{"id":21482,"date":"2022-05-24T13:00:04","date_gmt":"2022-05-24T13:00:04","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21482"},"modified":"2022-05-24T14:31:30","modified_gmt":"2022-05-24T14:31:30","slug":"qlaira","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/qlaira\/","title":{"rendered":"Qlaira &#8211; Estradiol valerate \/ Dienogest uses, dose and side effects"},"content":{"rendered":"\n<p>film-coated tablets<br>estradiol valerate \/ dienogest<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Qlaira is and what it is used for<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Qlaira is a\u00a0birth control pill\u00a0and is used to prevent pregnancy.<\/li><li>Qlaira is used to treat heavy menstrual bleeding (which is not due to any disease of the uterus) in women who want to use\u00a0oral contraceptives\u00a0(\u00a0oral\u00a0contraception).<\/li><li>Each colored, active tablet contains a small number of female\u00a0hormones, either estradiol valerate or estradiol valerate in combination with dienogest.<\/li><li>The two white tablets do not contain any active substances and are also called inactive tablets.<\/li><li>Birth control pills\u00a0that contain two\u00a0hormones\u00a0are called combination\u00a0birth control pills.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Qlaira<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Qlaira<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>General notes<\/strong>Before using Qlaira, read the information on blood clots in section 2. You must read the symptoms of blood clots &#8211; see section 2, &#8220;Blood clots&#8221;.<br>Before you can start taking Qlaira, the midwife \/ doctor will ask you some questions about your own and your immediate relatives&#8217; medical history.\u00a0The midwife \/ doctor will also measure your\u00a0blood pressure\u00a0and it is possible that the midwife\/doctor, depending on your situation, will also take other samples.<br>This leaflet describes several situations in which you need to stop taking Qlaira or when Qlaira&#8217;s reliability may be impaired.\u00a0In such situations, you should either refrain from having intercourse or use other non-hormonal contraceptives, e.g.\u00a0condom or any other\u00a0barrier method.\u00a0Do not use the rhythm method (safe periods) or the temperature method.\u00a0These methods can be unreliable, as Qlaira affects the monthly changes in body temperature and cervical secretions.<br>Qlaira, like other\u00a0birth control pills<strong>, does\u00a0not protect against\u00a0HIV\u00a0infection\u00a0(\u00a0AIDS\u00a0) or other sexually transmitted diseases.<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Do not use Qlaira if you have any of the conditions listed below.&nbsp;If you have any of these conditions, you need to tell your doctor.&nbsp;The doctor will discuss what other type of contraception may be more appropriate.<\/p>\n\n\n\n<p><strong>Do not use Qlaira:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have (or have had) a\u00a0<strong>blood clot<\/strong>\u00a0in a blood vessel in your legs (deep\u00a0vein thrombosis, DVT), in your lungs (\u00a0pulmonary embolism\u00a0), or any other organ<\/li><li>if you know you have a\u00a0disease that affects blood coagulation\u00a0&#8211; e.g.\u00a0protein\u00a0C deficiency,\u00a0protein\u00a0S deficiency, antithrombin III deficiency, Factor V Leiden or antiphospholipid antibodies<\/li><li>if you need to have an operation or if you stay in bed for a longer period (see section &#8220;Blood clots&#8221;)<\/li><li>if you have (or have had) a\u00a0heart attack\u00a0or a\u00a0stroke\u00a0(stroke)<\/li><li>if you have (or have had)\u00a0angina\u00a0(a condition that causes severe chest pain and maybe the first sign of a heart attack) or\u00a0transient\u00a0ischemic attack\u00a0(\u00a0TIA\u00a0&#8211; transient stroke symptoms)<\/li><li>if you have any of the following conditions that may increase the risk of a blood clot in your arteries:<ul><li>severe\u00a0diabetes\u00a0with damaged blood vessels<\/li><li>very\u00a0high\u00a0blood pressure<\/li><li>a very high level of\u00a0fat in the blood\u00a0(\u00a0cholesterol\u00a0or\u00a0triglycerides\u00a0)<\/li><li>a condition called\u00a0hyperhomocysteinemia<\/li><\/ul><\/li><li>if you have (or have had) a type of\u00a0migraine\u00a0called &#8220;migraine with aura&#8221;<\/li><li>if you have (or have had) liver disease\u00a0and your liver function is not yet normal<\/li><li>if you have (or have had) a\u00a0tumor\u00a0in your liver<\/li><li>if you have (or have had)\u00a0cancer or are suspected of having breast or genital cancer<\/li><li>if you have\u00a0unexplained vaginal bleeding<\/li><li>if you are allergic (hypersensitive) to estradiol valerate or dienogest, or any of the other ingredients of this medicine (listed in section 6).\u00a0This can cause\u00a0itching, rash, or swelling<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>When should you contact a doctor?<br><strong>Seek medical attention immediately<\/strong>if you notice any possible signs of a blood clot that may indicate a blood clot in your leg (ie deep\u00a0vein thrombosis\u00a0), a blood clot in your lung (ie\u00a0pulmonary embolism\u00a0), a heart attack, or a\u00a0stroke\u00a0(see section \u201cBlood clots\u201d below). For a description of the symptoms of these serious\u00a0side effects, go to &#8220;How to recognize a blood clot&#8221;.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Tell your doctor if any of the following conditions apply to you.<\/strong><\/p>\n\n\n\n<p>In some situations, you need to be especially careful when taking Qlaira or other combined\u00a0birth control pills, and you may need to be checked regularly by your midwife\/doctor.\u00a0If the condition occurs or worsens when you use Qlaira, you should also consult a doctor.