{"id":21274,"date":"2022-05-18T08:11:05","date_gmt":"2022-05-18T08:11:05","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21274"},"modified":"2022-05-18T15:50:32","modified_gmt":"2022-05-18T15:50:32","slug":"prograf","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/prograf\/","title":{"rendered":"Prograf &#8211; Tacrolimus uses, dose and side effects"},"content":{"rendered":"\n<p>0.5 mg, 1 mg, and 5 mg\u00a0hard<br>tacrolimus capsules<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Prograf is and what it is used for<\/h2>\n\n\n\n<p>Prograf belongs to a group of medicines called immunosuppressants.\u00a0After an organ transplant (eg liver, kidney, heart) your body tries to repel the new organ.\u00a0Prograf is used to check the immune system in your body for it to accept the transplanted organ.<\/p>\n\n\n\n<p>Prograf is often used in combination with other drugs that also suppress the immune system.<\/p>\n\n\n\n<p>You can also be given Prograf for an ongoing rejection reaction in your transplanted liver, kidney, heart, or another organ, or if other treatment you have received has not been able to control the immune system after your transplant.<\/p>\n\n\n\n<p>Tacrolimus contained in Prograf may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Prograf<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Prograf<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic (hypersensitive) to tacrolimus or any of the other ingredients of Prograf (listed in section 6).<\/li><li>If you are allergic (hypersensitive) to any&nbsp;antibiotic&nbsp;that belongs to the subgroup of macrolide antibiotics (eg erythromycin, clarithromycin, josamycin).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Prograf.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You will need to take Prograf every day for as long as you need immunosuppression to prevent rejection of the transplanted organ.\u00a0You should keep in regular contact with your doctor.<\/li><li>While taking Prograf, your doctor may occasionally want to perform several tests (such as blood, urine, heart function, vision, and nerve function).\u00a0This is completely normal and will help your doctor determine the appropriate\u00a0dose\u00a0of Prograf for you.<\/li><li>Avoid taking herbal medicines, e.g.\u00a0St. John&#8217;s wort\u00a0(Hypericum perforatum)\u00a0or any other herbal product as these may affect the effect and\u00a0dose\u00a0one of Prograf that you need to take.\u00a0If you are not sure, talk to your doctor before taking any herbal medicines or products.<\/li><li>If you have liver problems or have had a disease that may have affected your liver, tell your doctor as this may affect the\u00a0dose\u00a0of Prograf you receive.<\/li><li>If you experience severe abdominal pain with or without other symptoms, such as chills, fever, nausea, or vomiting.<\/li><li>If you get diarrhea for more than a day, tell your doctor as it may be necessary to adjust your\u00a0dose\u00a0of Prograf.<\/li><li>If you have a change in heart rate called &#8220;QT prolongation&#8221;.<\/li><li>When taking Prograf, you should limit your exposure to sunlight and UV light by wearing appropriate protective clothing and sunscreen with a high sun protection factor.\u00a0This is because there is a possible risk of malignant skin changes during immunosuppressive drug treatment.<\/li><li>If you need to be vaccinated, tell your doctor in advance.\u00a0Your doctor will advise you on the best course of action.<\/li><li>Patients treated with Prograf have been reported to be at increased risk of developing\u00a0lymphoma\u00a0(see section 4).\u00a0Contact your doctor for specific advice on these disorders.<\/li><\/ul>\n\n\n\n<p>Handling Precautions:<\/p>\n\n\n\n<p>Direct contact with any part of the body, such as skin or eyes, or inhalation of\u00a0solution for injection, powder, or\u00a0granules\u00a0with tacrolimus should be avoided.\u00a0In case of such contact, skin and eyes should be rinsed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Prograf<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription and herbal medicines.<\/p>\n\n\n\n<p>Prograf must not be taken with ciclosporin.