2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 20 mg film-coated tablets
ponesimod<\/p>\n\n\n\n
What Ponvory is<\/strong><\/p>\n\n\n\n Ponvory contains the active substance ponesimod. Ponesimod belongs to a group of medicines called sphingosine 1\u2011 phosphate (S1P) receptor modulators.<\/p>\n\n\n\n What Ponvory is used for<\/strong><\/p>\n\n\n\n Ponvory is used to treat adults with “relapsing multiple sclerosis” (RMS) with active disease.\u00a0Active disease in RMS is when there is a\u00a0relapse\u00a0or when the results of a magnetic resonance imaging examination (magnetic resonance imaging, MRI) show signs of\u00a0inflammation.<\/p>\n\n\n\n What is\u00a0multiple sclerosis?<\/strong><\/p>\n\n\n\n Multiple sclerosis (MS) affects the nerves in the brain and spinal cord ( central nervous system ).<\/p>\n\n\n\n In MS, the body’s immune system (one of the body’s main defense systems) does not work properly.\u00a0The immune system attacks a protective shell on the nerve cells called myelin sheath – this causes\u00a0inflammation.\u00a0This breakdown of the myelin sheath (also called demyelinating) leads to the nerves not functioning properly.<\/p>\n\n\n\n The symptoms of MS depend on which part of the brain and spinal cord is affected.\u00a0These can include gait and balance problems, weakness, numbness, double vision, and blurred vision, poor coordination, and bladder problems.<\/p>\n\n\n\n When the relapse is over, the symptoms may disappear completely, but some problems may persist.<\/p>\n\n\n\n How Ponvory works<\/strong><\/p>\n\n\n\n Ponvory reduces circulating lymphocytes ( white blood cells involved in the immune system) by retaining them in the lymphatic organs ( lymph nodes ). This means that fewer lymphocytes are available to attack the myelin sheath around the nerves in the brain and spinal cord.<\/p>\n\n\n\n By reducing nerve damage in patients with MS, the number of attacks ( relapses ) is reduced and thus the deterioration of the disease is slowed down.<\/p>\n\n\n\n If you are not sure if any of these apply to you, talk to your doctor before taking Ponvory.<\/p>\n\n\n\n Talk to your doctor before taking Ponvory if:<\/p>\n\n\n\n If any of the above apply to you (or you are not sure), talk to your doctor before taking Ponvory.<\/p>\n\n\n\n Tell your doctor immediately if<\/strong> you get any of the following side effects while taking Ponvory:<\/p>\n\n\n\n Slow heart rate ( bradycardia or bradyarrhythmia)<\/p>\n\n\n\n Ponvory can make your heartbeat slower, especially after you have taken the first\u00a0dose.\u00a0You should do an\u00a0electrocardiogram\u00a0(\u00a0ECG, to check the electrical activity of the heart) before taking the first\u00a0dose\u00a0of Ponvory or before starting treatment with Ponvory after stopping treatment.<\/p>\n\n\n\n Infection is<\/p>\n\n\n\n Ponvory can increase the risk of serious\u00a0infections\u00a0that can be life-threatening.\u00a0Ponvory reduces the number of\u00a0lymphocytes\u00a0in the blood.\u00a0These\u00a0blood cells\u00a0fight\u00a0infection.\u00a0Their number usually returns to normal levels within 1 week after the end of treatment.\u00a0Your doctor will examine your\u00a0blood cells\u00a0in a blood sample taken before you start taking Ponvory.<\/p>\n\n\n\n Contact your doctor immediately if you get any of these symptoms of an infection during treatment with Ponvory or 1 week after your last dose of Ponvory:<\/p>\n\n\n\n Macular edema<\/p>\n\n\n\n Ponvory can cause vision problems called macular edema (accumulation of fluid in the back of the eye (retina) that can cause vision changes, including blindness).<\/p>\n\n\n\n The symptoms of macular edema can cause similar visual symptoms as in an MS\u2011\u00a0(\u00a0optic\u00a0neuritis\u00a0)\u00a0relapse.\u00a0In the early course, there may be no symptoms.\u00a0If you experience vision changes, be sure to tell your doctor.\u00a0If macular edema occurs, this usually happens during the first 6 months after you start taking Ponvory.<\/p>\n\n\n\n Your doctor should check your vision before you start taking Ponvory and if you notice any vision changes during treatment.\u00a0The risk of developing macular edema is higher if you have\u00a0diabetes\u00a0or if you have had an\u00a0inflammation\u00a0of the eye called\u00a0uveitis.<\/p>\n\n\n\n Contact a doctor immediately if you get any of the following symptoms:<\/p>\n\n\n\n Liver problem<\/p>\n\n\n\n Ponvory can cause liver problems. Your doctor will take blood samples to check your liver function before you start taking Ponvory.