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if a close relative has or has had breast cancer<\/li><li>if you have any liver or bile disease<\/li><li>if you have jaundice<\/li><li>if you have\u00a0diabetes<\/li><li>if you suffer from depression<\/li><li>if you have\u00a0Crohn&#8217;s disease\u00a0or\u00a0ulcerative colitis\u00a0(\u00a0chronic\u00a0inflammatory\u00a0bowel disease)<\/li><li>if you have systemic lupus erythematosus (\u00a0SLE\u00a0&#8211; a disease that affects your natural immune system)<\/li><li>if you have\u00a0hemolytic uremic syndrome\u00a0(HUS &#8211; a disorder of blood coagulation that leads to\u00a0kidney failure\u00a0)<\/li><li>if you have\u00a0sickle cell anemia\u00a0(a hereditary disease of the red\u00a0blood cells\u00a0)<\/li><li>if you have high blood fats (\u00a0hypertriglyceridemia\u00a0) or a hereditary condition.\u00a0Hypertriglyceridemia\u00a0has been associated with an increased risk of developing\u00a0pancreatitis\u00a0(inflammation of the pancreas)<\/li><li>if you need to have an operation or stay in bed for a longer period (see section 2 &#8220;Blood clots)<\/li><li>if you have just given birth, you are at increased risk of getting blood clots.\u00a0Ask your doctor how soon after giving birth you can start using Qlaira<\/li><li>if you have an\u00a0inflammation\u00a0of the veins under the skin (superficial\u00a0thrombophlebitis\u00a0)<\/li><li>if you have varicose veins<\/li><li>if you have\u00a0epilepsy\u00a0(see &#8221;\u00a0<strong>Other medicines and Qlaira<\/strong>\u00a0&#8220;)<\/li><li>if you have a disease that first appeared during pregnancy or previous use of sex hormones, e.g.\u00a0hearing loss, a blood disease called\u00a0porphyria, skin rash with blisters during pregnancy (pregnancy herpes), a nerve disease that causes sudden twitching in the body (Sydenhams Korea)<\/li><li>if you have (or have had) golden brown pigment spots (chloasma), so-called &#8220;pregnancy spots&#8221;, especially on the face.\u00a0In this case, avoid\u00a0exposure\u00a0to sunlight or ultraviolet light<\/li><li>if you have hereditary or acquired\u00a0angioedema.\u00a0Stop taking Qlaira and see a doctor immediately if you experience symptoms such as swelling of the face, tongue, and\/or throat and\/or difficulty swallowing or hives along with breathing difficulties that may indicate\u00a0angioedema.\u00a0Products that contain\u00a0estrogen\u00a0can cause or worsen the symptoms of\u00a0angioedema<\/li><li>if you have heart or\u00a0kidney failure<\/li><\/ul>\n\n\n\n<p><strong>Talk to your doctor before taking Qlaira.<\/strong><\/p>\n\n\n\n<p><strong>Special patient groups<\/strong><\/p>\n\n\n\n<p><em>Children and young people<\/em><\/p>\n\n\n\n<p>Qlaira is not intended for use before the first menstrual period.<\/p>\n\n\n\n<p><strong>BLOOD CLOTS<\/strong><\/p>\n\n\n\n<p>Using combined hormonal contraceptives such as Qlaira increases the risk of blood clots compared to not using these drugs.&nbsp;In rare cases, a blood clot can block the blood vessels and cause serious problems.<\/p>\n\n\n\n<p>Blood clots can form<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>in veins (called venous\u00a0thrombosis\u00a0, venous\u00a0thromboembolism,\u00a0or VTE)<\/li><li>in\u00a0arteries\u00a0(called\u00a0arterial\u00a0thrombosis\u00a0,\u00a0arterial\u00a0thromboembolism,\u00a0or ATE)<\/li><\/ul>\n\n\n\n<p>It is not always possible to fully recover from blood clots.&nbsp;In rare cases, they can have serious lasting effects and, in very rare cases, be fatal.<\/p>\n\n\n\n<p><strong>It is important to remember that the overall risk of a dangerous blood clot due to Qlaira is small.<\/strong><\/p>\n\n\n\n<p><strong>HOW TO FEEL A BLOOD CLOTH AGAIN<\/strong><\/p>\n\n\n\n<p><strong>Seek medical attention immediately<\/strong>\u00a0if you notice any of the following signs or symptoms:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\">Do you experience any of these signs?<\/th><th scope=\"col\">What can you possibly suffer from?<\/th><\/tr><\/thead><tbody><tr><td>\u2022 swelling of a leg or along a vein in the leg or foot, especially if you also get:\u2022 pain or tenderness in the leg that is only felt when you stand or walk\u2022 increased heat in the affected leg\u2022 discoloration of the skin on the leg, e.g.&nbsp;pale, red or blue<\/td><td>Deep&nbsp;vein thrombosis<\/td><\/tr><tr><td>\u2022 sudden unexplained shortness of breath or rapid breathing\u2022 sudden cough for no apparent reason that could cause you to cough up blood\u2022 severe chest pain that may increase with deep breathing\u2022 strong instability or dizziness\u2022 fast or irregular heartbeat\u2022 severe pain in the abdomen<br>If you are not sure, talk to a doctor as some of these symptoms, such as cough and shortness of breath, can be mistaken for a mild condition such as a respiratory infection (such as a common cold).<\/td><td>Pulmonary embolism<\/td><\/tr><tr><td>Symptoms that usually occur in one eye: Immediate vision loss or\u2022 blurred vision without pain that can lead to vision loss<\/td><td>Retinal&nbsp;venous thrombosis&nbsp;(blood clot in the eye)<\/td><\/tr><tr><td>\u2022 chest pain, discomfort, pressure, heaviness\u2022 pressure or feeling of fullness in the chest, arm, or below the sternum\u2022 feeling full, indigestion or\u00a0<strong>suffocation<\/strong>\u2022 discomfort in the upper body that radiates to the back, jaw, neck, arm and abdomen\u2022 sweating, nausea, vomiting or dizziness\u2022\u00a0<strong>extreme weakness, anxiety or shortness of breath<\/strong>\u2022\u00a0<strong>fast or irregular heartbeat<\/strong><\/td><td>Myocardial infarction<\/td><\/tr><tr><td>\u2022 sudden weakness or&nbsp;<strong>numbness<\/strong>&nbsp;in the face, arms or legs,&nbsp;<strong>especially on one side of the body<\/strong>\u2022 sudden confusion,&nbsp;<strong>difficulty speaking or understanding<\/strong>\u2022&nbsp;<strong>sudden vision problems<\/strong>&nbsp;in one or both eyes\u2022 sudden difficulty walking, dizziness, loss of balance or coordination\u2022 sudden, severe or prolonged headache without a known cause\u2022&nbsp;<strong>unconsciousness or fainting<\/strong>&nbsp;with or without seizures<br>Sometimes the symptoms of a&nbsp;stroke&nbsp;can be short-lived with almost immediate or complete recovery, but you should still seek medical attention immediately because you are at risk of having a new&nbsp;stroke&nbsp;.