{"id":21278,"date":"2022-05-18T08:15:10","date_gmt":"2022-05-18T08:15:10","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21278"},"modified":"2022-05-18T15:49:58","modified_gmt":"2022-05-18T15:49:58","slug":"prohance","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/prohance\/","title":{"rendered":"ProHance &#8211; Gadoteridol uses, dose and side effects"},"content":{"rendered":"\n<p>279.3 mg\/ml\u00a0solution for injection\u00a0&amp;\u00a0solution for injection\u00a0in a pre-filled\u00a0syringe<br>gadoteridol<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What ProHance is and what it is used for<\/h2>\n\n\n\n<p>ProHance is a contrast agent for magnetic resonance imaging.<\/p>\n\n\n\n<p>You have had it prescribed for examination of the brain,\u00a0bone marrow,\u00a0and surrounding\u00a0tissue\u00a0or the whole body.<\/p>\n\n\n\n<p>This product is for diagnostic use only.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you are given ProHance<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use ProHance<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to gadoteridol or any of the other ingredients of this medicine (listed in section 6).<\/li><li>for children under 2 years.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Tell your doctor about:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>your kidneys are not functioning normally<\/li><li>you have recently undergone, or will soon undergo, a liver transplant<\/li><li>Your doctor may decide to take a blood test to check how well your kidneys are working before deciding to use ProHance, especially if you are 65 years of age or older.<\/li><li>you have or have had&nbsp;allergies&nbsp;are<\/li><li>you have or have had&nbsp;epilepsy&nbsp;or brain damage<\/li><\/ul>\n\n\n\n<p>Talk to your doctor if any of the above warnings apply to you, or have previously been agreed with you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>ProHance should not be used on children under 2 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and ProHance<\/h2>\n\n\n\n<p>To date, no\u00a0interaction\u00a0with other drugs has been detected.<br>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><strong><em>Pregnancy<\/em><\/strong><br>You must tell your doctor if you think you are or will become pregnant as ProHance should not be used during pregnancy unless necessary.<\/p>\n\n\n\n<p><strong><em>Breast-feeding<\/em><\/strong><br>Tell your doctor if you are breastfeeding or about to start breastfeeding.\u00a0Your doctor will discuss with you whether you should continue breastfeeding or stop breastfeeding for 24 hours after receiving ProHance.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>There is no information on the effects of ProHance on the ability to drive.&nbsp;If you feel unwell after the examination, such as nausea, do not drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">ProHance contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per\u00a0dose, ie essentially &#8216;sodium-free&#8217;.\u00a0is next to &#8220;sodium-free&#8221;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to be given ProHance<\/h2>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><b>adults&#8217;<\/b> most common\u00a0dose\u00a0for examining the brain and spinal cord is 0.2 ml\/kg body weight.\u00a0In some cases, such as in the case of invisible lesions in adults, the\u00a0dose\u00a0may be increased to 0.6 ml\/kg body weight.\u00a0The most common\u00a0dose\u00a0for examination of the whole body is 0.2 ml\/kg body weight.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Children (2 years and older)<\/strong>The most common\u00a0dose\u00a0for examining the brain and spinal cord is 0.2 ml\/kg body weight.<br>The safety and efficacy of\u00a0doses\u00a0higher than 0.2 ml\/kg body weight and repeated\u00a0administration\u00a0during the same study or within a short period are not known.<\/li><\/ul>\n\n\n\n<p><strong>Dosage&nbsp;for special patient groups<\/strong><br>The use of ProHance is not recommended for patients with severe kidney problems and patients who have recently undergone, or will soon undergo, a liver transplant.&nbsp;If use is necessary, you should only receive a&nbsp;dose&nbsp;of ProHance during an examination and you should not receive an additional&nbsp;injection&nbsp;for at least 7 days.<\/p>\n\n\n\n<p><strong><em>Elderly<\/em><\/strong><br>It is not necessary to adjust your&nbsp;dose&nbsp;if you are 65 years of age or older, but you may need a blood test to check how well your kidneys are working.