{"id":21707,"date":"2022-06-08T07:28:14","date_gmt":"2022-06-08T07:28:14","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21707"},"modified":"2022-06-08T10:09:52","modified_gmt":"2022-06-08T10:09:52","slug":"ratiograstim","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ratiograstim\/","title":{"rendered":"Ratiograstim &#8211; Cytokines uses, dose and side effects"},"content":{"rendered":"\n<p>30 MIU \/ 0.5 ml, 48 MIU \/ 0.8 ml&nbsp;solution for injection \/ infusion<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Ratiograstim is and what it is used for<\/h2>\n\n\n\n<p><strong>What Ratiograstim is<\/strong><\/p>\n\n\n\n<p>Ratiograstim is a\u00a0white blood cell\u00a0growth factor (granulocyte colony-stimulating factor) and belongs to a group of medicines called\u00a0cytokines.\u00a0Growth factors are\u00a0proteins\u00a0that are produced naturally in the body, but they can also be produced through biotechnology for use as medicines.\u00a0Ratiograstim works by stimulating the\u00a0bone marrow\u00a0to produce more\u00a0white blood cells.<\/p>\n\n\n\n<p><strong>What Ratiograstim is used for<\/strong><\/p>\n\n\n\n<p>The number of\u00a0white blood cells\u00a0can be low (\u00a0neutropenia\u00a0) for various reasons and this makes it harder for the body to fight\u00a0infection.\u00a0Ratiograstim stimulates\u00a0the bone marrow\u00a0to rapidly produce new\u00a0white blood cells.<\/p>\n\n\n\n<p>Ratiograstim can be used for the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>To increase the number of\u00a0white blood cells\u00a0after treatment with\u00a0chemotherapy\u00a0to help prevent\u00a0infection.<\/li><li>To increase the number of\u00a0white blood cells\u00a0after bone marrow transplantation to help prevent\u00a0infection.<\/li><li>Before\u00a0chemotherapy\u00a0in high\u00a0doses\u00a0you to make so that the\u00a0bone marrow\u00a0produces more\u00a0stem cells\u00a0that can be collected and given back to you after the treatment.\u00a0The stem cells\u00a0can be taken from you or a donor.\u00a0They are then returned to the\u00a0bone marrow\u00a0where they produce\u00a0blood cells.<\/li><li>To increase the number of\u00a0white blood cells\u00a0if you suffer from severe\u00a0chronic\u00a0neutropenia, to help prevent\u00a0infection.<\/li><li>To patients with advanced\u00a0HIV\u00a0infection, to\u00a0help reduce the risk of\u00a0infection.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Ratiograstim<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Ratiograstim<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to filgrastim or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Ratiograstim.<\/p>\n\n\n\n<p>Tell your doctor before starting treatment&nbsp;<strong>if you have any<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sickle cell anemia, as this medicine may cause sickle cell crisis<\/li><li>osteoporosis\u00a0(osteoporosis).<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately during treatment with Ratiograstim,&nbsp;<strong>if you<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>suffer from sudden signs of\u00a0allergy, such as rash,\u00a0itching\u00a0or\u00a0hives, swelling of the face, lips, tongue, or other body parts, shortness of breath, wheezing, or difficulty breathing as these may be signs of a severe\u00a0allergic reaction\u00a0(hypersensitivity).<\/li><li>suffer from swelling of the face or ankles, blood in the urine or brown urine, or if you find that you urinate less than usual (\u00a0glomerulonephritis\u00a0).<\/li><li>gets pain in the upper left part of the abdomen, below the ribs on the left side, or at the tip of the left shoulder blade (this may be a symptom of an enlarged\u00a0spleen\u00a0(so-called\u00a0splenomegaly\u00a0) or possibly a broken\u00a0spleen\u00a0).<\/li><li>bleeds or bruises unusually easily (there may be symptoms of low\u00a0platelet count\u00a0(\u00a0thrombocytopenia\u00a0), which causes the blood not to coagulate properly).