{"id":21653,"date":"2022-06-01T06:26:27","date_gmt":"2022-06-01T06:26:27","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21653"},"modified":"2022-06-01T09:59:04","modified_gmt":"2022-06-01T09:59:04","slug":"rapilysin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/rapilysin\/","title":{"rendered":"Rapilysin &#8211; Reteplas uses, dose and side effects"},"content":{"rendered":"\n<p>10 U\u00a0powder and solvent for\u00a0solution for\u00a0injection<br>reteplase<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Rapilysin is and what it is used for<\/h2>\n\n\n\n<p>Rapilysin contains the active substance reteplase (a\u00a0recombinant\u00a0plasminogen activator\u00a0) a thrombolytic medicine used to dissolve blood clots that have formed in certain blood vessels and to restore the blood flow in these clogged blood vessels (= thrombolysis).<\/p>\n\n\n\n<p>Rapilysin is used after an&nbsp;acute&nbsp;heart attack (heart attack) to dissolve the blood clot that has caused the heart attack.&nbsp;It should be given within 12 hours after the first symptoms.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Rapilysin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Rapilysin<\/h2>\n\n\n\n<p>Your doctor will ask you questions before taking Rapilysin to see if you are at increased risk of bleeding.<\/p>\n\n\n\n<p><strong>Do not use Rapilysin:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to reteplase or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have a bleeding disorder.<\/li><li>if you are taking medicines for blood thinning (oral\u00a0anticoagulants, such as\u00a0warfarin\u00a0).<\/li><li>if you have a brain tumor or blood vessel malformation or vascular wall dilation (\u00a0aneurysm\u00a0) in the brain.<\/li><li>if you have other\u00a0tumors\u00a0you may have an increased risk of bleeding.<\/li><li>if you have had a\u00a0stroke.<\/li><li>if you have had a\u00a0topical\u00a0heart massage in the last 10 days.<\/li><li>if you have severe uncontrolled high\u00a0blood pressure\u00a0(\u00a0hypertension\u00a0).<\/li><li>if you have\u00a0stomach ulcers\u00a0or small bowel ulcers.<\/li><li>if you have enlarged blood vessels in the esophagus (esophagus) (often caused by liver disease).<\/li><li>if you have severe liver or kidney disease.<\/li><li>if you have\u00a0acute\u00a0inflammation\u00a0of the pancreas or pericardium (the sac that surrounds the heart) or an\u00a0infection\u00a0of the heart muscle (bacterial\u00a0endocarditis\u00a0).<\/li><li>if you have had severe bleeding, extensive damage, or extensive\u00a0surgery\u00a0(eg coronary\u00a0bypass\u00a0surgery, surgery, or injury to the head or spine) in the last 3 months,\u00a0given birth, or undergone a tissue biopsy or other medical\/surgical procedure.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Bleeding<\/p>\n\n\n\n<p>The most common side effect of Rapilysin is bleeding.\u00a0Therefore, Rapilysin should only be given in the presence and under the instructions of a doctor.<\/p>\n\n\n\n<p>Pay close attention to any bleeding sites (eg injection sites).\u00a0Heparin, co-administered with Rapilysin, may also cause increased bleeding.<\/p>\n\n\n\n<p>The risks of Rapilysin treatment may increase if you have any of the following conditions:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diseases of the blood vessels of the brain<\/li><li>systolic&nbsp;blood pressure&nbsp;higher than 160 mmHg<\/li><li>gastrointestinal bleeding, bleeding in the urinary or genital tract during the last 10 days<\/li><li>high probability of blood clots in the heart (eg as a result of narrowing of a heart valve or&nbsp;atrial fibrillation&nbsp;)<\/li><li>bacterial&nbsp;inflammation&nbsp;in vein with blood clot (&nbsp;septic&nbsp;thrombophlebitis&nbsp;) or blocked blood vessels in the infected area<\/li><li>is over 75 years old<\/li><li>other conditions where bleeding can be particularly dangerous or can occur in areas where it can be difficult to control<\/li><\/ul>\n\n\n\n<p>There are currently little data on the use of Rapilysin in patients with diastolic\u00a0blood pressure\u00a0above 100 mmHg.<\/p>\n\n\n\n<p><strong>Abnormal heart rate (&nbsp;arrhythmias&nbsp;)<\/strong><\/p>\n\n\n\n<p>Thrombolytic therapy can cause the heart to beat irregularly.&nbsp;Therefore, tell your medical staff immediately if you<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>feel palpitations or irregular heartbeats<\/li><\/ul>\n\n\n\n<p><strong>Repeated use<\/strong><\/p>\n\n\n\n<p>There is currently no experience with repeated use of Rapilysin.\u00a0Therefore, repeated use is not recommended.\u00a0The formation of\u00a0antibodies\u00a0to the reteplase molecule has not been observed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>The safety and efficacy of Rapilysin in children have not been established.