{"id":21276,"date":"2022-05-18T08:12:55","date_gmt":"2022-05-18T08:12:55","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21276"},"modified":"2022-05-18T15:50:23","modified_gmt":"2022-05-18T15:50:23","slug":"progynon","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/progynon\/","title":{"rendered":"Progynon &#8211; Estradiol valerate uses, dose and side effects"},"content":{"rendered":"\n<p>1 mg and 2 mg, coated tablets<br>estradiol valerate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Progynon is and what it is used for<\/h2>\n\n\n\n<p>Progynon is a drug used\u00a0for\u00a0Hormone\u00a0Replacement\u00a0Therapy\u00a0(\u00a0HRT\u00a0).\u00a0It contains the female sex hormone\u00a0estrogen.\u00a0Progynon is used in women whose menstruation has stopped (\u00a0menopause\u00a0).<\/p>\n\n\n\n<p>Progynon is used to:<\/p>\n\n\n\n<p><strong>Relieving symptoms during and after<\/strong><br>menopause When menstruation ends (\u00a0menopause\u00a0), a woman&#8217;s\u00a0estrogen\u00a0decreases.\u00a0It can cause problems such as sweating and hot flashes.\u00a0Progynon relieves these symptoms after\u00a0menopause.\u00a0Progynon should only be used if the problems cause problems in daily life.<\/p>\n\n\n\n<p><em>Progynon 2 mg only<\/em>\u00a0:<br><strong>Preventing Osteoporosis<\/strong><br>After menopause, some women develop osteoporosis.\u00a0Discuss all possible options with your doctor.<br>If you have an increased risk of\u00a0fractures\u00a0(bone fractures) and other medicines that are not suitable for you, you can use Progynon to prevent osteoporosis after\u00a0menopause.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Progynon<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Progynon<\/h2>\n\n\n\n<p><strong>Medical background and regular check<\/strong><br>-ups The use of&nbsp;HRT&nbsp;involves risks that must be taken into account when deciding to start treatment or continue an ongoing treatment.<\/p>\n\n\n\n<p>Experience is limited for the treatment of women whose menstruation has stopped prematurely (when the ovaries have stopped working or the uterus has been removed).&nbsp;If you belong to that group, the risks of&nbsp;HRT&nbsp;may be different.&nbsp;Talk to your doctor.<\/p>\n\n\n\n<p>Before starting treatment (or resuming treatment), your doctor will ask you about your own, and your family&#8217;s, medical background.\u00a0Your doctor may do a general medical and gynecological examination, which also includes an examination of your breasts.<br>Once you have started treatment, you should go for regular medical check-ups, at least once a year.\u00a0During these check-ups, you should discuss with your doctor the benefits and risks of continued treatment.<\/p>\n\n\n\n<p>Perform regular examinations of the breasts according to the doctor&#8217;s recommendations.<\/p>\n\n\n\n<p><strong>Do not take Progynon<\/strong><\/p>\n\n\n\n<p>if any of the following apply to you.&nbsp;<strong>If you are not sure, talk to your doctor<\/strong>&nbsp;before taking Progynon.<\/p>\n\n\n\n<p>Do not take Progynon:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have or have had\u00a0<strong>breast cancer<\/strong>\u00a0or there is a suspicion that you may have it<\/li><li>if you have or have had\u00a0<strong>estrogen-dependent cancer<\/strong>, such as cancer of the uterine lining (endometrium) or there is a suspicion of such cancer<\/li><li>if you have\u00a0unexpected genital bleeding\u00a0that has not been investigated by a doctor<\/li><li>if you have\u00a0endometrial hyperplasia\u00a0(severe thickening of the uterine lining) and are not being treated for it<\/li><li>if you have or have had a\u00a0blood clot in a vein\u00a0(venous\u00a0thromboembolism\u00a0), in your legs (deep\u00a0vein thrombosis\u00a0), or your lungs (\u00a0pulmonary embolism\u00a0)<\/li><li>if you have a\u00a0coagulation disorder, a condition with an increased risk of