0infections\u00a0are caused by a special type of fungus that can affect the lungs or other parts of the body.<\/li><li>You can more easily get your\u00a0infection\u00a0when you are treated with Remicade.\u00a0If you are 65 years or older, the risk is higher.<\/li><li>These\u00a0infections\u00a0can be serious and include\u00a0tuberculosis,\u00a0infections\u00a0caused by\u00a0viruses, fungi, bacteria, or other\u00a0organisms\u00a0in the environment, and blood poisoning that can be life-threatening.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you get any signs of\u00a0infection\u00a0during treatment with Remicade.\u00a0Such signs include fever, cough, flu-like signs, general malaise, red or hot skin, sores, or dental problems.\u00a0Your doctor may recommend that Remicade treatment be stopped temporarily.<\/p>\n\n\n\n<p>Tuberculosis&nbsp;(TBC)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You must tell your doctor if you have ever had TB or if you have been in close contact with someone who has had or has TB.<\/li><li>Your doctor will check if you have TB.\u00a0Cases of TB have been reported in patients treated with Remicade, including in patients already treated with anti-TB drugs.\u00a0Your doctor will note the examinations on your Patient&#8217;s Card<\/li><li>If your doctor thinks you are at risk of getting TB, you can get TB medicine before you are given Remicade.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you get any signs of TB during treatment with Remicade.\u00a0Such signs include persistent cough, weight loss, feeling tired, fever, and night sweats.<\/p>\n\n\n\n<p>Hepatitis&nbsp;B&nbsp;virus<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor before receiving Remicade if you are a\u00a0hepatitis\u00a0B carrier or if you have ever had it.<\/li><li>Tell your doctor if you think you are at risk of getting\u00a0hepatitis\u00a0B.<\/li><li>Your doctor will test you for the\u00a0hepatitis\u00a0B\u00a0virus.<\/li><li>Treatment with\u00a0TNF\u00a0-antagonists such as Remicade may reactivate the\u00a0hepatitis\u00a0B\u00a0virus\u00a0in patients carrying the\u00a0virus, which in some cases may be life-threatening.<\/li><\/ul>\n\n\n\n<p>Heart problems<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you have heart problems such as mild\u00a0heart failure.<\/li><li>Your doctor will closely monitor your heart.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you get new or worsening signs of&nbsp;heart failure&nbsp;during treatment with Remicade.&nbsp;Such signs include shortness of breath or swollen feet.<\/p>\n\n\n\n<p>Cancer and&nbsp;lymphoma<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor before receiving Remicade if you have or have ever had\u00a0lymphoma\u00a0(a type of blood cancer) or any other cancer.<\/li><li>Patients with severe\u00a0rheumatoid arthritis\u00a0who have had the disease for a long time may have a higher risk of developing\u00a0lymphoma.<\/li><li>Children and adults treated with Remicade may be at increased risk of developing\u00a0lymphoma\u00a0or any other cancer<\/li><li>Some patients who have received\u00a0TNF\u00a0inhibitors, including Remicade, have developed a rare type of cancer called T-cell lymphoma in the liver and\u00a0spleen.\u00a0Of these patients, most were teenage boys or younger men, and most had either\u00a0Crohn&#8217;s disease\u00a0or\u00a0ulcerative colitis.\u00a0This type of cancer usually leads to death.\u00a0In addition to\u00a0TNF\u00a0inhibitors, almost all patients had also received medicines containing azathioprine or 6-mercaptopurine.<\/li><li>Some patients treated with infliximab have developed certain types of skin cancer.\u00a0Tell your doctor if there are any changes in the skin or growths on the skin during or after the treatment.<\/li><li>Some women who have been treated for\u00a0rheumatoid arthritis\u00a0with Remicade have developed cervical cancer.\u00a0For women taking Remicade, even those over 60 years of age: Your doctor may recommend regular examination for cervical cancer.