{"id":21844,"date":"2022-06-10T11:22:17","date_gmt":"2022-06-10T11:22:17","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21844"},"modified":"2023-02-17T13:22:32","modified_gmt":"2023-02-17T13:22:32","slug":"relifex","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/relifex\/","title":{"rendered":"Relifex &#8211; Nabumetone Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>Relifex 1g, Relifex 500mg Nabumetone Film Coated Tablets<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Relifex Is And What Relifex Used For?<\/h2>\n\n\n\n<p>Relifex belongs to a group of medicines called\u00a0NSAIDs\u00a0(non-steroidal anti-inflammatory \/ anti-rheumatic medicines). Relifex works by\u00a0inhibiting\u00a0a group of substances in the body called\u00a0prostaglandins, which are formed in increased amounts, including\u00a0inflammation.<\/p>\n\n\n\n<p><strong>Relifex used for stiff and sore joints in case of joint wear and tear (\u00a0osteoarthritis\u00a0).<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before Taking Relifex<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Take Relifex<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to nabumetone or any of the other ingredients of this medicine (listed in section 6)<\/li><li>If you have previously had allergic reactions such as\u00a0asthma, rash, or other types of allergic reactions when you have taken painkillers containing\u00a0acetylsalicylic acid\u00a0or other pain\/inflammation medicines within the\u00a0NSAID group<\/li><li>If you have an increased tendency to bleed<\/li><li>If you have\u00a0stomach ulcers\u00a0or duodenal ulcers<\/li><li>If you have had\u00a0stomach ulcers\u00a0or duodenal ulcers during treatment with nabumetone or similar preparations<\/li><li>If you have had recurrent\u00a0stomach ulcers, duodenal ulcers, or gastrointestinal disease<\/li><li>If you have a severe hepatic impairment, severe\u00a0heart failure,\u00a0or severe kidney disease<\/li><li>During the last 3 months of pregnancy<\/li><li>During breastfeeding<\/li><li>Ongoing cerebral hemorrhage or another bleeding<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p><em><strong>Never use several different painkillers at the same time without consulting a doctor or pharmacist.<\/strong><\/em><\/p>\n\n\n\n<p><em>The lowest possible&nbsp;dose&nbsp;and the shortest possible treatment time should always be sought to reduce the risk of&nbsp;side effects.&nbsp;For painkillers, it generally applies that higher&nbsp;doses&nbsp;than those recommended can lead to serious risks.<\/em><\/p>\n\n\n\n<p>Talk to your doctor or pharmacist before using Relifex if you have or have had the following diseases:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Connective tissue diseases (\u00a0SLE\u00a0or MCTD)<\/li><li>Impaired renal or hepatic function<\/li><li>Heart failure<\/li><li>High\u00a0blood pressure<\/li><li>Asthma<\/li><li>Inflammatory\u00a0bowel disease (such as\u00a0ulcerative colitis\u00a0or Crohn&#8217;s disease\u00a0)<\/li><li>Gastric ulcer\u00a0or duodenal ulcer<\/li><li>Diseases with an increased tendency to bleed<\/li><li>Fluid retention in the body (\u00a0fluid retention\u00a0)<\/li><\/ul>\n\n\n\n<p>Elderly people should be aware of the increased risk of\u00a0side effects\u00a0that exist in old age. Especially at the beginning of treatment, patients who have previously had problems with the gastrointestinal tract, especially elderly patients, should contact a doctor in case of symptoms from the abdomen.<\/p>\n\n\n\n<p>Stop taking Relifex and contact a doctor immediately if swelling of the face, tongue, and throat or difficulty swallowing or\u00a0hives\u00a0with breathing difficulties occur (\u00a0angioedema\u00a0).<\/p>\n\n\n\n<p>Severe skin reactions when using\u00a0NSAIDs\u00a0have been reported in very rare cases.\u00a0Stop taking Relifex and consult a doctor if you get a rash or damage to the mucous membranes. For chickenpox, this medicine should not be used.<\/p>\n\n\n\n<p>Like other&nbsp;NSAIDs, Relifex can mask signs or symptoms of&nbsp;infection.<\/p>\n\n\n\n<p>Medicines such as Relifex may have a small increased risk of heart attack or\u00a0stroke.\u00a0Such an increase in risk is more likely with high\u00a0doses\u00a0and long-term treatment.\u00a0Do not exceed the recommended\u00a0dose\u00a0or treatment time (two weeks).<\/p>\n\n\n\n<p>Tell your doctor if you develop blurred or impaired vision during treatment with Relifex. Talk to your doctor or pharmacist about your treatment if you have heart problems, had a stroke before, or think you have an increased risk of these conditions (eg if you have high\u00a0blood pressure,\u00a0diabetes, high cholesterol, or if you smoke).