{"id":21259,"date":"2022-05-18T07:54:03","date_gmt":"2022-05-18T07:54:03","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21259"},"modified":"2022-05-18T15:51:14","modified_gmt":"2022-05-18T15:51:14","slug":"privigen","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/privigen\/","title":{"rendered":"Privigen – Human normal immunoglobulin uses, dose and side effects"},"content":{"rendered":"\n

100 mg \/ ml (10%) solution for infusion
human normal immunoglobulin (IVIg)<\/p>\n\n\n\n

What Privigen is and what it is used for<\/h2>\n\n\n\n

What Privigen is<\/strong><\/p>\n\n\n\n

Privigen belongs to a group of medicines called human normal immunoglobulin. Immunoglobulins are also called antibodies and are blood proteins that help the body fight infections in healthy people.<\/p>\n\n\n\n

How Privigen works<\/strong><\/p>\n\n\n\n

Privigen contains immunoglobulins that have been produced from the blood of healthy people.\u00a0The drug works in the same way as the natural immunoglobulins found in the blood.<\/p>\n\n\n\n

What is Privigen used for?<\/strong><\/p>\n\n\n\n

Privigen is used for the treatment of adults and children (0-18 years) in the following situations:<\/p>\n\n\n\n

  1. To increase abnormally low immunoglobulin levels in the blood so that they reach normal levels (replacement therapy):
    1. Patients born with the impaired ability or inability to produce immunoglobulins (primary immunodeficiency disease (PID)).<\/li>
    2. Patients with an acquired immune deficiency (SID) who suffer from severe or recurrent\u00a0infection, ineffective\u00a0antimicrobial\u00a0treatment, and either demonstrated specific antibody deficiency or an IgG serum level of <4g \/ l.<\/li><\/ol><\/li>
    3. To treat certain inflammatory diseases (immune modulation).\u00a0There are 5 groups:
      1. Patients who do not have a sufficient number of\u00a0platelets\u00a0(\u00a0thrombocytes\u00a0) (primary immunological\u00a0thrombocytopenia\u00a0(ITP) and who are at high risk of bleeding or need surgery shortly.<\/li>
      2. Patients with\u00a0Guillain-Barr\u00e9 syndrome\u00a0.\u00a0This is an\u00a0acute\u00a0disease characterized by\u00a0inflammation\u00a0of the peripheral nerves, which causes severe muscle weakness, mainly in the legs and arms.<\/li>
      3. Patients with Kawasaki disease.\u00a0This is an\u00a0acute\u00a0illness that mainly affects young children.\u00a0It is characterized by\u00a0inflammation\u00a0of the blood vessels throughout the body.<\/li>
      4. Patients with\u00a0chronic\u00a0inflammatory\u00a0demyelinating\u00a0polyneuropathy\u00a0(CIDP).\u00a0This is a\u00a0chronic\u00a0disease characterized by\u00a0inflammation\u00a0of the peripheral nerves, which causes muscle weakness and\/or numbness mainly in the legs and arms.<\/li>
      5. Patients with\u00a0multifocal\u00a0motor\u00a0neuropathy\u00a0(MMN).\u00a0This is a slowly\u00a0progressive\u00a0disease of the motor neuron with weakness in the arms and legs.<\/li><\/ol><\/li><\/ol>\n\n\n\n

        What you need to know before using Privigen<\/h2>\n\n\n\n

        Do not use Privigen<\/h2>\n\n\n\n

        \u2192 Read this section carefully. You and your doctor should decide on the information before you receive Privigen.<\/p>\n\n\n\n

        DO NOT use Privigen<\/strong><\/p>\n\n\n\n

        • if you are allergic to human immunoglobulins or proline.<\/li>
        • if you have developed\u00a0antibodies against\u00a0IgA\u00a0immunoglobulins\u00a0in your blood.<\/li>
        • if you suffer from hyperprolinemia type I or II (a genetic disease that causes high levels of the amino acid\u00a0proline\u00a0in the blood).\u00a0This is an extremely rare disorder.\u00a0Only a few genera with this disease are known in the world.<\/li><\/ul>\n\n\n\n

          Warnings and cautions<\/h2>\n\n\n\n

          What circumstances may increase the risk of\u00a0side effects?<\/p>\n\n\n\n

          \u2192 Before treatment, tell your doctor or healthcare professional if any of the following apply to you:<\/p>\n\n\n\n

