{"id":21196,"date":"2022-05-17T09:41:39","date_gmt":"2022-05-17T09:41:39","guid":{"rendered":"https:\/\/zeepedia.com\/?p=21196"},"modified":"2022-05-17T15:43:30","modified_gmt":"2022-05-17T15:43:30","slug":"prevymis","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/prevymis\/","title":{"rendered":"PREVYMIS &#8211; Letermovir uses, dose and side effects"},"content":{"rendered":"\n<p>240 mg and 480 mg&nbsp;film-coated tablets<br>letermovir<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What PREVYMIS is and what it is used for<\/h2>\n\n\n\n<p>PREVYMIS is a prescription antiviral\u00a0medicine.\u00a0It contains the active substance letermovir.<\/p>\n\n\n\n<p>PREVYMIS is intended for adults who have recently undergone bone marrow transplantation.&nbsp;This medicine does not help you get&nbsp;CMV&nbsp;(&nbsp;cytomegalovirus&nbsp;).<\/p>\n\n\n\n<p>CMV\u00a0is a\u00a0virus\u00a0that many people have without knowing it.\u00a0Normally,\u00a0CMV\u00a0is present in their body without harming them, but if your immune system is weakened after a bone marrow transplant, you may have a greater risk of getting\u00a0CMV.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking PREVYMIS<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take PREVYMIS if:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>you are allergic to letermovir or any of the other ingredients of this medicine (listed in section 6).<\/li><li>you are taking any of the following medicines:<ul><li>pimozide &#8211; for the treatment of\u00a0Tourette&#8217;s syndrome<\/li><li>ergot alkaloids (eg\u00a0ergotamine\u00a0or dihydroergotamine) &#8211; are used for\u00a0migraines.<\/li><\/ul><\/li><li>you are taking the following herbal remedies:<ul><li>St. John&#8217;s wort\u00a0(\u00a0<em>Hypericum perforatum<\/em>\u00a0)<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Do not take PREVYMIS if any of the above apply to you.\u00a0If you are not sure, talk to your doctor, pharmacist, or nurse before taking PREVYMIS.<\/p>\n\n\n\n<p><strong>Do not take the following medicines if you are taking PREVYMIS with ciclosporin:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dabigatran &#8211; used to prevent blood clots<\/li><li>atorvastatin,&nbsp;simvastatin&nbsp;, rosuvastatin, pitavastatin &#8211; for high&nbsp;cholesterol<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>If you are also taking medicines for high&nbsp;cholesterol&nbsp;(see list of medicines in the section \u201cOther medicines and PREVYMIS\u201d below), you should tell your doctor immediately if you have unexplained muscle pain, especially if you feel sick or have a fever.&nbsp;Your medicine or&nbsp;dose&nbsp;may need to be changed.&nbsp;See the package leaflet for your other medicines for more information.<\/p>\n\n\n\n<p>Additional blood tests may be needed to monitor the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ciclosporin, tacrolimus, sirolimus<\/li><li>Voriconazole<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>PREVYMIS should not be used by persons under 18 years of age.&nbsp;This is because PREVYMIS has not been studied in this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and PREVYMIS<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.\u00a0PREVYMIS can affect the effectiveness of other medicines and other medicines can affect the effect of PREVYMIS.\u00a0Your doctor or pharmacist will tell you if it is safe to take PREVYMIS with other medicines.<\/p>\n\n\n\n<p>There are certain medicines you&nbsp;<strong>are not allowed to take<\/strong>&nbsp;with PREVYMIS (see the list under &#8220;Do not take PREVYMIS if you are taking any of the following medicines&#8221;).<\/p>\n\n\n\n<p>There are additional medicines you&nbsp;<strong>must not take<\/strong>&nbsp;PREVYMIS with ciclosporin (see list under &#8216;Do not take the following medicines if you are taking PREVYMIS with ciclosporin:&#8217;).<\/p>\n\n\n\n<p>Also tell your doctor if you are taking any of the following medicines.&nbsp;Your doctor may need to change your medication or change the&nbsp;dose&nbsp;.