&nbsp;Treatment of children with Rapilysin is not recommended.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Rapilysin<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Heparin&nbsp;and other blood thinners (&nbsp;anticoagulants&nbsp;) and&nbsp;acetylsalicylic acid&nbsp;(a substance found in many painkillers and antipyretics) may increase the risk of bleeding.<\/p>\n\n\n\n<p>For information on medicines that should not be physically mixed with Rapilysin liquid for\u00a0injection, see section 3.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>There is no experience with Rapilysin in pregnant women.&nbsp;Therefore, it should not be used except in life-threatening situations.&nbsp;You must tell your doctor if you are pregnant or think you may be pregnant.&nbsp;Your doctor may tell you about the risks and benefits of using Rapilysin during pregnancy.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>You should not breastfeed your baby during Rapilysin treatment as it is not known if Rapilysin is excreted in human milk.\u00a0Breast milk should be discarded for the first 24 hours after thrombolytic therapy.\u00a0Discuss with your doctor when you can start breastfeeding again.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Rapilysin<\/h2>\n\n\n\n<p>Rapilysin is usually given in a hospital.\u00a0The medicine is supplied in vials as a lyophilized powder for\u00a0injection.\u00a0Before use, the powder for\u00a0injection\u00a0must be dissolved in water for\u00a0injection\u00a0into the pre-filled syringe provided in the package.\u00a0Do not add any other medicines.\u00a0The finished solution must be used immediately.\u00a0The solution must be examined to ensure that only clear, colorless solutions are injected.\u00a0If the solution is not clear and colorless, discard it.<\/p>\n\n\n\n<p>Treatment with Rapilysin 10 U should be started as soon as possible after the onset of symptoms of a heart attack.<\/p>\n\n\n\n<p><strong><em>Heparin and Rapilysin can not be mixed in the same solution.\u00a0<\/em><\/strong>Other drugs are also not as miscible as Rapilysin.\u00a0No other drugs may be added to\u00a0the solution for injection\u00a0(see below).\u00a0Rapilysin should preferably be injected through an\u00a0intravenous\u00a0infusion used only for\u00a0injection\u00a0of Rapilysin.\u00a0No other drug should be injected through the reserved entrance of Rapilysin, either concomitantly, before, or after\u00a0injection\u00a0of Rapilysin.\u00a0This applies to all medicines, including\u00a0heparin\u00a0and\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiplo-citrus\/\">acetylsalicylic acid<\/a>, which are given before and after Rapilysin to reduce the risk of new blood clots.<\/p>\n\n\n\n<p>If the same inlet must be used, this inlet (including the Y-tube inlet) must be rinsed thoroughly with 0.9% sodium chloride solution or 5% glucose solution before and after\u00a0injection\u00a0of Rapilysin.<\/p>\n\n\n\n<p><strong>Dosage&nbsp;of Rapilysin<\/strong><\/p>\n\n\n\n<p>Rapilysin is given as a 10 U&nbsp;injection&nbsp;followed by a second 10 U&nbsp;injection&nbsp;30 minutes later (double bolus injection).<\/p>\n\n\n\n<p>Each\u00a0injection\u00a0should be given slowly within 2 minutes.\u00a0Injection\u00a0should not be accidentally given outside the vein.\u00a0Therefore, inform your medical staff if you experience pain during\u00a0injection.<\/p>\n\n\n\n<p><strong><em>Heparin&nbsp;and&nbsp;acetylsalicylic acid<\/em><\/strong>&nbsp;are given before and after Rapilysin to reduce the formation of new blood clots.<\/p>\n\n\n\n<p><strong>Dosage&nbsp;of&nbsp;Heparin<\/strong><\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0of\u00a0heparin\u00a0is 5000 IU as a single\u00a0injection\u00a0before Rapilysin.\u00a0This is accompanied by an\u00a0infusion\u00a0of 1000 IU per hour starting after the second Rapilysin\u00a0injection.\u00a0Heparin\u00a0should be given for at least 24 hours, preferably for 48-72 hours, to keep aPTT levels 1.5 to 2 times normal.<\/p>\n\n\n\n<p><strong>Dosage&nbsp;of&nbsp;Acetylsalicylic acid<\/strong><\/p>\n\n\n\n<p>One dose\u00a0of\u00a0acetylsalicylic acid\u00a0given before Rapilysin should be at least 250 mg-350 mg and should be accompanied by 75-150 mg\/day, at least until discharge from the hospital.