<\/li><\/ul>\n\n\n\n<p>Lung disease or heavy smoking<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor before receiving Remicade if you have a lung disease called&nbsp;chronic obstructive pulmonary disease&nbsp;(COPD), or if you are a heavy smoker.<\/li><li>Patients who have COPD or patients who are heavy smokers may have a higher risk of developing cancer during treatment with Remicade.<\/li><\/ul>\n\n\n\n<p>Diseases of the nervous system<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you have or have had problems affecting your nervous system before receiving Remicade.\u00a0These include\u00a0multiple sclerosis,\u00a0and Guillain-Barr\u00e9 syndrome\u00a0if you have a seizure or have been diagnosed with &#8220;optic neuritis&#8221;.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you experience symptoms of nerve disease during treatment with Remicade.\u00a0Such signs include altered vision, weakness in the arms or legs, and numbness or tingling in any part of the body.<\/p>\n\n\n\n<p>Fistulas<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you have any abnormal skin opening (&nbsp;fistula&nbsp;) before receiving Remicade.<\/li><\/ul>\n\n\n\n<p>Vaccinations<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you have recently had or are planning to get vaccinated<\/li><li>You should receive recommended vaccinations before starting treatment with Remicade.\u00a0You can get some vaccinations during treatment with Remicade but you should not get live vaccines (vaccines that contain a live but weakened infectious agent) as they can cause you\u00a0an infection.<\/li><li>If you received Remicade while you were pregnant, your baby may also have a higher risk of getting an\u00a0infection, as a result of receiving a live vaccine during the first year of life.\u00a0You must tell your child&#8217;s doctor and other healthcare professionals if you have been treated with Remicade.\u00a0They can then decide when their child should receive any vaccine, including live vaccines such as the BCG vaccine (used to prevent\u00a0tuberculosis\u00a0).<\/li><li>If you are breastfeeding, you must tell your child&#8217;s doctor and other healthcare professionals that you are using Remicade before your child receives any vaccine.\u00a0For more information, see the section on pregnancy and breastfeeding.<\/li><\/ul>\n\n\n\n<p>Antimicrobial agents<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you have recently received or are planning to receive treatment with an antimicrobial agent (such as BCG\u00a0installation\u00a0which is used to treat cancer).<\/li><\/ul>\n\n\n\n<p>Operations or dental treatments<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you are going to have any surgery or dental treatment.<\/li><li>Tell your doctor or dentist that you are being treated with Remicade by showing your Patient Card.<\/li><\/ul>\n\n\n\n<p>Liver problem<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Some patients receiving Remicade have developed severe liver problems.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you experience symptoms of liver problems during treatment with Remicade.\u00a0Such signs include yellowing of the skin and eyes, dark brown urine, pain or swelling in the upper right side of the abdomen, joint pain, rash, or fever.<\/p>\n\n\n\n<p>Low blood levels<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>In some patients receiving Remicade, the body may not be able to produce enough&nbsp;blood cells&nbsp;to help fight infections or to stop bleeding.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you experience symptoms of low blood pressure during treatment with Remicade.\u00a0Such signs include persistent fever, easy bleeding or bruising, and small red or purple spots caused by bleeding under the skin or pallor.<\/p>\n\n\n\n<p>Problems with the immune system<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Some patients receiving Remicade have developed symptoms of an immune disorder called lupus.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you develop symptoms of lupus during treatment with Remicade.&nbsp;Such signs include joint pain or rash on the cheeks or arms that are sensitive to the sun.