<\/td><td>Stroke<\/td><\/tr><tr><td>\u2022 swelling and slight blue discoloration of an arm or leg\u2022 severe pain in the abdomen (&nbsp;acute&nbsp;abdomen)<\/td><td>Blood clots that block other blood vessels<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>BLOOD CLOTS IN A FRIEND<\/strong><\/p>\n\n\n\n<p><strong>What can happen if a blood clot forms in a vein?<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The use of combined hormonal contraceptives has been associated with an increased risk of blood clots in the vein (venous&nbsp;thrombosis&nbsp;).&nbsp;However, these&nbsp;side effects&nbsp;are rare.&nbsp;They usually occur during the first year of using a combined hormonal contraceptive.<\/li><li>If a blood clot forms in a vein in the leg or foot, it can lead to deep&nbsp;vein thrombosis&nbsp;(DVT).<\/li><li>If a blood clot moves from the bone and stays in the lung, it can lead to a&nbsp;pulmonary embolism&nbsp;.<\/li><li>In very rare cases, a blood clot can form in a vein in another organ such as the eye (&nbsp;retinal&nbsp;venous thrombosis&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>When is the risk of developing a blood clot in a vein greatest?<\/strong><\/p>\n\n\n\n<p>The risk of developing a blood clot in a vein is greatest during the first year that you use combined hormonal contraceptives for the first time.&nbsp;The risk can also be higher if you start again with a combined hormonal contraceptive (same product or another product) after a break of 4 weeks or longer.<\/p>\n\n\n\n<p>After the first year, the risk decreases, but it is always slightly higher than if you did not use a combined hormonal contraceptive.<\/p>\n\n\n\n<p>When you stop using Qlaira, the risk of a blood clot returns to normal within a few weeks.<\/p>\n\n\n\n<p><strong>How big is the risk of developing a blood clot?<\/strong><\/p>\n\n\n\n<p>The risk depends on your natural risk of VTE and the type of combined hormonal contraceptive you are taking.<\/p>\n\n\n\n<p>The total risk of a blood clot in the leg or lungs with Qlaira is small.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Of 10,000 women who do not use a combined hormonal contraceptive and are not pregnant, about 2 develop a blood clot in one year.<\/li><li>Of 10,000 women who use a combined hormonal contraceptive that contains levonorgestrel or norethisterone or norgestimate, about 5-7 develop a blood clot in a year.<\/li><li>The risk of blood clots during treatment with Qlaira is about the same as for a combined hormonal contraceptive or a combined hormonal contraceptive containing levonorgestrel.<\/li><li>The risk of blood clots varies depending on your medical history (see &#8220;Factors that may increase the risk of a blood clot&#8221; below).<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><\/th><th scope=\"col\"><strong>Risk of developing a blood clot during a year<\/strong><\/th><\/tr><\/thead><tbody><tr><td>Women who&nbsp;<strong>do not use the<\/strong>&nbsp;combined hormonal&nbsp;contraceptive pill&nbsp;and who are not pregnant<\/td><td>About 2 out of 10,000 women<\/td><\/tr><tr><td>Women using a combined hormonal contraceptive containing\u00a0<strong>levonorgestrel, norethisterone,<\/strong>\u00a0or\u00a0<strong>norgestimate<\/strong><\/td><td>About 5-7 out of 10,000 women<\/td><\/tr><tr><td>Women using Qlaira<\/td><td>Approximately the same as for a combined hormonal contraceptive or a combined hormonal contraceptive containing levonorgestrel<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Factors that may increase the risk of a blood clot in a vein<\/strong><\/p>\n\n\n\n<p>The risk of a blood clot with Qlaira is small but some conditions increase the risk.&nbsp;The risk is higher:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are overweight (body mass index or\u00a0BMI\u00a0over 30 kg \/ m\u00a0<sup>2<\/sup>\u00a0)<\/li><li>if someone in your family has had a blood clot in the bones, lungs, or another organ at a young age (eg under 50 years) In this case you may have a hereditary blood clotting disease<\/li><li>if you need to undergo surgery or stay in bed for an extended period due to injury or illness, or if your leg is plastered.\u00a0The use of Qlaira may need to be stopped for several weeks before an operation or while you are less mobile.\u00a0If you have to stop taking Qlaira, ask your doctor when you can start taking it again<\/li><li>with increasing age (especially if you are over 35 years old)<\/li><li>if you gave birth a few weeks ago<\/li><\/ul>\n\n\n\n<p>The more conditions you have, the greater the risk of developing a blood clot.<\/p>\n\n\n\n<p>Air travel (over 4 hours) can temporarily increase the risk of a blood clot, especially if you have any of the other factors listed here.<\/p>\n\n\n\n<p>It is important that you tell your doctor if any of these conditions apply to you, even if you are unsure.&nbsp;Your doctor may decide that you need to stop taking Qlaira.<\/p>\n\n\n\n<p>If any of the above conditions change when you use Qlaira, such as close relative suffering from a blood clot for an unknown reason, or you gain a lot of weight, talk to your doctor.<\/p>\n\n\n\n<p><strong>BLOOD CLOTS IN AN&nbsp;ART<\/strong><\/p>\n\n\n\n<p><strong>What can happen if a blood clot forms in an&nbsp;artery&nbsp;?<\/strong><\/p>\n\n\n\n<p>In the same way as a blood clot in a vein, a clot in an\u00a0artery\u00a0can lead to serious problems.