<\/li><li>Inflammation\u00a0of the aorta (the large blood vessel that transports blood from the heart to the body) has been reported with the frequency &#8220;rare&#8221; in cancer patients and healthy donors.\u00a0Symptoms may include fever, abdominal pain, malaise, back pain, and increased inflammatory markers.\u00a0Tell your doctor if you experience these symptoms.<\/li><\/ul>\n\n\n\n<p><strong>Unsatisfactory treatment response<\/strong><\/p>\n\n\n\n<p>If you respond less or stop responding to filgrastim treatment, your doctor will investigate what is causing this.&nbsp;Among other things, your doctor will check if you have developed&nbsp;antibodies&nbsp;that neutralize the activity of filgrastim.<\/p>\n\n\n\n<p>Your doctor may want to monitor you closely, see section 4 of this leaflet.<\/p>\n\n\n\n<p>If you are a patient and have severe\u00a0chronic\u00a0neutropenia, there may be a risk of developing blood cancer (\u00a0leukemia,\u00a0myelodysplastic syndrome\u00a0(MDS)).\u00a0Talk to your doctor about the risks of getting cancer in the blood and what tests should be done.\u00a0If you get cancer or there is a chance that you may get blood cancer, do not use Ratiograstim unless your doctor tells you to.<\/p>\n\n\n\n<p>If you are a stem cell donor, you must be between 16 and 60 years old.<\/p>\n\n\n\n<p><strong>Take special care with other medicines that stimulate the white&nbsp;blood&nbsp;cells<\/strong><\/p>\n\n\n\n<p>Ratiograstim belongs to a group of medicines that stimulate the production of\u00a0white blood cells.\u00a0The healthcare staff must always note in the medical record exactly which medicine you are using.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Ratiograstim<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Ratiograstim has not been studied in pregnant or lactating women.<\/p>\n\n\n\n<p>Ratiograstim is not recommended during pregnancy.<\/p>\n\n\n\n<p>You must tell your doctor if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>is pregnant or breastfeeding<\/li><li>think you may be pregnant, or<\/li><li>plans to have children.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you become pregnant while you are being treated with Ratiograstim.\u00a0Unless your doctor tells you otherwise, stop breastfeeding if you are using Ratiograstim.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Ratiograstim may have less effect on the ability to drive and use machines.&nbsp;This medicine may cause dizziness.&nbsp;You should wait and see how you feel after using this medicine, before driving or using machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ratiograstim contains sorbitol and sodium<\/h2>\n\n\n\n<p><strong>Ratiograstim contains sorbitol<\/strong><\/p>\n\n\n\n<p>This medicine contains 50 mg of sorbitol per ml.<\/p>\n\n\n\n<p>Sorbitol is a source of fructose.\u00a0If you (or your child) have\u00a0hereditary\u00a0fructose intolerance, a rare, inherited disease, you (or your child) should not use this medicine.\u00a0Patients with\u00a0hereditary\u00a0fructose intolerance\u00a0can not break down fructose, which can cause serious\u00a0side effects.\u00a0Talk to your doctor before using this medicine if you (or your child) have\u00a0hereditary\u00a0fructose intolerance, or if your child can no longer eat sweet food or drink without feeling sick, vomiting, or feeling uncomfortable such as bloating stomach cramps, or diarrhea.<\/p>\n\n\n\n<p><strong>Ratiograstim contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per pre-filled\u00a0syringe, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Ratiograstim<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How do I get Ratiograstim and how big is&nbsp;dose&nbsp;one?<\/strong><\/p>\n\n\n\n<p>Ratiograstim is usually given as a daily\u00a0injection\u00a0into the tissue\u00a0just under the skin (a so-called\u00a0subcutaneous\u00a0injection\u00a0).