{"id":21219,"date":"2022-05-17T10:01:19","date_gmt":"2022-05-17T10:01:19","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21219"},"modified":"2022-05-17T15:42:01","modified_gmt":"2022-05-17T15:42:01","slug":"prismasol","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/prismasol\/","title":{"rendered":"Prismasol uses, dose and side effects"},"content":{"rendered":"\n<p>2 mmol \/ l&nbsp;potassium&nbsp;hemodialysis fluid \/ hemofiltration fluid<br>Calcium chloride dihydrate \/ Magnesium chloride hexahydrate \/ Glucose monohydrate \/ Lactic acid solution, 90% w \/ w \/ Sodium chloride \/ Potassium chloride \/ Sodium bicarbonate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Prismasol\u00ae is and what it is used for<\/h2>\n\n\n\n<p>Prismacolor contains the active substances calcium chloride dihydrate, magnesium chloride hexahydrate, glucose monohydrate, lactic acid solution 90% w \/ w, sodium chloride, potassium chloride, and sodium bicarbonate.<\/p>\n\n\n\n<p>Prismacolor is used in the treatment of\u00a0renal failure\u00a0as a solution in\u00a0continuous\u00a0hemofiltration\u00a0or hemodiafiltration (as a replacement for the fluid that the blood loses as it passes through a filter) and\u00a0continuous\u00a0hemodialysis\u00a0or hemodiafiltration (the blood circulates on one side of the dialysis membrane while the hemodialysis fluid circulates on the other side of\u00a0membrane\u00a0et).<\/p>\n\n\n\n<p>The solution can also be used in drug poisoning of dialyzable or filterable substances.<\/p>\n\n\n\n<p>Prismacolor 2 mmol \/ l\u00a0potassium\u00a0is especially indicated for patients with a tendency to\u00a0hyperkalemia\u00a0(high levels of\u00a0potassium\u00a0in the blood).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Prismasol\u00ae<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Prismasol 2 mmol \/ l potassium in:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>allergy&nbsp;to any of the active substances or any of the other ingredients of this medicine (listed in section 6)<\/li><li>low level of&nbsp;potassium&nbsp;in the blood (&nbsp;hypokalaemia&nbsp;)<\/li><li>high level of&nbsp;bicarbonate&nbsp;in the blood (&nbsp;metabolic alkalosis&nbsp;).<\/li><\/ul>\n\n\n\n<p>The presence of maize antigen in Prismasol cannot be ruled out.<\/p>\n\n\n\n<p><strong>Do not use haemofiltration\/dialysis if:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have&nbsp;kidney failure&nbsp;with pronounced hypercatabolism (abnormally increased&nbsp;catabolism&nbsp;) and the uremic symptoms (symptoms caused by high levels of&nbsp;urea&nbsp;in the blood) can not be corrected with&nbsp;hemofiltration<\/li><li>you have insufficient arterial pressure in the vessel access<\/li><li>you have systemic anticoagulation (decreased coagulation capacity) and there is a high risk of bleeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Prismasol.\u00a0The solution should only be used by, or under the supervision of, physicians competent in the treatment of\u00a0renal failures\u00a0such as\u00a0hemofiltration, hemodiafiltration, or\u00a0continuous\u00a0hemodialysis.<\/p>\n\n\n\n<p>Before and during treatment, the\u00a0hemodynamic\u00a0status will be checked, for example, the acid-base balance and the level of\u00a0electrolytes\u00a0(salts in the blood) will be monitored, including all fluid you receive (\u00a0intravenous\u00a0infusion\u00a0) and which you produce (urine production), including fluid that is not directly related to the treatment.<\/p>\n\n\n\n<p>Blood sugar levels should be closely monitored, especially if you have\u00a0diabetes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Prismasol\u00ae<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<br>Blood levels of other medicines may be reduced during treatment.\u00a0The doctor decides if the medication needs to be corrected.