\u00a0It can e.g.\u00a0cause a heart attack or\u00a0stroke.<\/p>\n\n\n\n<p><strong>Factors that may increase the risk of a blood clot in an&nbsp;artery<\/strong><\/p>\n\n\n\n<p>It is important to know that the risk of a heart attack or\u00a0stroke\u00a0due to the use of Qlaira is very small but may increase:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>with increasing age (after about 35 years of age)<strong>if you smoke.\u00a0<\/strong>When you use combined hormonal contraceptives like Qlaira, you should stop smoking.\u00a0If you can not stop smoking and are over 35 years old, your doctor may advise you to use another type of contraceptive if you are overweight if you have high\u00a0blood pressureif a close relative has had a heart attack or\u00a0stroke\u00a0at a young age (younger than 50 years).\u00a0In this case, you may also be at greater risk for a heart attack or\u00a0stroke if you or a close relative have high blood fats (\u00a0cholesterol\u00a0or\u00a0triglycerides\u00a0)if you get\u00a0migraines, especially\u00a0migraines\u00a0with an\u00a0aura if you have heart problems (valve disease, a heart rhythm disorder called\u00a0atrial fibrillation\u00a0)if you have\u00a0diabetes<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>If you have more than one of these conditions or if any of them are particularly serious, the risk of developing a blood clot can be even greater.<\/p>\n\n\n\n<p>If any of the above conditions change when you use Qlaira, e.g.\u00a0If you start smoking, a close relative suffers from thrombosis\u00a0of unknown cause, or you gain a lot of weight, talk to your doctor.<\/p>\n\n\n\n<p><strong>Qlaira and cancer<\/strong><\/p>\n\n\n\n<p><strong>Breast cancer<\/strong>\u00a0has been observed slightly more often in women using combined\u00a0oral contraceptives\u00a0, but it is not known if this is caused by the treatment.\u00a0It can e.g.\u00a0be that more\u00a0tumors\u00a0are detected in women who use combined\u00a0contraceptive pills\u00a0because they are more often examined by doctors.\u00a0The risk of breast tumors gradually decreases after stopping treatment with combined hormonal contraceptives.\u00a0It is important that you examine your breasts regularly, and you should consult your doctor if you feel any lumps.<\/p>\n\n\n\n<p>In rare cases,\u00a0<strong>benign liver tumors<\/strong>, and in even fewer cases\u00a0malignant liver tumors, have been reported in\u00a0birth control pill\u00a0users.\u00a0In rare cases, these\u00a0tumors\u00a0have led to life-threatening internal bleeding.\u00a0Contact your doctor if you experience unusually severe abdominal pain.<\/p>\n\n\n\n<p>Some studies suggest that long-term use of&nbsp;birth control pills&nbsp;increases a woman&#8217;s risk of developing&nbsp;<strong>cervical cancer<\/strong>&nbsp;.&nbsp;However, it is not clear to what extent sexual habits or other factors such as human papillomavirus (HPV) increase the risk.<\/p>\n\n\n\n<p><strong>Mental disorders&nbsp;<\/strong><\/p>\n\n\n\n<p>Some women who use hormonal contraceptives, including Qlaira, have reported depression or depression.&nbsp;Depression can be severe and can sometimes lead to suicidal thoughts.&nbsp;If you experience mood swings and symptoms of depression, you should contact a doctor as soon as possible for advice.<\/p>\n\n\n\n<p><strong>Intermittent bleeding<\/strong><\/p>\n\n\n\n<p>During the first months of using Qlaira, you may experience unexpected bleeding.\u00a0The bleeding usually starts on day 26, the day you take the second dark red tablet or the following days.\u00a0Information obtained from women through diaries they have written during a\u00a0clinical study\u00a0with Qlaira shows that it is not uncommon to have unexpected bleeding in a given menstrual cycle (10-18% of women).\u00a0If unexpected bleeding occurs for more than three consecutive months, or if it occurs after a few months, your midwife\/doctor should investigate the cause.<\/p>\n\n\n\n<p><strong>What to do if you do not experience any bleeding on day 26 or the following day (s)<\/strong><\/p>\n\n\n\n<p>Information obtained from women through diaries they have written during a&nbsp;clinical study&nbsp;with Qlaira shows that it is not uncommon for menstruation to occur after day 26 (observed in approximately 15% of menstrual cycles).<\/p>\n\n\n\n<p>If you have taken all the tablets correctly, have not had vomiting or severe diarrhea and you have not taken any other medicines, it is very unlikely that you are pregnant.<\/p>\n\n\n\n<p>If you have taken the tablets incorrectly or if the expected bleeding does not occur twice in a row, you may be pregnant.\u00a0Contact your midwife\/doctor immediately.\u00a0Do not start on the next tablet card until you are sure you are not pregnant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Qlaira<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Always tell your midwife\/doctor which medicines or herbal remedies you are already using.\u00a0Also, tell other doctors or dentists who prescribe other medicines (or the pharmacy staff from whom you are taking the medicine) that you are using Qlaira.\u00a0They can tell you if you need to use additional contraceptives (eg condoms), and if so, for how long.