{"id":21649,"date":"2022-06-01T06:20:39","date_gmt":"2022-06-01T06:20:39","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21649"},"modified":"2022-06-01T09:59:14","modified_gmt":"2022-06-01T09:59:14","slug":"rapamune","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/rapamune\/","title":{"rendered":"Rapamune &#8211; Sirolimus uses, dose and side effects"},"content":{"rendered":"\n<p>0.5 mg, 1 mg, 2 mg&nbsp;coated&nbsp;tablets&nbsp;sirolimus<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Rapamune is and what it is used for<\/h2>\n\n\n\n<p>Rapamune contains the active substance sirolimus, which belongs to a group of medicines called immunosuppressive agents.&nbsp;It helps you keep your body&#8217;s immune system under control after a kidney transplant.<\/p>\n\n\n\n<p>Rapamune is used in adults to prevent the body from rejecting a transplanted kidney and is usually combined with the immunosuppressive drugs&nbsp;corticosteroids&nbsp;and at the beginning of treatment (the first 2 to 3 months) with ciclosporin.<\/p>\n\n\n\n<p>Rapamune is also used to treat patients with sporadic lymphangioleiomyomatosis (S-LAM) with moderate to severe lung disease or ongoing deterioration of lung function.&nbsp;S-LAM is a rare and progressive lung disease that mainly affects women of&nbsp;childbearing&nbsp;age.&nbsp;The most common symptom of S-LAM is shortness of breath.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Rapamune<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Rapamune<\/h2>\n\n\n\n<p>if you are allergic to sirolimus or any of the other ingredients of this medicine (listed in section 6).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Rapamune<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have any liver problems or have had a disease that may have affected your liver, tell your doctor.\u00a0This may affect the\u00a0dose\u00a0of Rapamune prescribed by your doctor and may result in further blood sampling.<\/li><li>Rapamune, like other immunosuppressive drugs, can lower the body&#8217;s ability to fight\u00a0infections\u00a0and may increase the risk of developing cancer of the lymph tissue or skin.<\/li><li>if you have a\u00a0BMI\u00a0(\u00a0body mass index\u00a0) that is higher than 30 kg \/ m\u00a02, this can affect your wound healing ability.<\/li><li>if you are considered to be at high risk of rejection of a kidney transplant, for example, if you have previously lost a\u00a0transplant.<\/li><\/ul>\n\n\n\n<p>Your doctor will take samples to check the amount of Rapamune in your blood.\u00a0Your doctor will also take samples to check your kidney function, your blood fat levels (\u00a0cholesterol\u00a0and\/or\u00a0triglycerides\u00a0), and possibly your liver function, during treatment with Rapamune.<\/p>\n\n\n\n<p>Due to the increased risk of skin cancer, exposure to sunlight and ultraviolet (UV) light should be limited by wearing protective clothing and using sunscreen with a high sun protection factor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>There is limited experience with the use of Rapamune in children and adolescents under 18 years of age.&nbsp;The use of Rapamune is not recommended in this patient group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Rapamune<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0Some medicines may interfere with the effect of Rapamune and therefore dose adjustment of Rapamune may need to be done.\u00a0Your doctor or pharmacist must know if you are using any of the following remedies:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>other immunosuppressive agents.<\/li><li>antibiotics\u00a0or antifungal agents against\u00a0infection, e.g.