<\/p>\n\n\n\n Contact your doctor immediately if you get any of the following symptoms of liver problems:<\/p>\n\n\n\n Increased blood pressure<\/p>\n\n\n\n Because Ponvory may increase your\u00a0blood pressure, your doctor should check\u00a0your blood pressure\u00a0regularly during treatment with Ponvory.<\/p>\n\n\n\n Exposure to the sun and protection from the sun<\/p>\n\n\n\n Because Ponvory may increase the risk of skin cancer, you should limit your exposure to sunlight and UV (ultraviolet) light by:<\/p>\n\n\n\n Respiratory problems<\/p>\n\n\n\n Some people taking Ponvory experience shortness of breath. Contact a doctor immediately if you experience new or worsening breathing problems.<\/p>\n\n\n\n Swelling and narrowing of the blood vessels in the brain<\/p>\n\n\n\n A condition called PRES (posterior reversible encephalopathy syndrome) has arisen with drugs that work in a similar way to Ponvory.\u00a0The symptoms of PRES usually improve when you stop taking Ponvory.\u00a0If left untreated, however, it can lead to a\u00a0stroke.<\/p>\n\n\n\n Contact your doctor immediately if you get any of the following symptoms:<\/p>\n\n\n\n Exacerbation of multiple sclerosis after discontinuation of Ponvory<\/p>\n\n\n\n If you stop taking Ponvory, the symptoms of MS may return. They may get worse compared to before or during treatment. Always talk to your doctor before stopping Ponvory. Tell your doctor if the symptoms of MS have worsened after you stop taking Ponvory.<\/p>\n\n\n\n Ponvory has not been studied in children and adolescents and is therefore not recommended for children and adolescents under 18 years of age.<\/p>\n\n\n\n Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription, over-the-counter medicines,\u00a0vitamins,\u00a0and herbal supplements.\u00a0In particular, tell your doctor if you are taking:<\/p>\n\n\n\n Vaccine and Ponvory<\/strong><\/p>\n\n\n\n Tell your doctor if you have recently received any vaccinations or if you are planning to get vaccinated. You should avoid receiving live vaccines during treatment with Ponvory. If you are given a live vaccine, you can get the infection that the vaccine would protect you against. Ponvory treatment should be stopped 1 week before and for 4 weeks after receiving a live vaccine. It is also possible that other vaccines do not work as well if they are given while you are being treated with Ponvory.<\/p>\n\n\n\n If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.<\/p>\n\n\n\n Pregnancy<\/p>\n\n\n\n Women who may become pregnant \/ contraceptives in women<\/p>\n\n\n\n If you are a woman who may become pregnant:<\/p>\n\n\n\n Talk to your doctor about effective contraception.<\/p>\n\n\n\n If you become pregnant while taking Ponvory, stop taking Ponvory and contact your doctor immediately.<\/p>\n\n\n\n If you become pregnant within 1 week of stopping Ponvory, contact your doctor.<\/p>\n\n\n\n Breast-feeding<\/p>\n\n\n\n You should not breastfeed while taking Ponvory.\u00a0This is to prevent the risk of\u00a0side effects\u00a0in the baby as Ponvory may pass into breast milk.<\/p>\n\n\n\n Ponvory is not expected to affect your ability to drive or use machines.<\/p>\n\n\n\n Ponvory contains\u00a0lactose, which is a sugar.\u00a0If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n Ponvory contains sodium<\/strong><\/p>\n\n\n\n This medicine contains less than 1 mmol (23 mg) sodium per tablet, ie essentially ‘sodium-free’.<\/p>\n\n\n\n Always take this medicine exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n How to take<\/strong><\/p>\n\n\n\n Deposit packaging (14 days)<\/strong><\/p>\n\n\n\n Maintenance dose<\/strong><\/p>\n\n\n\n If you take more Ponvory than you should, contact a doctor or hospital immediately. Take the medicine pack and this leaflet with you.<\/p>\n\n\n\n Do not take a double dose to make up for a forgotten tablet.<\/p>\n\n\n\n Make a note of the date you start taking the medicine so that you know if you have missed 4 or more doses in a row.<\/p>\n\n\n\n Do not start Ponvory again after stopping treatment for more than 4 consecutive days without consulting your doctor. You will need to start treatment again with a new deposit pack.<\/p>\n\n\n\n If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n Some\u00a0side effects\u00a0may be or maybe\u00a0serious<\/strong><\/p>\n\n\n\n If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.