150 IU \/ 0.18 ml, 300 IU 0.36 ml, 600 IU \/ 0.72 ml, 900 IU \/ 1.08 ml solution for injection follitropin beta<\/p>\n\n\n\n
Puregon 300 IU \/ 0.36 ml solution for injection contains follitropin beta, a hormone called follicle-stimulating hormone ( FSH ).<\/p>\n\n\n\n
FSH belongs to the group of gonadotropins that play an important role in human fertility and reproduction. In women, FSH is needed for the growth and development of follicles in the ovaries. Follicles are small round sacs that contain egg cells. In men, FSH is needed for the production of sperm.<\/p>\n\n\n\n
Puregon is used to treat infertility in the following situations:<\/p>\n\n\n\n
Women<\/strong><\/p>\n\n\n\n In women who are not ovulating and who are not responding to treatment with clomiphene citrate, Puregon can be used to induce ovulation.<\/p>\n\n\n\n In women undergoing assisted reproduction, such as\u00a0in-vitro\u00a0fertilization (IVF) and other methods, Puregon may cause more\u00a0follicles\u00a0to develop.<\/p>\n\n\n\n Men<\/strong><\/p>\n\n\n\n In men who are infertile due to decreased hormone levels, Puregon can be used to produce sperm.<\/p>\n\n\n\n If you:<\/strong><\/p>\n\n\n\n Talk to your doctor before using Puregon if you<\/p>\n\n\n\n If you are a woman:<\/em><\/p>\n\n\n\n Ovarian overstimulation syndrome (OHSS)<\/strong><\/em><\/p>\n\n\n\n Your doctor will monitor the effectiveness of your treatment regularly to be able to choose the right\u00a0dose\u00a0of Puregon from day today.\u00a0You will probably undergo regular ultrasound examinations of the ovaries.\u00a0Your doctor can also check your hormone levels in the blood.\u00a0This is very important because an\u00a0overdose of\u00a0FSH\u00a0can cause serious but unusual complications, due to overstimulated ovaries and the growth of\u00a0follicles. becomes larger than normal.\u00a0This serious medical condition is called ovarian hyperstimulation syndrome (OHSS).\u00a0In rare cases, severe OHSS can be life-threatening.\u00a0OHSS causes a sudden accumulation of fluid in the abdomen and chest cavity and can cause the formation of blood clots.\u00a0Contact your doctor immediately if you experience severe abdominal pain, abdominal pain, nausea, vomiting, sudden weight gain due to fluid retention, diarrhea, decreased urine output, or difficulty breathing (see also section 4, Possible\u00a0side effects\u00a0).<\/p>\n\n\n\n \u2192 Regular monitoring of the response to\u00a0FSH\u00a0treatment helps prevent overstimulation.\u00a0Contact your doctor immediately if you get abdominal pain, even if they occur a few days after the last\u00a0injection.<\/p>\n\n\n\n Multiple births or congenital anomalies<\/strong><\/em><\/p>\n\n\n\n After treatment with gonadotropin preparations, there is an increased risk of multiple births even when only one embryo is inserted into the uterus. Multiple pregnancies entail an increased health risk at birth for both the mother and her children. In addition, multiple pregnancies and characteristics of the patients undergoing fertility treatment (eg woman’s age, characteristics of the sperm, genetic background of both parents) may be associated with an increased risk of congenital anomalies.<\/p>\n\n\n\n Pregnancy complications<\/em><\/strong><\/p>\n\n\n\n There is a slightly increased risk of an ectopic pregnancy (ectopic pregnancy). Your doctor should therefore perform an early ultrasound examination to rule out the risk of ectopic pregnancy.<\/p>\n\n\n\n Women undergoing fertility treatment have a slightly increased risk of miscarriage.<\/p>\n\n\n\n Blood clot ( thrombosis )<\/em><\/strong><\/p>\n\n\n\n Treatment with Puregon, as well as the pregnancy itself, may increase the risk of blood clots ( thrombosis ). Thrombosis is the formation of a blood clot in a blood vessel.<\/p>\n\n\n\n Blood clots can lead to serious medical conditions, such as:<\/p>\n\n\n\n Discuss this with your doctor before starting treatment, especially:<\/p>\n\n\n\n Ovarian torsion<\/strong><\/em><\/p>\n\n\n\n Ovarian torsion has occurred after treatment with gonadotropins including Puregon. Ovarian torsion is a twisting of an ovary. Twisting of the ovaries can cause the blood flow to the ovary to stop.<\/p>\n\n\n\n Before you start taking this medicine, tell your doctor if you:<\/p>\n\n\n\n Tumors are in the ovaries and other parts of the reproductive system<\/strong><\/em><\/p>\n\n\n\n There have been reports of tumors in the ovaries and other parts of the reproductive system in women who have undergone fertility treatment. It is not known whether treatment with fertility drugs increases the risk of these tumors in infertile women.