<\/p>\n\n\n\n<p><strong>If you need to see a doctor other than your transplant specialist, tell your doctor that you are taking tacrolimus.&nbsp;Your doctor may need to consult your transplant specialist if you are taking another medicine that may increase or decrease the tacrolimus concentration in your blood.<\/strong><\/p>\n\n\n\n<p>The blood levels of Prograf may be affected by other medicines you are taking and blood levels of other medicines may be affected by your taking Prograf, which means that the\u00a0dose\u00a0of Prograf may need to be stopped, increased, or decreased.<\/p>\n\n\n\n<p>In some patients, tacrolimus concentrations in the blood have increased when they were taking other medicines at the same time.\u00a0This can lead to serious\u00a0side effects, such as problems with the kidneys and nervous system as well as disorders of the heart rhythm (see section 4).<\/p>\n\n\n\n<p>Effects on Prograf concentrations in the blood may occur very quickly after starting another medicine.&nbsp;Therefore, continuous monitoring of the concentration of Prograf in the blood may be needed for the first few days after you start taking another medicine and at frequent intervals for the duration of treatment with the other medicine.&nbsp;Some other medicines may reduce the tacrolimus concentration in the blood, which may increase the risk of transplant rejection.&nbsp;You should especially tell your doctor if you are taking or have recently taken medicines that contain substances such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines for fungal infections and\u00a0antibiotics, especially so-called macrolide antibiotics that are used to treat\u00a0infections, e.g.\u00a0ketoconazole,\u00a0fluconazole, itraconazole, posaconazole, voriconazole, clotrimazole, isavuconazole,\u00a0miconazole, telithromycin, erythromycin, clarithromycin, josamycin, azithromycin, rifampicin, rifabutin,\u00a0isoniaxillin,\u00a0and fluid<\/li><li>Letermovir, is used to prevent diseases caused by\u00a0CMV\u00a0( human\u00a0cytomegalovirus\u00a0)<\/li><li>HIV\u00a0protease\u00a0inhibitors\u00a0(eg ritonavir, nelfinavir, saquinavir), the booster drug cobicistat and combination tablets, or non-nucleoside reverse transcriptase inhibitors against\u00a0HIV\u00a0(efavirenz, etravirine, nevirapine) used to\u00a0treat\u00a0HIV\u00a0infection<\/li><li>HCV\u00a0&#8211;\u00a0protease inhibitors\u00a0(eg telaprevir, boceprevir, the combination of ombitasvir \/ paritaprevir\/ritonavir with or without dasabuvir, elbasvir\/grazoprevir and glecaprevir \/ pibrentasvir), used to treat\u00a0hepatitis\u00a0C\u00a0infection<\/li><li>Nilotinib and imatinib, idelalisib, ceritinib, crizotinib, apalutamide, enzalutamide or mitotane (used to treat certain cancers)<\/li><li>Mycophenolic acid, is used to suppress the immune system to prevent rejection of the transplanted organ<\/li><li>Medicines for\u00a0stomach ulcers\u00a0and acid reflux (eg omeprazole, lansoprazole, or cimetidine)<\/li><li>Medicines used to treat nausea and vomiting (eg metoclopramide)<\/li><li>Magnesium\u00a0aluminum hydroxide (antacid) used to treat heartburn<\/li><li>Hormone therapies with Ethinyl estradiol (eg,\u00a0birth control pills\u00a0) or danazol<\/li><li>Medicines for high\u00a0blood pressure\u00a0or heart problems such as nifedipine, nicardipine,\u00a0diltiazem,\u00a0or verapamil<\/li><li>Antiarrhythmics\u00a0(\u00a0amiodarone\u00a0), are used to treat\u00a0arrhythmias\u00a0(irregular heartbeat)<\/li><li>Drugs are known as &#8220;statins&#8221; used to treat\u00a0high\u00a0cholesterol\u00a0and\u00a0triglycerides<\/li><li>The antiepileptic drugs carbamazepine,\u00a0phenytoin\u00a0and phenobarbital<\/li><li>Metamizole used to treat pain and fever<\/li><li>The corticosteroids\u00a0prednisolone\u00a0and\u00a0methylprednisolone<\/li><li>The antidepressant drug nefazodone<\/li><li>Herbal medicines contain St. John&#8217;s\u00a0wort\u00a0<em>(Hypericum perforatum)<\/em>\u00a0or extracts of\u00a0<em>Schisandra sphenanthera.<\/em><\/li><\/ul>\n\n\n\n<p>Tell your doctor if you are receiving treatment for&nbsp;hepatitis&nbsp;C. Drug treatment for&nbsp;hepatitis&nbsp;C can affect liver function and thus the tacrolimus concentration in the blood.