\u00a0It can also be given as a daily, slow\u00a0injection\u00a0into a vein (a so-called\u00a0intravenous\u00a0infusion\u00a0).\u00a0How much\u00a0doget depends on your illness and your weight?\u00a0Your doctor will tell you how much Ratiograstim to take.<\/p>\n\n\n\n<p>Patients undergoing bone marrow transplantation after chemotherapy:<\/p>\n\n\n\n<p>In normal cases, you will receive the first&nbsp;dose&nbsp;of Ratiograstim at least 24 hours after the chemotherapy treatment and at least 24 hours after receiving your bone marrow transplant.<\/p>\n\n\n\n<p>You, or the people who take care of you, can teach you how to give your subcutaneous\u00a0injection\u00a0so that you can continue your treatment at home.\u00a0However, you should not try this yourself if you have not received enough instruction first from your healthcare provider.<\/p>\n\n\n\n<p><strong>How long do I need to take Ratiograstim?<\/strong><\/p>\n\n\n\n<p>You will need to take Ratiograstim until your&nbsp;white blood cell count&nbsp;is normal.&nbsp;Blood samples will be taken regularly to check the number of&nbsp;white blood cells&nbsp;in your body.&nbsp;Your doctor will tell you how long you need to take Ratiograstim.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children<\/h2>\n\n\n\n<p>Ratiograstim is used to treat children who are receiving\u00a0chemotherapy\u00a0or who have low\u00a0white blood cell count\u00a0(\u00a0neutropenia\u00a0).\u00a0The dosage\u00a0for children receiving\u00a0chemotherapy\u00a0is the same as for adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Ratiograstim than you should&nbsp;<\/h2>\n\n\n\n<p>Do not increase the&nbsp;dose&nbsp;as prescribed by your doctor.&nbsp;If you use more Ratiograstim than you should, contact your doctor or pharmacist as soon as possible.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Ratiograstim<\/h2>\n\n\n\n<p>If you have missed an\u00a0injection, or have injected too little, contact your doctor as soon as possible.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Important&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>You must tell your doctor immediately<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you get an\u00a0allergic reaction\u00a0with weakness, drop in blood pressure, difficulty breathing, swelling of the face (\u00a0anaphylaxis\u00a0), skin rash, itchy rash (\u00a0hives\u00a0), swelling of the face, lips, mouth, tongue, or throat (\u00a0angioedema\u00a0) and shortness of breath (\u00a0dyspnoea\u00a0).<\/li><li>If you get a cough, fever, and difficulty breathing (\u00a0dyspnoea\u00a0).\u00a0This may be a sign of\u00a0acute\u00a0respiratory distress syndrome (ARDS).<\/li><li>If you get kidney damage (\u00a0glomerulonephritis\u00a0).\u00a0Kidney damage has been observed in patients receiving filgrastim.\u00a0Contact your doctor immediately if you get swollen in the face or around the ankles, get blood in the urine or brown urine, or notice that you do not urinate as often as usual.<\/li><li>If you get any of the following side effects: Swelling or fluid retention, which may be associated with urination more infrequently than usual, difficulty breathing, swollen abdomen and a feeling of satiety, and a general feeling of tiredness.\u00a0These symptoms often develop at a rapid rate. These symptoms can be a sign of a\u00a0side effect\u00a0called &#8220;capillary leakage syndrome&#8221;, which causes fluid to leak from small blood vessels into the body.\u00a0This condition must be treated immediately.<\/li><li>If you experience two or more of any of the following symptoms at the same time: fever, frostbite, or freezing sharply, rapid heartbeat, confusion or disorientation, shortness of breath, severe pain or discomfort, and cold sweaty, or sweaty skin.\u00a0This can be a symptom of a condition called &#8220;sepsis&#8221; (or &#8220;blood poisoning&#8221;), a serious\u00a0infection\u00a0with\u00a0inflammation\u00a0throughout the body, which can be life-threatening and requires immediate medical attention.