{"id":21207,"date":"2022-05-17T09:51:42","date_gmt":"2022-05-17T09:51:42","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21207"},"modified":"2022-05-17T15:42:33","modified_gmt":"2022-05-17T15:42:33","slug":"primperan","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/primperan\/","title":{"rendered":"Primperan &#8211; Metoclopramide uses, dose and side effects"},"content":{"rendered":"\n<p>5 mg \/ ml&nbsp;solution&nbsp;for injection<br>metoclopramide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Primperan is and what it is used for<\/h2>\n\n\n\n<p>Primperan is an&nbsp;antiemetic&nbsp;(medicine for nausea and vomiting).&nbsp;It contains a substance called metoclopramide.&nbsp;It acts on an area of \u200b\u200bthe brain that prevents you from getting nauseous and vomiting.<\/p>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<p>Primperan is used in adults to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>prevent nausea and vomiting that may occur after surgery<\/li><li>treat nausea and vomiting, including nausea and vomiting that may occur with&nbsp;migraines<\/li><li>prevent nausea and vomiting caused by radiation therapy.<\/li><\/ul>\n\n\n\n<p><strong>Children and young people<\/strong><\/p>\n\n\n\n<p>Primperan is used in children (aged 1-18 years) if other treatment does not work or can not be used to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>prevent delayed nausea and vomiting that may occur after chemotherapy<\/li><li>treat nausea and vomiting that have occurred after surgery.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Primperan<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Primperan<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to metoclopramide or any of the other ingredients of this medicine (listed in section 6.1)<\/li><li>if you have bleeding, obstruction, or ulcers in the gastrointestinal tract<\/li><li>if you have or may have a rare adrenal\u00a0tumor\u00a0(\u00a0pheochromocytoma\u00a0)<\/li><li>if you have ever had involuntary muscle twitching (\u00a0tardive dyskinesia\u00a0), after being treated with medication<\/li><li>if you have\u00a0epilepsy<\/li><li>if you have\u00a0Parkinson&#8217;s disease<\/li><li>if you are taking\u00a0levodopa\u00a0(a medicine used to\u00a0treat Parkinson&#8217;s disease\u00a0) or dopamine agonists (see below &#8220;Other medicines and Primperan&#8221;)<\/li><li>if you have ever had abnormal pigment levels in your blood (methemoglobinemia) or<\/li><li>or NADH cytochrome \u2011 b5 deficiency<\/li><\/ul>\n\n\n\n<p>Primperan should not be given to children under 1 year of age (see below \u201cChildren and adolescents\u201d).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Primperan if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have had an abnormal heart rhythm (\u00a0QT\u00a0prolongation) or other heart problems<\/li><li>you have high\u00a0blood pressure<\/li><li>you have problems with salt levels in the blood, such as\u00a0potassium,\u00a0sodium,\u00a0and\u00a0magnesium<\/li><li>you are using other medicines that affect your heart rhythm<\/li><li>you have a neurological condition (nerve or muscle disease)<\/li><li>you have kidney or liver problems.\u00a0Dose\u00a0one may need to be reduced (see section 3).<\/li><\/ul>\n\n\n\n<p>Your doctor may need to take blood samples to check your pigment levels in the blood.&nbsp;In case of abnormal levels (methemoglobinemia), treatment should be stopped immediately and permanently.<\/p>\n\n\n\n<p>Do not exceed three months of treatment due to the risk of involuntary muscle twitching.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Involuntary movements (extrapyramidal disorders) may occur in children and adolescents.&nbsp;Primperan must not be used in children under 1 year of age due to the increased risk of involuntary movements (see above &#8220;Do not use Primperan&#8221;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Primperan<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines.\u00a0The reason is that certain drugs can affect how Primperan works or that Primperan can affect how other drugs work.\u00a0These medicines include the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>levodopa\u00a0or other medicines used to treat\u00a0Parkinson&#8217;s disease\u00a0(see above &#8220;Do not use Primperan&#8221;)<\/li><li>anticholinergics (medicines for stomach cramps or\u00a0spasms\u00a0)<\/li><li>morphine derivatives (medicines used to treat severe pain)<\/li><li>sedative\u00a0(sedative) drugs, also include some\u00a0antihistamines\u00a0with a sedative effect<\/li><li>drugs for the treatment of\u00a0psychosis\u00a0and depression, such as\u00a0fluoxetine\u00a0and\u00a0paroxetine<\/li><li>digoxin\u00a0(a drug for the treatment of\u00a0heart failure\u00a0)<\/li><li>ciclosporin (medicines used to treat certain disorders of the immune system)<\/li><li>mivacurium and suxamethone (muscle relaxants)<\/li><li>atovaquone, a remedy for a certain type of\u00a0pneumonia\u00a0and\u00a0malaria<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Primperan with alcohol<\/h2>\n\n\n\n<p>Alcohol should not be consumed during treatment with metoclopramide as it increases the\u00a0sedative\u00a0(calming\/calming) effect of Primperan.