{"id":21795,"date":"2022-06-09T07:34:44","date_gmt":"2022-06-09T07:34:44","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21795"},"modified":"2022-06-09T11:34:04","modified_gmt":"2022-06-09T11:34:04","slug":"rectogesic","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/rectogesic\/","title":{"rendered":"Rectogesic &#8211; Glyceryl trinitrate uses, dose and side effects"},"content":{"rendered":"\n<p>4 mg \/ g&nbsp;rectal ointment&nbsp;glyceryl trinitrate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">WHAT KETOGENIC IS AND WHAT IT IS USED F<\/h2>\n\n\n\n<p>Rectogesic is a rectal ointment that contains the active substance\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/transiderm-nitro\/\">glyceryl trinitrate<\/a>.<\/p>\n\n\n\n<p>Glyceryl trinitrate\u00a0belongs to a group of medicines called\u00a0organic nitrates.<\/p>\n\n\n\n<p>The ointment helps relieve the pain caused by\u00a0chronic\u00a0anal fissures.\u00a0An\u00a0anal fissure\u00a0is a crack in the skin that surrounds the anal canal.\u00a0The topical application of\u00a0glyceryl trinitrate\u00a0in the anal canal reduces anal pressure and increases blood flow, reducing pain.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">WHAT YOU NEED TO KNOW BEFORE USING RECTOGESIC<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Rectogesic<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to\u00a0glyceryl trinitrate\u00a0or similar medicines<\/li><li>if you are allergic to any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have low\u00a0blood pressure<\/li><li>if you have a disease of the heart or blood vessels<\/li><li>if you have\u00a0narrow-angle glaucoma\u00a0(an eye disease in which the eye pressure rises rapidly and causes impaired vision)<\/li><li>if you have\u00a0migraines\u00a0or recurrent headaches<\/li><li>if you have increased\u00a0intracranial pressure\u00a0or high pressure inside the skull (eg head injury or cerebral hemorrhage &#8211; hemorrhage from a ruptured blood vessel in the brain which can lead to death if medical treatment is not started immediately. Cerebral hemorrhage generally means a type of\u00a0stroke\u00a0) or insufficient blood circulation in the brain (small amount of circulating blood in the brain).<\/li><li>if you have\u00a0anemia\u00a0(low level of iron in your blood)<\/li><li>if you are taking any of the following: medicines for\u00a0erectile dysfunction\u00a0such as sildenafil citrate, tadalafil, vardenafil;\u00a0drugs for angina (angina) or heart pain, such as\u00a0glyceryl\u00a0trinitrate (GTN),\u00a0isosorbide dinitrate, amyl or butyl nitrite;\u00a0medicines for high\u00a0blood pressure\u00a0or depression (\u00a0tricyclic antidepressants\u00a0), acetylcysteine \u200b\u200bor alteplase.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Take special care with Rectogesic<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have liver or kidney disease<\/li><li>If you are going to receive\u00a0heparin, a careful check of your blood is required as the dose of heparin may need to be changed.\u00a0Talk to your doctor before stopping using Rectogesic<\/li><li>if you also have\u00a0hemorrhoids\u00a0and notice that they bleed more than usual, stop using Rectogesic and discuss this with your doctor.<\/li><li>If you get severe headaches while using Rectogesic, tell your doctor.\u00a0Your doctor will decide if you need to take another\u00a0dose\u00a0of Rectogesic or stop using it altogether.<\/li><\/ul>\n\n\n\n<p>Rectogesic may lower your\u00a0blood pressure.\u00a0When you get up from lying down or sitting, you have to do it slowly, otherwise, you may feel dull \/ about to faint.\u00a0Blood pressure\u00a0is more likely to\u00a0drop if you drink alcohol while using Rectogesic.<\/p>\n\n\n\n<p><strong>Children and adolescents<\/strong><br>Rectogesic is not suitable for children and adolescents under 18 years of age as it has not been tested in people in this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Rectogesic<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<p>The following medicines may increase the blood pressure-lowering effect of Rectogesic<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>antidepressants (&nbsp;tricyclic antidepressants&nbsp;)<\/li><li>drugs for&nbsp;erectile dysfunction&nbsp;(male&nbsp;impotence&nbsp;) (sildenafil citrate, tadalafil, vardenafil)<\/li><li>medicines for high&nbsp;blood