<\/li><li>If you get pain in the upper left part of the abdomen (abdomen), pain under the ribs on the left side, or at the tip of the shoulder blade, it may indicate problems with the spleen (enlarged\u00a0spleen\u00a0(\u00a0splenomegaly\u00a0) or ruptured spleen).<\/li><li>If you are being treated for severe\u00a0chronic\u00a0neutropenia\u00a0and have blood in your urine (\u00a0haematuria\u00a0).\u00a0Your doctor may need to check your urine regularly if you experience this\u00a0side effect\u00a0or if you have\u00a0protein\u00a0(egg white) in your urine (\u00a0proteinuria\u00a0).<\/li><\/ul>\n\n\n\n<p>A common\u00a0side effect\u00a0of Ratiograstim is muscle and skeletal pain (musculoskeletal pain), which can be relieved with common painkillers (\u00a0analgesics\u00a0).\u00a0Patients undergoing a stem cell or bone marrow transplant may suffer from so-called\u00a0graft-versus-host disease (GvHD).\u00a0This is a reaction of the donated cells directed at the patient receiving the\u00a0transplant.\u00a0Signs and symptoms of this condition are rashes on the palms or soles of the feet, sores in the oral cavity, intestines, liver, skin, or the eyes, lungs,\u00a0vagina,\u00a0and joints.<\/p>\n\n\n\n<p>In healthy stem cell donors, an increase in the number of&nbsp;white blood cells&nbsp;(&nbsp;leukocytosis&nbsp;) and a decrease in the number of&nbsp;platelets may&nbsp;occur.&nbsp;This will be monitored by your doctor.<\/p>\n\n\n\n<p><strong>You may experience the following side effects:<\/strong><\/p>\n\n\n\n<p><em>Very common<\/em>&nbsp;(may affect more than 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased\u00a0platelet count, which reduces the blood&#8217;s ability to coagulate (\u00a0thrombocytopenia\u00a0)<\/li><li>low\u00a0red blood cell count\u00a0(\u00a0anemia\u00a0)<\/li><li>headache<\/li><li>diarrhea<\/li><li>vomiting<\/li><li>nausea<\/li><li>abnormal hair loss or thinning (\u00a0alopecia\u00a0)<\/li><li>fatigue (exhaustion)<\/li><li>soreness and swelling of the mucous membrane on the inside of the digestive tract, which runs from the mouth to the anus (mucositis)<\/li><li>fever (\u00a0pyrexia\u00a0).<\/li><\/ul>\n\n\n\n<p><em>Common<\/em>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation\u00a0of the lungs (\u00a0bronchitis\u00a0)<\/li><li>upper respiratory tract infection<\/li><li>urinary tract infection<\/li><li>decreased appetite<\/li><li>difficult to sleep (insomnia)<\/li><li>dizziness<\/li><li>decreased sensitivity to touch, in particular, skin stimulation (\u00a0hypesthesia\u00a0)<\/li><li>tingling or numbness in the hands or feet (\u00a0paresthesia\u00a0)<\/li><li>low\u00a0blood pressure\u00a0(\u00a0hypotension\u00a0)<\/li><li>high\u00a0blood pressure\u00a0(\u00a0hypertension\u00a0)<\/li><li>cough<\/li><li>bloody cough (hemoptysis)<\/li><li>pain in the mouth and throat (\u00a0oropharyngeal\u00a0pain)<\/li><li>nosebleeds (\u00a0epistaxis\u00a0)<\/li><li>constipation<\/li><li>pain in the mouth<\/li><li>enlarged liver (\u00a0hepatomegaly\u00a0)<\/li><li>rash<\/li><li>redness (\u00a0erythema\u00a0)<\/li><li>muscle spasms<\/li><li>pain associated with urination (\u00a0dysuria\u00a0)<\/li><li>chest pain<\/li><li>pain<\/li><li>a general feeling of weakness (\u00a0asthenia\u00a0)<\/li><li>general malaise<\/li><li>swelling of the hands and feet (peripheral\u00a0edema\u00a0)<\/li><li>elevated levels of certain\u00a0enzymes\u00a0in the blood<\/li><li>changes in blood chemistry<\/li><li>transfusion reactions.