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Primperan can be taken during pregnancy if necessary.&nbsp;Your doctor will decide if you should receive this medicine.<\/p>\n\n\n\n<p>Primperan is not recommended if you are breastfeeding because metoclopramide passes into breast milk and may affect your baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You may feel drowsy and dizzy.&nbsp;Extrapyramidal&nbsp;side effects&nbsp;such as involuntary movements and abnormal muscle tension may occur after taking Primperan.&nbsp;This may affect your ability to drive and use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Primperan<\/h2>\n\n\n\n<p>The medicine will normally be given to you by a doctor or nurse.&nbsp;It will be given as a slow&nbsp;injection&nbsp;into a vein (for at least 3 minutes) or by&nbsp;injection&nbsp;into a muscle.<\/p>\n\n\n\n<p>There must be at least 6 hours between each&nbsp;dose&nbsp;of Primperan to avoid overdose.<\/p>\n\n\n\n<p><strong>Adults:<\/strong><\/p>\n\n\n\n<p>For the treatment of nausea and vomiting including nausea and vomiting that may occur in&nbsp;migraine&nbsp;and for the prevention of nausea and vomiting during radiation therapy: The recommended single dose is 10 mg, which can be repeated up to 3 times daily.<\/p>\n\n\n\n<p>The maximum recommended\u00a0dose\u00a0per day is 30 mg or 0.5 mg\/kg body weight.<\/p>\n\n\n\n<p>To prevent nausea and vomiting that may occur after surgery, a single dose of 10 mg is recommended.<\/p>\n\n\n\n<p><strong>Children and adolescents (1-18 years):<\/strong><\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0is 0.1 to 0.15 mg\/kg body weight, which can be repeated up to three times a day, given as a slow\u00a0injection\u00a0into a vein.<\/p>\n\n\n\n<p>The maximum\u00a0dose\u00a0for 24 hours is 0.5 mg\/kg body weight.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><td>Age<\/td><td>Bodyweight<\/td><td>Dose<\/td><td>Frequency<\/td><\/tr><\/thead><tbody><tr><td>1-3 years<\/td><td>10-14 kg<\/td><td>1 mg<\/td><td>Up to 3 times daily<\/td><\/tr><tr><td>3-5 years<\/td><td>15-19 kg<\/td><td>2 mg<\/td><td>Up to 3 times daily<\/td><\/tr><tr><td>5-9 years<\/td><td>20-29 kg<\/td><td>2.5 mg<\/td><td>Up to 3 times daily<\/td><\/tr><tr><td>9-18 years<\/td><td>30-60 kg<\/td><td>5 mg<\/td><td>Up to 3 times daily<\/td><\/tr><tr><td>15-18 years<\/td><td>Over 60kg<\/td><td>10 mg<\/td><td>Up to 3 times daily<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Treatment should not exceed 48 hours for the treatment of nausea and vomiting that have occurred after surgery.<\/p>\n\n\n\n<p>Treatment should not exceed 5 days for the prevention of delayed nausea and vomiting that may occur after chemotherapy.<\/p>\n\n\n\n<p><strong>Elderly<\/strong><\/p>\n\n\n\n<p>Dose\u00a0one may need to be lowered depending on kidney problems, liver problems, and general condition.<\/p>\n\n\n\n<p><strong>Adults with kidney problems<\/strong><\/p>\n\n\n\n<p>Talk to your doctor if you have kidney problems.&nbsp;Dose&nbsp;one should be lowered if you have moderate or severe kidney problems.<\/p>\n\n\n\n<p><strong>Adults with liver problems<\/strong><\/p>\n\n\n\n<p>Talk to your doctor if you have liver problems.&nbsp;Dose&nbsp;one should be lowered if you have severe liver problems.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Metoclopramide should not be used in children under 1 year of age (see section 2).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Primperan than you should<\/h2>\n\n\n\n<p>It is unlikely that your doctor or nurse will give you too much medicine.&nbsp;Your doctor and nurse will monitor your treatment.&nbsp;Always ask if you are unsure why you are receiving a&nbsp;dose of&nbsp;medicine.<\/p>\n\n\n\n<p>The following symptoms may occur if you get too much Primperan: involuntary movements (extrapyramidal disorders), drowsiness, decreased level of consciousness, confusion, hallucinations, and heart problems.\u00a0Tell your healthcare provider if you experience any of these symptoms.\u00a0In that case, your doctor will prescribe treatment for these symptoms as needed.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse immediately if you get any of the following symptoms while taking this medicine, then treatment must be stopped:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>involuntary movements or muscle contractions (often involving the head or neck).\u00a0It can occur in children or adolescents and especially when high\u00a0doses\u00a0are used.\u00a0These symptoms usually appear at the beginning of treatment and may even occur after a single\u00a0dose.\u00a0These movements will cease after they have been treated appropriately.<\/li><li>high fever, high\u00a0blood pressure, cramps, sweating, salivation.