\u00a0clarithromycin, erythromycin, telithromycin, troleandomycin, rifabutin, clotrimazole,\u00a0fluconazole, itraconazole.\u00a0Concomitant use of Rapamune with rifampicin,\u00a0ketoconazole\u00a0or voriconazole is not recommended.<\/li><li>medicines for high\u00a0blood pressure\u00a0or heart problems, including nicardipine, verapamil, and\u00a0diltiazem.<\/li><li>medicines for\u00a0epilepsy, including carbamazepine, phenobarbital,\u00a0and phenytoin.<\/li><li>medicines used to treat\u00a0stomach ulcers\u00a0or other gastrointestinal diseases such as cisapride, cimetidine, and metoclopramide.<\/li><li>bromocriptine (used to treat Parkinson&#8217;s disease and various hormonal disorders), danazol (used to treat gynecological diseases), or\u00a0protease inhibitors\u00a0(eg for\u00a0HIV\u00a0and\u00a0hepatitis\u00a0C such as ritonavir, indinavir, boceprevir, and telaprevir).<\/li><li>St. John&#8217;s wort\u00a0(\u00a0Hypericum perforatum\u00a0).<\/li><li>letermovir (antiviral medicine used to prevent\u00a0cytomegalovirus\u00a0diseases ).<\/li><\/ul>\n\n\n\n<p>Live vaccines should be avoided when Rapamune is used concomitantly.&nbsp;Before vaccination, tell your doctor or pharmacist that you are taking Rapamune.<\/p>\n\n\n\n<p>The use of Rapamune may lead to elevated levels of\u00a0cholesterol\u00a0and\u00a0triglycerides\u00a0(blood fats) in the blood.\u00a0This may require treatment.\u00a0Drugs called statins or fibrates that are used to treat high\u00a0cholesterol\u00a0or\u00a0triglycerides\u00a0have been linked to an increased risk of muscle breakdown (\u00a0rhabdomyolysis\u00a0).\u00a0You should tell your doctor if you are taking medicines to lower your blood fats.<\/p>\n\n\n\n<p>Concomitant use of Rapamune with&nbsp;ACE inhibitors&nbsp;(a type of antihypertensive agent) may cause allergic reactions.&nbsp;Tell your doctor if you are taking other medicines that belong to this group of medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Rapamune with food, drink, and alcohol<\/h2>\n\n\n\n<p>Rapamune should be taken consistently either with or without food.\u00a0If you prefer to take Rapamune with a meal, always take it with a meal.\u00a0If you prefer to take Rapamune without food, always take it without food.\u00a0Food can affect the number of drugs that go into the bloodstream, by always taking your medication in the same way the levels of Rapamune in the blood are kept more stable.<\/p>\n\n\n\n<p>Rapamune should not be taken with grapefruit juice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Rapamune should only be used during pregnancy if necessary.\u00a0You must use effective contraception during treatment with Rapamune and 12 weeks after stopping treatment.\u00a0If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>It is not known if Rapamune passes into breast milk.\u00a0Patients taking Rapamune should stop breastfeeding during treatment.<\/p>\n\n\n\n<p>Decreased sperm counts have been associated with the use of Rapamune.&nbsp;This is usually normalized after stopping treatment with Rapamune.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Although Rapamune treatment is not expected to affect your ability to drive, you should talk to your doctor if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Rapamune contains lactose and sucrose<\/h2>\n\n\n\n<p>Rapamune contains 86.4 mg of&nbsp;lactose&nbsp;and up to 215.8 mg of sucrose.&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Rapamune<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Your doctor will decide what&nbsp;dose&nbsp;of Rapamune to take and how often to take it.&nbsp;Follow the doctor&#8217;s instructions exactly and never change the&nbsp;dose&nbsp;yourself.