{"id":21201,"date":"2022-05-17T09:44:47","date_gmt":"2022-05-17T09:44:47","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21201"},"modified":"2022-05-17T15:43:25","modified_gmt":"2022-05-17T15:43:25","slug":"prezista","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/prezista\/","title":{"rendered":"Prezista – Darunavir uses, dose and side effects"},"content":{"rendered":"\n
75 mg film-coated tablets darunavir<\/p>\n\n\n\n
What PREZISTA is and what it is used for<\/h2>\n\n\n\n
What PREZISTA is<\/strong><\/p>\n\n\n\n
PREZISTA contains the active substance darunavir.\u00a0PREZISTA is an antiretroviral medicine used to treat\u00a0human immunodeficiency virus (\u00a0HIV\u00a0)\u00a0infection.\u00a0It belongs to a group of medicines called\u00a0protease inhibitors.\u00a0PREZISTA works by reducing the amount of\u00a0HIV\u00a0in your body.\u00a0This improves your immune system and reduces the risk of developing diseases associated\u00a0with\u00a0HIV\u00a0infection.<\/p>\n\n\n\n
What is it used for<\/strong><\/p>\n\n\n\n
PREZISTA is used to treat adults and children over 3 years of age who weigh at least 15 kg who are infected with HIV and who have already used other antiretroviral medicines.<\/p>\n\n\n\n
PREZISTA must be taken in combination with a low dose of ritonavir and other HIV medicines. Your doctor will discuss with you which drug combination is best for you.<\/p>\n\n\n\n
What you need to know before taking PREZISTA<\/h2>\n\n\n\n
Do not take PREZISTA:<\/h2>\n\n\n\n
if you are allergic<\/strong> to darunavir or any of the other ingredients of this medicine (listed in section 6) or to ritonavir.<\/li>
if you have severe liver disease. <\/strong>Talk to your doctor if you are unsure about the severity of your liver disease. Additional tests may be necessary.<\/li><\/ul>\n\n\n\n
Tell your doctor about all<\/strong> medicines you take, including medicines you take by mouth, inhale, inject or lubricate your skin.<\/p>\n\n\n\n
Do not combine PREZISTA with any of the following medicines<\/strong><\/p>\n\n\n\n
If you take any of these, ask your doctor if you can switch to another medicine.<\/p>\n\n\n\n
Drug<\/strong><\/td>
Area of \u200b\u200bthe use of the drug<\/strong><\/td><\/tr>
Avanafil<\/em><\/td>
to treat erection problems<\/td><\/tr>
Astemizole<\/em> or terfenadine<\/em><\/td>
to treat allergy symptoms<\/td><\/tr>
Triazolam<\/em> and midazolam<\/em> taken by mouth<\/td>
to help you sleep and\/or to relieve anxiety<\/td><\/tr>
Cisapride<\/em><\/td>
to treat certain stomach problems<\/td><\/tr>
Colchicine<\/em>\u00a0(if you have kidney and\/or liver problems)<\/td>
to treat gout or familial Mediterranean fever<\/td><\/tr>
Lurasidone, pimozide, quetiapine<\/em> or sertindole<\/em><\/td>
to treat certain heart diseases, e.g. irregular heartbeat<\/td><\/tr>
Lovastatin, simvastatin and lomitapid<\/em><\/td>
to lower cholesterol levels<\/td><\/tr>
Rifampicin<\/em><\/td>
to treat certain infections such as tuberculosis<\/td><\/tr>
The combination drug lopinavir \/ ritonavir<\/em><\/td>
this anti- HIV drug belongs to the same class as PREZISTA<\/td><\/tr>
Elbasvir \/ grazoprevir<\/em><\/td>
to treat hepatitis C infection<\/td><\/tr>
Alfuzosin<\/em><\/td>
for the treatment of enlarged prostate<\/td><\/tr>
Sildenafil<\/em><\/td>
for the treatment of high blood pressure in the blood vessels of the lungs.<\/td><\/tr>
Dabigatran<\/em> , tikagrelor<\/em><\/td>
to prevent platelets from clotting in the treatment of patients who have had a heart attack<\/td><\/tr>
Naloxegol<\/em><\/td>
to treat constipation caused by opioids<\/td><\/tr>
Dapoxetine<\/em><\/td>
to treat premature ejaculation<\/td><\/tr>
Domperidone<\/em><\/td>
to treat nausea and vomiting<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
Do not take PREZISTA with products containing\u00a0St. John’s wort (\u00a0Hypericum perforatum<\/em>\u00a0).<\/p>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
Talk to your doctor, pharmacist, or nurse before taking PREZISTA.<\/p>\n\n\n\n
PREZISTA does not\u00a0cure\u00a0HIV\u00a0infection.\u00a0You can still transmit\u00a0HIV\u00a0infection when you take this medicine, even though the risk of effective\u00a0antiviral\u00a0therapy is reduced.\u00a0Discuss with your doctor the necessary steps to avoid infecting others.<\/p>\n\n\n\n