          • You will receive this medicine in high\u00a0doses, either on day 1 or for several days and you have blood type A, B, or AB and\/or an underlying\u00a0inflammatory\u00a0disease.\u00a0Under these circumstances, immunoglobulins have often been reported to increase the risk of red\u00a0blood cell\u00a0degradation (\u00a0hemolysis\u00a0).<\/li>
          • You are overweight, older, have\u00a0diabetes, have been in bed for a long time, have high\u00a0blood pressure, have too little blood volume (\u00a0hypovolemia\u00a0), have problems with blood vessels (vascular disease), and have an increased tendency to blood clots (thrombophilia or thrombotic episodes), or have a disease or condition that causes the blood to thicken (hypervisible blood).\u00a0Under these circumstances, immunoglobulins may increase the risk of a heart attack (heart attack), stroke,\u00a0blood clot in the lung (\u00a0pulmonary embolism\u00a0), or blockage of a blood vessel in the legs, but only in very rare cases.<\/li>
          • You have\u00a0diabetes.\u00a0Even if Privigen does not contain sugar, the product may have been diluted with a special sugar solution (5%\u00a0glucose\u00a0), which may affect your blood sugar level.<\/li>
          • You have or have had kidney problems before or are taking medicines that can damage your kidneys (nephrotoxic drugs).\u00a0Under these circumstances, immunoglobulins may increase the risk of severe renal impairment (\u00a0acute\u00a0renal failure\u00a0), but only in very rare cases.\u00a0Fatal renal failure\u00a0has occurred in isolated cases in connection with\u00a0hemolysis.<\/li><\/ul>\n\n\n\n

            What type of monitoring is needed during infusion one?<\/p>\n\n\n\n

            For your safety, one\u00a0infusion\u00a0of Privigen will be given under the supervision of your doctor or healthcare professional.\u00a0You will usually be observed throughout the\u00a0infusion\u00a0one and then for at least 20 minutes.\u00a0Under certain conditions, special precautions may be necessary.\u00a0Examples of such conditions are:<\/p>\n\n\n\n

            • you get Privigen with a high infusion rate or<\/li>
            • you receive Privigen for the first time or after a long break in treatment (eg several months)<\/li><\/ul>\n\n\n\n

              In these cases, you will be closely monitored throughout the infusion one and for at least 1 hour thereafter.<\/p>\n\n\n\n

              When may you need to slow down or stop the\u00a0infusion?<\/p>\n\n\n\n

              • You may be allergic (hypersensitive) to immunoglobulins without knowing it.\u00a0However, true allergic reactions are rare.\u00a0They can occur even if you have previously received human immunoglobulins and tolerated them well.\u00a0This can especially happen if you have developed\u00a0antibodies to\u00a0IgA\u00a0immunoglobulins.\u00a0In these rare cases, allergic reactions such as a sudden drop in blood pressure or\u00a0shock may\u00a0occur (see also section 4 \u201cPossible side effects\u201d).<\/li>
              • In very rare cases, transfusion-related\u00a0acute\u00a0lung injury (TRALI) may occur after receiving\u00a0immunoglobulins.\u00a0This leads to an accumulation of fluid in the lungs that is not due to heart problems (non-cardiogenic\u00a0pulmonary edema\u00a0).\u00a0TRALI is characterized by difficulty breathing (difficulty breathing), bluish skin (cyanosis), abnormally low blood oxygen levels (\u00a0hypoxia\u00a0), decreased\u00a0blood pressure\u00a0(\u00a0hypotension\u00a0), and increased body temperature (fever).\u00a0The symptoms usually appear during or within 6 hours after receiving the treatment.<\/li><\/ul>\n\n\n\n

                \u2192 Tell your doctor or healthcare professional immediately if you notice any such reactions while receiving an infusion of Privigen. He or she will decide whether to slow down the infusion rate or to stop the infusion altogether.<\/p>\n\n\n\n

                Blood tests<\/p>\n\n\n\n

                \u2192 Tell your doctor that you are being treated with Privigen before any blood tests.<\/p>\n\n\n\n

                Once you have received Privigen, the results of certain blood tests (serological tests) may be impaired for some time.<\/p>\n\n\n\n