<\/p>\n\n\n\n Other medical conditions<\/strong><\/em><\/p>\n\n\n\n Before you start taking this medicine, also tell your doctor if you:<\/p>\n\n\n\n If you are a man:<\/em><\/p>\n\n\n\n Men with elevated levels of FSH in their blood<\/strong><\/em><\/p>\n\n\n\n Elevated levels of FSH in the blood are a sign of damage to the testicles. Puregon is generally not effective in such cases. To check the effect of the treatment, your doctor may ask you for a semen sample to be analyzed 4 to 6 months after starting the treatment.<\/p>\n\n\n\n There is no relevant use of Puregon for children and adolescents.<\/p>\n\n\n\n Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n If Puregon is used in combination with clomiphene citrate, you can get an increased effect of Puregon. If a GnRH agonist (a medicine used to prevent premature ovulation) has been used, a higher dose of Puregon may be needed.<\/p>\n\n\n\n Ask your doctor or pharmacist for advice before taking any medicine. You should not use Puregon if you are already pregnant or if you think you may be pregnant.<\/p>\n\n\n\n Puregon can affect milk production. Puregon is unlikely to pass into breast milk.<\/p>\n\n\n\n If you are breastfeeding, talk to your doctor before using Puregon.<\/p>\n\n\n\n Puregon is unlikely to affect your ability to drive or use machines.<\/p>\n\n\n\n This medicine contains 10 mg of benzyl alcohol per ml.<\/p>\n\n\n\n Benzyl alcohol can cause allergic reactions.<\/p>\n\n\n\n If you have liver or kidney problems, talk to your doctor or pharmacist before taking this medicine. Large amounts of benzyl alcohol can be stored in the body and cause side effects (metabolic acidosis ).<\/p>\n\n\n\n If you are pregnant or breastfeeding, talk to your doctor or pharmacist before taking this medicine.\u00a0Large amounts of benzyl alcohol can be stored in the body and cause\u00a0side effects\u00a0(metabolic\u00a0acidosis\u00a0).<\/p>\n\n\n\n Puregon contains sodium<\/strong><\/p>\n\n\n\n This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per\u00a0injection, ie essentially ‘sodium-free’.<\/p>\n\n\n\n Always use this medicine exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n Dosage for women<\/strong><\/p>\n\n\n\n Your doctor will determine your starting dose. This dose can be adjusted during treatment. Further details on the treatment schedule are given below.<\/p>\n\n\n\n There are significant differences between different women in the response to\u00a0FSH\u00a0from the ovaries, which makes it impossible to provide a dosing schedule that suits all patients.\u00a0To find the right\u00a0dose, your doctor will check the growth of\u00a0follicles\u00a0with ultrasound examination and measurement of estradiol (female sex hormone) in the blood.<\/p>\n\n\n\n Your doctor will decide on a starting dose.\u00a0This\u00a0dose\u00a0is maintained for at least seven days.\u00a0If you have no response from the ovaries, increase the daily\u00a0dose\u00a0gradually until the growth of\u00a0follicles\u00a0and\/or the levels of estradiol in the blood show that you have the desired effect.\u00a0The daily\u00a0dose\u00a0is maintained until you have a\u00a0follicle\u00a0of the right size.\u00a0Usually, 7 to 14 days of treatment is enough.\u00a0Then the treatment with Puregon is stopped and ovulation will be started by giving chorionic gonadotropin (\u00a0hCG\u00a0).<\/p>\n\n\n\n A starting dose is determined by your doctor.\u00a0This\u00a0dose\u00a0is maintained for at least the first four days.\u00a0After that, your\u00a0dose\u00a0is adjusted based on the response from your ovaries.\u00a0When you have the desired number of\u00a0follicles\u00a0of the right size, the last maturation phase of the follicles is started by giving\u00a0hCG.\u00a0Egg picking can begin 34-35 hours later.<\/p>\n\n\n\n Dosage for men<\/strong><\/p>\n\n\n\n Puregon is usually given in a dose of 450 IU per week, usually in 3 doses of 150 IU, in combination with another hormone ( hCG ) for at least 3 to 4 months. The treatment period corresponds to the time it takes for sperm to form and the time during which an improvement can be expected. If your sperm production has not started within this period, your treatment may need to last for at least 18 months.<\/p>\n\n\n\n How the injections are given<\/strong><\/p>\n\n\n\n Puregon solution for injection in a cartridge has been developed for use in the Puregon Pen. The separate instructions for how to use the pen must be followed carefully. Do not use a cartridge if the solution contains particles or if the solution is not clear.