blood clots (lack of\u00a0protein\u00a0C,\u00a0protein\u00a0S, or antithrombin)<\/li><li>if you have or have recently had a disease caused by a blood clot in the\u00a0arteries, such as a\u00a0heart attack,\u00a0stroke,\u00a0or\u00a0angina<\/li><li>if you have or have had any\u00a0liver disease\u00a0and still have abnormal liver values<\/li><li>if you have\u00a0porphyria, a rare inherited blood disorder<\/li><li>if you are allergic to estradiol valerate or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If any of the above affects you the first time you use Progynon, stop taking Progynon and contact your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor if you have or have had any of the following problems before starting treatment.&nbsp;They may recur or worsen during treatment with Progynon.&nbsp;Should this occur, have more frequent check-ups with a doctor.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have any disease affecting the lining of the uterus, as well as muscle knots (\u00a0fibroids\u00a0),\u00a0endometriosis,\u00a0or have had\u00a0endometrial hyperplasia\u00a0(severe thickening of the uterine lining)<\/li><li>if you have an increased risk of getting a blood clot (see below &#8220;Blood clots in a vein (\u00a0thrombosis\u00a0)&#8221;)<\/li><li>if a close relative has had breast cancer or other estrogen-dependent cancer<\/li><li>high\u00a0blood pressure<\/li><li>liver disease e.g.\u00a0liver adenoma (benign\u00a0tumor\u00a0)<\/li><li>diabetes<\/li><li>gallstone disease<\/li><li>if you get a\u00a0migraine\u00a0or severe headache<\/li><li>if you have systemic lupus erythematosus (\u00a0SLE\u00a0) &#8211; an\u00a0autoimmune\u00a0disease that affects many organs in the body<\/li><li>epilepsy<\/li><li>asthma<\/li><li>otosclerosis (ossification of the middle ear leading to a hearing loss)<\/li><li>hypertriglyceridemia\u00a0(elevated blood lipids)<\/li><li>fluid retention due to heart or kidney disease<\/li><li>hereditary and acquired\u00a0angioedema<\/li><\/ul>\n\n\n\n<p><strong>You should contact a doctor immediately and discontinue treatment if any of the following occur:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>any of the things mentioned in the section &#8220;Do not take Progynon&#8221;<\/li><li>if skin or whites of the eyes turn yellow (jaundice);\u00a0it may be a sign of liver disease<\/li><li>swelling of the face, tongue, and\/or throat and\/or difficulty swallowing or\u00a0hives, together with difficulty breathing which may indicate\u00a0angioedema<\/li><li>if your\u00a0blood pressure\u00a0rises sharply (symptoms may include headache, fatigue, or dizziness)<\/li><li>if you are having a migraine headache for the first time<\/li><li>if you become pregnant<\/li><li>if you get symptoms of a blood clot, such as<ul><li>painful swelling and redness of the legs<\/li><li>sudden chest pain<\/li><li>breathing difficulties<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>For more information, see &#8220;Blood clots in a vein (&nbsp;thrombosis&nbsp;)&#8221;.<\/p>\n\n\n\n<p><strong>Note:<\/strong>&nbsp;Progynon is not a contraceptive.&nbsp;If it is less than 12 months since your last period, or if you are under 50, you may still need to use contraception to avoid pregnancy.&nbsp;Consult your doctor.<\/p>\n\n\n\n<p><strong>HRT&nbsp;and cancer<\/strong><\/p>\n\n\n\n<p><strong>Severe thickening of the uterine lining (&nbsp;endometrial hyperplasia&nbsp;) and cancer of the uterine lining (endometrial cancer)<\/strong><\/p>\n\n\n\n<p>The use of\u00a0HRT\u00a0with\u00a0estrogen\u00a0alone increases the risk of severe thickening of the uterine lining and cancer of the uterine lining.<\/p>\n\n\n\n<p>By taking\u00a0progestogen\u00a0as a supplement to\u00a0estrogen\u00a0for at least 12 days every 28-day cycle, you are protected against this extra risk.\u00a0The doctor will prescribe the\u00a0progestogen\u00a0if you have your uterus left.