                Safety information regarding your infection<\/p>\n\n\n\n

                Privigen is made from human blood plasma (this is the liquid part of the blood).<\/p>\n\n\n\n

                When medicines are made from human blood or\u00a0plasma, certain measures are taken to prevent\u00a0infection\u00a0from being transmitted to patients.\u00a0These include:<\/p>\n\n\n\n

                • careful selection of blood and plasma donors to ensure that those who may have an\u00a0infection\u00a0are excluded;<\/li>
                • testing of each donor and plasma pool for signs of viruses\/infections,<\/li>
                • introduction of steps in\u00a0the preparation\u00a0of blood or\u00a0plasma\u00a0that can inactivate or remove\u00a0viruses.<\/li><\/ul>\n\n\n\n

                  Despite these measures, the risk of transmitting infectious agents can not be completely ruled out when\u00a0administering\u00a0medicinal products derived from human blood or\u00a0plasma.\u00a0This also applies to any unknown or new\u00a0viruses\u00a0and other types of\u00a0infection.<\/p>\n\n\n\n

                  Measures taken are considered effective against enveloped\u00a0viruses, such as human immunodeficiency virus (\u00a0HIV\u00a0),\u00a0hepatitis\u00a0B\u00a0virus,\u00a0and\u00a0hepatitis\u00a0C\u00a0virus, as well as against\u00a0enveloped\u00a0viruses such as\u00a0hepatitis\u00a0A\u00a0virus\u00a0and parvovirus B19.<\/p>\n\n\n\n

                  Immunoglobulins have not been associated with\u00a0hepatitis\u00a0A or parvovirus B19\u00a0infections, possibly because\u00a0antibodies\u00a0to these\u00a0infections, which are present in the product, have a protective effect.<\/p>\n\n\n\n

                  • It is strongly recommended that each time you receive a dose of Privigen, note the product name and batch number to have a list of the batches that have been used.<\/li><\/ul>\n\n\n\n

                    Other medicines and Privigen<\/h2>\n\n\n\n

                    \u2192 Tell your doctor or healthcare professional if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n

                    Concomitant use of drugs that increase the excretion of water from the body (loop diuretics) should be avoided during treatment with Privigen. Your doctor will decide if you should use or continue treatment with loop diuretics.<\/p>\n\n\n\n

                    Vaccinations<\/p>\n\n\n\n

                    \u2192 Tell the vaccinating doctor that you are being treated with Privigen before the vaccination is given.<\/p>\n\n\n\n

                    Once you have received Privigen, the effect of some vaccinations may be reduced.\u00a0The vaccinations that are affected are vaccinations with live, attenuated virus vaccines, such as vaccinations against measles, mumps, rubella, and chickenpox.\u00a0Such vaccinations should be postponed for at least 3 months after the last\u00a0infusion\u00a0of Privigen.\u00a0In the case of measles vaccinations, this deterioration can persist for up to 1 year.\u00a0Therefore, the vaccinating doctor should check the effect of the measles vaccination.<\/p>\n\n\n\n

                    Pregnancy and breastfeeding<\/h2>\n\n\n\n

                    \u2192 If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or healthcare professional for advice before taking this medicine.\u00a0Your doctor will decide if you can receive Privigen during pregnancy or while you are breastfeeding.<\/p>\n\n\n\n

                    Nevertheless, drugs containing antibodies have been used in pregnant and lactating women. Long-term experience has shown that no harmful effects during pregnancy or in the newborn are expected.<\/p>\n\n\n\n

                    If you receive Privigen while you are breastfeeding, the\u00a0antibodies\u00a0in this medicine will also be present in your breast milk.\u00a0Thus, your child can also receive the protective\u00a0antibodies.<\/p>\n\n\n\n

                    Driving and using machines<\/h2>\n\n\n\n

                    During treatment with Privigen, patients may experience effects such as dizziness or nausea that may affect their ability to drive and use machines. If this happens, do not drive or use machines until these effects have disappeared.<\/p>\n\n\n\n

                    Privigen contains proline<\/h2>\n\n\n\n

                    You must not take this medicine if you have hyperprolinaemia (see also section 2 \u201cWhat you need to know before using Privigen\u201d).<\/p>\n\n\n\n