&nbsp;Tacrolimus blood levels may decrease or increase depending on the medicines prescribed for&nbsp;hepatitis&nbsp;C. Your doctor may need to check your tacrolimus blood levels carefully and adjust your Prograf&nbsp;dose&nbsp;one after you start treatment for&nbsp;hepatitis&nbsp;C.<\/p>\n\n\n\n<p>Tell your doctor if you are taking or need to take\u00a0ibuprofen, amphotericin B,\u00a0antibiotics\u00a0(trimethoprim\/sulfamethoxazole, vancomycin, or so-called aminoglycoside antibiotics such as gentamicin), or medicines for viral infections (eg aciclovir, ganciclovir, cidofovir or foscarnet).\u00a0They can aggravate kidney problems or problems with the nervous system if taken with Prograf.<\/p>\n\n\n\n<p>Your doctor must also know if you are taking potassium supplements or potassium-sparing\u00a0diuretics\u00a0(eg amiloride, triamterene, or\u00a0spironolactone\u00a0), or trimethoprim or trimethoprim\/sulfamethoxazole\u00a0antibiotics\u00a0that may increase the levels of potassium in your blood, certain painkillers (so-called\u00a0NSAIDs, t (eg\u00a0ibuprofen\u00a0), blood thinners or\u00a0oral\u00a0medication to treat\u00a0diabetes\u00a0while you are taking Prograf.<\/p>\n\n\n\n<p>If you need to be vaccinated, tell your doctor in advance.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Graduate with food and drink<\/h2>\n\n\n\n<p>You should normally take Prograf on an empty stomach or at least 1 hour before or 2 to 3 hours after a meal.&nbsp;Grapefruit and grapefruit juice should be avoided when taking Prograf.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Prograf is excreted in breast milk.\u00a0Therefore, you should not breastfeed while taking Prograf.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Do not drive or use any tools or machines if you feel dizzy or sleepy, or have trouble seeing clearly after taking Prograf.&nbsp;These effects are more common when Prograf is taken with alcohol.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Prograf contains lactose, sodium and lecithin (soy)<\/h2>\n\n\n\n<p>Prograf contains\u00a0lactose.\u00a0If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per capsule, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<p>The printing ink used on Prograf 0.5 mg and 1 mg capsules contains soy lecithin.&nbsp;If you are allergic to peanuts or soy, consult your doctor to determine if you should use this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Prograf<\/h2>\n\n\n\n<p>Always take Prograf exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Make sure you get the same tacrolimus medicine every time you pick up your prescription unless your transplant doctor has decided to switch to another tacrolimus medicine.<\/p>\n\n\n\n<p>This medicine should be taken twice daily.&nbsp;If the appearance of the medicine is not the same as usual, or if the dosing instructions have been changed, talk to your doctor or pharmacist as soon as possible to make sure you have received the correct medicine.<\/p>\n\n\n\n<p>The starting dose to prevent rejection of your transplanted organ is determined by your doctor and is calculated according to your body weight.&nbsp;The starting doses immediately after the transplant are normally within the range<\/p>\n\n\n\n<p>0.075\u20130.30 mg per kg body weight per day<\/p>\n\n\n\n<p>depending on the organ transplanted.<\/p>\n\n\n\n<p>Dose\u00a0one depends on your general condition and on which other immunosuppressive drug (s) you are receiving.\u00a0Regular blood tests are required by your doctor to determine the correct\u00a0dose and to adjust\u00a0the dose\u00a0from time to time.\u00a0The dose\u00a0is usually reduced by your doctor once your condition has stabilized.\u00a0Your doctor will tell you exactly how many capsules to take and how often.<\/p>\n\n\n\n<p>Prograf is taken twice daily, usually in the morning and in the evening.&nbsp;You should take Prograf on an empty stomach or at least 1 hour before or 2 to 3 hours after a meal.&nbsp;The capsules should be swallowed whole with a glass of water.&nbsp;Avoid grapefruit and grapefruit juice when taking Prograf.