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>alfentanil &#8211; for severe pain<\/li><li>fentanyl&nbsp;&#8211; for severe pain<\/li><li>quinidine&nbsp;&#8211; for abnormal heart rhythm<\/li><li>ciclosporin, tacrolimus, sirolimus &#8211; used to prevent&nbsp;transplant rejection<\/li><li>voriconazole &#8211; for fungal infections<\/li><li>statins, eg atorvastatin, fluvastatin, rusovastatin,&nbsp;simvastatin&nbsp;, pravastatin, pitavastatin &#8211; for high&nbsp;cholesterol<\/li><li>glyburide, repaglinide &#8211; for high blood sugar<\/li><li>carbamazepine, phenobarbital,&nbsp;phenytoin&nbsp;&#8211; for seizures or seizures<\/li><li>dabigatran,&nbsp;warfarin&nbsp;&#8211; used to thin the blood or prevent blood clots<\/li><li>midazolam &#8211; used as a sedative<\/li><li>amiodarone&nbsp;&#8211; used to correct irregular heartbeats<\/li><li>oral contraceptives &#8211; to prevent pregnancy<\/li><li>omeprazole, pantoprazole &#8211; for&nbsp;stomach ulcers&nbsp;and other stomach problems<\/li><li>nafcillin &#8211; against&nbsp;bacterial&nbsp;infection<\/li><li>rifabutin, rifampicin &#8211; against&nbsp;mycobacterial&nbsp;infection<\/li><li>thioridazine &#8211; for psychiatric disorders<\/li><li>bosentan&nbsp;&#8211; for high&nbsp;blood pressure&nbsp;in the blood vessels of the lungs<\/li><li>efavirenz, etravirine, nevirapine, lopinavir, ritonavir &#8211; for&nbsp;HIV<\/li><li>modafinil &#8211; wakefulness regulator<\/li><\/ul>\n\n\n\n<p>You can ask your doctor or pharmacist for a list of medicines that may or may not be affected by PREVYMIS.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.\u00a0PREVYMIS is not recommended during pregnancy.\u00a0This is because it has not been studied during pregnancy, and it is not known if PREVYMIS can harm the fetus during pregnancy.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>If you are breastfeeding or planning to breastfeed, ask your doctor for advice before taking this medicine.\u00a0Breastfeeding is not recommended during treatment with PREVYMIS.\u00a0It is not known if PREVYMIS passes into breast milk and on to the baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>PREVYMIS may have less effect on your ability to drive or use machines (see section 4 Possible&nbsp;side effects&nbsp;below).&nbsp;Some patients have reported fatigue or dizziness (a feeling of dizziness) during treatment with PREVYMIS.&nbsp;If you experience any of these effects, refrain from driving or using machines until the symptoms go away.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">PREVYMIS contains lactose<\/h2>\n\n\n\n<p>PREVYMIS contains\u00a0lactose monohydrate.\u00a0If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<p><strong>PREVYMIS contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per tablet, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take PREVYMIS<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How much to take<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;of PREVYMIS is one 480 mg tablet once daily.&nbsp;If you are also taking ciclosporin, your doctor will reduce the&nbsp;dose&nbsp;of PREVYMIS to a 240 mg tablet once a day.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take PREVYMIS at the same time each day.<\/li><li>Take it with or without food.<\/li><\/ul>\n\n\n\n<p><strong>How to take the medicine<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swallow the tablet whole with water.\u00a0The tablet must not be split, crushed, or chewed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more PREVYMIS than you should<\/h2>\n\n\n\n<p>Contact a doctor immediately if you have taken too much PREVYMIS.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take PREVYMIS<\/h2>\n\n\n\n<p>You mustn&#8217;t miss or skip a\u00a0dose\u00a0of PREVYMIS.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you forget to take a\u00a0dose\u00a0, take it as soon as you remember.\u00a0However, if it is almost time for your next\u00a0dose, skip the missed\u00a0dose.