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Rapilysin than you should&nbsp;<\/h2>\n\n\n\n<p>In case of overdose, there may be an increased risk of bleeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>&nbsp;Very common (may affect more than 1 user in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bleeding at the injection site, eg bleeding (hematoma)<\/li><li>Chest pain\/angina, low\u00a0blood pressure,\u00a0and heart failure\/shortness of breath may occur<\/li><li>Burning sensation when Rapilysin is injected<\/li><\/ul>\n\n\n\n<p>Common (may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bleeding from the gastrointestinal tract (eg bloody or black vomiting or feces), from the gums, or from the urogenital organs<\/li><li>Abnormal heart rate (\u00a0arrhythmia\u00a0), cardiac arrest, circulatory collapse, or another heart attack may occur<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bleeding around the heart, abdomen, brain or eyes, under the skin, from the nose, or bloody cough<\/li><li>Damage to the heart or heart valves, or blood clots in the lungs, brain, or another part of the body can occur<\/li><li>Hypersensitivity (eg allergic reactions)<\/li><\/ul>\n\n\n\n<p>Very rare (may affect up to 1 in 10,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Events related to the nervous system (eg epileptic seizures, convulsions, speech disorders,\u00a0delirium, agitation, confusion, depression,\u00a0psychosis\u00a0)<\/li><li>The severe\u00a0allergic reaction\u00a0that causes\u00a0shock\u00a0or collapse<\/li><\/ul>\n\n\n\n<p>Adverse reactions&nbsp;that have been reported (occurring in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blockage of blood vessels due to&nbsp;cholesterol&nbsp;(fat)<\/li><\/ul>\n\n\n\n<p>Side effects\u00a0related to the heart and blood vessels can be life-threatening or fatal.<\/p>\n\n\n\n<p>Patients with systolic\u00a0blood pressure\u00a0above 160 mm Hg have a higher risk of a cerebral hemorrhage.\u00a0The risk of\u00a0intracranial\u00a0hemorrhage or fatal\u00a0intracranial\u00a0hemorrhage increases with increasing age.\u00a0Blood transfusions\u00a0were rarely required.\u00a0Death or permanent disability is not uncommon in patients with\u00a0stroke\u00a0(including cerebral hemorrhage) or other severe bleeding problems.<\/p>\n\n\n\n<p>Notify hospital staff immediately if any of these symptoms occur.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Rapilysin<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and the vial label after EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Keep the vial in the outer carton.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>After&nbsp;reconstitution&nbsp;(&#8220;when dissolved&#8221;), the solution must be used immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is reteplase 10 U \/ 10 ml after\u00a0reconstitution.<\/li><li>Other ingredients are:<br>Powder: <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tranexamic-acid-accord\/\">Tranexamic acid<\/a> dipotassium hydrogen phosphate phosphoric acidsucrosepolysorbate 80<br><em>Solvent:<\/em>10 ml water for injections (pre-filled\u00a0syringe\u00a0)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Rapilysin consists of a powder and a solvent for\u00a0injection\u00a0(2 sets of 0.56 g of powder in a\u00a0vial, 10 ml of solvent in a pre-filled\u00a0syringe, a needle tip for transfer, and a needle).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Actavis Group PTC EHF.<\/p>\n\n\n\n<p>Reykjavikurvegur 76-78<\/p>\n\n\n\n<p>IS-220 Hafnarfjordur<\/p>\n\n\n\n<p>Iceland<\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>Actavis Italy SpA<\/p>\n\n\n\n<p>Nerviano Plant<\/p>\n\n\n\n<p>Via Pasteur 10<\/p>\n\n\n\n<p>20014 Nerviano (Milano)<\/p>\n\n\n\n<p>Italy<\/p>\n\n\n\n<p>Cenex<\/p>\n\n\n\n<p>52, Rue Marcel and Jacques Gaucher<\/p>\n\n\n\n<p>FR-94120 Fontenay-Sous-Bois<\/p>\n\n\n\n<p>France<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rapilysin contains the active substance reteplas (a recombinant plasminogen activator ) is a thrombolytic medicine used to dissolve blood clots that have formed in certain blood vessels and to restore the blood flow in these clogged blood vessels (= thrombolysis).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[22383,22378,22379,22382,22374,22377,22380,22375,22381,22376],"class_list":["post-21653","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-rapilysin","tag-benefits-of-reteplas","tag-rapilysin","tag-rapilysin-side-effects","tag-reteplas","tag-reteplas-side-effects","tag-what-is-rapilysin","tag-what-is-reteplas","tag-what-rapilysin-is-used-for","tag-what-reteplas-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21653","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21653"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21653\/revisions"}],"predecessor-version":[{"id":21684,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21653\/revisions\/21684"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21653"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}