&nbsp;Do not swallow the desiccant contained in the aluminum bag.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Prograf than you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0If a child has accidentally ingested the medicine, contact a doctor or hospital and Finland tel. 0800 147 111) immediately for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Prograf<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<p>If you forget to take your&nbsp;dose&nbsp;of Prograf capsules, wait until the next&nbsp;dose&nbsp;and then continue as usual.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Prograf<\/h2>\n\n\n\n<p>Ending treatment with Prograf may increase the risk of rejection of your transplanted organ.&nbsp;Do not stop your treatment as long as your doctor does not tell you to.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Prograf can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Prograf weakens the body&#8217;s defense mechanisms to prevent you from rejecting the transplanted organ.\u00a0As a result, your body will not be as good as usual at fighting\u00a0infection.\u00a0If you use Prograf, you can thus get more\u00a0infections\u00a0than normal, such as\u00a0infections\u00a0in the skin, mouth, gastrointestinal tract, lungs, and urinary tract.\u00a0Some\u00a0infections\u00a0can be serious or life-threatening and can include\u00a0infections\u00a0caused by bacteria,\u00a0viruses, fungi, parasites, or other\u00a0infections.<\/p>\n\n\n\n<p>Contact a doctor immediately if you get signs of\u00a0infection, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fever, cough, sore throat, feeling weak or generally unwell<\/li><li>Memory loss, difficulty thinking, difficulty walking, or vision loss &#8211; can be due to a very rare, serious\u00a0infection\u00a0in the brain, which can be life-threatening (\u00a0progressive\u00a0multifocal\u00a0leukoencephalopathy, or PML)<\/li><\/ul>\n\n\n\n<p>Serious\u00a0side effects, including those listed below, may occur.<\/p>\n\n\n\n<p><strong>Contact a doctor immediately if you have or suspect you have any of the following serious side effects:<\/strong><\/p>\n\n\n\n<p>Serious&nbsp;side effects&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Gastrointestinal\u00a0perforation: severe abdominal pain possibly accompanied by other symptoms, such as chills, fever, nausea, or vomiting.<\/li><li>The insufficient function of the transplanted organ.<\/li><li>Dimsyn.<\/li><\/ul>\n\n\n\n<p>Serious uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hemolytic uremic syndrome, s a condition with the following symptoms: low or no urine production (\u00a0acute\u00a0renal failure\u00a0), extreme fatigue, yellowing of the skin or eyes (jaundice), and abnormal bruising or bleeding and signs of\u00a0infection.<\/li><\/ul>\n\n\n\n<p>Serious rare&nbsp;side effects&nbsp;(may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Thrombotic thrombocytopenic purpura (or TTP): a condition characterized by fever and bruising under the skin that may appear as red pin-sized dots, with or without unexplained extreme fatigue, confusion, yellowing of the skin or eyes (jaundice), with symptoms of\u00a0acute\u00a0renal failure\u00a0(low or no urine production).<\/li><li>Toxic\u00a0epidermal\u00a0necrolysis: damage and blisters on the skin or mucous membranes, red swollen skin that can become detached from large parts of the body.<\/li><li>Blindness.<\/li><\/ul>\n\n\n\n<p>Serious very rare&nbsp;side effects&nbsp;(may affect up to 1 in 10,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stevens-Johnson syndrome: unexplained widespread pain in the skin, swelling of the face, severe disease with blistering of the skin, mouth, eyes, and genitals,\u00a0hives, swollen tongue, red or purple skin rash spreading, flaky skin.<\/li><li>Torsades de Pointes:\u00a0change in heart rate that may, but does not have to, be accompanied by symptoms such as chest pain (angina), weakness, dizziness or nausea, palpitations, and difficulty breathing.<\/li><\/ul>\n\n\n\n<p>Serious&nbsp;side effects&nbsp;ar &#8211; no known frequency (frequency can not be calculated from the available data):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Opportunistic\u00a0infections\u00a0(caused by bacteria, fungi,\u00a0viruses,\u00a0and\u00a0protozoa\u00a0): prolonged diarrhea, fever, and sore throat.