{"id":21414,"date":"2022-05-23T06:47:48","date_gmt":"2022-05-23T06:47:48","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21414"},"modified":"2022-05-23T15:01:05","modified_gmt":"2022-05-23T15:01:05","slug":"protamine-sulfate-leo-pharma","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/protamine-sulfate-leo-pharma\/","title":{"rendered":"Protamine Sulfate LEO Pharma &#8211; Protamine sulphate uses, dose and side effects"},"content":{"rendered":"\n<p>1400 anti-heparin IU \/ ml (equivalent to 10 mg \/ ml)&nbsp;solution&nbsp;for injection and&nbsp;infusion<br>protamine sulphate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Protamine Sulfate LEO Pharma is and what it is used for<\/h2>\n\n\n\n<p>The active ingredient is protamine sulfate which is used as anti-\u00a0heparin\u00a0to counteract the effects of\u00a0heparin\u00a0and low molecular weight\u00a0heparins\u00a0and reduce the effect of these substances in the body.<\/p>\n\n\n\n<p>Heparin&nbsp;is used to prevent blood clots and can cause bleeding.<\/p>\n\n\n\n<p>You may have been prescribed this medicine:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>to stop bleeding that has been caused by heparin \/ low molecular weight&nbsp;heparin<\/li><li>to prevent bleeding if you have been treated with heparin \/ low molecular weight&nbsp;heparin&nbsp;and need to undergo surgery<\/li><li>to cancel the effect of&nbsp;heparin&nbsp;used in certain types of heart surgery<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Protamine Sulfate LEO Pharma<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Protamine Sulfate LEO Pharma<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to protamine sulfate or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Protamine Sulfate LEO Pharma.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are diabetic and use\u00a0insulin\u00a0(especially protamine insulin)<\/li><li>if you are allergic to fish<\/li><li>if you are a man and are infertile (unable to have children) or if you have undergone vasectomy (surgery that makes the man\u00a0sterile\u00a0)<\/li><li>if you have been previously treated with protamine sulfate, protamine insulin, or protamine chloride<\/li><\/ul>\n\n\n\n<p>If you have already received your\u00a0injection, inform the hospital staff if any of the above apply to you.\u00a0If you are not sure, talk to your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Protamine sulfate LEO Pharma is not intended for the treatment of children and adolescents.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Protamine sulfate LEO Pharma<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor, nurse, or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>There is no information on the use of this medicine in pregnant women.\u00a0Protamine sulfate LEO Pharma should only be used during pregnancy if necessary.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>If you are breastfeeding, talk to your doctor, nurse, or pharmacist before using this medicine.<\/p>\n\n\n\n<p>There is no information on the use of this medicine in breastfeeding women.<\/p>\n\n\n\n<p>If treatment with Protamine Sulfate LEO Pharma is necessary, breastfeeding should be discontinued during treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Protamine sulfate LEO Pharma has no or negligible influence on the ability to drive and use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Protamine sulfate LEO Pharma contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per 5 ml, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Protamine Sulfate LEO Pharma<\/h2>\n\n\n\n<p>Your doctor will decide on the\u00a0dose\u00a0of Protamine Sulphate LEO Pharma you need.\u00a0Dose\u00a0one depends on the results of blood tests performed to determine which heparin dose to counteract.\u00a0Protamine sulfate LEO Pharma is for\u00a0intravenous\u00a0use and can be given as a slow\u00a0injection\u00a0(for about 10 minutes) into a vein or by drip.<\/p>\n\n\n\n<p>Dose&nbsp;one may need to be repeated, especially if low molecular weight&nbsp;heparin&nbsp;is to be counteracted, or if the operation will take a long time.<\/p>\n\n\n\n<p>A maximum of 5 ml of this medicine will be given within 10 minutes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Protamine Sulphate LEO Pharma than you should&nbsp;<\/h2>\n\n\n\n<p>This can affect the coagulation process by prolonging the time it takes for the blood to coagulate (clot).