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Some medicines<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>may affect the level of Qlaira in the blood<\/li><li>can make it&nbsp;<strong>less effective in preventing pregnancy<\/strong><\/li><li>may cause unexpected bleeding<\/li><\/ul>\n\n\n\n<p>This applies to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs used to treat:<ul><li>epilepsy\u00a0(eg primidone,\u00a0phenytoin\u00a0,\u00a0barbiturates\u00a0, carbamazepine, oxcarbamazepine, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/topiramate-1a-pharma\/\">topiramate<\/a>, felbamate)<\/li><li>tuberculosis\u00a0(eg rifampicin)<\/li><li>HIV\u00a0and\u00a0hepatitis\u00a0C virus infections (so-called\u00a0protease inhibitors\u00a0and non-nucleoside reverse transcriptase inhibitors such as ritonavir, nevirapine, efavirenz<\/li><li>Hepatitis\u00a0C\u00a0virus\u00a0(\u00a0HCV\u00a0) (such as the combination treatment ombitasvir\/paritaprevir\/ritonavir with or without dasabuvir as well as the treatment glekaprevir \/ pibrentasvir) may cause elevated liver function values \u200b\u200bin blood test results (increase in\u00a0ALT\u00a0liver enzyme) in women using combined hormonal contraceptives containing ethine.\u00a0Qlaira contains estradiol instead of Ethinylestradiol.\u00a0It is not known whether an increase in\u00a0ALT\u00a0liver enzyme may occur with the use of Qlaira in combination with this\u00a0HCV\u00a0combination therapy.\u00a0Your doctor will advise you<\/li><li>fungal infections (eg griseofulvin,\u00a0ketoconazole\u00a0)<\/li><\/ul><\/li><li>the herbal medicine St. John&#8217;s\u00a0wort<\/li><\/ul>\n\n\n\n<p>Qlaira may\u00a0<strong>affect the effectiveness<\/strong>\u00a0of other medicines, e.g.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines containing ciclosporin<\/li><li>the antiepileptic drug lamotrigine (this may lead to an increase in the number of seizures).<\/li><\/ul>\n\n\n\n<p><em>Ask your doctor or pharmacist for advice before taking any medicine.&nbsp;Your doctor or pharmacist may advise you on additional contraceptives when using other medicines with Qlaira.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Qlaira with food and drink<\/h2>\n\n\n\n<p>Qlaira can be taken with or without food and if necessary with a small amount of water.<\/p>\n\n\n\n<p><strong>Laboratory samples<\/strong><\/p>\n\n\n\n<p>If you need to take a blood sample or other laboratory samples, tell your doctor or laboratory staff that you are taking\u00a0birth control pills, as\u00a0birth control pills\u00a0can affect the results of certain tests.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Do not use Qlaira if you are pregnant.&nbsp;If you become pregnant while taking Qlaira, you must stop taking Qlaira immediately and contact your midwife \/ doctor.&nbsp;If you want to get pregnant, you can stop taking Qlaira at any time (see also &#8221;&nbsp;<strong>If you stop using Qlaira<\/strong>&nbsp;&#8220;).<\/p>\n\n\n\n<p>You should generally not use Qlaira while breast-feeding.\u00a0If you want to use\u00a0birth control pills\u00a0while breastfeeding, contact your midwife\/doctor.<\/p>\n\n\n\n<p><em>Consult a midwife\/doctor or pharmacist before taking any medicine while you are pregnant or breast-feeding.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>There is no information to suggest that the use of Qlaira affects the ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Qlaira contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your midwife\/doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Qlaira<\/h2>\n\n\n\n<p>Each tablet map contains 26 colored active tablets and 2 white inactive tablets.<\/p>\n\n\n\n<p>Take one tablet of Qlaira daily, with a little water if needed.&nbsp;You can take the tablets with or without food, but you should take the tablets at about the same time each day.<\/p>\n\n\n\n<p><strong>Preparation for the start of a new tablet map<\/strong><\/p>\n\n\n\n<p>To help you keep track of the tablets, each tablet card comes with 7 memory strips with 7 days a week.<\/p>\n\n\n\n<p>Select the memory strip that starts with the day of the week when you start taking the tablets.&nbsp;An example: if you start on a Wednesday, use the memory strip that starts with &#8220;ONS&#8221;.<\/p>\n\n\n\n<p>Paste the memory strip at the top of the tablet map where it says &#8220;attach the memory strip here&#8221; so that the first day is above the tablet marked &#8220;1&#8221;.<\/p>\n\n\n\n<p>A day of the week is now indicated above each tablet, so that you can see if you have taken the contraceptive pill on a particular day.&nbsp;Follow the direction of the arrow on the tablet map until all 28 tablets have been taken.<\/p>\n\n\n\n<p>Normally, a so-called dropout bleeding starts when you take the other dark red tablet or tablets, and the bleeding may not have stopped when you start on the next tablet chart.&nbsp;Some women still bleed after taking the first tablets on the new tablet chart.<\/p>\n\n\n\n<p>Start on the next tablet chart without interruption, in other words, the day after you finish the current tablet chart, even if the bleeding is still ongoing.\u00a0This means that you should start the following tablet\u00a0chart on the same day of the week as the current tablet chart, and that dropout bleeding should occur during the same days of the week in each month.<\/p>\n\n\n\n<p>If you use Qlaira in this way, you are protected against pregnancy even during the two days when you take inactive tablets.<\/p>\n\n\n\n<p><strong>When can you start with the first tablet map?<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em>If you have not used a hormonal contraceptive in the previous month<br><\/em>Start taking Qlaira on the first day of your menstrual cycle (ie the first day of your period).<\/li><li><em>Changing from another hormonal\u00a0oral contraceptive pill\u00a0or combination preparation in the form of\u00a0a vaginal ring\u00a0or contraceptive\u00a0patch<br><\/em>Start with Qlaira the day after you take the last active tablet (the last tablet containing the active substances) of your previous\u00a0oral contraceptive pill.\u00a0When changing from a combination preparation in the form of a\u00a0vaginal ring\u00a0or contraceptive\u00a0patch\u00a0, start with Qlaira on the day it is removed or follow your midwife&#8217;s \/ doctor&#8217;s advice.