<\/li><li>Benign and malignant\u00a0tumors\u00a0have been reported after treatment due to immunosuppression.<\/li><li>Cases of pure erythrocyte plasma (a very severe decrease in\u00a0red blood cell count\u00a0),\u00a0hemolytic anemia\u00a0(decreased\u00a0red blood cell count\u00a0due to increased degradation, together with fatigue), and febrile\u00a0neutropenia\u00a0(a decrease in white\u00a0blood cells\u00a0fighting\u00a0infection, together with fever ) have been reported.\u00a0It is not known exactly how often these\u00a0side effects\u00a0occur.\u00a0You may be asymptomatic or experience symptoms such as fatigue,\u00a0lethargy, abnormal pallor, shortness of breath, dizziness, headache, chest pain, and cold in the hands and feet, depending on the severity of the condition.<\/li><li>Cases of\u00a0agranulocytosis\u00a0(severe decrease in\u00a0white blood cell count\u00a0along with mouth ulcers, fever, and\u00a0infection\u00a0(s)).\u00a0You may be asymptomatic or experience symptoms such as sudden fever, stiffness, and sore throat.<\/li><li>Allergic and anaphylactic reactions with the following symptoms: sudden itchy rash (\u00a0hives\u00a0), swelling of the hands, feet, ankles, face, lips, mouth, or throat (which may cause difficulty swallowing or breathing) and you may feel that you are about to faint.<\/li><li>Posterior reversible encephalopathy syndrome (PRES): headache, confusion, mood swings, seizures, and visual disturbances.\u00a0This may be a sign of a disease called posterior reversible encephalopathy syndrome, which has been reported in some patients treated with tacrolimus.<\/li><li>Optic\u00a0neuropathy\u00a0(visual nerve damage): problems with your vision such as blurred vision, changes in color vision, difficulty seeing details, or that your field of\u00a0vision\u00a0is limited.<\/li><\/ul>\n\n\n\n<p>The side effects&nbsp;listed below can also occur after you receive Prograf and can be serious:<\/p>\n\n\n\n<p>Very common&nbsp;side effects&nbsp;(may affect more than 1 user in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Increased blood sugar,\u00a0diabetes mellitus, and increased levels of\u00a0potassium\u00a0in the blood.<\/li><li>Difficulty sleeping.<\/li><li>Shaking, headache.<\/li><li>Increased\u00a0blood pressure.<\/li><li>Abnormal liver function tests.<\/li><li>Diarrhea, nausea.<\/li><li>Kidney problems.<\/li><\/ul>\n\n\n\n<p>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased number of\u00a0blood cells\u00a0(\u00a0platelets, red or\u00a0white blood cells\u00a0), increased number of\u00a0white blood cells, changes in the number of\u00a0red blood cells\u00a0(seen in blood samples)<\/li><li>Decreased\u00a0magnesium,\u00a0phosphate,\u00a0potassium,\u00a0calcium,\u00a0or\u00a0sodium\u00a0in the blood, increased amount of fluid in the body, increased amount of\u00a0uric acid\u00a0or fats in the blood, decreased appetite, increased acidity in the blood, and other changes in blood salts.<\/li><li>Anxiety, confusion, difficulty orienting oneself, depression, mood swings, nightmares, hallucinations, and mental illnesses.<\/li><li>Seizures, disturbances of consciousness, crawling or numbness (sometimes painful) in the hands and feet, dizziness, impaired writing ability, and disorders of the nervous system.<\/li><li>Increased photosensitivity, eye diseases.<\/li><li>Earrings.<\/li><li>Decreased blood flow in the heart\u00a0vessels, and a faster heartbeat.<\/li><li>Bleeding, partial or complete blockage of blood vessels decreased\u00a0blood pressure.<\/li><li>Shortness of breath, changes in the lungs, fluid accumulation around the lungs,\u00a0inflammation\u00a0of the throat, cough,\u00a0and flu-like symptoms.<\/li><li>Inflammation\u00a0or ulcers that cause abdominal pain or diarrhea, bleeding in the stomach,\u00a0inflammation\u00a0or ulcers in the mouth, fluid accumulation in the abdomen, vomiting, abdominal pain, digestive problems, constipation, gas problems, bloating, loose stools, and stomach problems.