                    \u2192 Tell your doctor before treatment.<\/p>\n\n\n\n

                    Sodium content<\/strong><\/p>\n\n\n\n

                    This medicine contains less than 2.3 mg\u00a0sodium\u00a0(the main ingredient in table salt\/table salt) per 100 ml.\u00a0This corresponds to 0.12% of the highest recommended daily intake of\u00a0sodium\u00a0for adults.<\/p>\n\n\n\n

                    3. How to use Privigen<\/h2>\n\n\n\n

                    Privigen is for intravenous infusion only\u00a0(\u00a0intravenous\u00a0infusion\u00a0).\u00a0It is usually given by your doctor or healthcare professional.<\/p>\n\n\n\n

                    Your doctor will calculate the correct\u00a0dose\u00a0for you taking into account your weight, the specific circumstances described in section 2 “Warnings and precautions” and your response to treatment. The dose calculation for children and younger patients does not differ from that for adults. of\u00a0infusion\u00a0one, you will receive Privigen at a low infusion rate, if you tolerate this well your doctor may gradually increase the infusion rate.<\/p>\n\n\n\n

                    If you have received too much Privigen<\/h2>\n\n\n\n

                    Overdose is highly unlikely as Privigen is usually given under medical supervision.\u00a0If you, despite this, receive too much Privigen, your blood may become too thick (hypervisible), which may increase the risk of blood clots forming.\u00a0This can especially happen if you are a patient at risk for it, for example, if you are elderly or if you suffer from a heart or kidney disease.\u00a0Tell your doctor if you know you have any medical problems.<\/p>\n\n\n\n

                    Possible side effects<\/h2>\n\n\n\n

                    Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0Any\u00a0side effects\u00a0can be reduced or even avoided altogether by giving Privigen at a slow rate.\u00a0Such\u00a0side effects\u00a0can occur even if you have previously received human immunoglobulins (\u00a0antibodies\u00a0) and have tolerated them well.<\/p>\n\n\n\n

                    In rare and isolated cases, the following side effects have been reported with immunoglobulin preparations:<\/p>\n\n\n\n

                    • severe\u00a0hypersensitivity reactions, such as a sudden drop in blood pressure or anaphylactic\u00a0shock\u00a0(eg you may feel dizzy, faint when standing up, have cold hands and feet, abnormal heartbeat or chest pain, or blurred vision) even if you have not shown any hypersensitivity to the previous\u00a0infusion\u00a0er.<\/li><\/ul>\n\n\n\n

                      \u2192 Tell your doctor or healthcare professional immediately if you notice any such signs during infusion with Privigen. He or she will decide if the infusion rate should be reduced or if the infusion should be stopped completely.<\/p>\n\n\n\n

                      • formation of blood clots that can be transported away by the blood circulation (thromboembolic reactions) and cause e.g.\u00a0myocardial infarction (eg if you experience sudden chest pain or shortness of breath),\u00a0stroke\u00a0(eg if you experience a sudden onset of muscle weakness, loss of sensation and\/or impaired balance, decreased alertness or difficulty speaking), blood clots in the pulmonary arteries (t. eg if you experience chest pain, difficulty breathing or coughing up blood), deep\u00a0vein thrombosis\u00a0(eg if you get\u00a0redness, feeling hot, pain, tenderness or swelling in one or both legs).<\/li>
                      • chest pain, chest discomfort, painful breathing due to transfusion-related lung injury (TRALI)<\/li><\/ul>\n\n\n\n

                        \u2192 Tell a doctor or healthcare professional immediately if you get any of the above symptoms. Anyone with such symptoms should be taken immediately to the hospital’s emergency department for examination and treatment.<\/p>\n\n\n\n

                        • temporary non-infectious\u00a0meningitis\u00a0(\u00a0reversible\u00a0aseptic\u00a0meningitis\u00a0)<\/li><\/ul>\n\n\n\n

                          \u2192 Tell your doctor or healthcare professional immediately if you feel stiff in the neck and also have one or more of the following symptoms: fever, nausea, vomiting, headache, abnormal photosensitivity, and mental disorders.<\/p>\n\n\n\n

                          • increase in creatinine levels in the blood<\/li>
                          • proteins<\/li>
                          • acute\u00a0renal failure<\/li>
                          • transient decrease in\u00a0red blood cell count\u00a0(\u00a0reversible\u00a0hemolytic anemia\/hemolysis),\u00a0anemia,\u00a0leukopenia, and anisocytosis (including microcytosis).<\/li><\/ul>\n\n\n\n