<\/li><li>Switching from the\u00a0progestogen\u00a0-only method ( mini-pills,\u00a0injection, IUD, or IUD)<br>You can change from\u00a0IUDs\u00a0(from an IUD or IUD on the day they are removed, from an injectable contraceptive the day after the next\u00a0injection\u00a0).\u00a0), but in all these cases you must use extra protection (eg condoms) during the first\u00a09 days\u00a0of using Qlaira.<\/li><li>After a miscarriage<br>Follow the midwife&#8217;s \/ doctor&#8217;s advice.<\/li><li>After delivery<br>You can start with Qlaira between\u00a021 and 28 days\u00a0after delivery.\u00a0If you start later than\u00a0day 28, you must use a so-called\u00a0barrier method\u00a0(eg condom) for the first\u00a09 days\u00a0of using Qlaira.<br>If you have had intercourse before using Qlaira again after giving birth, you must first check that you are not pregnant or wait until the next period.<br>If you are breastfeeding and want to start taking Qlaira again after having children, read the section &#8220;Pregnancy and breast-feeding&#8221;.<\/li><\/ul>\n\n\n\n<p>Ask your midwife\/doctor what to do if you are unsure when to start.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Qlaira than you should<\/h2>\n\n\n\n<p>There are no reports of serious adverse effects due to taking too many Qlaira tablets.<\/p>\n\n\n\n<p>If you take several active tablets at the same time, you may feel sick or vomit.&nbsp;Young girls may experience vaginal bleeding.<\/p>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0If a child has ingested the medicine by mistake, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Qlaira<\/h2>\n\n\n\n<p><strong>Inactive tablets:<\/strong>\u00a0If you forget to take a white tablet (the two tablets last on the tablet map), you do not need to take them later as they do not contain any active substances.\u00a0However, you must discard the white tablet (s) you forgot to take so that the number of days you take inactive tablets does not increase, as this would increase the risk of pregnancy.\u00a0Take the next tablet at the usual time.<\/p>\n\n\n\n<p><strong>Active tablets:<\/strong>\u00a0Depending on the day of the cycle that you forgot to take\u00a0<strong>an<\/strong>\u00a0active tablet, you may need to use\u00a0<strong>extra protection<\/strong>, e.g.\u00a0a\u00a0barrier method\u00a0such as a condom.\u00a0<strong>Take the tablets according to the following principles: See also the diagram\u00a0<u>&#8220;forgotten tablets&#8221;<\/u>\u00a0for more information.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If\u00a0<strong>less than 12 hours<\/strong>\u00a0have passed since the tablet was taken, pregnancy protection is not reduced.\u00a0Take the tablet as soon as you remember and then continue to take the tablets again at the usual time.<\/li><li>If it has been\u00a0more than 12 hours\u00a0since the tablet was taken, the pregnancy protection may be reduced.\u00a0Depending on the day on the bike you forgot a tablet use extra protection, e.g.\u00a0a\u00a0barrier method\u00a0such as a condom.\u00a0See also the diagram\u00a0&#8220;forgotten tablets&#8221;\u00a0for more information.<\/li><li>More than one tablet forgotten in the tablet map<br>Contact your midwife\/doctor.<br><strong>Do not take more than two active tablets in one day.<\/strong><\/li><\/ul>\n\n\n\n<p>If you have forgotten to start a new tablet chart or if you have forgotten one or more tablets during\u00a0<strong>days 3-9<\/strong>\u00a0in the tablet chart, there is a risk that you are already pregnant (if you have had intercourse during the 7 days before you forgot the tablet) .\u00a0In this case, contact your midwife\/doctor.\u00a0The more tablets you have forgotten (especially\u00a0days<strong> 3-24<\/strong>\u00a0) and the closer they are to the inactive tablet phase (the two white tablets), the greater the risk that the protection against pregnancy is reduced.\u00a0<strong>See also the diagram\u00a0<u>&#8220;forgotten tablets&#8221;<\/u>\u00a0for more information.<\/strong><\/p>\n\n\n\n<p>If you have forgotten any of the active tablets in a tablet chart and you do not experience any bleeding at the end of the tablet chart, you may be pregnant.\u00a0You must then contact the midwife\/doctor before starting on the next tablet chart.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20071129000015#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Bayer20AB202c20Division20Consumer20Care\/Media\/Qlaira\/Qlaira20JPEG.jpg\" alt=\"The &quot;forgotten tablets&quot; chart\" title=\"The &quot;forgotten tablets&quot; chart\"\/><\/a><\/figure>\n\n\n\n<p><strong>Use in children<\/strong><\/p>\n\n\n\n<p>There is no experience from children under 18 years.<\/p>\n\n\n\n<p><strong>What to do if you vomit or have severe diarrhea<\/strong><\/p>\n\n\n\n<p>If you vomit within 3-4 hours after taking an active tablet, or if you have severe diarrhea, there is a risk that the active substances in the contraceptive pill will not be completely absorbed by the body.<\/p>\n\n\n\n<p>It&#8217;s almost the same as forgetting a tablet.\u00a0After vomiting or diarrhea, you must take a new tablet as soon as possible.\u00a0Take it if possible within 12 hours from the time you normally take your\u00a0pill.\u00a0If this is not possible or if 12 hours have already passed, you should follow the advice under\u00a0<em>&#8221;\u00a0<\/em><strong>If you forget to take Qlaira\u00a0<\/strong><em>&#8220;<\/em>\u00a0.<br>If you do not want to change your normal tablet intake, take the corresponding tablet from another tablet chart.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Qlaira<\/h2>\n\n\n\n<p>You can stop taking Qlaira whenever you want.\u00a0If you do not want to get pregnant, consult your midwife\/doctor about other reliable methods of contraception.\u00a0If you want to get pregnant, stop taking Qlaira and wait for your period before trying to conceive.\u00a0You will then be able to more easily calculate the expected date of birth.