<\/li><li>Changes in liver enzyme values \u200b\u200band function, yellowing of the skin due to liver problems, damage to liver tissue, and hepatitis.<\/li><li>Itching, rash, hair loss,\u00a0acne, increased sweating.<\/li><li>Pain in joints, limbs, back and feet, muscle twitching.<\/li><li>Insufficient renal function, decreased urine output, impaired or painful urination.<\/li><li>General weakness, fever, fluid retention in the body, pain and discomfort, increase in alkaline phosphatases in the blood, weight gain, feeling of disturbed temperature perception.<\/li><\/ul>\n\n\n\n<p>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Changes in the blood&#8217;s ability to coagulate, a decrease in the number of all kinds of\u00a0blood cells.<\/li><li>Dehydration.<\/li><li>Decreased\u00a0protein\u00a0or sugar in the blood, increased\u00a0phosphate\u00a0in the blood.<\/li><li>Coma, cerebral hemorrhage,\u00a0stroke, paralysis, brain disease, speech and language difficulties, and memory problems.<\/li><li>Clouding in the lens of the eye.<\/li><li>Impaired hearing.<\/li><li>Irregular heartbeat, cardiac arrest, decreased heart rate, heart muscle disease, enlargement of the heart muscle, heavier heartbeat, abnormal\u00a0ECG, abnormal heart rate, and\u00a0heart rate.<\/li><li>Blood clot in a friend in leg or arm,\u00a0shock.<\/li><li>Breathing difficulties, respiratory disease,\u00a0asthma.<\/li><li>Obstacles in the intestinal passage increased blood levels of\u00a0enzyme\u00a0et amylase, acid reflux, and slow emptying of the stomach.<\/li><li>Eczema is, a burning sensation in the sun.<\/li><li>Joint diseases.<\/li><li>Inability to urinate, painful menstruation, and abnormal menstrual bleeding.<\/li><li>Failure of certain organs,\u00a0flu-like symptoms, increased sensitivity to heat and cold, pressure over the chest, nervousness or abnormal feeling, increase of\u00a0enzyme\u00a0and\u00a0lactate dehydrogenase\u00a0in the blood, and weight loss.<\/li><\/ul>\n\n\n\n<p>Rare&nbsp;side effects&nbsp;(may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Small skin bleeds due to clotted blood.<\/li><li>Increased muscle stiffness.<\/li><li>Deafness.<\/li><li>Accumulation of fluid around the heart.<\/li><li>Acute breathing difficulties.<\/li><li>Cyst formation in the pancreas.<\/li><li>Problems with blood flow in the liver.<\/li><li>Increased hair.<\/li><li>Thirst falls, feeling of pressure over the chest, decreased mobility, sores.<\/li><\/ul>\n\n\n\n<p>Very rare&nbsp;side effects&nbsp;(may affect up to 1 in 10,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Muscle weakness.<\/li><li>Abnormal echocardiogram.<\/li><li>Liver failure, narrowing of the bile ducts.<\/li><li>Painful urination with blood in the urine.<\/li><li>The increased amount of adipose tissue.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How Prograf should be stored<\/h2>\n\n\n\n<p>Keep Prograf out of sight and reach of children.<\/p>\n\n\n\n<p>Take the hard capsules immediately after they are pushed out of the blister.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.&nbsp;All capsules should be used within one year after opening the aluminum bag.<\/p>\n\n\n\n<p>No special temperature instructions.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>Prograf 0.5 mg hard capsules:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tacrolimus.\u00a0Each capsule contains 0.5 mg tacrolimus as tacrolimus monohydrate.<\/li><li>Excipients:<br>Capsule contents: hypromellose, croscarmellose sodium,\u00a0lactose monohydrate, magnesium stearate.\u00a0Capsule shell: titanium dioxide (E171), yellow iron oxide (E172), gelatin.<br>Printing inks: shellac, lecithin (soy), hydroxypropylcellulose, simethicone, red iron oxide (E172).<\/li><\/ul>\n\n\n\n<p>Prograf 1 mg hard capsules:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tacrolimus.\u00a0Each capsule contains 1 mg of tacrolimus as tacrolimus monohydrate.<\/li><li>Excipients:<br>Capsule contents: hypromellose, croscarmellose sodium,\u00a0lactose monohydrate, magnesium stearate.\u00a0Capsule shell: titanium dioxide (E171), gelatin.<br>Printing inks: shellac, lecithin (soy), hydroxypropylcellulose, simethicone, red iron oxide (E172).