<\/li><\/ul>\n\n\n\n<p><em>Uncommon<\/em>&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased\u00a0white blood cell count\u00a0(\u00a0leukocytosis\u00a0)<\/li><li>allergic reaction\u00a0(hypersensitivity)<\/li><li>transplant\u00a0bone marrow\u00a0rejection (\u00a0graft-versus-host disease)<\/li><li>high levels of\u00a0uric acid\u00a0in the blood, which can cause\u00a0gout\u00a0(hyperuricemia) (elevated level of\u00a0uric acid\u00a0in the blood)<\/li><li>liver damage caused by blockage of the thin veins inside the liver (veno-occlusive disease)<\/li><li>Impaired lung function leading to shortness of breath (respiratory failure)<\/li><li>swelling and\/or fluid accumulation in the lungs (\u00a0pulmonary edema\u00a0)<\/li><li>inflammation\u00a0of the lungs (interstitial lung disease)<\/li><li>abnormal X-ray of the lungs (lung infiltrate)<\/li><li>hemorrhage from the lungs (\u00a0pulmonary\u00a0hemorrhage)<\/li><li>decreased oxygen uptake in the lungs (\u00a0hypoxia\u00a0)<\/li><li>elevated skin rash (maculopapular rash)<\/li><li>a disease that makes the skeleton more fragile, which makes the skeleton weaker and easier to break (\u00a0osteoporosis\u00a0)<\/li><li>reaction at the injection site.<\/li><\/ul>\n\n\n\n<p><em>Rare<\/em>&nbsp;(may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe pain in the skeleton, chest, intestines, or joints (\u00a0sickle cell anemia\u00a0with crisis)<\/li><li>sudden life-threatening\u00a0allergic reaction\u00a0(\u00a0anaphylactic reaction\u00a0)<\/li><li>gout-like pain and swelling in joints (pseudoarthrosis)<\/li><li>changes in fluid regulation in the body, which can lead to swelling (fluid volume disturbances)<\/li><li>inflammation\u00a0of the blood vessels of the skin (\u00a0cutaneous\u00a0vasculitis\u00a0)<\/li><li>plum-colored, raised, painful sores on the arms and legs and sometimes on the face and neck, with fever (Sweets syndrome)<\/li><li>aggravated\u00a0rheumatoid arthritis<\/li><li>unusual changes in the urine<\/li><li>reduced bone density<\/li><li>inflammation\u00a0of the aorta (the large blood vessel that carries blood from the heart to the body), see section 2.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Ratiograstim<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the outer carton and prefilled syringe after EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C \u2011 8 \u00b0 C).<\/p>\n\n\n\n<p>When used in environments without access to a refrigerator within the shelf life, the medicine can be taken out of the refrigerator (2 \u00b0 C \u2011 8 \u00b0 C) and stored at temperatures up to 25 \u00b0 C for a continuous period of up to 4 days.&nbsp;If not used within 4 days, it can be stored again in a refrigerator (2 \u00b0 C \u2011 8 \u00b0 C) until the expiration date.&nbsp;Syringes that have been stored above 8 \u00b0 C for more than 4 days should be discarded.<\/p>\n\n\n\n<p>Do not use this medicine if it is cloudy or contains particles.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is filgrastim.\u00a0One ml solution for injection \/ infusion contains 60 million international units [MIU] (600 micrograms) filgrastimRatiograstim 30 MIU \/ 0.5 ml: A pre-filled\u00a0syringe\u00a0contains 30 million international units [MIU] (300 micrograms) filgrastim in 0.5 ml liquid.Ratiograstim 48 MIU \/ 0.8 ml: A pre-filled\u00a0syringe\u00a0contains 48 million international units [MIU] (480 micrograms) filgrastim in 0.8 ml liquid.<\/li><li>The other ingredients are sodium hydrochloride, acetic acid, sorbitol, polysorbate 80, and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Ratiograstim is a solution for injection\/infusion in a pre-filled\u00a0syringe\u00a0with or without a safety device.\u00a0Ratiograstim is a clear and colorless solution.\u00a0Each pre-filled\u00a0syringe\u00a0contains either 0.5 ml or 0.8 ml of liquid.<\/p>\n\n\n\n<p>Ratiograstim is supplied in packs of 1, 5, or 10 pre-filled syringes or multiple packs of 10 (2 packs of 5) pre-filled syringes.