People taking PREZISTA may still develop\u00a0infections\u00a0or\u00a0other illnesses associated with\u00a0HIV\u00a0infection.\u00a0You must continue to have regular contact with your doctor.<\/p>\n\n\n\n
People taking PREZISTA may develop a skin rash. In rare cases, a rash can be serious or potentially life-threatening. Always consult your doctor if you develop a rash.<\/p>\n\n\n\n
Rash (usually mild or moderate) may occur more frequently in patients taking both PREZISTA and raltegravir (in case of HIV infection ) than in patients taking either of these medicines.<\/p>\n\n\n\n
Inform your doctor about your situation BEFORE and DURING your treatment<\/strong><\/p>\n\n\n\n
Check the following points and tell your doctor if any of these apply to you.<\/p>\n\n\n\n
Tell your doctor if you have a\u00a0history of liver problems<\/strong>, including\u00a0hepatitis\u00a0B or C\u00a0infection.\u00a0Your doctor can assess the severity of your liver disease before deciding if you can take PREZISTA.<\/li>
Tell your doctor if you have\u00a0diabetes.\u00a0PREZISTA may increase blood sugar levels.<\/li>
Tell your doctor immediately if you notice any\u00a0symptoms of\u00a0infection\u00a0(such as enlarged\u00a0lymph nodes\u00a0or fever).\u00a0In some patients with advanced\u00a0HIV\u00a0infection\u00a0and\u00a0who have previously had an\u00a0opportunistic infection, signs, and symptoms of\u00a0inflammation\u00a0from a previous\u00a0infection\u00a0may appear shortly after starting treatment with\u00a0HIV\u00a0medicines.\u00a0It is believed that these symptoms are due to an improvement in the body’s\u00a0immune response, which enables the body to fight\u00a0infections\u00a0that may have been present without giving clear symptoms.<\/li>
In addition to opportunistic\u00a0infections, autoimmune disorders (conditions in which the immune system attacks healthy body tissue) can also occur after you start taking medicines to treat\u00a0your\u00a0HIV\u00a0infection.\u00a0Autoimmune disorders can occur several months after starting treatment.\u00a0If you notice any symptoms of\u00a0infection\u00a0or other symptoms such as muscle weakness, a weakness that starts in the hands or feet and moves to the torso, palpitations, tremors, or hyperactivity,inform your doctor immediately for the necessary treatment.<\/li>
Tell your doctor if you have\u00a0hemophilia.\u00a0PREZISTA may increase the risk of bleeding.<\/li>
Tell your doctor if you are\u00a0allergic to\u00a0sulphonamides\u00a0(such as those used to treat certain\u00a0infections\u00a0).<\/li>
Tell your doctor if you notice any\u00a0problems with your muscles and bones.\u00a0Some patients taking combination\u00a0antiviral\u00a0therapy may develop a skeletal disease called\u00a0osteonecrosis\u00a0(dead bone tissue due to loss of blood supply to the skeleton).\u00a0The length of the combination antiviral therapy,\u00a0corticosteroid\u00a0use, alcohol consumption, severe immunosuppression (severely weakened immune system), and high\u00a0BMI\u00a0(\u00a0body mass index\u00a0), can be some of the many risk factors for developing the disease.\u00a0Signs of\u00a0osteonecrosis are stiff and aching joints (especially in the hip, knee, and shoulder) and difficulty moving.\u00a0If you notice any of these symptoms, talk to your doctor.<\/li><\/ul>\n\n\n\n
Older<\/strong><\/p>\n\n\n\n
PREZISTA has only been used in a limited number of patients aged 65 years or older. If you belong to this age group, discuss with your doctor if you can use PREZISTA.<\/p>\n\n\n\n
Children<\/h2>\n\n\n\n
PREZISTA should not be used in children under 3 years of age or weighing less than 15 kg.<\/p>\n\n\n\n
Other medicines and PREZISTA<\/h2>\n\n\n\n
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines.<\/p>\n\n\n\n
There are certain medicines that you must not combine<\/strong> with PREZISTA. These are listed above under the heading “Do not combine PREZISTA with any of the following medicines”.<\/p>\n\n\n\n
In most cases, PREZISTA can be combined with anti-\u00a0HIV\u00a0medicines belonging to other classes (eg NRTIs (\u00a0nucleoside analogs), NNRTIs (non-nucleoside analogs), CCR5\u00a0antagonists,\u00a0and FIs (fusion inhibitors). Ritonavir has not been tested with all PIs (\u00a0protease inhibitors ), and must not be\u00a0used\u00a0with other\u00a0HIV\u00a0-PIs. other medicines for\u00a0HIV\u00a0and carefully follow your doctor’s instructions on which medicines can be combined.<\/p>\n\n\n\n