                            Adverse reactions\u00a0observed in controlled\u00a0clinical trials\u00a0and post-marketing experiences are presented in descending order of frequency:<\/p>\n\n\n\n

                            Very common<\/strong> (may affect more than 1 in 10 people):<\/p>\n\n\n\n

                            Headache, (including sinus headache,\u00a0migraine, headache, tension headache), pain (including back pain,\u00a0extremity\u00a0pain, joint and skeletal pain (\u00a0arthralgia\u00a0), neck pain, facial pain), fever (including chills), flu-like illness (including runny nose) nose (\u00a0nasopharyngitis\u00a0) sore throat, (pharyngolaryngeal pain), blisters in the mouth and throat (oropharyngeal blisters), feeling of tightness in the throat).<\/p>\n\n\n\n

                            Common<\/strong> (may affect up to 1 in 10 people):<\/p>\n\n\n\n

                            A temporary decrease in\u00a0red blood cell count\u00a0(\u00a0anemia\u00a0),\u00a0red blood cell\u00a0degradation (\u00a0hemolysis\u00a0including\u00a0hemolytic anemia\u00a0)\u00a0\u03b2, decreased\u00a0white blood cell count\u00a0(\u00a0leukopenia\u00a0), hypersensitivity, dizziness (including dizziness),\u00a0hypertension\u00a0(\u00a0hypertension\u00a0),\u00a0redness\u00a0(including hot flashes,\u00a0hyperemia)\u00a0),\u00a0hypotension\u00a0(including decreased\u00a0blood pressure\u00a0), shortness of breath (\u00a0dyspnoea including chest pain, chest discomfort, painful breathing), upset stomach (nausea), vomiting, loose stools (diarrhea), abdominal pain, skin problems (including rash,\u00a0itching\u00a0(\u00a0pruritus\u00a0),\u00a0hives\u00a0(\u00a0urticaria\u00a0), maculopapular rash,\u00a0redness\u00a0(\u00a0erythema\u00a0) scaling (skin exfoliation)), muscle pain (including muscle cramps and stiffness), fatigue, physical weakness (\u00a0asthenia\u00a0) and muscle weakness.<\/p>\n\n\n\n

                            Routine laboratory tests can often show changes in liver function (hyperbilirubinemia) as well as changes in the number of\u00a0blood cells\u00a0(eg positive Coombs (direct) test), an increase in\u00a0alanine aminotransferase, an increase in\u00a0aspartate aminotransferase, increase in\u00a0lactate dehydrogenase\u00a0in the blood.<\/p>\n\n\n\n

                            Uncommon<\/strong> (may affect up to 1 in 100 people):<\/p>\n\n\n\n

                            Transient non-communicable\u00a0meningitis\u00a0(\u00a0reversible\u00a0aseptic\u00a0meningitis\u00a0), irregular shape of\u00a0red blood cells\u00a0(microscopic findings), presence of high\u00a0platelets\u00a0in the blood (\u00a0thrombocytosis\u00a0), drowsiness, tremors (\u00a0tremor\u00a0), palpitations, rapid\u00a0pulse\u00a0(\u00a0tachycardia\u00a0) blood supply to the legs such as\u00a0causes pain when walking (\u00a0peripheral\u00a0vascular disease), high levels of serum proteins in the urine (\u00a0proteinuria\u00a0with elevated blood creatinine), pain at the injection site (including discomfort at the infusion site).<\/p>\n\n\n\n

                            In isolated cases (post-marketing experience) the following have been observed in patients treated with Privigen: abnormally low levels of a certain type of\u00a0white blood cell\u00a0called\u00a0neutrophils\u00a0(decreased\u00a0neutrophils\u00a0), anaphylactic\u00a0shock, painful breathing due to transfusion-related\u00a0acute\u00a0lung injury (TRALI) and\u00a0acute\u00a0renal failure.<\/p>\n\n\n\n

                            \u03b2<\/sup>\u00a0Cases of\u00a0hemolytic anemia\u00a0after completion of a controlled\u00a0clinical trial\u00a0were observed with a\u00a0significant\u00a0decrease in frequency due to improvements in the manufacturing process of Privigen.<\/p>\n\n\n\n