\u00a0Take the next\u00a0dose\u00a0at the usual time.<\/li><li>Do not take two\u00a0doses\u00a0of PREVYMIS at the same time to compensate for a missed\u00a0dose.<\/li><li>Contact your doctor or pharmacist if you are not sure what to do.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Do not stop taking PREVYMIS<\/h2>\n\n\n\n<p>Do not stop taking PREVYMIS without talking to your doctor first.&nbsp;Make sure you do not run out of PREVYMIS.&nbsp;This will give the medicine the greatest chance to help you avoid getting&nbsp;CMV&nbsp;after a bone marrow transplant.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea<\/li><li>nausea<\/li><li>vomiting<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reaction\u00a0(hypersensitivity) &#8211; signs of this may be wheezing\/wheezing, difficulty breathing, skin rash or\u00a0hives,\u00a0itching, swelling<\/li><li>decreased appetite<\/li><li>taste changes<\/li><li>headache<\/li><li>the feeling of spinning (dizziness)<\/li><li>stomach ache<\/li><li>abnormal liver values \u200b\u200bduring laboratory tests<\/li><li>muscle twitching<\/li><li>high creatinine levels in the blood &#8211; shown in blood tests<\/li><li>feeling tired<\/li><li>swelling in hands or feet<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store PREVYMIS<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special temperature instructions.&nbsp;Store in the original package.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p><strong>Content declaration<\/strong><\/p>\n\n\n\n<p>The active substance is letermovir.&nbsp;One film-coated tablet contains 240 mg letermovir or 480 mg letermovir.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p><strong>Tablet core<\/strong><\/p>\n\n\n\n<p>Microcrystalline cellulose (E460), croscarmellose sodium (E468), povidone (E1201),&nbsp;colloidal&nbsp;anhydrous silicon (E551), magnesium stearate (E470b).<\/p>\n\n\n\n<p><strong>Film coating<\/strong><\/p>\n\n\n\n<p>Lactose monohydrate, hypromellose (E464), titanium dioxide (E171), triacetin (E1518), yellow iron oxide (E172), red iron oxide (only 480 mg tablets) (E172), carnauba wax (E903).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p><strong>PREVYMIS 240 mg film-coated tablets<\/strong><\/p>\n\n\n\n<p>PREVYMIS 240 mg film-coated tablet is a yellow, oval tablet, debossed with \u201c591\u201d on one side and the MSD logo on the other.&nbsp;The tablet is 16.5 mm long and 8.5 mm wide.<\/p>\n\n\n\n<p>The 240 mg tablets are packaged in a carton containing four (4) polyamide \/ aluminum \/ PVC blister cards of 7 tablets.&nbsp;Each carton contains a total of 28 tablets.<\/p>\n\n\n\n<p><strong>PREVYMIS 480 mg film-coated tablets<\/strong><\/p>\n\n\n\n<p>PREVYMIS 480 mg film-coated tablet is a pink, oval, biconvex tablet, debossed with \u201c595\u201d on one side and the MSD logo on the other.&nbsp;The tablet is 21.2 mm long and 10.3 mm wide.<\/p>\n\n\n\n<p>The 480 mg tablets are packaged in a carton containing four (4) polyamide\/aluminum \/ PVC blister cards of 7 tablets.\u00a0Each carton contains a total of 28 tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Holder of approval<\/strong><strong>for&nbsp;<\/strong>&nbsp;<strong>sale<\/strong>Merck Sharp &amp; Dohme BVWaarderweg 392031 BN HaarlemNetherlands<\/td><td><strong>Manufacturer<\/strong>Schering-Plow Labo NVIndustrial Park 30 &#8211; Zone AB-2220 Heist-op-den-BergBelgium<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<br><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20170403000113#\" rel=\"noopener\">Show larger<\/a><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>MSD BelgiumTel: +32 (0) 27766211dpoc_belux@merck.com<\/td><td><strong>Lithuania<\/strong>UAB Merck Sharp &amp; DohmeTel.