<\/li><\/ul>\n\n\n\n<p>Prograf 5 mg hard capsules:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tacrolimus.\u00a0Each capsule contains 5 mg of tacrolimus as tacrolimus monohydrate.<\/li><li>Excipients:<br>Capsule contents: hypromellose, croscarmellose sodium,\u00a0lactose monohydrate, magnesium stearate.\u00a0Capsule shell: titanium dioxide (E171), red iron oxide (E172), gelatin.<br>Printing inks: shellac, titanium dioxide (E171), and propylene glycol.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Prograf 0.5 mg hard capsules:<\/p>\n\n\n\n<p>Opaque, light yellow gelatin capsules, marked with \u201c0.5 mg\u201d and \u201c[f] 607\u201d in red, containing white powder.\u00a0Prograf 0.5 mg hard capsules are supplied in pressure packs or in perforated unit dose blisters of 10 capsules each in a protective foil pouch containing desiccant which protects the capsules from moisture.\u00a0The desiccant should not be swallowed.\u00a0Pack sizes of 20, 30, 50, 60 and 100 hard capsules are available in blisters and pack sizes of 20&#215;1, 30&#215;1, 50&#215;1, 60&#215;1, and 100&#215;1 hard capsules are available in perforated unit dose blisters.<\/p>\n\n\n\n<p>Prograf 1 mg hard capsules:<\/p>\n\n\n\n<p>Opaque white gelatin capsules, marked with \u201c1 mg\u201d and \u201c[f] 617\u201d in red, containing white powder.\u00a0Prograf 1 mg hard capsules are supplied in pressure packs or in perforated unit dose blisters of 10 capsules each in a protective foil pouch containing desiccant which protects the capsules from moisture.\u00a0The desiccant should not be swallowed.\u00a0Pack sizes of 20, 30, 50, 60, 90, and 100 hard capsules are available in blisters and pack sizes of 20&#215;1, 30&#215;1, 50&#215;1, 60&#215;1, 90&#215;1, and 100&#215;1 hard capsules are available in perforated unit dose blisters.<\/p>\n\n\n\n<p>Prograf 5 mg hard capsules:<\/p>\n\n\n\n<p>Opaque, gray-red gelatin capsules, marked with \u201c5 mg\u201d and \u201c[f] 657\u201d in white, containing white powder.\u00a0Prograf 5 mg hard capsules are supplied in pressure packs or in perforated unit dose blisters of 10 capsules each in a protective foil pouch containing desiccant that protects the capsules from moisture.\u00a0The desiccant should not be swallowed.\u00a0Pack sizes of 30, 50, 60 and 100 hard capsules are available in blisters and pack sizes of 30&#215;1, 50&#215;1, 60&#215;1, and 100&#215;1 hard capsules are available in perforated unit dose blisters.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Marketing Authorisation Holder:<\/p>\n\n\n\n<p>Astellas Pharma a \/ s<\/p>\n\n\n\n<p>Arne Jacobsens All\u00e9 15<\/p>\n\n\n\n<p>2300 Copenhagen S<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p>Manufacturer<\/p>\n\n\n\n<p>Astellas Ireland Co.&nbsp;Ltd.<\/p>\n\n\n\n<p>Killorglin<\/p>\n\n\n\n<p>County Kerry, V93FC86<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p>Prograf&nbsp;:<\/p>\n\n\n\n<p>Austria, Cyprus, Czech Republic, Denmark, Germany, Greece, Spain, Finland, France, Hungary, Iceland, Ireland, Italy, Malta, Norway, Poland, Portugal, Slovakia, Slovenia, and Sweden.<\/p>\n\n\n\n<p>Prograf:<\/p>\n\n\n\n<p>Belgium, Luxembourg, and the Netherlands.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prograf belongs to a group of medicines called immunosuppressants. After an organ transplant (of eg liver, kidney, heart) your body tries to repel the new organ. Prograf is used to check the immune system in your body in order for it to accept the transplanted organ.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21869,11513,21865,21868,4095,6185,4097,21867,11512],"class_list":["post-21274","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-prograf","tag-benefits-of-tacrolimus","tag-prograf","tag-prograf-side-effects","tag-tacrolimus","tag-tacrolimus-capsule","tag-tacrolimus-side-effects","tag-what-prograf-is-used-for","tag-what-tacrolimus-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21274"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21274\/revisions"}],"predecessor-version":[{"id":21303,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21274\/revisions\/21303"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}