\u00a0If your uterus has undergone surgery (\u00a0hysterectomy\u00a0), you should consult your doctor if you can take the medicine without\u00a0a progestogen.<\/p>\n\n\n\n<p>For women with the uterus left who do not take\u00a0HRT, an average of 5 out of 1,000 women aged 50-65 will be diagnosed with endometrial cancer.<br>For women aged 50 &#8211; 65 who have the uterus left and who take\u00a0HRT\u00a0with\u00a0estrogen\u00a0alone, between 10 and 60 women out of 1,000 users will be diagnosed with endometrial cancer (ie between 5 and 55 extra cases), depending on\u00a0the dose\u00a0one and for how long it is taken.<\/p>\n\n\n\n<p><strong>Unexpected bleeding<\/strong><br>You will have a bleeding once a month (so-called dropout bleeding) when you take Progynon.&nbsp;But if you get unexpected bleeding or splashing bleeding in addition to your monthly bleeding, and these:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lasts longer than 6 months<\/li><li>starts after you take Progynon for 6 months<\/li><li>continues after you stop taking Progynon<\/li><\/ul>\n\n\n\n<p><strong>you should see a doctor as soon as possible.<\/strong><\/p>\n\n\n\n<p><strong>Breast cancer<\/strong><br>Data show that hormone replacement therapy (\u00a0HRT\u00a0) with a combination of\u00a0estrogen-progestogen\u00a0or with\u00a0estrogen\u00a0alone increases the risk of breast cancer.\u00a0The increased risk depends on how long you use\u00a0HRT.\u00a0The increased risk is seen within 3 years.\u00a0When treatment is stopped, the increased risk decreases over time, but it can persist for 10 years or more if you have used\u00a0HRT\u00a0for more than 5 years.<\/p>\n\n\n\n<p><em>Comparison<\/em><br>Of 1,000 women aged 50 to 54 who do not take\u00a0HRT, an average of 13 to 17 will be diagnosed with breast cancer over 5 years.<\/p>\n\n\n\n<p>In women who are 50 years old and start taking&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone for 5 years, 16-17 cases per 1,000 users (ie 0-3 extra cases) will occur.<\/p>\n\n\n\n<p>In women who are 50 years old and start taking\u00a0HRT\u00a0with\u00a0estrogen-progestogen\u00a0for 5 years, there will be 21 cases per 1,000 users (ie 4 &#8211; 8 extra cases).<\/p>\n\n\n\n<p>Among women aged 50\u201359 who do not use\u00a0HRT, an average of 27<\/p>\n\n\n\n<p>of 1,000 to be diagnosed with breast cancer over 10 years.<\/p>\n\n\n\n<p>In women who are 50 years old and start taking&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone for 10 years, 34 cases per 1,000 users (ie 7 extra cases) will occur.<\/p>\n\n\n\n<p>In women who are 50 years old and start taking\u00a0HRT\u00a0with\u00a0estrogen-progestogen\u00a0for 10 years, 48 \u200b\u200bcases per 1,000 users (ie 21 extra cases) will occur.<\/p>\n\n\n\n<p><strong>Check your breasts regularly.&nbsp;Contact a doctor if you notice changes such as:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>indentations or pits<\/li><li>changes of the nipple<\/li><li>nodules you can see or feel<\/li><\/ul>\n\n\n\n<p>You are also advised to go for the mammography examinations that you are called to.\u00a0You must tell the nurse\/healthcare professional who is performing the mammogram that you are taking\u00a0HRT, as this medicine may increase the density (density) of your breasts, and it may affect the results of the mammogram.\u00a0An increased density in the breasts can make it more difficult to detect lumps on the mammography images.<\/p>\n\n\n\n<p><strong>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/strong><\/p>\n\n\n\n<p>Ovarian cancer is rare &#8211; much more rare than breast cancer.\u00a0The use of\u00a0HRT\u00a0with\u00a0estrogen\u00a0alone or combined\u00a0estrogen-progestogen\u00a0has been associated with a slightly increased risk of ovarian cancer.<\/p>\n\n\n\n<p>The risk of ovarian cancer varies with age.