&nbsp;+ 370 5 278 02 47msd_lietuva@merck.com<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Mark Harp and Doom Bulgaria BulgariaTel: +359 2 819 3737info-msdbg@merck.com<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>MSD BelgiumTel: +32 (0) 27766211dpoc_belux@merck.com<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Merck Sharp &amp; Dohme sroTel: +420 233 010 111dpoc_czechslovak@merck.com<\/td><td><strong>Hungary<\/strong>MSD Pharma Hungary Kft.Tel .: +36 1 888 5300hungary_msd@merck.com<\/td><\/tr><tr><td><strong>Denmark<\/strong>MSD Danmark ApSTel: + 45 4482 4000dkmail@merck.com<\/td><td><strong>Malta<\/strong>Merck Sharp &amp; Dohme Cyprus LimitedTel: 8007 4433 (+356 99917558)malta_info@merck.com<\/td><\/tr><tr><td><strong>Germany<\/strong>MSD Sharp &amp; Dohme GmbHTel: 0800 673 673 673 (+49 (0) 89 4561 0)e-mail@msd.de<\/td><td><strong>The Netherlands<\/strong>Merck Sharp &amp; Dohme BVTel: 0800 9999000 (+31 23 5153153)medicalinfo.nl@merck.com<\/td><\/tr><tr><td><strong>Eesti<\/strong>Merck Sharp &amp; Dohme O\u00dcTel .: +372 6144 200msdeesti@merck.com<\/td><td><strong>Norway<\/strong>MSD (Norge) ASTel: +47 32 20 73 00msdnorge@msd.no<\/td><\/tr><tr><td><strong>Greece<\/strong>MSD \u0391.\u03a6.\u0392.\u0395.\u0395.:\u0397\u03bb: +30 210 98 97 300dpoc_greece@merck.com<\/td><td><strong>Austria<\/strong>Merck Sharp &amp; Dohme Ges.mbHTel: +43 (0) 1 26 044msd-medizin@merck.com<\/td><\/tr><tr><td><strong>Spain<\/strong>Merck Sharp &amp; Dohme de Espa\u00f1a, SATel: +34 91 321 06 00msd_info@merck.com<\/td><td><strong>Poland<\/strong>MSD Polska Sp.&nbsp;z ooTel: +48 22 549 51 00msdpolska@merck.com<\/td><\/tr><tr><td><strong>France<\/strong>MSD FranceTel: + 33 (0) 1 80 46 40 40<\/td><td><strong>Portugal<\/strong>Merck Sharp &amp; Dohme, LdaTel: +351 21 4465700inform_pt@merck.com<\/td><\/tr><tr><td><strong>Croatia:<\/strong>Merck Sharp &amp; Dohme dooTel: + 385 1 6611 333croatia_info@merck.com<\/td><td><strong>Romania<\/strong>Merck Sharp &amp; Dohme Romania SRLTel: +40 21 529 29 00msdromania@merck.com<\/td><\/tr><tr><td><strong>Ireland<\/strong>Merck Sharp &amp; Dohme Ireland (&nbsp;Human&nbsp;Health) LimitedTel: +353 (0) 1 2998700medinfo_ireland@merck.com<\/td><td><strong>Slovenia<\/strong>Merck Sharp &amp; Dohme, innovative zdravila dooTel: +386 1 5204 201msd.slovenia@merck.com<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: + 354 535 7000<\/td><td><strong>Slovak Republic<\/strong>Merck Sharp &amp; Dohme, sroTel: +421 2 58282010dpoc_czechslovak@merck.com<\/td><\/tr><tr><td><strong>Italy<\/strong>MSD Italia SrlTel: +39 06 361911medicalinformation.it@merck.com<\/td><td><strong>Finland \/ Finland<\/strong>MSD Finland OyPuh \/ Tel: +358 (0) 9 804 650info@msd.fi<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>Merck Sharp &amp; Dohme Cyprus Limited.:\u0397\u03bb .: 800 00 673 (+357 22866700)cyprus_info@merck.com<\/td><td><strong>Sweden<\/strong>Merck Sharp &amp; Dohme (Sweden) ABTel: +46 77 5700488medicinskinfo@merck.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Merck Sharp &amp; Dohme LatvijaTel: + 371 67364224msd_lv@merck.com<\/td><td><strong>United Kingdom<\/strong><strong>(Northern Ireland)<\/strong>Merck Sharp &amp; DohmeIreland (&nbsp;Human&nbsp;Health)LimitedTel: +353 (0) 1 2998700 medinfoNI@msd.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>PREVYMIS is a prescription antiviral medicine . It contains the active substance letermovir.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21831,21837,21826,21830,21829,21832,21835,21827,21833,21828,21834],"class_list":["post-21196","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-letermovir","tag-benefits-of-prevymis","tag-letermovir","tag-letermovir-side-effects","tag-letermovir-tablet","tag-prevymis","tag-prevymis-tablet","tag-what-is-letermovir","tag-what-is-prevymis","tag-what-letermovir-is-used-for","tag-what-prevymis-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=21196"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21196\/revisions"}],"predecessor-version":[{"id":21255,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/21196\/revisions\/21255"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=21196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=21196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=21196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}