{"id":21780,"date":"2022-06-09T07:24:45","date_gmt":"2022-06-09T07:24:45","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21780"},"modified":"2022-06-09T11:34:45","modified_gmt":"2022-06-09T11:34:45","slug":"rebif","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/rebif\/","title":{"rendered":"Rebif &#8211; Interferon beta-1a uses, dose and side effects"},"content":{"rendered":"\n<p>8.8 micrograms \/ 0.1 ml and 22 micrograms \/ 0.25 ml solution for injection in a cartridge, cartridge.&nbsp;Interferon&nbsp;beta-1a.&nbsp;Initial packaging.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Rebif is and what it is used for<\/h2>\n\n\n\n<p>Rebif belongs to a group of medicines called\u00a0interferons.\u00a0They are natural substances that transmit messages between cells.\u00a0Interferon\u00a0is produced by the body and plays an important role in the immune system.\u00a0Through mechanisms that are not fully understood,\u00a0interferon\u00a0helps you to limit damage to the\u00a0central nervous system\u00a0associated with\u00a0multiple sclerosis.<\/p>\n\n\n\n<p>Rebif is a very pure, soluble\u00a0protein\u00a0that is similar to the natural\u00a0interferon-beta produced in the body.<\/p>\n\n\n\n<p>Rebif is used to treat\u00a0multiple sclerosis.\u00a0The drug has been shown to reduce the number and severity of relapses and delay the development of disability.\u00a0It is also approved for use in patients who have had a single clinical episode that was probably the first sign of\u00a0multiple sclerosis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Rebif<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Rebif<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to natural or&nbsp;recombinant&nbsp;interferon&nbsp;beta or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are severely depressed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Rebif.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rebif should only be used under the supervision of your doctor.<\/li><li>Before starting treatment with Rebif, you should read carefully and then follow the instructions given under the heading &#8220;How to use Rebif&#8221;, this to reduce the risk of\u00a0necrosis\u00a0at the injection site (degradation of the skin and tissue death) which has been reported for patients treated with Rebif.\u00a0Contact your doctor if you experience troublesome local reactions.<\/li><li>Talk to your doctor or pharmacist before taking Rebif if you are allergic (hypersensitive) to any other medicine.<\/li><li>During treatment, blood clots may form in the small blood vessels.\u00a0Blood clots can affect your kidneys.\u00a0This can happen several weeks or up to\u00a0several years\u00a0after you start Rebif.\u00a0Your doctor may want to check your\u00a0blood pressure, blood count (\u00a0platelet count\u00a0), and kidney function.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you have<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>bone marrow disease<\/li><li>kidney disease<\/li><li>liver disease<\/li><li>heart disease<\/li><li>thyroid disease<\/li><li>or if you have been depressed<\/li><li>or if you have had epileptic seizures<\/li><\/ul>\n\n\n\n<p>so that the doctor can closely monitor the treatment and the possible worsening of these conditions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Rebif<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>In particular, you should tell your doctor if you are taking medicines for\u00a0epilepsy\u00a0(\u00a0antiepileptics\u00a0) or depression (antidepressants).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>No harmful effects on breastfed newborns\/infants are expected.\u00a0Rebif can be used during breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Both the disease itself and the treatment can affect your ability to drive and use machines.&nbsp;Talk to your doctor if you have any concerns.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Rebif contains sodium and benzyl alcohol<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per\u00a0dose, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<p>This medicine contains 0.5 mg benzyl alcohol per 0.1 ml\u00a0dose\u00a0and 1.25 mg benzyl alcohol per\u00a00.25 ml\u00a0dose.\u00a0Benzyl alcohol can cause allergic reactions.<\/p>\n\n\n\n<p>Benzyl alcohol is associated with the risk of serious&nbsp;side effects&nbsp;such as difficulty breathing in young children.<\/p>\n\n\n\n<p>Do not use the medicine for more than 1 week in newborns (younger than 3 years) unless recommended by a doctor or pharmacist.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, or if you have impaired liver or kidney function, consult your doctor or pharmacist before using this medicine.