\u00a0It may be a symptom of a condition called a malignant neuroleptic syndrome.<\/li><li>itching\u00a0or rash, difficulty breathing, shortness of breath, swelling of the face, lips, throat, or tongue, cold sweaty skin, palpitations, dizziness, weakness, or fainting.\u00a0It can be a symptom of an\u00a0allergic reaction, which can be serious.<\/li><\/ul>\n\n\n\n<p><br>The following&nbsp;side effects&nbsp;may occur:<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fatigue and increased need for sleep.<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Depression<\/li><li>involuntary movements such as\u00a0tics, tremors, twisting movements, or muscle contractions (stiffness, stiffness)<\/li><li>symptoms similar to\u00a0Parkinson&#8217;s disease\u00a0(stiffness, tremors)<\/li><li>restlessness<\/li><li>lowering of blood pressure (especially with\u00a0intravenous\u00a0administration\u00a0)<\/li><li>diarrhea<\/li><li>feeling weak.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>elevated levels in the blood of a\u00a0hormone\u00a0called\u00a0prolactin, which can cause: milk production in men and in women who are not breastfeeding<\/li><li>irregular menstruation<\/li><li>hallucinations<\/li><li>impaired consciousness<\/li><li>slow heart rhythm (especially with\u00a0intravenous\u00a0administration\u00a0)<\/li><li>allergy<\/li><li>dry mouth<\/li><li>rash<\/li><li>visual disturbances and involuntary eye movements<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>state of confusion<\/li><li>seizures (especially in patients with&nbsp;epilepsy&nbsp;)<\/li><li>high&nbsp;blood pressure<\/li><li>hives<\/li><\/ul>\n\n\n\n<p><strong>No known frequency<\/strong>&nbsp;(can not be calculated from the available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions (such as\u00a0anaphylaxis,\u00a0angioedema,\u00a0and\u00a0hives\u00a0).\u00a0Symptoms may include rash,\u00a0itching, difficulty breathing, shortness of breath, swelling of the face, lips, throat, or tongue, cold sweaty skin, palpitations, dizziness, weakness, or fainting.\u00a0Contact a doctor or other healthcare professional immediately or see the nearest emergency department.<\/li><li>Abnormal levels of blood pigments that can change the color of your skin<\/li><li>abnormal development of the breast (\u00a0gynecomastia\u00a0)<\/li><li>involuntary muscle spasms after prolonged use, especially in elderly patients<\/li><li>high fever, high\u00a0blood pressure, cramps, sweating, salivation.\u00a0It can be a symptom of a condition called neuroleptic malignant syndrome<\/li><li>changes in heart rate that can be seen on an\u00a0ECG\u00a0test<\/li><li>cardiac arrest (especially with\u00a0injection\u00a0)<\/li><li>shock\u00a0(severe decrease in heart pressure) (especially with\u00a0injection\u00a0)<\/li><li>fainting (especially with\u00a0intravenous\u00a0administration\u00a0)<\/li><li>increase in\u00a0blood pressure\u00a0et<\/li><li>very high\u00a0blood pressure<\/li><li>suicidal thoughts<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.\u00a0This also applies to any side effects not mentioned in this information.\u00a0You can also report side effects directly to the Medical Products Agency,\u00a0www.lakemedelsverket.se.\u00a0By reporting side effects, you can help increase drug safety information. <a href=\"javascript:void(0);\">Postal address<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Primperan<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;or EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is metoclopramide<\/li><li>The other ingredients are sodium chloride 7.5 mg, water for injections<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Each pack contains 12&nbsp;glass&nbsp;ampoules of 2 ml<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Sanofi AB, Box 30052, 104 25 Stockholm<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Primperan is an antiemetic (medicine for nausea and vomiting). It contains a substance called metoclopramide. It acts on an area of \u200b\u200bthe brain that prevents you from getting nauseous and vomiting.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21798,21803,21794,21797,21799,21802,21795,21800,21796,21801],"class_list":["post-21207","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-metoclopramide","tag-benefits-of-primperan","tag-metoclopramide","tag-metoclopramide-side-effects","tag-primperan","tag-primperan-side-effects","tag-what-is-metoclopramide","tag-what-is-primperan","tag-what-metoclopramide-is-used-for","tag-what-primperan-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21207","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21207"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21207\/revisions"}],"predecessor-version":[{"id":21251,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21207\/revisions\/21251"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21207"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21207"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21207"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}