The effect of PREZISTA may be reduced if you take any of the following medicines. Tell your doctor if you are taking:<\/p>\n\n\n\n
The plastic jar has a child-resistant lid and should be opened as follows: Press the plastic cap down while turning it counterclockwise. Remove the lid.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
If you take more PREZISTA than you should<\/h2>\n\n\n\n
Contact a doctor, pharmacist, or nurse immediately.<\/p>\n\n\n\n
If you forget to take PREZISTA<\/h2>\n\n\n\n
If you notice this\u00a0within 6 hours<\/strong>, take the tablets immediately.\u00a0Always take the tablets with ritonavir and food.\u00a0If you notice it\u00a0later than 6 hours\u00a0after the missed\u00a0dose, skip the tablets and take the next\u00a0dose\u00a0as usual.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n
If you vomit after taking PREZISTA and ritonavir<\/strong><\/p>\n\n\n\n
If you vomit\u00a0within 4 hours<\/strong>\u00a0of taking the medicine, take another\u00a0dose\u00a0of PREZISTA and ritonavir with food as soon as possible.\u00a0If you vomit\u00a0more than 4 hours<\/strong>\u00a0after taking the medicine, you do not need to take another\u00a0dose\u00a0of PREZISTA and ritonavir until you take the next scheduled\u00a0dose.<\/p>\n\n\n\n
Contact your doctor if you are not sure<\/strong> what to do if you miss a dose or vomit.<\/p>\n\n\n\n
Do not stop taking PREZISTA without talking to your doctor<\/h2>\n\n\n\n
Anti – HIV drugs can make you feel better. Even if you feel better, do not stop taking PREZISTA. Talk to your doctor first.<\/p>\n\n\n\n
If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
During HIV treatment, weight gain and increased levels of lipids and glucose in the blood may occur. This is partly related to restored health and lifestyle, but when it comes to blood lipids, there can sometimes be a connection with HIV drugs. The doctor will perform tests to find such changes.<\/p>\n\n\n\n
Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n
Tell your doctor if you experience any of the following side effects<\/strong><\/p>\n\n\n\n
Liver problems that can sometimes be serious have been reported.\u00a0Your doctor should take a blood sample before starting treatment with PREZISTA.\u00a0If you have\u00a0chronic\u00a0hepatitis\u00a0B or C\u00a0infection, your doctor should take blood tests more often because you have an increased risk of developing liver problems.\u00a0Talk to your doctor about the signs and symptoms of liver problems.\u00a0These may include yellowing of the skin or whites of the eyes, dark (tea-colored) urine, pale stools (bowel movements), nausea, vomiting, loss of appetite, or pain, aches or pains, and discomfort on the right side below the ribs.<\/p>\n\n\n\n
Skin rash (more often when used in combination with raltegravir),\u00a0itching.\u00a0The rash is usually mild to moderate.\u00a0A skin rash can also be a symptom of a rare difficult situation.\u00a0It is therefore important that you talk to your doctor if you get a rash.\u00a0Your doctor will advise you on how to deal with your symptoms or if PREZISTA needs to be stopped.<\/p>\n\n\n\n
Other serious side effects were diabetes (common) and inflammation of the pancreas (less common).<\/p>\n\n\n\n
Very common side effects (may affect more than 1 user in 10)<\/p>\n\n\n\n
diarrhea.<\/li><\/ul>\n\n\n\n
Common side effects (may affect up to 1 in 10 people)<\/p>\n\n\n\n
vomiting, nausea, stomach pain or tension, indigestion, flatulence<\/li>
headache, fatigue, dizziness, drowsiness, numbness, tingling or pain in hands and feet, weakness, and difficulty falling asleep.<\/li><\/ul>\n\n\n\n
Uncommon side effects (may affect up to 1 in 100 people)<\/p>\n\n\n\n
impaired or abnormal sensitivity of the skin, tingling, attention deficit, memory loss, balance problems<\/li>
difficulty breathing, cough, nosebleeds, irritation of the throat<\/li>
inflammation\u00a0of the stomach or mouth, heartburn, ulceration, dry mouth, abdominal discomfort, constipation, belching<\/li>
kidney failure,\u00a0kidney stones, difficulty urinating, frequent or heavy urination, sometimes at night<\/li>
hives, severe swelling of the skin or other\u00a0tissues\u00a0(usually lips or eyes),\u00a0eczema, excessive sweating, night sweats, hair loss,\u00a0acne, scaly skin, the coloring of the nails<\/li>