<\/p>\n\n\n\n<p><em>If you have any further questions on the use of this product, ask your midwife\/doctor, or pharmacist.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Qlaira can cause\u00a0side effects, although not everybody gets them.\u00a0If you get any\u00a0side effects\u00a0, especially if they are serious or persistent, or if your health changes and you think it may be due to Qlaira, talk to your doctor.<\/p>\n\n\n\n<p>As with all women taking combined hormonal contraceptives, there is an increased risk of blood clots in your veins (venous\u00a0thromboembolism\u00a0, VTE) or blood clots in your\u00a0arteries\u00a0(\u00a0arterial\u00a0thrombosis, ATE).\u00a0For more information on the different risks of taking combined hormonal contraceptives, see section 2 &#8220;What you need to know before taking Qlaira&#8221;.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Serious&nbsp;side effects&nbsp;associated with the use of&nbsp;birth control pills&nbsp;and related symptoms are described in the following sections: &#8221;&nbsp;<strong>Blood clots<\/strong>&nbsp;&#8221; and &#8221;&nbsp;<strong>Qlaira and cancer<\/strong>&nbsp;&#8220;.&nbsp;Read these sections carefully and contact your doctor immediately if necessary.<\/p>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been linked using Qlaira:<\/p>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(<\/strong>&nbsp;between 1 and 10 in 100 people may be affected):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>abdominal pain, nausea<\/li><li>acne<\/li><li>missed menstruation, discomfort in the breasts, painful menstruation, irregular bleeding, (abundant irregular bleeding)<\/li><li>weight gain<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(<\/strong>&nbsp;between 1 and 10 users in 1,000 may be affected):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fungal infections, fungal infection of the abdomen,\u00a0vaginal\u00a0infection<\/li><li>increased appetite<\/li><li>depression, depression, emotional disturbances, sleep problems, decreased sex drive, mental imbalance, mood swings<\/li><li>dizziness,\u00a0migraine<\/li><li>hot flashes, high\u00a0blood pressure<\/li><li>diarrhea, vomiting<\/li><li>increased liver enzymes<\/li><li>hair loss, heavy sweating (\u00a0hyperhidrosis\u00a0),\u00a0itching, rash<\/li><li>muscle cramps<\/li><li>swollen breasts, lumps in the breasts, abnormal cell growth in the cervix (cervical dysplasia), abnormal genital bleeding, pain during intercourse, fibrocystic breast disease, heavy menstruation, menstrual disorders, ovarian cysts, pelvic pain, premenstrual syndrome , uterus \/ vaginal bleeding incl splashing, vaginal discharge, dryness of the abdomen<\/li><li>fatigue, irritation, swelling of parts of the body e.g.\u00a0ankles (\u00a0edema\u00a0)<\/li><li>weight loss, changes in blood pressure.<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;(<\/strong>&nbsp;between 1 and 10 users in 10,000 may be affected):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>candida infection, oral herpes,\u00a0inflammation\u00a0of the pelvis, a vascular disease of the eye similar to fungal infection (suspected\u00a0ocular\u00a0histoplasmosis\u00a0), a fungal infection of the skin (\u00a0tinea\u00a0versicolor), urinary tract infection, bacterial\u00a0inflammation\u00a0of the vagina<\/li><li>fluid accumulation in the body, increase in certain blood fats (\u00a0triglycerides\u00a0)<\/li><li>aggression, anxiety, feeling unwell, increased interest in sex, nervousness, nightmares, restlessness, difficulty sleeping, stress<\/li><li>decreased attention, tingling sensation, dizziness<\/li><li>intolerance to contact lenses, dry eyes, swollen eyes<\/li><li>heart attack, palpitations<\/li><li>bleeding varicose veins, low\u00a0blood pressure,\u00a0inflammation\u00a0of superficial veins, pain in the veins<\/li><li>dangerous blood clots in a vein or\u00a0artery, eg:<ul><li>in one leg or foot (ie DVT)<\/li><li>in the lungs<\/li><li>myocardial infarction<\/li><li>stroke<\/li><li>mini-stroke\u00a0or transient stroke-like symptoms, called\u00a0transient\u00a0ischemic attack (\u00a0TIA\u00a0)<\/li><li>blood clots in the liver, stomach\/intestines, kidneys, or eyes. The risk of developing a blood clot may be higher if you have other conditions that increase this risk (see section 2 for more information on the conditions that increase the risk of blood clots and the symptoms of a blood clot).<\/li><\/ul><\/li><li>constipation,\u00a0dry mouth, indigestion, heartburn<\/li><li>hepatic nodules (focal\u00a0nodular\u00a0hyperplasia\u00a0),\u00a0chronic\u00a0inflammation\u00a0of the gallbladder<\/li><li>allergic skin reactions, golden-brown pigment spots (chloasma) and other pigment changes, male hair, increased hair growth, skin conditions such as\u00a0dermatitis\u00a0and neurodermatitis, dandruff and oily skin (\u00a0seborrhea\u00a0) and other skin conditions<\/li><li>back pain, pain in the jaw, a feeling of heaviness<\/li><li>pain in the urinary tract<\/li><li>abnormal ejaculation bleeding benign breast lumps, early stage of breast cancer, breast cysts,\u00a0secretion\u00a0from the breasts,\u00a0a polyp\u00a0on the cervix,\u00a0redness\u00a0of the cervix, bleeding during intercourse, the flow of breast milk in women who are not breastfeeding, bleeding from the abdomen, light menstruation, breastfeeding, delayed menstruation, bad smell from the genitals, burning sensation in the genitals, discomfort in the genitals<\/li><li>swollen\u00a0lymph nodes<\/li><li>asthma, difficulty breathing, nosebleeds<\/li><li>chest pain, fatigue and general malaise, fever<\/li><li>abnormal cell sample from the cervix.