pressure<\/li><li>diuretics&nbsp;(&#8220;diuretic&#8221;)<\/li><li>commonly used sedatives<\/li><li>drugs used to treat heart problems (&nbsp;isosorbide dinitrate&nbsp;and amyl or butyl nitrite)<\/li><\/ul>\n\n\n\n<p>Other medicines<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Acetylcysteine \u200b\u200bmay increase the effect of Rectogesic on blood flow<\/li><li>The effect of\u00a0heparin\u00a0(used to control blood clotting capacity) can be reduced if used at the same time as Rectogesic<\/li><li>The effect of alteplase (used to treat heart problems) can be reduced if given at the same time as Rectogesic<\/li><li>If you take Rectogesic together with dihydroergotamine (used to treat\u00a0migraines\u00a0) the effect of dihydroergotamine may increase and lead to contraction of the coronary arteries (blood vessels in the heart constrict so that blood flow is slower)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiplo-citrus\/\">Acetylsalicylic acid<\/a>\u00a0and non-steroidal anti-inflammatory drugs (certain types of painkillers) may alter the effect of Rectogesic<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Rectogesic with alcohol<\/h2>\n\n\n\n<p>Be careful with alcohol as alcohol may increase the effect of the ointment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Do not use Rectogesic during pregnancy or breastfeeding.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine while you are pregnant or breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>No studies on the effects of Rectogesic 4 mg \/ g rectal ointment on the ability to drive and use machines have been performed.\u00a0If you feel dizzy, sleepy, or have blurred vision when you start using the ointment, do not drive or use machines until these effects have disappeared.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Rectogesic contains lanolin and propylene glycol<\/h2>\n\n\n\n<p>This medicine contains lanolin (sheep wool fat) which may cause a skin reaction (eg&nbsp;contact dermatitis&nbsp;).&nbsp;The product also contains propylene glycol which can cause skin irritation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">HOW TO USE RECTOGESIC<\/h2>\n\n\n\n<p><strong>Method of administration<\/strong><\/p>\n\n\n\n<p>Rectogesic 4 mg \/ g rectal ointment is intended for use in the anal canal.<\/p>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.&nbsp;The recommended&nbsp;dose&nbsp;is about 375 mg of ointment (about 1.5 mg&nbsp;of glyceryl trinitrate&nbsp;) which is applied to the anal canal every 12 hours.<\/p>\n\n\n\n<p>You can put a finger guard, e.g.\u00a0plastic film or a fingertip, on the finger used to apply the ointment.\u00a0Fingers can be bought at the pharmacy or health care retailers, and plastic film is available in grocery stores.\u00a0The covered finger is placed along the 2.5 cm long dosing line located on the outside of the carton, and an ointment string as long as the line is squeezed onto the fingertip with light pressure on the tube.\u00a0Carefully insert the ointment into the anal canal with your finger.\u00a0The finger with the ointment should be inserted into the outermost finger joint (approximately 1 cm) in the anus.<\/p>\n\n\n\n<p>Apply the ointment every twelve hours according to the doctor&#8217;s instructions and do not exceed\u00a0dose\u00a0one.\u00a0Wash your hands after use and dispose of your fingertip or plastic wrap (except on the toilet seat).<\/p>\n\n\n\n<p>The treatment can continue until the pain subsides, or for a maximum of 8 weeks.&nbsp;If the anal pain does not improve after using Rectogesic, talk to your doctor again so that you can check that nothing else is causing the pain.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Rectogesic than you should<\/h2>\n\n\n\n<p>If you may have used more ointment than you should, you may feel dizzy and faint.&nbsp;You may also have a fast heartbeat or palpitations.&nbsp;If you experience these symptoms, wipe off any extra ointment and then talk to a doctor or pharmacist immediately.<\/p>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0If a child has ingested the medicine by mistake, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Rectogesic<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.\u00a0Apply the next\u00a0dose\u00a0at the usual time.