<\/p>\n\n\n\n<p>Rapamune should only be taken by mouth.\u00a0The tablets must not be crushed, chewed, or divided.\u00a0Tell your doctor if you have difficulty taking the tablet.<\/p>\n\n\n\n<p>Several 0.5 mg tablets should not be taken instead of 1 mg or 2 mg tablets as the different strengths are not directly interchangeable.<\/p>\n\n\n\n<p>Rapamune should always be taken with or without food.<\/p>\n\n\n\n<p>Kidney transplantation<\/p>\n\n\n\n<p>Your doctor will give you a starting dose of 6 mg as soon as possible after the kidney transplant.&nbsp;Then you must take 2 mg Rapamune every day until your doctor gives you other instructions.&nbsp;Your&nbsp;dose&nbsp;will be adjusted depending on the levels of Rapamune in your blood.&nbsp;Your doctor may need to take blood samples to measure Rapamune concentrations.<\/p>\n\n\n\n<p>If you are also taking ciclosporin, both medicines should be taken about 4 hours apart.<\/p>\n\n\n\n<p>It is recommended that Rapamune be used first in combination with ciclosporin and\u00a0corticosteroids.\u00a0After 3 months, your doctor may discontinue treatment with either Rapamune or ciclosporin, as it is not recommended that these medicines be taken together beyond this period.<\/p>\n\n\n\n<p>Sporadic lymphangioleiomyomatosis (S-LAM)<\/p>\n\n\n\n<p>Your doctor will give you 2 mg of Rapamune every day until your doctor tells you otherwise.&nbsp;Your&nbsp;dose&nbsp;will be adjusted according to how much Rapamune you have in your blood.&nbsp;Your doctor will need to take blood samples to measure your Rapamune concentration.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Rapamune than you should<\/h2>\n\n\n\n<p>If you have taken more medicine than you were prescribed, see a doctor or go to the hospital&#8217;s emergency department as soon as possible.&nbsp;Always carry the marked blister pack, even if it is empty.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Rapamune<\/h2>\n\n\n\n<p>If you forget to take Rapamune, take it as soon as you remember, but not if it is less than 4 hours until you take ciclosporin.\u00a0Then continue to take your medication as usual.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose, and make sure you always take Rapamune and ciclosporin at about 4-hour intervals.\u00a0If you forget to take a\u00a0dose\u00a0of Rapamune tell your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Rapamune<\/h2>\n\n\n\n<p>Do not stop taking Rapamune unless your doctor tells you to, you can lose the\u00a0transplant.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Allergic reactions<\/strong><\/p>\n\n\n\n<p><strong>Contact a doctor immediately<\/strong>\u00a0if you experience symptoms such as swelling of the face, tongue, and\/or throat (back of the mouth) and\/or difficulty breathing (\u00a0angioedema\u00a0) or a severe skin inflammation where the skin is scaly (exfoliative\u00a0dermatitis\u00a0).\u00a0These may be symptoms of severe allergic reactions.<\/p>\n\n\n\n<p><strong>Kidney damage with low\u00a0platelet count\u00a0(thrombocytopenic purpura \/ hemolytic\u00a0uremia\u00a0syndrome)<\/strong><\/p>\n\n\n\n<p>Rapamune may increase the risk of kidney damage with low\u00a0platelet counts\u00a0and low\u00a0red blood cell counts\u00a0with or without rash (thrombocytopenic purpura \/ hemolytic\u00a0uremia\u00a0syndrome) when taken at the same time as medicines called calcineurin inhibitors (cyclosporine or tacrolimus).\u00a0If you experience symptoms such as bruising or rash, changes in the urine or changes in behavior, or other symptoms that are severe, unusual, or long-lasting, contact your doctor.