\u00a0The diagnosis of ovarian cancer will, for example, be made on about 2 women out of 2000 aged 50 to 54 who do not take\u00a0HRT\u00a0for 5 years.\u00a0For women who have taken\u00a0HRT\u00a0for 5 years, there will be about 3 cases per 2000 users (ie about 1 extra case).<\/p>\n\n\n\n<p><strong>How&nbsp;HRT&nbsp;affects the heart and blood circulation<\/strong><\/p>\n\n\n\n<p><strong>Blood clots in a vein (&nbsp;thrombosis&nbsp;)<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;<strong>blood clots in the veins<\/strong>&nbsp;is 1.3 &#8211; 3 times higher for women who take&nbsp;HRT&nbsp;than for those who do not, especially during the first year of treatment.<\/p>\n\n\n\n<p>Blood clots can be serious.&nbsp;If a blood clot ends up in the lungs, it can cause chest pain, shortness of breath, collapse or even lead to death.<\/p>\n\n\n\n<p>You are more likely to get a blood clot in a vein as you get older and if any of the following apply to you.&nbsp;Tell your doctor if any of the following apply to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have not been able to walk or stand for a long time due to a major operation, injury or illness (see also section 3, \u201cIf you need surgery\u201d)<\/li><li>you are severely overweight (\u00a0BMI\u00a0over 30 kg \/ m\u00a0<sup>2<\/sup>\u00a0)<\/li><li>you have a coagulation disorder that requires long-term treatment with drugs that prevent blood clots<\/li><li>if a close relative has had a blood clot in the bone, lung or another organ you have\u00a0SLE\u00a0(systemic lupus erythematosus)<\/li><li>you have cancer.<\/li><\/ul>\n\n\n\n<p>The symptoms of a blood clot are described in the section &#8220;You should contact a doctor immediately and stop the treatment&#8221;.<\/p>\n\n\n\n<p><em>Comparison<\/em><br>For women in their 50s who do not take\u00a0HRT, an average of 4 &#8211; 7 out of 1,000 people are expected to have a blood clot in a vein over 5 years.<br>For women in their 50s who have taken\u00a0HRT\u00a0with\u00a0estrogen-progestogen\u00a0for more than 5 years, 9 &#8211; 12 out of 1,000 users are expected to get a blood clot in a vein (ie 5 extra cases).<br>For women in their 50s without a uterus who take\u00a0estrogen\u00a0alone for more than 5 years, 5 &#8211; 8 out of 1,000 users are expected to get a blood clot in a vein (ie 1 extra case).<\/p>\n\n\n\n<p><strong>Heart disease (heart attack)<\/strong><br>There is no evidence that\u00a0HRT\u00a0prevents heart attack.<br>For women over the age of 60 who take\u00a0HRT\u00a0with\u00a0estrogen-progestogen, the risk of developing heart disease is slightly higher than for those who do not take\u00a0HRT.<\/p>\n\n\n\n<p>For women without a uterus who take\u00a0estrogen\u00a0alone, there is no increased risk of developing heart disease.<\/p>\n\n\n\n<p><strong>Stroke<\/strong><br>The risk of&nbsp;stroke&nbsp;<strong>is<\/strong>&nbsp;about 1.5 times higher for those who take&nbsp;HRT&nbsp;compared to those who do not.&nbsp;The risk of&nbsp;stroke&nbsp;is age-dependent, therefore the number of cases of&nbsp;stroke&nbsp;increases due to the use of&nbsp;HRT&nbsp;with increasing age.<\/p>\n\n\n\n<p><em>Comparison<\/em><br>For women in their 50s who do not take\u00a0HRT, an average of 8 out of 1,000 people are expected to have a\u00a0stroke\u00a0over 5 years.<br>For women in their 50s who have taken\u00a0HRT\u00a0for more than 5 years, 11 out of 1,000 users are expected to have a\u00a0stroke\u00a0(ie 3 extra cases).<\/p>\n\n\n\n<p><strong>Other conditions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Using&nbsp;HRT&nbsp;does not prevent memory loss.&nbsp;The risk of memory loss may be slightly higher in women who start using&nbsp;HRT&nbsp;after the age of 65.&nbsp;Consult your doctor.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Progynon<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription, (traditional) herbal medicines, and herbal medicines.<\/p>\n\n\n\n<p>Some medicines can affect the way Progynon works, which can lead to irregular bleeding.