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">POSSIBLE SIDE EFFECTS<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anaphylactoid reaction (\u00a0allergic reaction, which can be fatal with swelling of the face, lips, tongue, or throat, difficulty breathing, shortness of breath, or collapse).\u00a0<strong>If you get any of these symptoms, stop using the ointment and seek medical advice immediately.<\/strong><\/li><li>Allergic skin reactions (which can be serious).\u00a0<strong>If you get an allergic skin reaction, you must stop using the ointment and see a doctor.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Other side effects:<\/strong><\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache, which can be severe.\u00a0If you get a headache as a\u00a0side effect, wipe off all ointment.\u00a0If the headache is unpleasant, you may need to ask your doctor if you should stop using the medicine.<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dizziness<\/li><li>Nausea<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea<\/li><li>Vomiting<\/li><li>Bleeding in the rectum, disturbance in the rectum<\/li><li>Anal discomfort,\u00a0itching,\u00a0or burning in the anal canal<\/li><li>Fast heartbeat or palpitations<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Weakness when you get up<\/li><\/ul>\n\n\n\n<p><strong>Side effects&nbsp;of unknown frequency (frequency can not be calculated from the available data)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fainting sensation, fainting<\/li><li>Low\u00a0blood pressure<\/li><li>Irritation, rash, or pain at the application site<\/li><\/ul>\n\n\n\n<p><strong>Other known&nbsp;side effects&nbsp;associated with glyceryl trinitrate products (frequency unknown)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hemorrhoids<\/li><li>Unstable angina\u00a0(chest pain)<\/li><li>High\u00a0blood pressure\u00a0when treatment is stopped<\/li><li>Methemoglobinemia (symptoms are blue\/purple discoloration of the skin and shortness of breath)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">HOW TO STORE RECTOGESIC<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br>Do not use this medicine after the expiry date which is stated on the tube and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not store above 25 \u00b0 C.<\/li><li>Do not freeze<\/li><li>Close the tube tightly<\/li><li>The ointment should be used within 8 weeks after opening<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">CONTENTS OF THE PACKAGING AND OTHER INFORMATION<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is\u00a0glyceryl trinitrate.\u00a0One gram of rectal ointment contains 4 mg\u00a0of glyceryl trinitrate.\u00a0There is approximately 1.5 mg of\u00a0glyceryl trinitrate\u00a0in the usual 375 mg\u00a0dose\u00a0of Rectogesic.<\/p>\n\n\n\n<p>The other ingredients are propylene glycol, lanolin, sorbitan sesquiplane, hard paraffin, and white, soft paraffin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Rectogesic is an off-white, smooth, opaque rectal ointment found in 30 g aluminum tubes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorization Holder<\/strong><br>Kyowa Kirin Holdings BV<\/p>\n\n\n\n<p>Bloemlaan 2<\/p>\n\n\n\n<p>2132NP Hoofddorp<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Local representative:<\/strong><br>Kyowa Kirin AB<\/p>\n\n\n\n<p>Kista<br>Tfn: +46 (0) 8-50 90 74 10<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><br>PHARBIL Waltrop GmbH<br>I&#8217;m Wirrigen 25<br>45731 Waltrop<br>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rectogesic is a rectal ointment that contains the active substance glyceryl trinitrate .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[14147,22539,14143,14148,22535,22538,14145,14144,22536,22537],"class_list":["post-21795","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-glyceryl-trinitrate","tag-benefits-of-rectogesic","tag-glyceryl-trinitrate","tag-glyceryl-trinitrate-side-effects","tag-rectogesic","tag-rectogesic-side-effects","tag-what-glyceryl-trinitrate-is-used-for","tag-what-is-glyceryl-trinitrate","tag-what-is-rectogesic","tag-what-rectogesic-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21795","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21795"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21795\/revisions"}],"predecessor-version":[{"id":21828,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21795\/revisions\/21828"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}