<\/p>\n\n\n\n<p><strong>How to use ProHance<\/strong><br>Healthcare professionals will give you ProHance as an&nbsp;injection&nbsp;into a blood vessel (&nbsp;intravenously&nbsp;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more ProHance than you should&nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0If a child has ingested the medicine by mistake, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The safety precautions and procedures to be followed when using MRI must be considered when administering ProHance for contrast enhancement.<\/p>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hypersensitivity reactions\u00a0(commonly reported symptoms include throat tightness, throat irritation, difficulty breathing, chest discomfort, feeling hot, difficulty swallowing, burning sensation, swelling in the throat, and low\u00a0blood pressure\u00a0)<\/li><li>Headache, changes in sensations, drowsiness, taste changes<\/li><li>Increased tear formation<\/li><li>Hot flashes, low\u00a0blood pressure<\/li><li>Dry mouth, vomiting<\/li><li>Itching, rash,\u00a0hives<\/li><li>Injection site pain<\/li><li>Reaction at the injection site<\/li><li>Increased\u00a0heart rate<\/li><li>Feeling weak<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anxiety<\/li><li>Confusion, abnormal coordination of movements, seizures<\/li><li>Tinnitus<\/li><li>Changes in heart rhythm<\/li><li>Sore throat, shortness of breath, runny nose, cough, shortness of breath, wheezing<\/li><li>Stomach pain, swelling of the tongue,&nbsp;itching&nbsp;in the mouth,&nbsp;inflammation&nbsp;of the gums, loose stools<\/li><li>Facial swelling<\/li><li>Stiff muscles<\/li><li>Chest pain, fever<\/li><\/ul>\n\n\n\n<p>Has been reported (occurs in an unknown number of users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Loss of consciousness<\/li><li>Coma<\/li><li>Cardiac arrest<\/li><li>Respiratory arrest, fluid in the lungs<\/li><li>Kidney failure<\/li><li>Vasovagal reaction (common symptoms include nausea, dizziness, and profuse sweating. In severe cases, symptoms may include pallor, profuse sweating, slow\u00a0heart rate,\u00a0and possible loss of consciousness. Other symptoms may include worry or anxiety, restlessness, weakness, and increased salivation).<\/li><\/ul>\n\n\n\n<p>Isolated cases of nephrogenic systemic&nbsp;fibrosis&nbsp;(which causes hardening of the skin and may also affect soft tissue and internal organs) have been reported with the use of ProHance, most of which occurred in patients receiving concomitant gadolinium-containing contrast agents.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store ProHance<\/h2>\n\n\n\n<p>Keep the vial\/syringe in the outer carton.\u00a0Sensitive to light.<\/p>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p><strong>Expiry date:<\/strong>&nbsp;Use before the expiry date which is stated on the label \/ outer carton after \u201cEXP\u201d.&nbsp;The first 2 digits indicate the month and the last digits the year.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is gadoteridol.<\/li><li>The other ingredients are calteridol calcium, tromethamine,\u00a0hydrochloric acid, sodium hydroxide, and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>ProHance is a clear and colorless or yellowish solution.&nbsp;<\/p>\n\n\n\n<p><em>Vials<\/em>&nbsp;:<\/p>\n\n\n\n<p>ProHance vials contain 5, 10, 15, 20 or 50 ml solution.<\/p>\n\n\n\n<p>Pack sizes: 5 x 5 ml, 10 x 5 ml, 5 x 10 ml, 10 x 10 ml, 5 x 15 ml, 10 x 15 ml,<\/p>\n\n\n\n<p>5 x 20 ml, 10 x 20 ml, 1 x 50 ml, 5 x 50 ml and 10 x 50 ml.<\/p>\n\n\n\n<p><em>Pre-filled syringes:<\/em><\/p>\n\n\n\n<p>ProHance pre-filled&nbsp;syringe&nbsp;contains 10, 15 or 17 ml solution.<\/p>\n\n\n\n<p>Pack sizes: 1 x 10 ml, 1 x 15 ml and 1 x 17 ml.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Bracco International BV<br>Strawinskylaan 3051<br>NL-1077 ZX Amsterdam<br>The Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><br>BIPSO GmbH, Robert-Gerwig-Strasse 4, 78224 Singen, Germany<\/p>\n\n\n\n<p>Bracco Imaging SPA, Bioindustry Park, Via Ribes, 5, 10010 Colleretto Giacosa (TO), Italy<\/p>\n","protected":false},"excerpt":{"rendered":"<p>You have had it prescribed for examination of the brain, bone marrow and surrounding tissue or the whole body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21852,21857,21848,21851,21853,21856,21850,21849,21854,21855],"class_list":["post-21278","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-gadoteridol","tag-benefits-of-prohance","tag-gadoteridol","tag-gadoteridol-side-effects","tag-prohance","tag-prohance-side-effects","tag-what-gadoteridol-is-used-for","tag-what-is-gadoteridol","tag-what-is-prohance","tag-what-prohance-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21278"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21278\/revisions"}],"predecessor-version":[{"id":21301,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21278\/revisions\/21301"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21278"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21278"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}