{"id":21786,"date":"2022-06-09T07:29:22","date_gmt":"2022-06-09T07:29:22","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21786"},"modified":"2022-06-09T11:34:34","modified_gmt":"2022-06-09T11:34:34","slug":"recarbrio","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/recarbrio\/","title":{"rendered":"Recarbrio | Imipenem, cilastatin, relebaktam uses, dose and side effects"},"content":{"rendered":"\n<p><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tenam\/\">imipenem<\/a> \/ <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tenam\/\">cilastatin<\/a> \/ relebaktam<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Recarbrio is and what it is used for<\/h2>\n\n\n\n<p>Recarbrio is an\u00a0antibiotic.\u00a0It contains the active substances imipenem, cilastatin, and sulbactam.<\/p>\n\n\n\n<p>Recarbrio is used in adults to treat:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>some bacterial\u00a0infection\u00a0in your lungs (\u00a0pneumonia\u00a0)<\/li><li>infection\u00a0in the blood linked to\u00a0infection\u00a0in the lungs mentioned above<\/li><li>the infection\u00a0you caused by bacteria that other\u00a0antibiotics\u00a0may not be able to kill<\/li><\/ul>\n\n\n\n<p>Recarbrio is used in patients 18 years of age or older.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you get Recarbrio<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should not receive Recarbrio if:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>you are allergic to imipenem, cilastatin, sulbactam or any of the other ingredients of this medicine (listed in section 6)<\/li><li>you are allergic to\u00a0carbapenem\u00a0antibiotics<\/li><li>you have ever had a severe\u00a0allergic reaction\u00a0to\u00a0antibiotics, such as\u00a0penicillin\u00a0er or\u00a0cephalosporin\u00a0er<\/li><\/ul>\n\n\n\n<p>You should not receive Recarbrio if any of the above apply to you.&nbsp;If you are not sure, talk to your doctor or nurse before taking Recarbrio.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before receiving Recarbrio:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to any medicines &#8211; especially\u00a0antibiotics<\/li><li>if you have ever had seizures (seizures or seizures)<\/li><li>if you have ever had confusion or muscle twitching due to a drug<\/li><li>if you are taking a medicine containing\u00a0valproic acid<\/li><li>if you have had diarrhea after taking\u00a0antibiotics\u00a0in the past<\/li><li>if you have kidney problems &#8211; your doctor may need to lower\u00a0your dose.<\/li><\/ul>\n\n\n\n<p>Contact a doctor immediately if you have an\u00a0allergic reaction, seizures (cramps or seizures), diarrhea, or kidney problems while being treated with Recarbrio (see section 3).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Recarbrio should not be used in children and adolescents under 18 years of age.&nbsp;This is because it is not known whether it is safe for these patients to use the medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Recarbrio<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tell your doctor about all the medicines you are taking, especially if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines containing ganciclovir, which are used to treat certain viral infections<\/li><li>medicines containing\u00a0valproic acid\u00a0or divalproex sodium commonly used to treat\u00a0epilepsy,\u00a0bipolar disorder,\u00a0or\u00a0migraine<\/li><li>blood-thinning drugs such as\u00a0warfarin<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Recarbrio can make you feel dizzy, shaky, or have seizures or seizures.\u00a0This may affect your ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Recarbrio contains sodium<\/h2>\n\n\n\n<p>This medicine contains approximately 37.5 mg\u00a0sodium\u00a0(the main ingredient in table salt\/table salt) per\u00a0vial.