\u00a0Large amounts of benzyl alcohol can be stored in the body and cause\u00a0side effects\u00a0(metabolic\u00a0acidosis\u00a0).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Rebif<\/h2>\n\n\n\n<p>For multiple-dose use.<\/p>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Consult a doctor if you are unsure.<\/p>\n\n\n\n<p><strong>When treatment begins<\/strong><\/p>\n\n\n\n<p>Treatment begins with a gradual increase in\u00a0dose\u00a0one (so-called dose titration) over 4 weeks to reduce some of the\u00a0side effects.\u00a0Therefore, it is recommended that:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>During weeks one and two, Rebif injects 8.8 micrograms three times a week.<\/li><li>During weeks three and four, Rebif injects 22 micrograms three times a week.<\/li><\/ul>\n\n\n\n<p>From the fifth week and for the rest of the treatment period after you have completed your initiation period, you will follow the usual\u00a0dosage\u00a0prescribed by your doctor.<\/p>\n\n\n\n<p><strong>Dose<\/strong><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is 44 micrograms (12 million IU) given three times a week.<\/p>\n\n\n\n<p>A lower\u00a0dose\u00a0of 22 micrograms (6 million IU) given three times a week is recommended for patients with\u00a0multiple sclerosis\u00a0who do not tolerate the higher\u00a0dose.<\/p>\n\n\n\n<p>Rebif should be taken three times a week, and if possible:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>on the same three weekdays each week (at least 48 hours between each time, eg Monday, Wednesday, Friday)<\/li><li>at the same time of day (preferably in the evening).<\/li><\/ul>\n\n\n\n<p><strong>Use for children and adolescents (2 to 17 years)<\/strong><\/p>\n\n\n\n<p>No formal\u00a0clinical studies\u00a0have been performed on children or adolescents.\u00a0However, there are some clinical data available that suggest that the safety profile of children and adolescents receiving Rebif 22 micrograms or Rebif 44 micrograms three times a week is similar to that seen in adults.<\/p>\n\n\n\n<p><strong>Use for children (under 2 years)<\/strong><\/p>\n\n\n\n<p>Rebif is not recommended for use in children under 2 years of age.<\/p>\n\n\n\n<p><strong>Method of administration<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rebif should be injected\u00a0subcutaneously\u00a0(under the skin).<\/li><li>The first injection\u00a0(\u00a0s) must be given in the presence of specially trained healthcare professionals.\u00a0After receiving adequate training, you, a family member, friend, or caregiver can use Rebif\u00a0cartridges, cartridges, with your injection aid to inject the medicine at home.<\/li><li>The initial pack contains two identical\u00a0cartridges, cassettes, with Rebif and you can start treatment with any\u00a0cartridge, cartridge.<\/li><li>The cartridge, and cassette, should be used with the RebiSmart electronic injection device.<\/li><li>Complete instructions for use are included with your injection aid.\u00a0Read this carefully.<\/li><li>Brief instructions for using the Rebif cartridge\u00a0are\u00a0provided below.<\/li><\/ul>\n\n\n\n<p><em>Before you begin<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Wash your hands thoroughly with soap and water.<\/li><li>Take\u00a0cartridge\u00a0one, the cartridge, with Rebif from the blister pack by tearing off the plastic film.<\/li><li>Check (when removing the Rebif from the refrigerator) that\u00a0the cartridge, the cartridge, has not been frozen in the package or the injection aid.\u00a0Only a ready-to-opalescent solution without particles and visible signs of deterioration should be used.<\/li><li>To place\u00a0the cartridge\u00a0one, the cartridge, in the injection aid and make the\u00a0injection\u00a0one, follow the instructions for use that come with your injection aid.<\/li><\/ul>\n\n\n\n<p>Where to inject Rebif<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20080701000091#\" rel=\"noopener\"><\/a><\/td><td>Choose an injection site.\u00a0Your doctor or nurse will show you possible injection sites on the body (good places are the upper part of the thighs and the lower part of the abdomen).\u00a0Remember to vary the injection sites so that no area is injected too often.\u00a0This is to reduce the risk of\u00a0necrosis\u00a0(local tissue death) at the injection site.<br>NOTE: Do not inject where you feel lumps, hard lumps, or pain.\u00a0Tell your doctor or healthcare professional if you find any. Use an alcohol swab to wash the skin at the injection site before\u00a0injection.\u00a0Let the skin dry.\u00a0If there is a little alcohol left on the skin, it can sting.