<\/p>\n\n\n\n<p><strong>Children and young people<\/strong><\/p>\n\n\n\n<p>The above information also applies to children and young people.&nbsp;In addition:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Some children and teens who have received\u00a0TNF\u00a0inhibitors, such as Remicade, have developed cancer, even rare types, which have sometimes led to death.<\/li><li>More children taking Remicade to get you\u00a0infection\u00a0compared to adults<\/li><li>Children should receive recommended vaccinations before starting treatment with Remicade.\u00a0Children may receive certain vaccines during treatment with Remicade but should not receive live vaccines while using Remicade.<\/li><\/ul>\n\n\n\n<p>If you are not sure if any of the above applies to you, talk to your doctor before receiving Remicade.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Remicade<\/h2>\n\n\n\n<p>Patients with inflammatory diseases are already taking medication to treat their problems.\u00a0These drugs can cause\u00a0side effects.\u00a0Your doctor will tell you which other medicines you must continue to use when you receive Remicade.<\/p>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines, including medicines to treat\u00a0Crohn&#8217;s disease,\u00a0ulcerative colitis,\u00a0rheumatoid arthritis,\u00a0ankylosing spondylitis, psoriatic arthritis or\u00a0psoriasis, or over-the-counter medicines such as\u00a0vitamins\u00a0and herbal remedies.<\/p>\n\n\n\n<p>In particular, tell your doctor if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drugs that affect the immune system<\/li><li>Kineret (anakinra).&nbsp;Remicade and Kineret should not be used together.<\/li><li>Orencia (abatacept).&nbsp;Remicade and Orencia should not be used together.<\/li><\/ul>\n\n\n\n<p>You should not receive live vaccines when using Remicade.\u00a0If you have been pregnant and taken Remicade at the same time, or if you are taking Remicade while breastfeeding, talk to your baby&#8217;s doctor and other healthcare professionals who have contact with your baby.\u00a0Inform about your treatment with Remicade before the child receives any vaccine.<\/p>\n\n\n\n<p>If you are not sure if any of the above applies to you, talk to your doctor or pharmacist before taking Remicade.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.\u00a0Remicade should only be used during pregnancy or breastfeeding if your doctor considers it necessary.<\/li><li>You should avoid becoming pregnant when you are treated with Remicade and for 6 months after stopping treatment.\u00a0Discuss the use of appropriate contraceptives during this time with your doctor.<\/li><li>If you received Remicade during your pregnancy, your baby may be at higher risk of getting an\u00a0infection.<\/li><li>You must tell your child&#8217;s doctor and other healthcare professionals if you have been treated with Remicade before giving your child any vaccine.\u00a0If you received Remicade during pregnancy and your baby is given the BCG vaccine (used to prevent\u00a0tuberculosis\u00a0) within 12 months of birth, it can lead to\u00a0infection\u00a0with serious complications, even fatal.\u00a0Live vaccines such as the BCG vaccine should not be given to your baby within 12 months of birth unless your baby&#8217;s doctor recommends otherwise.\u00a0For more information, see the section on vaccinations.<\/li><li>If you are breastfeeding, you must tell your child&#8217;s doctor and other healthcare professionals that you are using Remicade before your child receives any vaccine.\u00a0Live vaccines should not be given to your baby while you are breastfeeding unless your baby&#8217;s doctor recommends otherwise.<\/li><li>Sharp reductions in\u00a0white blood cell counts\u00a0have been reported in infants born to women treated with Remicade during pregnancy.\u00a0If your child has a constant fever or\u00a0infection, contact your child&#8217;s doctor immediately.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Remicade is unlikely to affect your ability to drive or use tools or machines.