&nbsp;The following applies:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines used to treat\u00a0<strong>epilepsy<\/strong>\u00a0(eg\u00a0barbiturates,\u00a0phenytoin, primidone, carbamazepine, and possibly oxcarbazepine, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/topiramate-1a-pharma\/\">topiramate<\/a>, and felbamate)<\/li><li>medicines used to treat\u00a0tuberculosis\u00a0(eg rifampicin, rifabutin)<\/li><li>drugs used to treat\u00a0HIV\u00a0and\u00a0hepatitis\u00a0C virus infections\u00a0(so-called\u00a0protease inhibitors\u00a0and non-nucleoside reverse transcriptase inhibitors such as nevirapine, efavirenz, ritonavir, nelfinavir)<\/li><li>(traditional) herbal medicines containing\u00a0St. John&#8217;s wort\u00a0(\u00a0Hypericum perforatum\u00a0)<\/li><li>drugs against\u00a0hepatitis\u00a0C\u00a0virus\u00a0(\u00a0HCV\u00a0) (such as the combination treatment ombitasvir\/paritaprevir\/ritonavir with or without dasabuvir as well as the treatment glekaprevir \/ pibrentasvir) may cause elevated liver function values \u200b\u200bin blood test results (increase in\u00a0ALT\u00a0liver enzyme) in women using combined hormonal contraceptives.\u00a0Progynon contains estradiol instead of Ethinylestradiol.\u00a0It is not known whether an increase in\u00a0ALT\u00a0liver enzyme may occur with the use of Progynon in combination with this\u00a0HCV\u00a0combination therapy.\u00a0Your doctor will advise you.<\/li><li>medicines used to treat\u00a0<strong>fungal infections<\/strong>\u00a0(eg griseofulvin,\u00a0fluconazole\u00a0, itraconazole,\u00a0ketoconazole\u00a0and voriconazole)<\/li><li>drugs used to treat\u00a0<strong>bacterial\u00a0infections<\/strong>\u00a0(eg clarithromycin, erythromycin\u00a0<strong>)<\/strong><\/li><li>medicines used to treat\u00a0<strong>certain heart diseases, high\u00a0blood pressure<\/strong>\u00a0(eg verapamil,\u00a0diltiazem\u00a0)<\/li><li><strong>grapefruit juice<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Results from blood test analyze<\/strong><\/p>\n\n\n\n<p>If you need to take a blood sample, tell your doctor, or the person taking the blood sample, that you are taking Progynon as it may affect the results of some tests.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Progynon is intended for women whose menstruation has stopped.&nbsp;If you become pregnant, stop taking Progynon and consult a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>No effects on the ability to drive and use machines have been observed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Progynon contains excipients<\/h2>\n\n\n\n<p><strong>Progynon contains&nbsp;lactose monohydrate&nbsp;and sucrose<\/strong><\/p>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Progynon<\/h2>\n\n\n\n<p>Always take Progynon exactly as your doctor has told you.\u00a0If you are not sure, talk to your doctor or pharmacist.\u00a0Dose\u00a0one should be determined by a doctor who adapts it individually for you.\u00a0Your doctor will strive to give you the lowest\u00a0dose, which will give you relief of symptoms, and you should use Progynon for the shortest possible time.\u00a0Talk to your doctor if you do not get any relief from the symptoms, or feel that the\u00a0dose\u00a0is too high.<\/p>\n\n\n\n<p>Progynon is given as either&nbsp;continuous&nbsp;or cyclic treatment.&nbsp;Continuous&nbsp;treatment means that Progynon is used without interruption, while cyclic treatment means that Progynon is used for 3 weeks followed by a one-week break.<\/p>\n\n\n\n<p><em>Continuous&nbsp;treatment<\/em><br>Take one tablet daily without interruption.<\/p>\n\n\n\n<p><em>Cyclic treatment<\/em><br>Package containing tablet maps:<br>The package contains three maps, each containing 28 tablets of the active substance.\u00a0Take one tablet a day for three weeks, then take a one-week break.