\u00a0This corresponds to about 2% of the highest recommended daily intake of\u00a0sodium\u00a0for adults and needs to be considered if you have been prescribed a low-salt diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to get Recarbrio<\/h2>\n\n\n\n<p>The usual\u00a0dose\u00a0is one\u00a0vial\u00a0(containing 500 mg imipenem, 500 mg cilastatin, and 250 mg sulbactam) every 6 hours.\u00a0If you have kidney problems, your doctor may need to lower\u00a0your dose.<\/p>\n\n\n\n<p>Recarbrio is given as a drip directly into a blood vessel (&#8220;intravenous infusion&#8221;).&nbsp;Infusion&nbsp;one lasts for 30 minutes.<\/p>\n\n\n\n<p>The treatment usually lasts from 5 up to 14 days, depending on the type of&nbsp;infection&nbsp;you have and how you respond to the treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Recarbrio than you should<\/h2>\n\n\n\n<p>You will receive Recarbrio from a doctor or nurse, so it is unlikely that you will receive the wrong\u00a0dose.\u00a0If you think you have had too much Recarbrio, talk to your doctor or nurse immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have not received your dose of Recarbrio<\/h2>\n\n\n\n<p>Tell your doctor or nurse immediately if you think you have not received your&nbsp;dose&nbsp;of Recarbrio.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Contact a doctor immediately if you notice any of the following serious&nbsp;side effects&nbsp;&#8211; treatment must be stopped:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions &#8211; signs may include\u00a0hives, swelling of the face, lips, tongue, and\/or throat, difficulty breathing or swallowing<\/li><li>severe skin reactions (such as severe rash, dandruff, or blistering)<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong>Common<\/strong>&nbsp;: (may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea, vomiting, diarrhea<\/li><li>blood test results that may indicate changes in the liver<\/li><li>blood test results that may show an increase in the number of certain types of\u00a0blood cells, so-called &#8220;eosinophils&#8221;<\/li><li>blood test results that may indicate an increase in certain\u00a0white blood cells<\/li><li>rash<\/li><li>inflammation\u00a0and pain caused by a blood clot in a vein<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hives<\/li><li>itching\u00a0of the skin<\/li><li>seizures and other problems with the nervous system such as tremors<\/li><li>confusion<\/li><li>to see, hear or feel something that does not exist (hallucinations)<\/li><li>dizziness, fatigue<\/li><li>low\u00a0blood pressure<\/li><li>blood test results that may indicate changes in the kidneys<\/li><li>blood test results that may show a decrease in the number of\u00a0red blood cells,\u00a0white blood cells,\u00a0and\u00a0blood cells\u00a0called\u00a0platelets\u00a0(\u00a0platelets\u00a0)<\/li><li>blood test results that may show an increase in the number of\u00a0blood cells, called\u00a0platelets\u00a0(\u00a0platelets\u00a0)<\/li><li>abnormal kidney, liver, and blood function detected with blood tests<\/li><li>pain,\u00a0redness,\u00a0or hardening at the injection site<\/li><li>fever<\/li><li>blood test results show\u00a0antibodies\u00a0that can cause\u00a0anemia\u00a0by destroying\u00a0red blood cells\u00a0(called the Coombs test)<\/li><\/ul>\n\n\n\n<p><strong>Rare:<\/strong>&nbsp;(may affect up to 1 in 1,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fungal infection\u00a0(\u00a0candida\u00a0infection\u00a0)<\/li><li>taste changes<\/li><li>brain disease, stinging sensation, local tremors<\/li><li>hearing loss<\/li><li>discoloration of teeth and\/or tongue<\/li><li>colitis with severe diarrhea (\u00a0colitis\u00a0)<\/li><li>the