{"id":21429,"date":"2022-05-23T07:04:56","date_gmt":"2022-05-23T07:04:56","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21429"},"modified":"2022-05-23T14:59:58","modified_gmt":"2022-05-23T14:59:58","slug":"pulmozyme","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/pulmozyme\/","title":{"rendered":"Pulmozyme &#8211; Alfa uses, dose and side effects"},"content":{"rendered":"\n<p>1 mg \/ ml (2,500 U \/ 2.5 ml)&nbsp;solution for&nbsp;the alpha of the nebulizer&nbsp;thorns<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Pulmozyme is and what it is used for<\/h2>\n\n\n\n<p>Pulmozyme contains the alpha active ingredient alpha.&nbsp;It is a manufactured version of a&nbsp;protein&nbsp;that is found in your body and is called DNase.<\/p>\n\n\n\n<p>Pulmozyme is used in patients with\u00a0cystic fibrosis.\u00a0It works by dissolving the thick mucus present in the lungs.\u00a0This helps the lungs of patients with\u00a0cystic fibrosis\u00a0to function better.<\/p>\n\n\n\n<p>Pulmozyme is inhaled (inhaled) with something called a&nbsp;nebulizer&nbsp;(see section 3: How to use Pulmozyme).&nbsp;You will usually continue to take your other medicines for&nbsp;cystic fibrosis&nbsp;while taking Pulmozyme (see \u201cOther medicines and Pulmozyme\u201d in section 2).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Pulmozyme<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Pulmozyme<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic (hypersensitive) to the alpha of thorns or any of the other ingredients of Pulmozyme (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Pulmozyme.<\/p>\n\n\n\n<p><strong>Children<\/strong><\/p>\n\n\n\n<p><strong>Pulmozyme is not recommended for children under 5 years of age.&nbsp;<\/strong>Talk to your doctor or pharmacist before using Pulmozyme if it has been prescribed for a child under 5 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Pulmozyme<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription and natural remedies.\u00a0This is because Pulmozyme may affect the effectiveness of other medicines.\u00a0In addition, other medicines may affect the way Pulmozyme works.<\/p>\n\n\n\n<p>You can continue to take your other common medicines for\u00a0cystic fibrosis\u00a0while taking Pulmozyme (for example,\u00a0antibiotics, pancreatic enzymes, bronchodilators, and painkillers).\u00a0If you are not sure before using Pulmozyme, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Do not use Pulmozyme if you are pregnant, trying to conceive, or breastfeeding, unless your doctor tells you to.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Pulmozyme is unlikely to affect your ability to drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Pulmozyme<\/h2>\n\n\n\n<p>Always use Pulmozyme exactly as your doctor has told you.&nbsp;Pulmozyme is inhaled (inhaled) using a&nbsp;nebulizer&nbsp;(see &#8220;Which&nbsp;nebulizer&nbsp;to use&#8221;).&nbsp;Consult a doctor if you are unsure.<\/p>\n\n\n\n<p>During the Pulmozyme treatment, you should continue with your standard treatment with breathing exercises.<\/p>\n\n\n\n<p><strong>People who are 5 years or older<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You should use Pulmozyme\u00a0<strong>every day.<\/strong><\/li><li>The recommended\u00a0dose\u00a0is one\u00a0ampoule\u00a0each day, inhaled using your\u00a0nebulizer.<\/li><li>If you are over 21 years old, your doctor may tell you to take one\u00a0ampoule\u00a0twice a day.<\/li><\/ul>\n\n\n\n<p><strong>Persons under 5 years<\/strong><\/p>\n\n\n\n<p>Pulmozyme is not recommended for children under 5 years of age.<\/p>\n\n\n\n<p><strong>Which&nbsp;nebulizer&nbsp;to use<\/strong><\/p>\n\n\n\n<p>Use a&nbsp;nebulizer&nbsp;such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hudson T Up-draft II \/ Pulmo-Aide, Airlife Misty \/ Pulmo-Aide, custom-made Respirgard \/ Pulmo-Aide, or AcornII \/ Pulmo-Aide.<\/li><li>Pulmozyme can also be used with a reusable nebulization system such as Pari LL \/ Inhailerboy, Pari LC \/ Inhailerboy, or Master.\u00a0Aiolos \/ 2 Aiolos, Side Stream \/ CR50 or MobilAire or\u00a0Porta\u00a0-Neb.<\/li><li>Part eFlow Rapid\u00a0nebulizer, a general electronic\u00a0nebulizer\u00a0with a vibrating\u00a0diaphragm\u00a0can be used.\u00a0Part eFlow Rapid\u00a0nebulizer\u00a0should be cleaned according to the manufacturer&#8217;s instructions.\u00a0In addition, it is recommended that the Pari Easycare cleaning additive be used after every seventh use.<\/li><li><strong>Ultrasonic nebulizers should not be used<\/strong>\u00a0as they may prevent Pulmozyme from working properly.<\/li><\/ul>\n\n\n\n<p>Carefully read and follow the manufacturer&#8217;s instructions for using each\u00a0nebulizer.\u00a0Talk to your doctor who can tell you which\u00a0nebulizer\u00a0can be used with Pulmozyme.<\/p>\n\n\n\n<p><strong>How to use Pulmozyme with the nebulizer<\/strong><\/p>\n\n\n\n<p>When preparing the nebulizer for use with Pulmozyme, keep&nbsp;<strong>these important points in mind<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not mix Pulmozyme with other liquids or medicines in the nebulizer.<\/li><li>Do not use leftover Pulmozyme, this should always be discarded.<\/li><li>If you have a reusable\u00a0nebulizer, remember to clean it after use.\u00a0The manufacturer of the nebulizer can advise on the best way to clean the nebulizer after using Pulmozyme.