\u00a0The seven tablets left on the map can be saved.\u00a0After seven tablet-free days, a new map begins.\u00a0After three treatment periods, the saved tablets from the three blister cards can be used for the fourth month.<br>Jar of Progynon with 100 tablets:<br>Take Progynon for 21 days and take a break for seven days.\u00a0<em>In a cyclical treatment, it is important to note which day of the week the treatment should start again.<\/em><\/p>\n\n\n\n<p>Women who still have regular bleeding should start treatment on the fifth day of bleeding.\u00a0Patients without bleeding can start treatment at any time.\u00a0Women switching from hormonal\u00a0replacement therapy\u00a0should start treatment the day after the end of the previous cycle.<\/p>\n\n\n\n<p>Treatment with&nbsp;estrogen&nbsp;alone can lead to overstimulation of the uterine lining.&nbsp;To avoid this, it is recommended that women who have the uterus remain are given a supplement of corpus luteum hormone, a so-called progestogen&nbsp;hormone&nbsp;for 12-14 days every month or continuously.<br>During cyclic treatment, menstrual-like bleeding usually occurs two to four days after the end of progestogen treatment.<\/p>\n\n\n\n<p>The tablets should be swallowed whole with some liquid at about the same time each day.<br>Symptom relief usually occurs during the first treatment cycle.<\/p>\n\n\n\n<p><strong>If you need surgery<\/strong><br>If you are going to have surgery, tell your surgeon that you are taking Progynon.&nbsp;You may need to stop taking Progynon for 4 to 6 weeks before surgery to avoid the risk of blood clots (see section 2, \u201cBlood clots in a vein (&nbsp;thrombosis&nbsp;)\u201d).&nbsp;Ask your doctor when it is appropriate to start taking Progynon again.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Progynon than you should<\/h2>\n\n\n\n<p>Overdose can cause nausea and vomiting and irregular bleeding.\u00a0No specific treatment is necessary, but if you have ingested too much medicine or if, for example, a child has ingested the medicine by mistake, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Progynon<\/h2>\n\n\n\n<p>If you forget to take a tablet, you can take it as soon as possible within 12 hours from the usual time, otherwise, discard the forgotten tablet and take the next tablet, as usual, the next day.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten tablet.<\/p>\n\n\n\n<p>The risk of breakthrough bleeding or splashing bleeding may increase if a tablet is forgotten.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>The following diseases are more common in women who take&nbsp;HRT&nbsp;than in those who do not:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Breast cancer<\/li><li>Severe thickening of the uterine lining (&nbsp;endometrial hyperplasia&nbsp;) or cancer of the uterine lining (endometrial cancer)<\/li><li>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/li><li>Blood clots in veins in bones or lungs (venous&nbsp;thromboembolism&nbsp;)<\/li><li>Heart disease<\/li><li>Stroke&nbsp;_<\/li><li>Probable memory loss, if treatment with&nbsp;HRT&nbsp;is started after the age of 65<\/li><\/ul>\n\n\n\n<p>See section 2 for more information on these\u00a0side effects.<\/p>\n\n\n\n<p>Like all medicines, Progynon can cause\u00a0side effects, although not everybody gets them.\u00a0Most\u00a0side effects\u00a0occur during the first months of treatment and usually disappear with continued treatment.<\/p>\n\n\n\n<p><em>Common\u00a0(may affect up to 1 in 10 people):<\/em><br>Weight gain or loss, headache, abdominal pain, nausea, skin rash,\u00a0itching, unforeseen bleeding from the abdomen including\u00a0spotting.<\/p>\n\n\n\n<p><em>Uncommon\u00a0(may affect 1 in 100 people):<\/em><br>Hypersensitivity reactions, depression, dizziness, visual disturbances, palpitations, sour stomach,\u00a0hives, erythema nodosum (characterized by painful reddish-purple bumps on the skin), pain in the breasts, tenderness in the breasts, and fluid accumulation.