low number of\u00a0white blood cells\u00a0which can make it difficult for the body to fight\u00a0infection\u00a0you<\/li><li>inflammation\u00a0of the liver<\/li><li>liver failure<\/li><li>the inability of the kidney to function normally<\/li><li>changes in urine output and color<\/li><li>skin swelling<\/li><li>a painful rash with\u00a0flu-like symptoms<\/li><li>redness\u00a0and flaking of the skin<\/li><\/ul>\n\n\n\n<p><strong>Very rare:<\/strong>&nbsp;(may affect up to 1 in 10,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation\u00a0of the stomach or intestines (gastrointestinal\u00a0catarrh\u00a0)<\/li><li>anemia\u00a0due to the destruction of\u00a0red blood cells, leading to symptoms such as fatigue and pale skin<\/li><li>headache<\/li><li>worsening of a rare disease associated with muscle weakness (worsening of\u00a0myasthenia gravis\u00a0)<\/li><li>dizziness<\/li><li>tinnitus\u00a0_\u00a0_<\/li><li>irregular heartbeat, the heart beats powerfully or fast<\/li><li>the feeling of discomfort in the chest, difficulty breathing, abnormally fast and shallow breathing, pain in the upper spine<\/li><li>pain in the throat<\/li><li>redness, bluish discoloration of the face and lips, altered skin structure, excessive sweating<\/li><li>increased saliva production<\/li><li>inflammation\u00a0of the intestine with bloody diarrhea (\u00a0hemorrhagic\u00a0colitis\u00a0)<\/li><li>abdominal pain<\/li><li>heartburn<\/li><li>red swollen tongue, growth of normal parts of the tongue which gives a hairy appearance<\/li><li>severe hepatic impairment due to\u00a0inflammation\u00a0(\u00a0fulminant\u00a0hepatitis\u00a0)<\/li><li>pain in several joints<\/li><li>genital itching\u00a0in women<\/li><li>weakness, lack of energy<\/li><\/ul>\n\n\n\n<p><strong>No known frequency:<\/strong>&nbsp;(can not be calculated from the available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>anxiety \/ upset<\/li><li>abnormal movements<\/li><li>jaundice (yellowing of the skin and whites of the eyes)<\/li><li>blood test results show an increase in a substance called\u00a0lactate dehydrogenase\u00a0(LDH) which may be a sign of tissue damage<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Recarbrio<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the vial.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store the medicine in the outer carton.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are imipenem, cilastatin, and sulbactam.\u00a0One\u00a0vial\u00a0contains 500 mg imipenem, 500 mg cilastatin, and 250 mg sulbactam.<\/li><li>The other ingredient is sodium bicarbonate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Recarbrio is a white to light yellow powder for solution for\u00a0infusion\u00a0in a\u00a0glass\u00a0vial.\u00a0Pack size: 25 vials.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Merck Sharp &amp; Dohme BV<\/p>\n\n\n\n<p>Waarderweg 39<\/p>\n\n\n\n<p>2031 BN Haarlem<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>FAREVA Mirabel<\/p>\n\n\n\n<p>Route de Mars, Riom<\/p>\n\n\n\n<p>63963, Clermont-Ferrand Cedex 9<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>MSD BelgiumTel: +32 (0) 27766211dpoc_belux@merck.com<\/td><td><strong>Lithuania<\/strong>UAB Merck Sharp &amp; DohmeTel: + 370 5 278 02 47msd_lietuva@merck.com<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Mark Harp and Doom Bulgaria BulgariaTel: +359 2 819 3737info-msdbg@merck.com<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>MSD BelgiumTel: +32 (0) 27766211dpoc_belux@merck.com<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Merck Sharp &amp; Dohme sroTel: +420 233 010 111dpoc_czechslovak@merck.com<\/td><td><strong>Hungary<\/strong>MSD Pharma Hungary Kft.Tel: +36 1 888 5300hungary_msd@merck.com<\/td><\/tr><tr><td><strong>Denmark<\/strong>MSD