<\/p>\n\n\n\n<p><strong>Infection&nbsp;is<\/strong><\/p>\n\n\n\n<p>Rapamune reduces the body&#8217;s defense mechanisms.\u00a0In case of\u00a0infection, therefore, your body&#8217;s ability to fight\u00a0infection\u00a0will not be as good as usual.\u00a0Therefore, if you take Rapamune, you may get more\u00a0infections\u00a0than usual, such as\u00a0infections\u00a0of the skin, mouth, stomach, intestines, lungs, and urinary tract.\u00a0You should contact your doctor if you experience symptoms that are severe, unusual, or prolonged.<\/p>\n\n\n\n<p><strong>Frequency of side effects<\/strong><\/p>\n\n\n\n<p>Very common: may affect more than 1 user in 10<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fluid accumulation around the kidney<\/li><li>Swelling of the body including hands and feet<\/li><li>Pain<\/li><li>Fever<\/li><li>Headache<\/li><li>High\u00a0blood pressure<\/li><li>Stomach pain, diarrhea, constipation, nausea<\/li><li>Low\u00a0red blood cell count, low\u00a0platelet count<\/li><li>Elevated levels of fat in the blood (\u00a0cholesterol\u00a0and\/or\u00a0triglycerides\u00a0), elevated blood sugar, low potassium levels in the blood, low levels of\u00a0phosphate\u00a0in the blood, elevated lactate dehydrogenase protein in the blood, elevated levels of\u00a0creatinine\u00a0in the blood<\/li><li>Joint pain<\/li><li>Acne<\/li><li>Urinary tract infection<\/li><li>Pneumonia\u00a0and other bacterial,\u00a0viral,\u00a0and fungal infections<\/li><li>Decreased number of anti-infective cells in the blood (\u00a0white blood cells\u00a0)<\/li><li>Diabetes<\/li><li>Abnormal liver function tests, elevated\u00a0AST\u00a0and\/or\u00a0ALT\u00a0(liver enzymes)<\/li><li>Rash<\/li><li>Elevated protein levels in the urine<\/li><li>Menstrual disorders (such as missed, irregular, or heavy menstruation)<\/li><li>Impaired healing ability (this may include rupture of surgical wounds or loosening of surgical stitches)<\/li><li>Palpitation<\/li><li>There is a general tendency for fluid to accumulate in\u00a0various\u00a0tissues<\/li><\/ul>\n\n\n\n<p>Common: may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Infection\u00a0(including life-threatening\u00a0infection\u00a0)<\/li><li>Blood clots in the legs<\/li><li>Blood clots in the lungs<\/li><li>Cold sores<\/li><li>Fluid accumulation in the abdomen<\/li><li>Kidney damage with low\u00a0platelet count\u00a0and low\u00a0red blood cell count, with or without skin rash (hemolytic\u00a0uremia\u00a0syndrome)<\/li><li>Low levels of a type of\u00a0white blood cell\u00a0called\u00a0a\u00a0neutrophil<\/li><li>Weakening of the bones in the body<\/li><li>Inflammation\u00a0that can lead to lung damage, fluid in the alveoli<\/li><li>Nosebleed<\/li><li>Skin cancer<\/li><li>Kidney infection<\/li><li>Cysts on the ovaries<\/li><li>Accumulation of fluid in the pericardium, which in some cases can reduce the heart&#8217;s ability to pump blood<\/li><li>Pancreatitis<\/li><li>Allergic reactions<\/li><li>Shingles<\/li><li>Cytomegalovirus infection<\/li><\/ul>\n\n\n\n<p>Uncommon: may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lymphatic cancer (lymphoma \/ lymphoproliferative disease after transplantation), a combined reduction in the number of\u00a0red blood cells,\u00a0white blood cells,\u00a0and\u00a0platelets<\/li><li>Bleeding from the lungs<\/li><li>Protein\u00a0in the urine, sometimes in larger amounts associated with\u00a0side effects\u00a0such as swelling<\/li><li>Scarring of the kidneys, which may impair kidney function<\/li><li>Accumulation of fluid in the\u00a0tissues\u00a0due to disturbance in the lymphatic system<\/li><li>Low\u00a0platelet count, with or without rash (thrombocytopenic purpura)<\/li><li>Severe