<\/p>\n\n\n\n When using the pen, the injections can be given just under the skin (eg in the lower abdomen) by yourself or your partner. Your doctor will tell you when and how to proceed. If you inject yourself with Puregon, follow the instructions carefully so that Puregon is given correctly and with the least possible discomfort.<\/p>\n\n\n\n The first dose of Puregondo should only be given in the presence of a doctor or nurse.<\/p>\n\n\n\n Talk to your doctor immediately.<\/p>\n\n\n\n Too high a\u00a0dose\u00a0of Puregon may cause ovarian hyperstimulation (OHSS).\u00a0It can be felt as abdominal pain.\u00a0If you get abdominal pain, tell your doctor immediately.\u00a0See also section 4, Possible\u00a0side effects.<\/p>\n\n\n\n If you miss a\u00a0dose\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n \u2192 Contact your doctor.<\/p>\n\n\n\n If you have any further questions on the use of this product, ask your doctor.<\/p>\n\n\n\n Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n Serious side effects are in women<\/strong><\/p>\n\n\n\n A complication of\u00a0FSH\u00a0treatment is overstimulation of the ovaries.\u00a0Overstimulation of the ovaries can develop into a medical condition called\u00a0ovarian hyperstimulation syndrome (OHSS)<\/strong>, which can be a serious medical problem.\u00a0The risk can be reduced by careful monitoring of follicle development during treatment.\u00a0Your doctor will perform ultrasound examinations of the ovaries to closely monitor the number of maturing\u00a0follicles.\u00a0Your doctor may also check the hormone levels in your blood.\u00a0Abdominal pain, nausea, and diarrhea are the first symptoms.\u00a0In more severe cases, the symptoms can also be enlargement of the ovaries, accumulation of fluid in the abdomen and\/or thoracic cavity (which can cause sudden weight gain due to fluid accumulation), and the formation of blood clots in\u00a0vessels.\u00a0See Warnings and Precautions in Section 2.<\/p>\n\n\n\n \u2192 Contact your doctor immediately if you experience abdominal pain or any of the other symptoms of ovarian overstimulation, even if it occurs a few days after the last\u00a0injection.<\/p>\n\n\n\n If you are a woman:<\/em><\/p>\n\n\n\n Common side effects (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n Uncommon side effects (may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n Rare side effects (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n Ectopic pregnancy (ectopic pregnancy), miscarriage, and multiple births have also been reported.\u00a0These\u00a0side effects\u00a0are not considered related to the use of Puregon, but to assisted reproduction or subsequent pregnancy.<\/p>\n\n\n\n If you are a man:<\/em><\/p>\n\n\n\n Common side effects (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n Storage in pharmacies<\/strong><\/p>\n\n\n\n Store at 2 \u00b0 C – 8 \u00b0 C (in a refrigerator). Do not freeze.<\/p>\n\n\n\n Storage by patient<\/strong><\/p>\n\n\n\n There are two options:<\/p>\n\n\n\n Make a note of when you start storing the product outside the refrigerator.<\/p>\n\n\n\n Store cartridge one in the outer carton.<\/p>\n\n\n\n Once the needle has been pushed through the rubber insert of\u00a0the cartridge, the product is stable for 28 days.<\/p>\n\n\n\n Make a note of the first day of use for the\u00a0cartridge\u00a0on the notecard according to the Puregon Pen’s Instruction Manual.<\/p>\n\n\n\n Do not use this medicine after the expiry date which is stated on the label after \u201cEXP\u201d and the carton after \u201cEXP\u201d. The expiration date is the last day of the specified month.<\/p>\n\n\n\n Used needles should be discarded immediately after\u00a0injection.<\/p>\n\n\n\n Do not mix in any other medicines in cartridge one. Empty cartridges must not be refilled.<\/p>\n\n\n\n Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n Puregon solution for injection ( solution for injection ) is a clear, colorless liquid. It is available in glass cartridges. It is available in packs of a glass cartridge.<\/p>\n\n\n\n NV Organon<\/p>\n\n\n\n Kloosterstraat 6<\/p>\n\n\n\n 5349 AB Oss<\/p>\n\n\n\n Netherlands<\/p>\n\n\n\n Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n Puregon 300 IU \/ 0.36 ml solution for injection contains follitropin beta, a hormone called follicle-stimulating hormone ( FSH ).