muscle pain, muscle cramps or muscle weakness, pain in the\u00a0extremities,\u00a0osteoporosis<\/li>
impaired thyroid function.\u00a0This can be seen in a blood test.<\/li>
high\u00a0blood pressure, hemorrhage<\/li>
red or dry eyes<\/li>
fever, swelling of the legs due to fluid, malaise, irritability, pain<\/li>
sleep problems, drowsiness, depression, anxiety, abnormal dreams, and decreased sexual desire.<\/li><\/ul>\n\n\n\n
Rare side effects (may affect up to 1 in 1,000 people)<\/p>\n\n\n\n
a reaction called DRESS [severe rash that may be accompanied by fever, fatigue, swelling of the face or\u00a0lymph nodes, increased\u00a0eosinophils\u00a0(type of\u00a0white blood cells\u00a0), effect on liver, kidney, or lung]<\/li>
heart attack, or slow heartbeat, palpitations<\/li>
visual disturbance<\/li>
chills, feeling abnormal<\/li>
state of confusion or disorientation, altered mood, restlessness<\/li>
fainting, epileptic seizures, altered or lost sense of taste<\/li>
cold sores, vomiting,\u00a0inflammation\u00a0of the lips, dry lips, coating on the tongue<\/li>
Runny nose<\/li>
skin changes, dry skin<\/li>
stiffness in muscles or joints, joint pain with or without\u00a0inflammation<\/li>
changes in certain blood levels.\u00a0These can be seen in the results of blood and urine tests.\u00a0Your doctor will explain this to you.\u00a0Examples are an increase in certain\u00a0white blood cells.<\/li><\/ul>\n\n\n\n
Some side effects are typical of anti – HIV medicines that belong to the same group as PREZISTA. These are:<\/p>\n\n\n\n
muscle aches, soreness, or weakness.\u00a0In rare cases, muscle problems have been severe.<\/li><\/ul>\n\n\n\n
How to store PREZISTA<\/h2>\n\n\n\n
Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n
Do not use this medicine after the expiry date which is stated on the carton and can after EXP. The expiration date is the last day of the specified month.<\/p>\n\n\n\n
No special storage instructions.<\/p>\n\n\n\n
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
The active substance is darunavir.\u00a0Each tablet contains 75 mg of darunavir (as ethanolate).<\/li>
The other ingredients are microcrystalline cellulose,\u00a0colloidal\u00a0anhydrous silica, crospovidone, and magnesium stearate.\u00a0The film coating contains poly (vinyl alcohol) – partially hydrolyzed, macrogol 3350, titanium dioxide (E171), and talc.<\/li><\/ul>\n\n\n\n
What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
Film-coated white oval tablet with TMC printed on one side and 75 on the other side. 480 tablets in a plastic jar.<\/p>\n\n\n\n
PREZISTA is also available in strengths of 150 mg, 400 mg, 600 mg, and 800 mg film-coated tablets and as a 100 mg\/ml\u00a0oral\u00a0suspension.<\/p>\n\n\n\n
Marketing Authorisation Holder<\/h2>\n\n\n\n
Janssen \u2011 Cilag International NV, 30 Turnhoutseweg, B-2340 Beerse, Belgium<\/p>\n\n\n\n
Manufacturer:<\/strong><\/p>\n\n\n\n
Janssen-Cilag SpA, Via C. Janssen, Borgo San Michele, 04100 Latina, Italy<\/p>\n\n\n\n
Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n
PREZISTA contains the active substance darunavir. PREZISTA is an antiretroviral medicine used to treat human immunodeficiency virus ( HIV ) infection . It belongs to a group of medicines called protease inhibitors . PREZISTA works by reducing the amount of HIV in your body. This improves your immune system and reduces the risk of developing diseases associated with HIV infection .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21820,6112,6114,6115,21821,21825,21824,21819,6113,21822,21823],"class_list":["post-21201","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-darunavir","tag-darunavir","tag-darunavir-side-effects","tag-darunavir-tablet","tag-prezista","tag-prezista-side-effects","tag-prezista-tablet","tag-what-darunavir-is-used-for","tag-what-is-darunavir","tag-what-is-prezista","tag-what-prezista-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21201","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21201"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21201\/revisions"}],"predecessor-version":[{"id":21254,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21201\/revisions\/21254"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21201"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21201"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21201"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}