allergic reactions that can lead to flaky skin<\/li><li>Tuberculosis<\/li><li>Epstein-Barr\u00a0virus infection<\/li><li>Infectious\u00a0diarrhea with\u00a0<em>Clostridium difficile<\/em><\/li><li>Serious liver damage<\/li><\/ul>\n\n\n\n<p>Rare: may affect up to 1 in 1,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Protein storage in the air sacs of the lungs, can affect breathing<\/li><li>Severe allergic reactions that may affect the blood vessels (see above for allergic reactions)<\/li><\/ul>\n\n\n\n<p>Has been reported: occurs in an unknown number of users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Posterior reversible encephalopathy syndrome is a severe syndrome that affects the nervous system with the following symptoms: headache, nausea, vomiting, confusion, seizures, and loss of vision.\u00a0If any of these occur together, consult your doctor<\/li><\/ul>\n\n\n\n<p>S-LAM patients had the same&nbsp;side effects&nbsp;as kidney transplant patients, with the addition of weight loss that can occur in up to 1 in 10 people.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Rapamune<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton after &#8220;EXP&#8221;: The expiry date refers to the last day of that month.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Store the blister in the outer carton to protect it from light.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is sirolimus.<\/p>\n\n\n\n<p>Each Rapamune 0.5 mg coated tablet contains 0.5 mg sirolimus.<\/p>\n\n\n\n<p>Each Rapamune 1 mg coated tablet contains 1 mg sirolimus.<\/p>\n\n\n\n<p>Each Rapamune 2 mg tablet contains 2 mg sirolimus.<\/p>\n\n\n\n<p>The other ingredients are:<\/p>\n\n\n\n<p><em>Tablet core:\u00a0<\/em>lactose monohydrate, macrogol, magnesium stearate, talc.<\/p>\n\n\n\n<p><em>Tablet coating:\u00a0<\/em>\u00a0macrogol, glycerol monooleate, shellac (pharmaceutical glaze), calcium sulfate, microcrystalline cellulose, sucrose, titanium dioxide, poloxamer 188, \u03b1-tocopherol, povidone, carnauba wax, printing ink (shellac, red iron oxide, propylene glycol one (E20) ammonium glycol (ammonia).\u00a0The strengths 0.5 mg and 2 mg also contain yellow iron oxide (E172) and brown iron oxide (E172).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Rapamune 0.5 mg is supplied as light brown, triangular-coated\u00a0tablets marked \u201cRAPAMUNE 0.5 mg\u201d on one side.<\/p>\n\n\n\n<p>Rapamune 1 mg is supplied as white, triangular-coated\u00a0tablets marked \u201cRAPAMUNE 1 mg\u201d on one side.<\/p>\n\n\n\n<p>Rapamune 2 mg is supplied as yellow-beige, triangular-coated\u00a0tablets marked \u201cRAPAMUNE 2 mg\u201d on one side.<\/p>\n\n\n\n<p>The tablets are supplied in blister packs of 30 and 100 tablets.&nbsp;Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder:<\/strong><\/p>\n\n\n\n<p>Pfizer Europe MA EEIG<\/p>\n\n\n\n<p>Boulevard de la Plaine 17<\/p>\n\n\n\n<p>1050 Brussels<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Pfizer Ireland Pharmaceuticals<\/p>\n\n\n\n<p>Little Connell<\/p>\n\n\n\n<p>Newbridge<\/p>\n\n\n\n<p>Co.&nbsp;Kildare<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Pfizer Manufacturing Deutschland GmbH<\/p>\n\n\n\n<p>Operating office Freiburg<\/p>\n\n\n\n<p>Mooswaldallee 1<\/p>\n\n\n\n<p>79090 Freiburg<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>For any information about this medicinal product, please contact the local representative of the Marketing Authorization Holder.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Luxembourg \/ LuxemburgPfizer NV \/ SATel: +32 (0) 2 554 62 11<\/td><td><strong>Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaTel.&nbsp;+3705 2514000<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Pfizer Luxembourg SARE, Clone of BulgariaTel + 359 2 970 4333<\/td><td><strong>Hungary<\/strong>Pfizer Kft.Tel: +36 1 488 3700<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Pfizer, spol.&nbsp;s roTel: +420 283 004 111<\/td><td><strong>Malta<\/strong>Vivian Corporation Ltd.Tel: +35621 344610<\/td><\/tr><tr><td><strong>Denmark<\/strong>Pfizer ApSTel: +45 44 201 100<\/td><td><strong>The Netherlands<\/strong>Pfizer bvTel: +31 (0) 10 406 43 01<\/td><\/tr><tr><td><strong>Germany<\/strong>Pfizer Pharma GmbHTel: +49 (0) 30 550055-51000<\/td><td><strong>Norway<\/strong>Pfizer ASTel: +47 67 52 61 00<\/td><\/tr><tr><td><strong>Eesti<\/strong>Pfizer Luxembourg SARL Eesti subsidiaryTel: +372 666 7500<\/td><td><strong>Austria<\/strong>Pfizer Corporation Austria Ges.mbHTel: +43 (0) 1 521 15-0<\/td><\/tr><tr><td><strong>Greece<\/strong>PFIZER \u0395\u039b\u039b\u0391\u03a3 AE.:\u0397\u03bb .: +30 210 6785 800<\/td><td><strong>Poland<\/strong>Pfizer Polska Sp.&nbsp;z oo,Tel .: +48 22 335 61 00<\/td><\/tr><tr><td><strong>Spain<\/strong>Pfizer, SLTel: +34914909900<\/td><td><strong>Portugal<\/strong>Pfizer Laboratories, Lda.Tel: +351 21 423 5500<\/td><\/tr><tr><td><strong>France<\/strong>PfizerPhone +33 (0) 1 58 07 34 40<\/td><td><strong>Romania<\/strong>Pfizer Romania SRLTel: +40 (0) 21 207 28 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>Pfizer Croatia dooTel: + 385 1 3908 777<\/td><td><strong>Slovenia<\/strong>Pfizer Luxembourg SARL, Pfizer, manufacturing and manufacturing pharmaceutical services, LjubljanaTel: +386 (0) 1 52 11 400<\/td><\/tr><tr><td><strong>Ireland<\/strong>Pfizer Healthcare IrelandTel: +1800 633 363 (toll free)Tel: +44 (0) 1304 616161<\/td><td><strong>Slovak Republic<\/strong>Pfizer Luxembourg SARL, organizerTel: + 421 2 3355 5500<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hfTel: +354 540 8000<\/td><td><strong>Finland \/ Finland<\/strong>Pfizer OyPuh \/ Tel: +358 (0) 9 430 040<\/td><\/tr><tr><td><strong>Italy<\/strong>Pfizer SrlTel: +39 06 33 18 21<\/td><td><strong>Sweden<\/strong>Pfizer ABTel: +46 (0) 8 550 520 00<\/td><\/tr><tr><td><strong>\u038e\u03c0\u03c1\u03bf\u03c2<\/strong>PFIZER \u0395\u039b\u039b\u0391\u03a3 \u0391.\u0395.&nbsp;(Cyprus Branch)T\u03b7\u03bb: +357 22 817690<\/td><td><strong>United Kingdom<\/strong><strong>(Northern Ireland)<\/strong>Pfizer LimitedTel: +44 (0) 1304 616161<\/td><\/tr><tr><td><strong>Latvia<\/strong>Pfizer Luxembourg SARL subsidiary Latvij\u0101Tel.&nbsp;+371 67035775<\/td><td><\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Rapamune contains the active substance sirolimus, which belongs to a group of medicines called immunosuppressive agents. It helps you keep your body&#8217;s immune system under control after a kidney transplant.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18529],"tags":[22399,22394,22398,22397,22389,22393,22392,22395,22390,22396,22391],"class_list":["post-21649","post","type-post","status-publish","format-standard","hentry","category-medicines","category-r","tag-benefits-of-rapamune","tag-rapamune","tag-rapamune-side-effects","tag-rapamune-tablet","tag-sirolimus","tag-sirolimus-side-effects","tag-sirolimus-tablet","tag-what-is-rapamune","tag-what-is-sirolimus","tag-what-rapamune-is-used-for","tag-what-sirolimus-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21649"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21649\/revisions"}],"predecessor-version":[{"id":21686,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21649\/revisions\/21686"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21649"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}