<\/p>\n\n\n\n<p><em>Rare\u00a0(may affect up to 1 in 1,000 people):<\/em><br>Anxiety, increased or decreased sex drive,\u00a0migraines, problems wearing lenses, bloating, bloating, increased hair,\u00a0acne, muscle cramps, painful menstruation, discharge, symptoms similar to PMS, breast enlargement, and fatigue.<\/p>\n\n\n\n<p>Breakthrough bleeding\/spotting may occur in some women during the first months of treatment.\u00a0You should contact your doctor if the irregular bleeding lasts longer than a few months or if it starts to occur after a period of treatment, or if it continues after the end of treatment, as the cause may need to be investigated further.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been reported with other HRTs:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The disease of the gallbladder<\/li><li>Various skin diseases:<ul><li>dark skin spots, especially on the face and neck, so-called &#8220;pregnancy spots&#8221; (chloasma)<\/li><li>painful reddish-purple bumps on the skin (erythema nodosum)<\/li><li>annular\u00a0redness\u00a0or sore rash (erythema multiforme)<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Progynon<\/h2>\n\n\n\n<p>Keep out of sight and reach of children.<br>No special storage instructions.<br>Do not use this medicine after the expiry date which is stated on the carton.&nbsp;The expiration date is the last day of the specified month.<br>The medicine should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>Progynon 1 mg:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is 1 mg estradiol valerate.<\/li><li>The other ingredients are\u00a0lactose monohydrate\u00a0(47 mg), maize starch, povidone 25,000 and 700,000, talc, magnesium stearate, sucrose (34 mg), macrogol 6000,\u00a0calcium carbonate,\u00a0glycerol, titanium dioxide (E 171), yellow iron oxide (E 172), montan glycol wax.<\/li><\/ul>\n\n\n\n<p>The tablets are yellow, round, and have a diameter of 6.8 mm.<\/p>\n\n\n\n<p>Progynon 2 mg:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is 2 mg estradiol valerate.<\/li><li>The other ingredients are\u00a0lactose monohydrate\u00a0(46 mg), corn starch, povidone 25,000 and 700,000, talc, magnesium stearate, sucrose (34 mg), macrogol 6000,\u00a0calcium carbonate, montan glycol wax.<\/li><\/ul>\n\n\n\n<p>The tablets are white, round, and have a diameter of 6.8 mm.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Bayer AB<br>Box 606<\/p>\n\n\n\n<p>SE-169 26 Solna<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><em>Progynon 1 m&nbsp;<\/em><em>g:<\/em>Bayer AG<br>M\u00fcllerstra\u00dfe 17813353 BerlinGermany<br><em>Progynon 2 mg:<\/em>Bayer Weimar GmbH &amp; Co.&nbsp;KGD\u00f6bereinerstra\u00dfe 2099427 WeimarGermany<\/td><td>Bayer Weimar GmbH and Co.&nbsp;KG<br>D\u00f6bereinerstra\u00dfe 2099427 Weimar<br>Germany<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Progynon is a drug used for Hormone Replacement Therapy ( HRT ) . It contains the female sex hormone estrogen . Progynon is used in women whose menstruation has stopped ( menopause ).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21864,5406,5408,5409,21859,21863,21862,21858,5407,21860,21861],"class_list":["post-21276","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-progynon","tag-estradiol-valerate","tag-estradiol-valerate-side-effects","tag-estradiol-valerate-tablet","tag-progynon","tag-progynon-side-effects","tag-progynon-tablet","tag-what-estradiol-valerate-is-used-for","tag-what-is-estradiol-valerate","tag-what-is-progynon","tag-what-progynon-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21276"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21276\/revisions"}],"predecessor-version":[{"id":21302,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21276\/revisions\/21302"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}