<\/li><li>If anyone else uses your Pulmozyme accidentally, they should contact a doctor immediately.<\/li><\/ul>\n\n\n\n<p><strong>Using your&nbsp;nebulizer<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Make sure the nebulizer is clean.<\/li><li>Break off the top of a Pulmozyme ampoule.<\/li><li>Pour the contents into the nebulizer chamber.<\/li><li>Follow the nebulizer instructions and inhale Pulmozyme at once.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Pulmozyme than you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0a child ingested the medicine accidentally contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<p><strong>If you forget to use Pulmozyme<\/strong><\/p>\n\n\n\n<p>\u2022 If you forget to take a\u00a0dose, take it as soon as you remember.<\/p>\n\n\n\n<p>\u2022 If it is soon time for your next\u00a0dose, do not take the missed dose.<\/p>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<p><strong>If you stop using Pulmozyme<\/strong><\/p>\n\n\n\n<p>If you stop using Pulmozyme, your chest symptoms may get worse.&nbsp;Talk to your doctor if you would like to stop using Pulmozyme.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Pulmozyme can cause\u00a0side effects, although not everybody gets them.\u00a0Pulmozyme\u00a0side effects are uncommon.\u00a0They occur in less than 1 in 1000 users.<\/p>\n\n\n\n<p>Side effects&nbsp;include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Chest pain.<\/li><li>Fever.<\/li><li>Anxious stomach (indigestion).<\/li><li>Changes in the voice, including hoarseness or loss of voice.<\/li><li>Sore throat.<\/li><li>Difficulty breathing.<\/li><li>Runny or stuffy nose and sneezing (&nbsp;rhinitis&nbsp;).<\/li><li>Irritation of the eye (&nbsp;conjunctivitis&nbsp;).&nbsp;Symptoms include red and itchy eyes and discharge from the eye.<\/li><li>Skin rash, which may be uneven and itchy (&nbsp;hives&nbsp;).<\/li><li>When you start treatment, your lung function may deteriorate and you may form more mucus than normal.&nbsp;This effect is usually transient.<\/li><\/ul>\n\n\n\n<p>If any of the&nbsp;side effects&nbsp;gets serious, or if you notice any&nbsp;side effects&nbsp;not listed in this leaflet, please tell your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Pulmozyme<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The Pulmozyme ampoules should be stored in a refrigerator (2\u00baC -8\u00baC) in the original carton.\u00a0Sensitive to light.<\/li><li>You can still use an\u00a0ampoule\u00a0if it has been left outside the refrigerator for a short time at a higher temperature (only stored outside the refrigerator once and for a maximum of 24 hours at a maximum of 30\u00baC).<\/li><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the carton after EXP.\u00a0The expiration date is the last day of the specified month.<\/li><li>Do not dispose of leftover\u00a0ampoules\u00a0in drains or household waste.\u00a0Ask your pharmacist how to dispose of medicines no longer required.\u00a0These measures will help to protect the environment.\u00a0Keep them only if your doctor tells you to.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Content declaration<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance of Pulmozyme 1 mg\/ml (2,500 U \/ 2.5 ml),\u00a0nebulizer\u00a0solution is the alpha of the thorns.\u00a0This is also called\u00a0recombinant\u00a0human deoxyribonuclease I or rhDNase.\u00a02.5 ml solution contains 2500 units (or 2.5 mg) of alpha thorns.<\/li><li>The other ingredients are sodium chloride, calcium chloride dihydrate, and water for injections.<\/li><\/ul>\n\n\n\n<p><strong>What Pulmozyme Nebulizer Solution looks like and what <\/strong>contents of the pack<br>Pulmozyme solution for\u00a0nebulizer\u00a0is supplied in\u00a0clear plastic ampoules.\u00a0The ampoules\u00a0contain 2.5 ml of liquid.\u00a0The drug is clear and colorless to slightly yellowish.<\/p>\n\n\n\n<p>Pulmozyme is available in cartons containing 6 or 30\u00a0ampoules.\u00a0Not all pack sizes may be marketed.<\/p>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Roche AB<br>Box 1228<\/p>\n\n\n\n<p>171 23 Solna<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Roche Pharma AG<\/p>\n\n\n\n<p>Emil-Barell-Strasse 1<\/p>\n\n\n\n<p>79639 Grenzach-Wyhlen<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pulmozyme contains the alpha active ingredient alpha. It is a manufactured version of a protein that is found in your body and is called DNase.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[22053,22056,22061,22057,22063,22062,22060,22055,22054,22058,22059],"class_list":["post-21429","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-alfa","tag-alfa-nebulizer","tag-benefits-of-pulmozyme","tag-pulmozyme","tag-pulmozyme-dosage","tag-pulmozyme-nebulizer","tag-pulmozyme-side-effects","tag-what-alfa-is-used-for","tag-what-is-alfa","tag-what-is-pulmozyme","tag-what-pulmozyme-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21429","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21429"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21429\/revisions"}],"predecessor-version":[{"id":21455,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21429\/revisions\/21455"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21429"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21429"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21429"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}