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Relifex<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0This also applies to over-the-counter medicines and (traditional) herbal and herbal medicines. Treatment with Relifex may affect or be affected by certain drug substances against:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blood clots (eg\u00a0warfarin, ticlopidine)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">Cancer<\/a> and disorders of the immune system (methotrexate)<\/li><li>Depression (so-called\u00a0SSRIs\u00a0)<\/li><li>High\u00a0blood pressure\u00a0and heart disease (eg so-called beta-receptor blockers,\u00a0diuretics,\u00a0ACE inhibitors,\u00a0angiotensin\u00a0II inhibitors)<\/li><li>Inflammation\u00a0and\u00a0hypersensitivity reactions\u00a0(\u00a0corticosteroids\u00a0)<\/li><li>Manic depression (lithium)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">Pain<\/a> (so-called\u00a0NSAIDs\u00a0)<\/li><li>Organ rejection after transplantation (cyclosporine, tacrolimus)<\/li><li>Epilepsy\u00a0(eg\u00a0phenytoin\u00a0)<\/li><li>Arrhythmias in the heart (cardiac glycosides)<\/li><li>Infection\u00a0is (\u00a0sulfonamides,\u00a0quinolones\u00a0are)<\/li><li>Diabetes\u00a0(sulphonylureas)<\/li><li>Termination of pregnancy (mifepristone)<\/li><li>Gout\u00a0(probenecid)<\/li><\/ul>\n\n\n\n<p>Concomitant use of alcohol, bisphosphonates, oxpentifylline (pentoxifylline), and sulfinpyrazone may increase the risk of bleeding or ulceration of the gastric mucosa.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Using Relifex With Food And Drink<\/h2>\n\n\n\n<p>Relifex can be taken with or without food.&nbsp;For alcohol use, see section &#8216;Other medicines and Relifex&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, Breastfeeding, And Fertility<\/h2>\n\n\n\n<p>Pregnant women should not use Relifex during the last three months of pregnancy.\u00a0Relifex should be avoided by women who are planning to become pregnant or are pregnant.<\/p>\n\n\n\n<p>Treatment during any part of the pregnancy should only be done after a doctor&#8217;s\u00a0prescription. It is not known whether nabumetone passes into breast milk.\u00a0You should not take Relifex if you are breastfeeding.\u00a0Your doctor will decide if you should stop taking Relifex or breastfeed your baby.\u00a0<strong>Always consult your doctor.<\/strong><\/p>\n\n\n\n<p>Relifex, like all medicines that inhibit cyclooxygenase\/prostaglandin synthesis, may make it difficult for you to get pregnant.\u00a0Talk to your doctor if you are planning a pregnancy or have problems getting pregnant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>During treatment with Relifex, dizziness, confusion, and fatigue may occur.\u00a0If such or similar symptoms occur, this should be considered when sharper attention is required, for example, when driving a car.<\/p>\n\n\n\n<p>You are responsible for assessing whether you can drive a motor vehicle or perform work that requires sharpened vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\u00a0side effects.<\/p>\n\n\n\n<p>Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Relifex Contains Sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Take Relifex?<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Always take this medicine as described in this leaflet or as your doctor or pharmacist has told you.\u00a0Ask your doctor or pharmacist if you are unsure.<\/li><li><em>The usual\u00a0dose\u00a0for adults<\/em><\/li><li>2 tablets of 500 mg once daily.<\/li><li>The analgesic effect occurs gradually.\u00a0Higher\u00a0doses\u00a0do not increase the effect, so the recommended\u00a0dose\u00a0should not be exceeded.<\/li><\/ul>\n\n\n\n<p>Contact a doctor if the condition does not improve within two weeks.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Use More Relifex Than You Should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has ingested the medicine by mistake, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible Relifex Side Effects<\/h2>\n\n\n\n<p>Relifex can cause side effects like all medicines, although not everybody gets them.<\/p>\n\n\n\n<p><em><strong>Common Relifex side effects (may affect up to 1 in 10 people):<\/strong><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhoea<\/li><li>Indigestion (including acid reflux)<\/li><li>Abdominal pain<\/li><li>Gastritis<\/li><li>Nausea<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/flatulence\/\">Flatulence<\/a><\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/constipation\/\">Constipation<\/a><\/li><li>Blood in the stool<\/li><li>Edema\u00a0(accumulation of fluid in\u00a0tissues\u00a0)<\/li><li>Drowsiness<\/li><li>Itching<\/li><li>Rash<\/li><li>Blurred vision<\/li><li>Tinnitus<\/li><li>High\u00a0blood pressure<\/li><\/ul>\n\n\n\n<p><em><strong>Uncommon (may affect up to 1 in 100 people):<\/strong><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Shortness of breath<\/li><li>Anxiety<\/li><li>Depression<\/li><li>Stomach ulcers<\/li><li>Duodenal ulcers<\/li><li>Photosensitivity<\/li><li>Hives<\/li><li>Sweating<\/li><li>Confusion<\/li><li>Nervousness<\/li><li>Drowsiness<\/li><li>Fatigue<\/li><li>Weakness<\/li><li>Dizziness<\/li><li>Headache<\/li><li>Crawling<\/li><li>Insomnia<\/li><li>Visual disturbances<\/li><li>Eye effects<\/li><li>Lung disease<\/li><li>Nosebleeds<\/li><li>Bleeding from the stomach and intestines<\/li><li>Disorders of the gastrointestinal tract<\/li><li>Black stools<\/li><li>Vomiting<\/li><li>Elevated liver function values<\/li><li>Muscle disease<\/li><li>Disorders of the urinary tract<\/li><li>Inflammation\u00a0of the mouth<\/li><li>Dry mouth<ul><li>If\u00a0dry mouth\u00a0occurs, careful oral hygiene is important (toothbrushing with fluoride toothpaste twice daily).