\u00a0If you feel tired, dizzy, or unwell after receiving Remicade, do not drive or use any tools or machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Remicade contains sodium<\/h2>\n\n\n\n<p>Remicade contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per unit dose, ie essentially &#8216;sodium-free&#8217;.\u00a0Remicade is prepared with a sodium-containing solution\u00a0before it is given to you.\u00a0Talk to your doctor if you have been prescribed a low-salt (sodium-poor) diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Remicade is given<\/h2>\n\n\n\n<p><strong>Rheumatoid arthritis<\/strong><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is 3 mg per kg body weight.<\/p>\n\n\n\n<p><strong>Psoriatic Arthritis,\u00a0Ankylosing Spondylitis\u00a0(Bechterew&#8217;s Disease),\u00a0Psoriasis<\/strong>,\u00a0Ulcerative Colitis,<strong>\u00a0And\u00a0Crohn&#8217;s Disease<\/strong><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is 5 mg per kg body weight.<\/p>\n\n\n\n<p><strong>How Remicade is given<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Remicade will be given to you by a doctor or nurse.<\/li><li>Your doctor or nurse will prepare the medicine for\u00a0infusion.<\/li><li>The drug will be given as an\u00a0infusion\u00a0(drip) (for 2 hours) into a vein, usually in your arm.\u00a0After the third treatment, your doctor may decide to give you your\u00a0dose\u00a0of Remicade for 1 hour.<\/li><li>You will be monitored while receiving Remicade and also 1-2 hours afterward.<\/li><\/ul>\n\n\n\n<p><strong>Amount of Remicade given<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will decide on your\u00a0dose\u00a0and how often you should receive Remicade.\u00a0It depends on your illness, weight, and how well you respond to Remicade<\/li><li>The table below shows how you will most likely receive this medicine after your first\u00a0dose.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>2nd&nbsp;dos&nbsp;en<\/td><td>2 weeks after 1st&nbsp;dose&nbsp;one<\/td><\/tr><tr><td>3rd&nbsp;dose&nbsp;en<\/td><td>6 weeks after 1st&nbsp;dose&nbsp;one<\/td><\/tr><tr><td>Additional&nbsp;dose&nbsp;er<\/td><td>Every 6 to 8 weeks depending on the disease<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Use for children and adolescents<\/strong><\/p>\n\n\n\n<p>Remicade should only be given to children being treated for\u00a0Crohn&#8217;s disease\u00a0or\u00a0ulcerative colitis.\u00a0These children must be 6 years or older.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Remicade than you should<\/h2>\n\n\n\n<p>Because this medicine is given by a doctor or nurse, it is unlikely that you will receive too much.<\/p>\n\n\n\n<p>There are no known&nbsp;side effects&nbsp;after taking too much Remicade.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget or miss your Remicade infusion<\/h2>\n\n\n\n<p>If you have forgotten or missed a visit to get Remicade, book a new visit as soon as possible<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0Most\u00a0side effects\u00a0are mild to moderate.\u00a0However, some patients may experience serious\u00a0side effects\u00a0that may require treatment.\u00a0Side effects\u00a0may also occur after treatment with Remicade has ended.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately if you notice any of the following:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Signs of an\u00a0allergic reaction<\/strong>\u00a0such as swelling of the face, lips, mouth, or throat, which can cause difficulty swallowing or breathing, skin rash, hives, swollen hands, feet, or ankles.\u00a0Some of these reactions can be serious or life-threatening.\u00a0An\u00a0allergic reaction\u00a0can occur within 2 hours after\u00a0injection\u00a0or later.\u00a0Several signs of allergic\u00a0side effects\u00a0that can occur up to 12 days after\u00a0injection\u00a0include muscle pain, fever, joint or jaw pain, sore throat, or headache.<\/li><li>Signs of heart problems\u00a0such as discomfort or pain in the chest, pain in the arm, abdominal pain, shortness of breath, anxiety, dizziness, dizziness, fainting, sweating, nausea, vomiting, fluttering or throbbing beats in the chest, rapid or slow heartbeat, and\/or swelling feet.