<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, nurse, or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong>&nbsp;:<\/p>\n\n\n\n<p>If you get any of these\u00a0side effects, talk to your doctor, nurse, or nearest hospital\u00a0immediately.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Severe allergic reaction.\u00a0<\/strong>With symptoms such as severe breathing problems, wheezing or wheezing, swelling of the face and lips, heart problems, collapse (fainting due to low\u00a0blood pressure\u00a0)<\/li><li><strong>High\u00a0blood pressure\u00a0in the lungs.\u00a0<\/strong>With symptoms such as severe breathing problems<\/li><li><strong>Severe and persistent low\u00a0blood pressure<\/strong>.\u00a0With symptoms such as slow heartbeat, bluish skin, fainting, or collapse (especially if Protamine Sulphate LEO Pharma was given too quickly)<\/li><\/ul>\n\n\n\n<p><strong>The following minor&nbsp;side effects&nbsp;have been observed with&nbsp;Protamine&nbsp;Sulfate LEO Pharma:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Low\u00a0blood pressure.\u00a0With symptoms such as dizziness<\/li><li>Vomiting<\/li><li>Back hurts<\/li><li>Bleeding<\/li><li>Allergic reaction, similar to\u00a0hives\u00a0or other rashes.\u00a0With symptoms such as feeling hot,\u00a0redness\u00a0of the skin, shortness of breath, and swelling of the deeper layers of the skin (sometimes with swelling of the tongue and airways).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Protamine Sulphate LEO Pharma<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Use immediately after opening the\u00a0ampoule.<\/p>\n\n\n\n<p>All remaining solutions must be discarded.<\/p>\n\n\n\n<p>May only be used if the solution is clear and&nbsp;the ampoule&nbsp;is intact.<\/p>\n\n\n\n<p>When the solution is diluted to be given as a slow\u00a0infusion, the\u00a0mixture\u00a0should\u00a0be used immediately.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is protamine sulfate.\u00a01 ml contains 1400 anti-\u00a0heparin\u00a0IU protamine sulfate (equivalent to 10 mg), 5 ml contains 7000 anti-\u00a0heparin\u00a0IU protamine sulfate (equivalent to 50 mg)<\/li><li>The other ingredients are: Sodium chloride,\u00a0hydrochloric acid\u00a0(for\u00a0pH\u00a0adjustment), sodium hydroxide (for\u00a0pH\u00a0adjustment), water for injections<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>This medicine is supplied as a clear, colorless solution for injection and\u00a0infusion\u00a0in 5 ml\u00a0ampoules.<\/p>\n\n\n\n<p>Pack size: 5 or 50\u00a0ampoules.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>LEO Pharma A \/ S,<\/p>\n\n\n\n<p>Industriparken 55,<\/p>\n\n\n\n<p>DK-2750 Ballerup,<\/p>\n\n\n\n<p>Denmark.<\/p>\n\n\n\n<p>Local representative&nbsp;<strong>:<\/strong><\/p>\n\n\n\n<p>LEO Pharma AB,<\/p>\n\n\n\n<p>Box 404,<\/p>\n\n\n\n<p>201 24 Malm\u00f6.<\/p>\n\n\n\n<p>Tel.&nbsp;040-35 22 00.<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>CENEX SAS<\/p>\n\n\n\n<p>52, rue Marcel et Jacques Gaucher, 94120 Fontenay-sous-Bois, France<\/p>\n\n\n\n<p>Further information about this medicine is available on the Medical Products Agency&#8217;s website www.lakemedelsverket.se.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The active ingredient is protamine sulphate which is used as an anti- heparin to counteract the effects of heparin and low molecular weight heparins and reduce the effect of these substances in the body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[22117,22112,22113,22116,22108,22111,22114,22109,22115,22110],"class_list":["post-21414","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-protamine-sulfate-leo-pharma","tag-benefits-of-protamine-sulphate","tag-protamine-sulfate-leo-pharma","tag-protamine-sulfate-leo-pharma-side-effects","tag-protamine-sulphate","tag-protamine-sulphate-side-effects","tag-what-is-protamine-sulfate-leo-pharma","tag-what-is-protamine-sulphate","tag-what-protamine-sulfate-leo-pharma-is-used-for","tag-what-protamine-sulphate-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21414"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21414\/revisions"}],"predecessor-version":[{"id":21462,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21414\/revisions\/21462"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21414"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21414"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}