\u00a0Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>ratiopharm GmbH<\/p>\n\n\n\n<p>Graf Arco Stra\u00dfe 3<\/p>\n\n\n\n<p>89079 Ulm<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Teva Biotech GmbH<\/p>\n\n\n\n<p>Dornierstra\u00dfe 10<\/p>\n\n\n\n<p>89079 Ulm<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Merckle GmbH<\/p>\n\n\n\n<p>Graf-Arco-Stra\u00dfe 3<\/p>\n\n\n\n<p>89079 Ulm<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Teva Pharma Belgium NV \/ SA \/ AGTel: +32 38207373<\/td><td><strong>Lithuania<\/strong>UAB Teva BalticsTel: +370 52660203<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Teva TV LADTel: +359 24899585<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>ratiopharm GmbHGermany \/ GermanyTel: +49 73140202<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Teva Pharmaceuticals CR, sroTel: +420 251007111<\/td><td><strong>Hungary<\/strong>Teva Gy\u00f3gyszergy\u00e1r Zrt.Tel: +36 12886400<\/td><\/tr><tr><td><strong>Denmark<\/strong>Teva Denmark A \/ STel: +45 44985511<\/td><td><strong>Malta<\/strong>Teva Pharmaceuticals IrelandL-IrelandTel: +44 2075407117<\/td><\/tr><tr><td><strong>Germany<\/strong>ratiopharm GmbHTel: +49 73140202<\/td><td><strong>The Netherlands<\/strong>Teva Nederland BVTel: +31 8000228400<\/td><\/tr><tr><td><strong>Eesti<\/strong>UAB Teva Baltics Eesti subsidiaryTel: +372 6610801<\/td><td><strong>Norway<\/strong>Teva Norway ASTel: +47 66775590<\/td><\/tr><tr><td><strong>Greece<\/strong>Specifar \u0391.\u0392.\u0395.\u0395.:\u0397\u03bb: +30 2118805000<\/td><td><strong>Austria<\/strong>ratiopharm Arzneimittel Vertriebs-GmbHTel: +43 1970070<\/td><\/tr><tr><td><strong>Spain<\/strong>Teva Pharma, SLUTel: +34 913873280<\/td><td><strong>Poland<\/strong>Teva Pharmaceuticals Polska Sp.&nbsp;z ooTel: +48 223459300<\/td><\/tr><tr><td><strong>France<\/strong>Teva HealthTel: +33 155917800<\/td><td><strong>Portugal<\/strong>ratiopharm &#8211; Commerce and Industry of Pharmaceutical Products, Lda.Tel: +351 214767550<\/td><\/tr><tr><td><strong>Croatia<\/strong>Pliva Hrvatska dooTel: +385 13720000<\/td><td><strong>Romania<\/strong>Teva Pharmaceuticals SRLTel: +40 212306524<\/td><\/tr><tr><td><strong>Ireland<\/strong>Teva Pharmaceuticals IrelandTel: +44 2075407117<\/td><td><strong>Slovenia<\/strong>Pliva Ljubljana dooTel: +386 15890390<\/td><\/tr><tr><td><strong>Iceland<\/strong>Teva Pharma Iceland ehf.Phone: +354 5503300<\/td><td><strong>Slovak Republic<\/strong>TEVA Pharmaceuticals Slovakia sroTel: +421 257267911<\/td><\/tr><tr><td><strong>Italy<\/strong>Teva Italia SrlTel: +39 028917981<\/td><td><strong>Finland \/ Finland<\/strong>Teva Finland OyPuh \/ Tel: +358 201805900<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>Specifar \u0391.\u0392.\u0395.\u0395.Greece:\u0397\u03bb: +30 2118805000<\/td><td><strong>Sweden<\/strong>Teva Sweden ABTel: +46 42121100<\/td><\/tr><tr><td><strong>Latvia<\/strong>UAB Teva Baltics subsidiary Latvij\u0101Tel: +371 67323666<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Teva Pharmaceuticals IrelandIrelandTel: +44 2075407117<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Ratiograstim is a white blood cell growth factor (granulocyte colony stimulating factor) and belongs to a group of medicines called cytokines . Growth factors are proteins that are produced naturally in the body, but they can also be produced through biotechnology for use as medicines. Ratiograstim works by stimulating the bone marrow to produce more white blood cells .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[22466,22471,22462,22465,22467,22470,22464,22463,22468,22469],"class_list":["post-21707","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-cytokines","tag-benefits-of-ratiograstim","tag-cytokines","tag-cytokines-side-effects","tag-ratiograstim","tag-ratiograstim-side-effects","tag-what-cytokines-is-used-for","tag-what-is-cytokines","tag-what-is-ratiograstim","tag-what-ratiograstim-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21707","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21707"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21707\/revisions"}],"predecessor-version":[{"id":21744,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21707\/revisions\/21744"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}