<\/li><li>Signs of\u00a0infection\u00a0(includes TBC)\u00a0such as fever, tiredness, cough which may be persistent, shortness of breath,\u00a0flu-like symptoms, weight loss, night sweats, diarrhea, ulcers, accumulation of var in the intestine or around the anus (abscess), dental problems or burning sensation when urinating.<\/li><li>Possible signs of cancer, include but are not limited to swollen\u00a0lymph nodes, weight loss, fever, unusual lumps in the skin, changes in skin spots or skin color, or unusual bleeding from the abdomen.<\/li><li>Signs of lung problems\u00a0such as cough, difficulty breathing, or tightness in the chest.<\/li><li>Signs of nervous system problems (including eye problems)\u00a0such as signs of\u00a0stroke\u00a0(sudden numbness or weakness in the face, arms, or legs, especially on one side of the body; sudden confusion, difficulty speaking or understanding; difficulty seeing with one or both eyes, difficulty walking, dizziness, loss of balance or coordination, or severe headache), seizures, tingling\/numbness in any part of the body, or weakness in the arms or legs, altered vision such as double vision or other eye problems.<\/li><li>Signs of liver problems\u00a0(including\u00a0hepatitis\u00a0B\u00a0infection\u00a0if you have previously had\u00a0hepatitis\u00a0B) such as yellowing of the skin or eyes, dark brown urine, pain or swelling in the upper right side of the abdomen, joint pain, rash, or fever.<\/li><li>Signs of an immune disease\u00a0such as joint pain or rash on the cheeks or arms that are sensitive to the sun (lupus) or cough, shortness of breath, fever, or rash (\u00a0sarcoidosis\u00a0).<\/li><li>Signs of low blood levels\u00a0such as persistent fever, easy to get bleeding or bruising, and small red or purple spots caused by bleeding under the skin or pallor.<\/li><li>Signs of severe skin problems\u00a0such as reddish spots, or round spots often with blisters in the middle, localized on the upper body, large areas of scaly and tender skin (exfoliation), cold sores, sores in the throat, nose, genitals, and eyes, or small lumps that are can spread throughout the body.\u00a0These skin reactions may be accompanied by fever.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you notice any of the above.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been observed with Remicade:<\/p>\n\n\n\n<p><strong>Very common: may affect more than 1 user in 10<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Abdominal pain, nausea<\/li><li>Viral infections such as\u00a0herpes\u00a0or\u00a0flu<\/li><li>Upper respiratory tract infections such as sinusitis<\/li><li>Headache<\/li><li>A side effect\u00a0is of an\u00a0infusion<\/li><li>Pain.<\/li><\/ul>\n\n\n\n<p><strong>Common: may affect up to 1 in 10 users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Changes in how the liver works, increase in liver enzyme values \u200b\u200b(shown by blood tests)<\/li><li>Infection\u00a0is in the lungs or breasts such as\u00a0bronchitis\u00a0or\u00a0pneumonia<\/li><li>Severe or painful breathing, chest pain<\/li><li>Bleeding in the stomach or intestines, diarrhea, indigestion, heartburn, constipation<\/li><li>Hives (\u00a0urticaria\u00a0), itchy rash, or dry skin<\/li><li>Balance problems or dizziness<\/li><li>Fever, increased sweating<\/li><li>Circulatory problems such as low or high\u00a0blood pressure<\/li><li>Bruising, hot flashes or nosebleeds, hot, red skin (\u00a0redness\u00a0)<\/li><li>Feeling tired or weak<\/li><li>Bacterial infections such as sepsis, abscess, or skin infection (\u00a0cellulite\u00a0)<\/li><li>Fungal infection of the skin<\/li><li>Blood problems such as\u00a0anemia\u00a0or low\u00a0white blood cell count<\/li><li>Swollen\u00a0lymph nodes<\/li><li>Depression, sleep problems<\/li><li>Eye problems that include red eyes\u00a0and\u00a0infection<\/li><li>Rapid heartbeat (\u00a0tachycardia\u00a0) or palpitations<\/li><li>Pain in joints, muscles, or back<\/li><li>Urinary tract infection<\/li><li>Psoriasis, skin problems such as\u00a0eczema\u00a0and hair loss<\/li><li>Injection site reactions such as pain, swelling,\u00a0redness,\u00a0or\u00a0itching<\/li><li>Chills, accumulation of fluid under the skin that causes swelling<\/li><li>Numbness or a stinging sensation.