Danmark ApSTel: + 45 4482 4000dkmail@merck.com<\/td><td><strong>Malta<\/strong>Merck Sharp &amp; Dohme Cyprus LimitedTel: 8007 4433 (+356 99917558)malta_info@merck.com<\/td><\/tr><tr><td><strong>Germany<\/strong>MSD Sharp &amp; Dohme GmbHTel: 0800 673 673 673 (+49 (0) 89 4561 0)e-mail@msd.de<\/td><td><strong>The Netherlands<\/strong>Merck Sharp &amp; Dohme BVTel: 0800 9999000(+31 23 5153153)medicalinfo.nl@merck.com<\/td><\/tr><tr><td><strong>Eesti<\/strong>Merck Sharp &amp; Dohme O\u00dcTel .: +372 6144 200msdeesti@merck.com<\/td><td><strong>Norway<\/strong>MSD (Norge) ASTel: +47 32 20 73 00msdnorge@msd.no<\/td><\/tr><tr><td><strong>Greece<\/strong>MSD \u0391.\u03a6.\u0392.\u0395.\u0395.:\u0397\u03bb: +30 210 98 97 300dpoc_greece@merck.com<\/td><td><strong>Austria<\/strong>Merck Sharp &amp; Dohme Ges mbHTel: +43 (0) 1 26 044msd-medizin@merck.com<\/td><\/tr><tr><td><strong>Spain<\/strong>Merck Sharp &amp; Dohme de Espa\u00f1a, SATel: +34 91 321 06 00msd_info@merck.com<\/td><td><strong>Poland<\/strong>MSD Polska Sp.&nbsp;z ooTel: +48 22 549 51 00msdpolska@merck.com<\/td><\/tr><tr><td><strong>France<\/strong>MSD FranceTel: + 33 (0) 1 80 46 40 40<\/td><td><strong>Portugal<\/strong>Merck Sharp &amp; Dohme, LdaTel: +351 21 4465700inform_pt@merck.com<\/td><\/tr><tr><td><strong>Croatia<\/strong>Merck Sharp &amp; Dohme dooTel: + 385 1 6611 333croatia_info@merck.com<\/td><td><strong>Romania<\/strong>Merck Sharp &amp; Dohme Romania SRLTel: +40 21 529 29 00msdromania@merck.com<\/td><\/tr><tr><td><strong>Ireland<\/strong>Merck Sharp &amp; Dohme Ireland (&nbsp;Human&nbsp;Health) LimitedTel: +353 (0) 1 2998700medinfo_ireland@merck.com<\/td><td><strong>Slovenia<\/strong>Merck Sharp &amp; Dohme, innovative zdravila dooTel: +386 1 5204 201msd.slovenia@merck.com<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: + 354 535 7000<\/td><td><strong>Slovak Republic<\/strong>Merck Sharp &amp; Dohme, sroTel: +421 2 58282010dpoc_czechslovak@merck.com<\/td><\/tr><tr><td><strong>Italy<\/strong>MSD Italia SrlTel: +39 06 361911medicalinformation.it@merck.com<\/td><td><strong>Finland \/ Finland<\/strong>MSD Finland OyPuh \/ Tel: +358 (0) 9 804 650info@msd.fi<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>Merck Sharp &amp; Dohme Cyprus Limited:\u0397\u03bb: 800 00 673 (+357 22866700)cyprus_info@merck.com<\/td><td><strong>Sweden<\/strong>Merck Sharp &amp; Dohme (Sweden) ABTel: +46 77 5700488medicinskinfo@merck.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Merck Sharp &amp; Dohme LatvijaTel: + 371 67364224msd_lv@merck.com<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Merck Sharp &amp; Dohme Ireland (&nbsp;Human&nbsp;Health) LimitedTel: +353 (0) 1 2998700medinfoNI@msd.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Recarbrio is an antibiotic . It contains the active substances imipenem, cilastatin and relebactam.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[22562,22556,13060,22558,22564,22561,22563,22557,22559,22560],"class_list":["post-21786","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-recarbrio","tag-cilastatin","tag-imipenem","tag-recarbrio","tag-recarbrio-dosage","tag-recarbrio-side-effects","tag-recarbrio-usage","tag-relebaktam","tag-what-is-recarbrio","tag-what-recarbrio-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21786","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21786"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21786\/revisions"}],"predecessor-version":[{"id":21832,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21786\/revisions\/21832"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21786"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21786"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21786"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}