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[22045,22050,22041,22044,22046,22049,22043,22042,22047,22048],"class_list":["post-21431","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-follitropin-beta","tag-benefits-of-puregon","tag-follitropin-beta","tag-follitropin-beta-side-effects","tag-puregon","tag-puregon-side-effects","tag-what-follitropin-beta-is-used-for","tag-what-is-follitropin-beta","tag-what-is-puregon","tag-what-puregon-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21431","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21431"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21431\/revisions"}],"predecessor-version":[{"id":21454,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21431\/revisions\/21454"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21431"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21431"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21431"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}What you need to know before you use Puregon<\/h2>\n\n\n\n
Do not use Puregon<\/h2>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
Children and young people<\/h2>\n\n\n\n
Other medicines and Puregon<\/h2>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Puregon contains benzyl alcohol<\/h2>\n\n\n\n
How to use Puregon<\/h2>\n\n\n\n
If you use more Puregon than you should <\/h2>\n\n\n\n
If you forget to use Puregon<\/h2>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
How to store Puregon<\/h2>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Belgium \/ Belgique \/ Belgien<\/strong>Organon BelgiumPhone: 0080066550123 (+32 2 2418100)dpoc.benelux@organon.com<\/td> Lithuania<\/strong>Organon Pharma BV Lithuania atstovyb\u0117Tel .: +370 52041693dpoc.lithuania@organon.com<\/td><\/tr> Bulgaria<\/strong>ORGANON (USA) B.V. – clone of BulgariaTel: +359 2 806 3030dpoc.bulgaria@organon.com<\/td> Luxembourg \/ Luxemburg<\/strong>Organon BelgiumPhone: 0080066550123 (+32 2 2418100)dpoc.benelux@organon.com<\/td><\/tr> Czech Republic<\/strong>Organon Czech Republic sroTel: +420 233 010 300dpoc.czech@organon.com<\/td> Hungary<\/strong>Organon Hungary Kft.Tel .: +36 1 766 1963dpoc.hungary@organon.com<\/td><\/tr> Denmark<\/strong>Organon Denmark ApSTel: +45 4484 6800info.denmark@organon.com<\/td> Malta<\/strong>Organon Pharma BV, Cyprus branchTel: +356 2277 8116dpoc.cyprus@organon.com<\/td><\/tr> Germany<\/strong>Organon Healthcare GmbHTel .: 0800 3384 726 (+49 (0) 89 2040022 10)dpoc.germany@organon.com<\/td> The Netherlands<\/strong>NV OrganonTel: 00800 66550123(+32 2 2418100)dpoc.benelux@organon.com<\/td><\/tr> Eesti<\/strong>Organon Pharma BV Estonian ROTel: +372 66 61 300dpoc.estonia@organon.com<\/td> Norway<\/strong>Organon Norway ASTel: +47 24 14 56 60info.norway@organon.com<\/td><\/tr> Greece<\/strong>BIANE\u039e \u0391.\u0395.:\u0397\u03bb: +30 210 80091 11Mailbox@vianex.gr<\/td> Austria<\/strong>Organon Austria GmbHTel: +43 (0) 1 263 28 65medizin-austria@organon.com<\/td><\/tr> Spain<\/strong>Organon Salud, SLTel: +34 91 591 12 79organon_info@organon.com<\/td> Poland<\/strong>Organon Polska Sp. z ooTel .: +48 22 105 50 01organonpolska@organon.com<\/td><\/tr> France<\/strong>Organon FranceTel: +33 (0) 1 57 77 32 00<\/td> Portugal<\/strong>Organon Portugal, Sociedade Unipessoal Lda.Tel: +351 218705500geral_pt@organon.com<\/td><\/tr> Croatia<\/strong>Organon Pharma dooTel: +385 1 638 4530dpoc.croatia@organon.com<\/td> Romania<\/strong>Organon Biosciences SRLTel: +40 21 527 29 90info.romania@organon.com<\/td><\/tr> Ireland<\/strong>Organon Pharma (Ireland) LimitedTel: +353 15828260medinfo.ROI@organon.com<\/td> Slovenia<\/strong>Organon Pharma BV, Oss, Ljubljana CompanyTel: +386 1 300 10 80info.slovenia@organon.com<\/td><\/tr> Iceland<\/strong>Vistor hf.Phone: + 354 535 7000<\/td> Slovak Republic<\/strong>Organon Slovakia sroTel: +421 2 44 88 98 88dpoc.slovakia@organon.com<\/td><\/tr> Italy<\/strong>Organon Italia SrlTel: +39 06 3336407dpoc.italy@organon.com<\/td> Finland \/ Finland<\/strong>Organon Finland OyPuh \/ Tel: +358 (0) 29 170 3520dpoc.finland@organon.com<\/td><\/tr> .\u03a0\u03c1\u03bf\u03c2<\/strong>Organon Pharma BV, Cyprus branch:\u0397\u03bb: +357 22866730dpoc.cyprus@organon.com<\/td> Sweden<\/strong>Organon Sweden ABTel: +46 8 502 597 00dpoc.sweden@organon.com<\/td><\/tr> Latvia<\/strong>Komrvalsts komersanta \u201cOrganon Pharma BV\u201d p\u0101rst\u0101vniec\u012bbaTel: +371 66968876dpoc.latvia@organon.com<\/td> United Kingdom (Northern Ireland)<\/strong>Organon Pharma (Ireland) LimitedTel: +353 15828260medinfo.ROI@organon.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"