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon: may affect up to 1 in 100 people<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Poor blood supply, swelling in a blood vessel<\/li><li>Accumulation of blood outside the blood vessels (hematoma) or bruising<\/li><li>Skin problems such as blisters, warts, abnormal skin color or\u00a0pigmentation\u00a0or swollen lips, thickening of the skin, or red, scaly, and flaky skin<\/li><li>Severe\u00a0allergic reaction\u00a0(eg\u00a0anaphylaxis\u00a0), an immune disease called lupus, allergic reactions to\u00a0foreign\u00a0proteins<\/li><li>Impaired wound healing<\/li><li>Swollen liver (\u00a0hepatitis\u00a0) or gallbladder, liver damage<\/li><li>Feeling forgetful, annoyed, confused, nervous<\/li><li>Eye problems that include blurred vision or impaired vision, swollen eyes, or\u00a0vagal<\/li><li>New onset or worsening of existing\u00a0heart failure, slow heartbeat<\/li><li>Fainting<\/li><li>Cramps, nerve problems<\/li><li>Intestinal perforation or obstruction in the intestine, abdominal pain or cramps<\/li><li>Swollen\u00a0pancreas\u00a0(\u00a0pancreatitis\u00a0)<\/li><li>Fungal infections such as\u00a0yeast\u00a0infection or fungal infection of the nails<\/li><li>Lung problems (such as\u00a0edema\u00a0)<\/li><li>Fluid around the lungs (alveolar discharge)<\/li><li>Narrowing of the airways in the lungs that causes difficulty breathing<\/li><li>Pneumonia, which causes sharp chest pain that worsens with breathing<\/li><li>Tuberculosis<\/li><li>Kidney infections<\/li><li>Low\u00a0platelet count, too many\u00a0white blood cells<\/li><li>Infection\u00a0is in the\u00a0vagina<\/li><li>Blood tests that show\u00a0antibodies\u00a0are against your own body.<\/li><li>Changes in\u00a0cholesterol\u00a0and fat levels in the blood.<\/li><\/ul>\n\n\n\n<p><strong>Rare: may affect up to 1 in 1,000 users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A type of blood cancer (\u00a0lymphoma\u00a0)<\/li><li>The blood does not supply enough oxygen to the body, and circulatory problems such as narrowing of a blood vessel<\/li><li>Meningitis\u00a0(\u00a0meningitis\u00a0)<\/li><li>Infection\u00a0is caused by a weakened immune system<\/li><li>Hepatitis\u00a0B\u00a0infection\u00a0if you have had\u00a0hepatitis\u00a0B before<\/li><li>Inflammation\u00a0of the liver caused by problems with the immune system (\u00a0autoimmune\u00a0hepatitis\u00a0)<\/li><li>Liver problems that cause yellowing of the skin or eyes (jaundice)<\/li><li>Abnormal swelling or growth of\u00a0tissue<\/li><li>The severe\u00a0allergic reaction\u00a0may cause unconsciousness and may be life-threatening (anaphylactic\u00a0shock\u00a0)<\/li><li>Swelling of small blood vessels (\u00a0vasculitis\u00a0)<\/li><li>Immune disorders that may affect the lungs, skin, and\u00a0lymph nodes\u00a0(such as\u00a0sarcoidosis\u00a0)<\/li><li>Accumulation of immune cells resulting from an inflammatory response (granulomatous changes)<\/li><li>Lack of interest or feelings<\/li><li>Severe skin problems such as\u00a0toxic epidermal necrolysis,\u00a0Stevens-Johnson syndrome,\u00a0and\u00a0acute\u00a0generalized exanthematous\u00a0pustulosis<\/li><li>Other skin problems such as erythema multiforme, lichenoid reactions (itchy red-purple rash and\/or thread-like white-gray lines on mucous membranes), blisters and scaly skin, or boils (\u00a0furunculosis\u00a0)<\/li><li>Severe nervous system disorders such as transverse\u00a0myelitis,\u00a0multiple sclerosis-like diseases,\u00a0optic\u00a0neuritis,\u00a0and\u00a0Guillain-Barr\u00e9 syndrome<\/li><li>Inflammation\u00a0of the eye that can cause changes in vision, including blindness<\/li><li>Fluid around the pericardium (pouring into the pericardium)<\/li><li>Severe lung problems (such as interstitial lung disease)<\/li><li>Melanoma\u00a0(a type of skin cancer)<\/li><li>Cervical cancer<\/li><li>Low blood levels, even greatly reduced\u00a0white blood cell, count<\/li><li>Small red or purple spots caused by bleeding under the skin<\/li><li>Abnormal levels of a\u00a0protein\u00a0in the blood are called a &#8220;complement factor&#8221; that is part of the immune system.