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><em>How to inject Rebif<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will tell you how to choose the right\u00a0dose.\u00a0Also, read the instructions in the instruction manual that comes with your injection device (RebiSmart).<\/li><\/ul>\n\n\n\n<p><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20080701000091#\" rel=\"noopener\">Show larger<\/a><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>RebiSmart<br><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20080701000091#\" rel=\"noopener\"><\/a><\/td><td>RebiSmart is programmed to guide you through the entire initiation process and automatically increases the\u00a0dose\u00a0one during the initiation period.\u00a0It will also inform you when you need to change\u00a0the cartridge, cartridge. You must select the\u00a0dose\u00a0prescribed by your doctor via the RebiSmart menu to ensure proper registration of your\u00a0dose.To activate an &#8220;initialization \/ titration&#8221; menu, you must first select 44 micrograms, then &#8220;initialization \/ titration&#8221;, press &#8220;change&#8221;, select &#8220;on&#8221;, press &#8220;ok&#8221; and confirm &#8220;initialization \/ titration on&#8221; by to press &#8220;ok&#8221;.<\/td><\/tr><tr><td>The injection aid ensures that: Rebif 8.8 micrograms are injected three times a week during weeks one and two. Rebif 22 micrograms are injected three times a week during weeks three and four.RebiSmart automatically switches to regular\u00a0dosing\u00a0from week five. Place RebiSmart perpendicular (90 \u00b0) to the skin. Press the injection button.\u00a0During\u00a0injection, the button flashes a green light. Wait until the green light goes out.\u00a0This indicates that the\u00a0injection\u00a0is complete. Remove RebiSmart from the injection site.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><em>After&nbsp;injection&nbsp;of Rebif with RebiSmart<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Remove and discard the needle according to the instructions for use provided with your injection device.<\/li><li>Gently massage the injection site with a dry cotton ball or gauze.<\/li><li>Store your injection device containing a\u00a0cartridge, or cassette, with Rebif according to the instructions in section 5 &#8220;How to store Rebif&#8221;.<\/li><\/ul>\n\n\n\n<p>If you have any further questions, ask your doctor, nurse, or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Rebif than you should&nbsp;<\/h2>\n\n\n\n<p>In case of overdose, contact your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Rebif<\/h2>\n\n\n\n<p>If you miss a\u00a0dose, continue injecting on the next injection day.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Rebif<\/h2>\n\n\n\n<p>The effect of Rebif may not be immediately noticeable.&nbsp;You should therefore not stop taking Rebif, but continue to use it regularly to achieve the desired result.&nbsp;If you are not sure about the benefits of treatment, you should consult your doctor.<\/p>\n\n\n\n<p>You should not stop treatment without first consulting your doctor.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Contact your doctor immediately and stop using Rebif if you experience any of the following serious side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Severe allergic (hypersensitivity) reaction.\u00a0<\/strong>If shortly after Rebif\u00a0injection\u00a0you suddenly feel difficult to breathe, which can occur in connection with swelling of the face, lips, tongue, or throat,\u00a0hives,\u00a0itching\u00a0all over the body, and a feeling of weakness or dullness, you should immediately contact your doctor or seek\u00a0emergency\u00a0medical attention.\u00a0These reactions are\u00a0<em>rare<\/em>\u00a0(may affect up to 1 in 1,000 people).<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor immediately if you experience any of the following possible symptoms of\u00a0<strong>liver problems<\/strong>: jaundice (yellowing of the skin or whites of the eyes), widespread\u00a0itching, loss of appetite followed by nausea and vomiting, and bruising of the skin.\u00a0Serious liver problems can be associated with additional signs, e.g.\u00a0difficulty concentrating, drowsiness, and confusion.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Depression<\/strong>\u00a0is\u00a0<em>common<\/em>\u00a0(may affect up to 1 in 10 people) in patients with\u00a0multiple sclerosis.\u00a0If you feel\u00a0depressed or have suicidal thoughts, report this to your doctor immediately.<\/li><\/ul>\n\n\n\n<p><strong>Talk to your doctor if you experience any of the following side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Influenza-like symptoms<\/strong>, such as headache, fever, chills, muscle and joint pain, fatigue, and nausea are\u00a0very common\u00a0(may affect more than 1 in 10 people).