<\/p>\n\n\n\n<p>Your doctor needs to know if you are using:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Digitalis preparations (for the treatment of certain heart diseases), as\u00a0digitalis\u00a0increases the risk of\u00a0cardiac arrhythmia\u00a0(the heart beats irregularly or quickly) in case of\u00a0hypokalaemia\u00a0(low potassium content in the blood).<\/li><li>Vitamin D\u00a0and\u00a0calcium-containing medicines\u00a0may increase the risk of\u00a0hypercalcemia\u00a0(high blood calcium).<\/li><li>Any addition of sodium bicarbonate (or another buffer source) may increase the risk of\u00a0metabolic alkalosis\u00a0(excess\u00a0bicarbonate\u00a0in the blood).<\/li><li>When citrate is used as an anticoagulant (as a protective additive in dialysis equipment), it may lower\u00a0plasma\u00a0calcium levels.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.\u00a0It is up to the doctor to decide if you should be treated with Prismasol when you are pregnant or breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Prismacolor is not known to affect your ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Prismasol\u00ae<\/h2>\n\n\n\n<p>Method of administration: For\u00a0intravenous\u00a0use and hemodialysis.<\/p>\n\n\n\n<p>The operating instructions can be found in the section &#8220;The following information is intended only for healthcare professionals&#8221; below.<\/p>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The volume of Prismasol to be used varies depending on your clinical condition and desired fluid balance.&nbsp;Dosage&nbsp;one is therefore the responsibility of the treating physician.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you think you have used too much Prismasol\u00ae<\/h2>\n\n\n\n<p>Your fluid,\u00a0electrolyte,\u00a0and acid-base balance will be closely monitored.<\/p>\n\n\n\n<p>If an overdose is unlikely to occur, your doctor will take the necessary corrective action and adjust your\u00a0dose.<\/p>\n\n\n\n<p>Overdose can result in:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>too much fluid in the blood<\/li><li>elevated bicarbonate level in the blood (\u00a0metabolic alkalosis\u00a0)<\/li><li>and\/or decreased salt levels in the blood (\u00a0hypophosphatemia,\u00a0hypokalemia\u00a0). Overdose can have serious consequences such as\u00a0heart failure,\u00a0and electrolyte\u00a0or acid-base disorders.<\/li><\/ul>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been reported:<\/p>\n\n\n\n<p>Has been reported: occurs in an unknown number of users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Changes in salt levels in the blood (disturbed electrolyte balance such as\u00a0hypophosphatemia,\u00a0hypokalaemia\u00a0)<\/li><li>Increased level of\u00a0bicarbonate\u00a0in blood plasma (\u00a0metabolic alkalosis\u00a0) or decreased level of\u00a0bicarbonate\u00a0in blood plasma (metabolic\u00a0acidosis\u00a0)<\/li><li>The abnormally high or low fluid level in the body (hyper- or\u00a0hypovolemia\u00a0)<\/li><li>Abnormally high level of\u00a0glucose\u00a0in the blood (hyperglycemia)<\/li><li>Nausea<\/li><li>Vomiting<\/li><li>Muscle cramps<\/li><li>Hypotension\u00a0(low\u00a0blood pressure\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Prismasol\u00ae<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store at least + 4 \u00b0 C.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;or EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>For the reconstituted solution, chemical and physical in-use stability have been demonstrated for 24 hours at 22 \u00b0 C.\u00a0If not used immediately, in-use storage times and conditions before\u00a0administration\u00a0are the responsibility of the user and should not exceed 24 hours, including treatment time.