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported: occurs in an unknown number of users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Cancer in children and adults<\/li><li>An unusual blood cancer that mostly affects teenage boys or young men (T-cell lymphoma in the liver and\u00a0spleen\u00a0)<\/li><li>Liver failure<\/li><li>Merkel cell carcinoma (a type of skin cancer)<\/li><li>Kaposi&#8217;s sarcoma, rare cancer associated with human herpes virus\u00a0infection\u00a08. Kaposi&#8217;s sarcoma\u00a0usually appears as purple spots on the skin.<\/li><li>Exacerbation of a condition called\u00a0dermatomyositis\u00a0(seen as a skin rash with muscle weakness)<\/li><li>Heart attack<\/li><li>Stroke<\/li><li>Temporary vision loss during or within 2 hours after\u00a0infusion<\/li><li>Infection\u00a0is caused by a live vaccine due to a weakened immune system.<\/li><\/ul>\n\n\n\n<p><strong>Additional&nbsp;side effects&nbsp;are in children and adolescents<\/strong><\/p>\n\n\n\n<p>Children taking Remicade for Crohn&#8217;s disease had some differences in\u00a0side effects\u00a0compared to adults taking Remicade for\u00a0Crohn&#8217;s disease.\u00a0The most common\u00a0side effects\u00a0in children were: low\u00a0red blood cell count\u00a0(\u00a0anemia\u00a0), bloody stools, low\u00a0white blood cell levels\u00a0(\u00a0leukopenia\u00a0), red skin or redness (swelling), viral infections, low\u00a0white blood cell levels\u00a0fighting\u00a0infection\u00a0(\u00a0neutropenia\u00a0), bone fractures, bacterial\u00a0infection\u00a0and allergic reactions of the respiratory tract.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Remicade<\/h2>\n\n\n\n<p>Remicade is usually stored by healthcare professionals.\u00a0The storage instructions are as follows if you need to know them:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.\u00a0The expiration date is the last day of the specified month.<\/li><li>Store in a refrigerator (2\u00baC-8\u00baC).<\/li><li>This medicine can also be stored in the original package outside the refrigerator at a maximum of 25 \u00b0 C for a single period of up to 6 months, but without exceeding the original expiry date.\u00a0In such a situation, it should not be stored in the refrigerator again.\u00a0Write the new expiration date on the box, with day\/month\/year.\u00a0Discard the medicine if it is not used before the new expiry date or the expiry date which is stated on the carton, whichever comes first.<\/li><li>When Remicade is ready for\u00a0infusion, it is recommended that it be used as soon as possible (within 3 hours).\u00a0However, if the solution is prepared under bacteria-free conditions, it can be stored in a refrigerator at 2\u00baC-8\u00baC for up to 28 days and a further 24 hours at 25 \u00b0 C after removal from the refrigerator.<\/li><li>Do not use this medicine if it is discolored or contains particles.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is infliximab.\u00a0Each\u00a0vial\u00a0contains 100 mg of infliximab.\u00a0After\u00a0reconstitution, each ml contains 10 mg of infliximab.<\/li><li>The other ingredients are sucrose, polysorbate 80, monobasic sodium phosphate, and dibasic sodium phosphate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Remicade is supplied in a glass\u00a0vial\u00a0containing a powder for concentrate for solution for\u00a0infusion.\u00a0The powder is a freeze-dried white\u00a0pellet.<\/p>\n\n\n\n<p>Remicade is manufactured in packs of 1, 2, 3, 4, or 5 vials.\u00a0Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Janssen Biologics BV<\/p>\n\n\n\n<p>Einsteinweg 101<\/p>\n\n\n\n<p>2333 CB Leiden<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>MSD BelgiumTel: +32 (0) 27766211dpoc_belux@merck.com<\/td><td><strong>Lithuania<\/strong>UAB Merck Sharp &amp; DohmeTel.