<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><em><strong>Very rare (may affect up to 1 in 10,000 people)<\/strong>:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased\u00a0platelet count<\/li><li>Hypersensitivity reactions<\/li><li>Pneumonia<\/li><li>Liver failure<\/li><li>Jaundice<\/li><li>Hypersensitivity reaction\u00a0in the form of swelling of the face, lips, tongue, and throat (\u00a0angioedema\u00a0see Warnings and caution)<\/li><li>Hair loss<\/li><li>Severe skin effects such as:<ul><li>Epidermis<\/li><li>Multiple skin redness and skin reaction with\u00a0inflammation<\/li><\/ul><\/li><li>High <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a><\/li><li>Skin changes with blistering (pseudoporphyria)<\/li><li>Kidney failure<\/li><li>Kidney effects<\/li><li>Heavy menstruation<\/li><li>Widespread rash<\/li><li>Fever<\/li><li>Elevated liver enzyme levels<\/li><li>Blood abnormalities (\u00a0eosinophilia\u00a0)<\/li><li>Enlarged lymph nodes<\/li><li>Involvement of other body organs (drug reaction with\u00a0eosinophilia\u00a0and systemic symptoms, also <\/li><li>called DRESS, or drug hypersensitivity syndrome)<\/li><\/ul>\n\n\n\n<p><strong>Stop using Relifex immediately if you develop these symptoms, and contact your doctor or seek medical attention immediately.\u00a0See also section 2.\u00a0<\/strong><\/p>\n\n\n\n<p><strong><em>The following\u00a0side effects\u00a0have also been reported (occurring in an unknown number of users):<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>High\u00a0blood pressure<\/li><li>Heart failure<\/li><li>Oedema\u00a0(fluid accumulation in\u00a0tissues\u00a0)<\/li><li>Bloody vomiting<\/li><li>Black stools<\/li><li>Inflammation of the\u00a0lining\u00a0of the stomach<\/li><li>Inflammation\u00a0of the mouth, swelling of\u00a0colitis<\/li><li>Crohn&#8217;s disease<\/li><li>Various forms of\u00a0anemia<\/li><li>Hallucinations<\/li><li>Meningitis<\/li><\/ul>\n\n\n\n<p><strong>In rare cases<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe skin infections are associated with chickenpox.<\/li><\/ul>\n\n\n\n<p>Medicines such as Relifex, especially in <strong>high\u00a0doses\u00a0and with long-term treatment,<\/strong> may have a small increased risk of <strong>heart attack or\u00a0stroke.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Store Relifex?<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep out of sight and reach of children.<\/li><li>Do not use this medicine after the expiry date stated on the carton after EXP.<\/li><li>Medicines should not be disposed of via wastewater or household waste.\u00a0Ask at the pharmacy how to dispose of medicines that are no longer required.\u00a0These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Of The Pack And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><em>Active substance:<\/em>\u00a0Nabumetone 500 mg.<\/li><li><em>The other ingredients<\/em>\u00a0are sodium starch glycolate, sodium lauryl sulfate, hypromellose, microcrystalline cellulose, saccharin sodium, macrogol, titanium dioxide (dye E 171), and caramel flavouring.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And The Contents Of The Pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>White, oblong tablet.<\/li><li>Printed packaging: 30 tablets (non-prescription) and 20 and 100 tablets (prescription).<\/li><li>Not all pack sizes may be marketed.<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Relifex is used to treat arthritis and rheumatoid pain, and inflammation. To avoid upsetting the stomach, it should ideally be taken with food.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[22601,22592,22596,22595,22597,22600,22593,22598,22594,22599],"class_list":["post-21844","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-relifex","tag-nabumetone","tag-nabumetone-side-effects","tag-nabumetone-tablet","tag-relifex","tag-relifex-side-effects","tag-what-is-nabumetone","tag-what-is-relifex","tag-what-nabumetone-is-used-for","tag-what-relifex-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21844","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21844"}],"version-history":[{"count":49,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21844\/revisions"}],"predecessor-version":[{"id":49323,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21844\/revisions\/49323"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21844"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21844"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21844"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}