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p><strong>The active substances are<\/strong><\/p>\n\n\n\n<p><strong>Before\u00a0mixing<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Calcium chloride dihydrate<\/td><td>5.145 g<\/td><\/tr><tr><td>Magnesium chloride hexahydrate<\/td><td>2,033 g<\/td><\/tr><tr><td>Glucose<\/td><td>22,000 g<\/td><\/tr><tr><td>(S) &#8211;&nbsp;lactic acid<\/td><td>5,400 g<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Sodium chloride<\/td><td>6,450 g<\/td><\/tr><tr><td>Sodium bicarbonate<\/td><td>3,090 g<\/td><\/tr><tr><td>Potassium chloride<\/td><td>0.157 g<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>After\u00a0mixing<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><\/th><th scope=\"col\"><\/th><th scope=\"col\">mmol \/ l<\/th><th scope=\"col\">mEq \/ l<\/th><\/tr><\/thead><tbody><tr><td>Calcium<\/td><td>Ca&nbsp;<sup>2+<\/sup><\/td><td>1.75<\/td><td>3.50<\/td><\/tr><tr><td>Magnesium<\/td><td>Mg&nbsp;<sup>2+<\/sup><\/td><td>0.50<\/td><td>1.00<\/td><\/tr><tr><td>Sodium<\/td><td>Na&nbsp;<sup>+<\/sup><\/td><td>140.00<\/td><td>140.00<\/td><\/tr><tr><td>Chloride<\/td><td>Cl&nbsp;<sup>&#8211;<\/sup><\/td><td>111.50<\/td><td>111.50<\/td><\/tr><tr><td>Lactate<\/td><td>&nbsp;<\/td><td>3.00<\/td><td>3.00<\/td><\/tr><tr><td>Hydrocarbonate<\/td><td>HCO&nbsp;<sub>3&nbsp;<\/sub><sup>&#8211;<\/sup><\/td><td>32.00<\/td><td>32.00<\/td><\/tr><tr><td>Potassium<\/td><td>K&nbsp;<sup>+<\/sup><\/td><td>2.00<\/td><td>2.00<\/td><\/tr><tr><td>Glucose<\/td><td>&nbsp;<\/td><td>6.10<\/td><td>&nbsp;<\/td><\/tr><tr><td>Theoretical osmolarity<\/td><td>297 mOsm \/ l<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>The other ingredients are:\u00a0<\/strong>carbon dioxide\u00a0(E290), water for injections<br>the pH\u00a0of the reconstituted solution: 7.0-8.5<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Prismacolor is packed in a two-chamber bag with electrolyte solution in the smaller chamber A and buffer solution in the larger chamber B. The ready-mixed solution is obtained by opening the so-called peel-seal closure and mixing the two solutions.\u00a0The reconstituted solution is clear and pale yellow.\u00a0Each bag (A + B) contains 5000 ml of replacement solution for\u00a0haemofiltration\u00a0and\u00a0hemodialysis.\u00a0The bag has an outer packaging of transparent\u00a0film.<br>Each box contains two bags and a package leaflet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Baxter Holding BV<\/p>\n\n\n\n<p>Kobaltweg 49<\/p>\n\n\n\n<p>3542CE Utrecht<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Bieffe Medital SpA, Via Stelvio 94, 23035 Sondalo (SO), Italy<\/p>\n\n\n\n<p>Baxter Healthcare SA, Moneen Road, Castlebar, County Mayo, F23 XR63, Ireland<\/p>\n\n\n\n<p><strong>Local representative<\/strong><\/p>\n\n\n\n<p>Baxter Medical AB<\/p>\n\n\n\n<p>Box 63<\/p>\n\n\n\n<p>164 94 Kista<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prismasol contains the active substances calcium chloride dihydrate, magnesium chloride hexahydrate, glucose monohydrate, lactic acid solution 90% w \/ w, sodium chloride, potassium chloride and sodium bicarbonate.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21767,21766,21769,5012,21768,14284,4230,21762,21765,14699,11616,21763,21764],"class_list":["post-21219","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-90-w-w","tag-benefits-of-prismasol","tag-calcium-chloride-dehydrate","tag-glucose-monohydrate","tag-lactic-acid-solution","tag-magnesium-chloride-hexahydrate","tag-potassium-chloride","tag-prismasol","tag-prismasol-side-effects","tag-sodium-bicarbonate","tag-sodium-chloride","tag-what-is-prismasol","tag-what-prismasol-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21219","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21219"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21219\/revisions"}],"predecessor-version":[{"id":21246,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21219\/revisions\/21246"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21219"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21219"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}