<\/li><\/ul>\n\n\n\n<p>Further information (taken from the diaries written by women during a&nbsp;clinical study&nbsp;with Qlaira) on the possible&nbsp;side effects&nbsp;of &#8220;irregular bleeding (heavy irregular bleeding)&#8221; and &#8220;missed periods&#8221; can be found in the sections &#8221;&nbsp;<strong>Intermittent bleeding<\/strong>&nbsp;&#8221; and &#8221;&nbsp;<strong>What to do if you do not may have any bleeding on day 26 or the following day (s)<\/strong>&nbsp;&#8216;.<\/p>\n\n\n\n<p><br><strong>Description of selected&nbsp;adverse&nbsp;reactions<\/strong><\/p>\n\n\n\n<p>Listed below are&nbsp;side effects&nbsp;with very low incidence or with delayed onset of symptoms that are considered to be associated with the group of combined&nbsp;contraceptive pills&nbsp;and may also occur during treatment with Qlaira (see also section &#8220;Do not use Qlaira&#8221;, &#8220;Warnings and precautions&#8221;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver tumors (both malignant and benign)<\/li><li>Erythema nodosum (sore red bumps under the skin), Erythema multiforme (skin rash with red spots or sores)<\/li><li>hypersensitivity (including symptoms such as rash,&nbsp;urticaria&nbsp;)<\/li><li>in women with hereditary&nbsp;angioedema&nbsp;(characterized by sudden swelling of eg eyes, mouth, throat, etc.),&nbsp;estrogen&nbsp;in combined&nbsp;contraceptive pills&nbsp;can cause or worsen the symptoms of&nbsp;angioedema<\/li><\/ul>\n\n\n\n<p>In case of impaired liver function, it may be necessary to temporarily discontinue the use of combined&nbsp;oral contraceptives&nbsp;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Qlaira<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><strong>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substances are estradiol valerate or estradiol valerate in combination with dienogest.<\/p>\n\n\n\n<p>Each tablet map (28 film-coated tablets) with Qlaira contains 26 active tablets in four different colors on rows 1, 2, 3 and 4 and two white inactive tablets on rows 4.<\/p>\n\n\n\n<p><em>Composition of the colored tablets containing one or two active substances:<\/em><\/p>\n\n\n\n<p>2 dark yellow tablets each containing 3 mg estradiol valerate<br>5 red tablets each containing 2 mg estradiol valerate and 2 mg dienogest<br>17 light yellow tablets each containing 2 mg estradiol valerate and 3 mg dienogest<br>2 dark red tablets each containing 1 mg estradiol valerate<\/p>\n\n\n\n<p><em>Composition of the white inactive tablets:<\/em><\/p>\n\n\n\n<p>These tablets do not contain any active substances.<\/p>\n\n\n\n<p><em>The other ingredients in the colored active tablets are:<\/em><\/p>\n\n\n\n<p><em>Tablet core:\u00a0<\/em>lactose monohydrate, maize starch, pregelatinized maize starch, povidone K25 (E1201), magnesium stearate (E572)<\/p>\n\n\n\n<p><em>Tablet coating:<\/em>&nbsp;hypromellose type 2910 (E464), macrogol 6000, talc (E553b), titanium dioxide (E171), yellow iron oxide (E172) and \/ or red iron oxide (E172)<\/p>\n\n\n\n<p><em>The other ingredients in the white inactive tablets are:<\/em><\/p>\n\n\n\n<p><em>Tablet core:\u00a0<\/em>lactose monohydrate, corn starch, povidone K25 (E1201), magnesium stearate (E572)<\/p>\n\n\n\n<p><em>Tablet coating:<\/em>&nbsp;hypromellose type 2910 (E464), talc (E553b), titanium dioxide (E171)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Qlaira looks like and the contents of the package<\/h2>\n\n\n\n<p>The Qlaira tablets are film-coated;&nbsp;the core of the tablet is covered by an outer layer.<\/p>\n\n\n\n<p>Each tablet (28 film-coated tablets) contains 2 dark yellow tablets on row 1, 5 red tablets on row 1, 17 light yellow tablets on rows 2, 3, and 4, and 2 dark red, and 2 white tablets on row 4.<\/p>\n\n\n\n<p>The dark yellow active tablet is round with biconvex surfaces, on one side marked with the letters DD in an equilateral hexagon.<\/p>\n\n\n\n<p>The red active tablet is round with biconvex surfaces, on one side marked with the letters DJ in an equilateral hexagon.<\/p>\n\n\n\n<p>The light yellow active tablet is round with biconvex surfaces, on one side marked with the letters DH in an equilateral hexagon.<\/p>\n\n\n\n<p>The dark red active tablet is round with biconvex surfaces, on one side marked with the letters DN in an equilateral hexagon.<\/p>\n\n\n\n<p>The white inactive tablet is round with biconvex surfaces, on one side marked with the letters DT in an equilateral hexagon.<\/p>\n\n\n\n<p>Qlaira is available in packs of 1, 3, or 6 tablets, and each tablet contains 28 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Bayer Weimar GmbH and Co.&nbsp;KG99427 Weimar<br>Germany<\/td><td>and<\/td><td>Bayer AG13342 Berlin<br>Germany<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>This medicinal product is authorized in the European Economic Area and the United Kingdom (Northern Ireland) under the names:<\/strong><\/p>\n\n\n\n<p>\u2022 Austria, Belgium, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, United Kingdom (Northern Ireland):\u00a0<strong>QLAIRA \/ Qlaira<\/strong><\/p>\n\n\n\n<p>\u2022 Italy:&nbsp;<strong>KLAIRA<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>film-coated tablets<br \/>\nestradiol valerate \/ dienogest<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18528],"tags":[4220,5635,5406,5409,22146,22149,22150,21858,5407,22147,22148],"class_list":["post-21482","post","type-post","status-publish","format-standard","hentry","category-medicines","category-q","tag-dienogest","tag-dienogest-tablet","tag-estradiol-valerate","tag-estradiol-valerate-tablet","tag-qlaira","tag-qlaira-tablet","tag-what-dienogest-is-used-for","tag-what-estradiol-valerate-is-used-for","tag-what-is-estradiol-valerate","tag-what-is-qlaira","tag-what-qlaira-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21482"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21482\/revisions"}],"predecessor-version":[{"id":21505,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21482\/revisions\/21505"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21482"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}