\u00a0These symptoms are usually mild, are more common at the beginning of treatment, and subside with continued use.<br>To reduce these symptoms, your doctor may advise you to take an antipyretic and painkiller before taking a\u00a0dose\u00a0of Rebif and then for 24 hours after each\u00a0injection.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Injection site reactions<\/strong>\u00a0such as\u00a0redness, swelling, discoloration,\u00a0inflammation, pain, and breakdown of the skin are\u00a0very common.<br>The incidence of injection site reactions usually decreases with time.<br>Tissue death (\u00a0necrosis\u00a0), abscesses, and lumps at the injection site are\u00a0less common\u00a0(may affect up to 1 in 100 people).<br>See the recommendations in the section &#8220;Warnings and precautions&#8221; to minimize the risk of injection site reactions.<br>The injection site may become infected (less common\u00a0);\u00a0the skin may become swollen, sore, and hard and the whole area may be sore.\u00a0Contact your doctor for advice if you experience any of these symptoms.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Some\u00a0<strong>laboratory tests<\/strong>\u00a0may change.\u00a0These changes are generally not noticed by the patient (no symptoms), are usually transient and mild, and usually do not require special treatment.<br>The number of\u00a0red blood cells,\u00a0white blood cells,\u00a0or\u00a0platelets\u00a0can decrease either only one variety (\u00a0very common\u00a0) or all varieties at once (\u00a0rare\u00a0).\u00a0These changes can result in possible symptoms such as fatigue, decreased resistance to\u00a0infections, bruising, or unexplained bleeding.\u00a0Liver function tests may be affected (\u00a0very common)).\u00a0Hepatitis has also been reported (uncommon\u00a0).\u00a0Contact a doctor immediately (see above &#8220;Contact your doctor immediately &#8230;&#8221;) if you experience symptoms that indicate liver disorder such as loss of appetite followed by other symptoms such as nausea, vomiting, or jaundice.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Disrupted thyroid activity<\/strong>\u00a0is\u00a0<em>less common<\/em>.\u00a0The thyroid gland can function either excessively or insufficiently.\u00a0These changes in thyroid activity are rarely felt by the patient as a symptom, but your doctor may recommend laboratory testing.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>False MS\u00a0relapse<\/strong>\u00a0(\u00a0<em>no known frequency<\/em>\u00a0): It is possible that at the beginning of your treatment with Rebif you experience symptoms reminiscent of a\u00a0multiple sclerosis\u00a0relapse.\u00a0For example, your muscles may feel sore or very weak, which prevents you from moving the way you want.\u00a0In some cases, such symptoms are associated with fever or\u00a0flu-like symptoms\u00a0as described above.\u00a0Talk to your doctor if you notice any of these\u00a0side effects.<\/li><\/ul>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;are:<\/strong><\/p>\n\n\n\n<p>Very common (may affect more than 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><\/ul>\n\n\n\n<p>Common (may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Insomnia\u00a0(difficulty sleeping)<\/li><li>Diarrhea, nausea, vomiting<\/li><li>Itching, exanthema (rash)<\/li><li>Muscle and joint pain<\/li><li>Fatigue, fever, chills<\/li><li>Hair loss<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hives<\/li><li>Epileptic seizures<\/li><li>Hepatitis&nbsp;_&nbsp;_<\/li><li>Breathing difficulties<\/li><li>Blood clots such as deep&nbsp;vein thrombosis<\/li><li>Retinal&nbsp;disturbance (posterior part of the eye) such as&nbsp;inflammation&nbsp;or blood clots with visual disturbance as a result (visual disturbances, loss of vision)<\/li><li>Increased sweating<\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Suicide attempt<\/li><li>Severe skin reactions &#8211; sometimes with damage to mucous membranes<\/li><li>Blood clots in the small blood vessels can affect the kidneys (thrombotic thrombocytopenic purpura or\u00a0hemolytic uremic syndrome\u00a0).\u00a0Symptoms may include bruising, bleeding, fever, extreme weakness, headache, dizziness, or fainting.\u00a0Your doctor may notice changes in your blood and kidney function.<\/li><li>Drug-induced lupus erythematosus: a\u00a0side effect\u00a0of long-term use of Rebif.\u00a0Symptoms may include muscle aches, aching and swollen joints, and skin rash.\u00a0You may also experience other signs such as fever, weight loss, and fatigue.\u00a0Usually, the symptoms disappear within one or two weeks after the end of treatment.