                            \u2192 If you get\u00a0any side effects, talk to your doctor or healthcare professional.\u00a0This also applies to any\u00a0side effects\u00a0not mentioned in this information.<\/p>\n\n\n\n

                            Also, read section 2 \u201cWhat you need to know before using Privigen\u201d for further information on the circumstances that increase the risk of\u00a0side effects.<\/p>\n\n\n\n

                            How to store Privigen<\/h2>\n\n\n\n
                            • Keep out of sight and reach of children.<\/li>
                            • Do not use this medicine after the expiry date which is stated on the outer carton and vial label after EXP.\u00a0The expiration date is the last day of the specified month.<\/li>
                            • As the solution does not contain any\u00a0preservative, healthcare professionals must inject it as soon as possible after opening the vial.<\/li>
                            • Do not store above 25 \u00b0 C.<\/li>
                            • Do not freeze.<\/li>
                            • Keep the vial in the outer carton.\u00a0Sensitive to light.<\/li>
                            • Do not use this medicine if you notice that the solution is cloudy or contains particles.<\/li><\/ul>\n\n\n\n

                              Contents of the pack and other information<\/h2>\n\n\n\n

                              Content declaration<\/h2>\n\n\n\n
                              • The\u00a0active substance<\/strong>\u00a0is human, normally immunoglobulin (\u00a0IgG-type\u00a0antibodies ).\u00a0Privigen contains 100 mg\/ml (10%) of human\u00a0protein\u00a0of which at least 98% is IgG.\u00a0The approximate percentage distribution of the IgG subclasses is as follows:<\/li><\/ul>\n\n\n\n
                                IgG 1<\/sub> ………………………………………… ………<\/td>69%<\/td><\/tr>
                                IgG 2<\/sub> ………………………………………… ………<\/td>26%<\/td><\/tr>
                                IgG 3<\/sub> ………………………………………… ……….<\/td>3%<\/td><\/tr>
                                IgG 4<\/sub> ………………………………………… ……….<\/td>2%<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

                                The drug contains trace amounts of\u00a0IgA\u00a0(not more than 25 micrograms\/ml).<\/p>\n\n\n\n

                                • The other ingredients<\/strong>\u00a0(excipients) are the amino acid\u00a0proline, water for injections, and\u00a0hydrochloric acid\u00a0or sodium hydroxide (for\u00a0pH\u00a0adjustment).<\/li><\/ul>\n\n\n\n

                                  What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n

                                  Privigen is available as an infusion solution.<\/p>\n\n\n\n

                                  The solution is clear or slightly shimmery and colorless to pale yellow.<\/p>\n\n\n\n

                                  Pack sizes:<\/p>\n\n\n\n

                                  1 vial (2.5 g \/ 25 ml, 5 g \/ 50 ml, 10 g \/ 100 ml, 20 g \/ 200 ml or 40 g \/ 400 ml),<\/p>\n\n\n\n

                                  3 vials (10 g \/ 100 ml or 20 g \/ 200 ml).<\/p>\n\n\n\n

                                  Not all pack sizes may be marketed.<\/p>\n\n\n\n

                                  Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n

                                  CSL Behring GmbH<\/strong><\/p>\n\n\n\n

                                  Emil-von-Behring-Strasse 76<\/p>\n\n\n\n

                                  D-35041 Marburg<\/p>\n\n\n\n

                                  Germany<\/p>\n","protected":false},"excerpt":{"rendered":"

                                  Privigen belongs to a group of medicines called human normal immunoglobulin. Immunoglobulins are also called antibodies and are blood proteins that help the body fight infections in healthy people.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[13449,21928,2828,2831,21924,21927,9070,9069,21925,21926],"class_list":["post-21259","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-human-normal-immunoglobulin","tag-benefits-of-privigen","tag-human-normal-immunoglobulin","tag-human-normal-immunoglobulin-side-effects","tag-privigen","tag-privigen-side-effects","tag-what-human-normal-immunoglobulin-is-used-for","tag-what-is-human-normal-immunoglobulin","tag-what-is-privigen","tag-what-privigen-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21259"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21259\/revisions"}],"predecessor-version":[{"id":21310,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21259\/revisions\/21310"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21259"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21259"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}