&nbsp;+ 370 5 278 02 47msd_lietuva@merck.com<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Mark Harp and Doom Bulgaria BulgariaTel: +359 2 819 3737info-msdbg@merck.com<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>MSD BelgiumTel: +32 (0) 27766211dpoc_belux@merck.com<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Merck Sharp &amp; Dohme sroTel: +420 233 010 111dpoc_czechslovak@merck.com<\/td><td><strong>Hungary<\/strong>MSD Pharma Hungary Kft.&nbsp;Tel .: +36 1 888 5300hungary_msd@merck.com<\/td><\/tr><tr><td><strong>Denmark<\/strong>MSD Danmark ApSTel: + 45 4482 4000dkmail@merck.com<\/td><td><strong>Malta<\/strong>Merck Sharp &amp; Dohme Cyprus LimitedTel: 8007 4433 (+356 99917558)malta_info@merck.com<\/td><\/tr><tr><td><strong>Germany<\/strong>MSD Sharp &amp; Dohme GmbHTel: 0800 673 673 673 (+49 (0) 89 4561 0)e-mail@msd.de<\/td><td><strong>The Netherlands<\/strong>Merck Sharp &amp; Dohme BVTel: 0800 9999000(+31 23 5153153)medicalinfo.nl@merck.com<\/td><\/tr><tr><td><strong>Eesti<\/strong>Merck Sharp &amp; Dohme O\u00dcTel .: +372 6144 200msdeesti@merck.com<\/td><td><strong>Norway<\/strong>MSD (Norge) ASTel: +47 32 20 73 00msdnorge@msd.no<\/td><\/tr><tr><td><strong>Greece<\/strong>MSD \u0391.\u03a6.\u0392.\u0395.\u0395.:\u0397\u03bb: +30 210 98 97 300dpoc_greece@merck.com<\/td><td><strong>Austria<\/strong>Merck Sharp &amp; Dohme Ges.mbHTel: +43 (0) 1 26 044msd-medizin@merck.com<\/td><\/tr><tr><td><strong>Spain<\/strong>Merck Sharp &amp; Dohme de Espa\u00f1a, SATel: +34 91 321 06 00msd_info@merck.com<\/td><td><strong>Poland<\/strong>MSD Polska Sp.&nbsp;z ooTel: +48 22 549 51 00msdpolska@merck.com<\/td><\/tr><tr><td><strong>France<\/strong>MSD FranceTel: + 33 (0) 1 80 46 40 40<\/td><td><strong>Portugal<\/strong>Merck Sharp &amp; Dohme, LdaTel: +351 21 4465700inform_pt@merck.com<\/td><\/tr><tr><td><strong>Croatia<\/strong>Merck Sharp &amp; Dohme dooTel: + 385 1 6611 333croatia_info@merck.com<\/td><td><strong>Romania<\/strong>Merck Sharp &amp; Dohme Romania SRLTel: +40 21 529 29 00msdromania@merck.com<\/td><\/tr><tr><td><strong>Ireland<\/strong>Merck Sharp &amp; Dohme Ireland (&nbsp;Human&nbsp;Health) LimitedTel: +353 (0) 1 2998700medinfo_ireland@merck.com<\/td><td><strong>Slovenia<\/strong>Merck Sharp &amp; Dohme, innovative zdravila dooTel: +386 1 5204 201msd.slovenia@merck.com<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: + 354 535 7000<br><\/td><td><strong>Slovak Republic<\/strong>Merck Sharp &amp; Dohme, sroTel: +421 2 58282010dpoc_czechslovak@merck.com<\/td><\/tr><tr><td><strong>Italy<\/strong>MSD Italia SrlTel: +39 06 361911medicalinformation.it@merck.com<\/td><td><strong>Finland \/ Finland<\/strong>MSD Finland OyPuh \/ Tel: +358 (0) 9 804 650info@msd.fi<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>Merck Sharp &amp; Dohme Cyprus Limited.:\u0397\u03bb .: 800 00 673 (+357 22866700)cyprus_info@merck.com<\/td><td><strong>Sweden<\/strong>Merck Sharp &amp; Dohme (Sweden) ABTel: +46 77 5700488medicinskinfo@merck.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Merck Sharp &amp; Dohme LatvijaTel: + 371 67364224msd_lv@merck.com<\/td><td><strong>United Kingdom<\/strong><strong>(Northern Ireland)<\/strong>Merck Sharp &amp; Dohme Ireland (&nbsp;Human&nbsp;Health) LimitedTel: +35312998700medinfoNI@msd.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Remicade contains the active substance infliximab. Infliximab is a monoclonal antibody &#8211; a type of protein that binds to a specific target in the body called TNF alpha ( tumor necrosis factor alpha).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[12824,22673,2796,2799,22669,22672,12823,12822,22670,22671],"class_list":["post-21876","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-infliximab","tag-benefits-of-remicade","tag-infliximab","tag-infliximab-side-effects","tag-remicade","tag-remicade-side-effects","tag-what-infliximab-is-used-for","tag-what-is-infliximab","tag-what-is-remicade","tag-what-remicade-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21876"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21876\/revisions"}],"predecessor-version":[{"id":21907,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21876\/revisions\/21907"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}