<\/li><li>Kidney problems include scarring that can impair your kidney function.<br>If you get any or all of these symptoms:<ul><li>frothy urine<\/li><li>fatigue<\/li><li>swelling, especially in the ankles and eyelids, and weight gain. Talk to your doctor as it may be a sign of a possible kidney problem.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been reported with&nbsp;interferon&nbsp;beta (no known frequency):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dizziness<\/li><li>Nervousness<\/li><li>Loss of appetite<\/li><li>Dilated blood vessels and palpitations<\/li><li>Irregular and\/or altered menstruation<\/li><li>Pulmonary\u00a0arterial\u00a0hypertension\u00a0&#8211; a disease with severe narrowing of the blood vessels of the lungs that leads to high\u00a0blood pressure\u00a0in the blood vessels that transport blood from the heart to the lungs.\u00a0Pulmonary\u00a0arterial\u00a0hypertension\u00a0has been observed at various times during treatment, even up to several years after initiating treatment with Rebif.<\/li><li>Inflammation\u00a0of the adipose tissue under the skin (panniculitis), can make the skin feel hard, with the possible development of painful red bumps or spots.<\/li><\/ul>\n\n\n\n<p>You should not stop or change your medication without consulting your doctor.<\/p>\n\n\n\n<p><strong>Children and young people<\/strong><\/p>\n\n\n\n<p>Side effects&nbsp;in children and adolescents are similar to those observed in adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Rebif<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label after EXP.<\/p>\n\n\n\n<p>Store in a refrigerator (2\u00baC-8\u00baC).<\/p>\n\n\n\n<p>Do not freeze.&nbsp;<em>(To prevent the medicine from freezing, avoid placing it near the cooling element).<\/em><\/p>\n\n\n\n<p>After the first injection: use within 28 days.<\/p>\n\n\n\n<p>The injection device (RebiSmart) containing a pre-filled\u00a0cartridge, and cassette, with Rebif, must be stored in the product storage box in the refrigerator (2\u00baC-8\u00baC).\u00a0At the end-user, Rebif can be removed from the refrigerator and stored at a maximum of 25 \u00b0 C for a single period of up to 14 days.\u00a0Rebif must then be put back in the refrigerator and used before the expiry date.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Do not use this medicine if you notice any signs of deterioration, e.g.&nbsp;if the solution in&nbsp;cartridge&nbsp;one, the cartridge, is no longer clear and colorless or if it contains particles.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is\u00a0interferon\u00a0beta-1a.\u00a0Each\u00a0cartridge, cartridge, contains 132 micrograms equivalent to 36 million international units (IU) of\u00a0interferon\u00a0beta-1a.<\/li><li>The other ingredients are mannitol, poloxamer 188, L-methionine, benzyl alcohol, sodium acetate, acetic acid, sodium hydroxide, and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Pre-filled cartridge,\u00a0cartridge, (type I glass) with a flask, a stopper (rubber), and a shrinking cap (aluminum and halobutyl rubber), containing 1.5 ml solution.\u00a0Pack size: 2\u00a0cartridges, cartridges.<\/p>\n\n\n\n<p>The cartridge, and cassette, should be used with the RebiSmart electronic injection device.\u00a0The injection aid is provided separately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Merck Europe BV<\/p>\n\n\n\n<p>Gustav Mahlerplein 102<\/p>\n\n\n\n<p>1082 MA Amsterdam<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Merck Serono SpA<br>Via Delle Magnolia 15<br>I-70026 Modugno (Bari)<br>Italy<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rebif belongs to a group of medicines called interferons . They are natural substances that transmit messages between cells. Interferon is produced by the body and plays an important role in the immune system. Through mechanisms that are not fully understood, interferon helps you to limit damage to the central nervous system associated with multiple sclerosis .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[22576,22581,9555,22575,22577,22580,9558,9556,22578,22579],"class_list":["post-21780","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-interferon-beta-1a","tag-benefits-of-rebif","tag-interferon-beta-1a","tag-interferon-beta-1a-side-effects","tag-rebif","tag-rebif-side-effects","tag-what-interferon-beta-1a-is-used-for","tag-what-is-interferon-beta-1a","tag-what-is-rebif","tag-what-rebif-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21780"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21780\/revisions"}],"predecessor-version":[{"id":21834,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21780\/revisions\/21834"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}