<\/p>\n\n\n\n Common<\/strong> (may affect up to 1 in 10 people)<\/p>\n\n\n\n Uncommon<\/strong> (may affect up to 1 in 100 people)<\/p>\n\n\n\n Other side effects are<\/p>\n\n\n\n Very common<\/strong> (may affect more than 1 user in 10)<\/p>\n\n\n\n Common<\/strong> (may affect up to 1 in 10 people)<\/p>\n\n\n\n Uncommon<\/strong> (may affect up to 1 in 100 people)<\/p>\n\n\n\n Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n Do not use this medicine after the expiry date which is stated on the carton and blister after EXP. The expiration date is the last day of the specified month.<\/p>\n\n\n\n No special storage instructions.<\/p>\n\n\n\n Medicines should n<\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n not be disposed of via wastewater or household waste.\u00a0Ask your pharmacist how to dispose of medicines no longer required.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n Ponvory 2 mg film-coated tablets are white, round, biconvex, 5 mm diameter film-coated tablets with \u201c2\u201d on one side and a bow on the other side.<\/p>\n\n\n\n Ponvory 3 mg film-coated tablets are red, round, biconvex, 5 mm diameter film-coated tablets with \u201c3\u201d on one side and an arc on the other side.<\/p>\n\n\n\n Ponvory 4 mg film-coated tablets are purple, round, biconvex, 5 mm diameter film-coated tablets with \u201c4\u201d on one side and a bow on the other side.<\/p>\n\n\n\n Ponvory 5 mg film-coated tablets are green, round, biconvex, 8.6 mm-diameter film-coated tablets with a \u201c5\u201d on one side and an arc and an \u201cA\u201d on the other side.<\/p>\n\n\n\n Ponvory 6 mg film-coated tablets are white, round, biconvex, 8.6 mm diameter film-coated tablets with a \u201c 6 \u201d on one side and an arc and an \u201cA\u201d on the other side.<\/p>\n\n\n\n Ponvory 7 mg film-coated tablets are red, round, biconvex, film-coated tablets with a diameter of 8.6 mm with a \u201c7\u201d on one side and an arc and an \u201cA\u201d on the other side.<\/p>\n\n\n\n Ponvory 8 mg film-coated tablets are purple, round, biconvex, film-coated tablets with a diameter of 8.6 mm with \u201c8\u201d on one side and a bow and an \u201cA\u201d on the other side.<\/p>\n\n\n\n Ponvory 9 mg film-coated tablets are brown, round, biconvex, film-coated tablets with a diameter of 8.6 mm with a \u201c 9 \u201d on one side and an arc and an \u201cA\u201d on the other side.<\/p>\n\n\n\n Ponvory 10 mg film-coated tablets are orange, round, biconvex, 8.6 mm diameter film-coated tablets with a \u201c10\u201d on one side and an arc and an \u201cA\u201d on the other side.<\/p>\n\n\n\n Ponvory 20 mg film-coated tablets are yellow, round, biconvex, 8.6 mm-diameter film-coated tablets with \u201c20\u201d on one side and an arc and an \u201cA\u201d on the other side.<\/p>\n\n\n\n Ponvory deposit packaging (folding packaging)<\/p>\n\n\n\n Each blister pack of 14 film-coated tablets for 2 weeks of treatment contains:<\/p>\n\n\n\n 2 film-coated tablets of 2 mg<\/p>\n\n\n\n 2 film-coated tablets of 3 mg<\/p>\n\n\n\n 2 4 mg film-coated tablets<\/p>\n\n\n\n 1 5 mg film-coated tablet<\/p>\n\n\n\n 1 film-coated tablet of 6 mg<\/p>\n\n\n\n 1 film-coated tablet of 7 mg<\/p>\n\n\n\n 1 8 mg film-coated tablet<\/p>\n\n\n\n 1 9 mg film-coated tablet<\/p>\n\n\n\n 3 film-coated tablets of 10 mg<\/p>\n\n\n\n Ponvory 20 mg film-coated tablets (maintenance pack) (folding pack)<\/p>\n\n\n\n A pack containing 28 film-coated tablets for 4 weeks of treatment or a multi-pack containing 84 (3 packs of 28) film-coated tablets for 12 weeks of treatment.<\/p>\n\n\n\n Not all pack sizes may be marketed.<\/p>\n\n\n\n Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n Janssen \u2011 Cilag International NV<\/p>\n\n\n\n Turnhoutseweg 30<\/p>\n\n\n\n B \u2011 2340 Beerse<\/p>\n\n\n\n Belgium<\/p>\n\n\n\n Manufacturer<\/strong><\/p>\n\n\n\n Janssen Pharmaceutica NV<\/p>\n\n\n\n Turnhoutseweg 30<\/p>\n\n\n\n B \u2011 2340 Beerse<\/p>\n\n\n\n Belgium<\/p>\n","protected":false},"excerpt":{"rendered":" Ponvory contains the active substance ponesimod. Ponesimod belongs to a group of medicines called sphingosine 1\u2011 phosphate (S1P) receptor modulators.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21446,21442,21445,21472,21447,21450,21473,21443,21448,21444,21449],"class_list":["post-20951","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-ponesimod","tag-ponesimod","tag-ponesimod-side-effects","tag-ponesimod-tablet","tag-ponvory","tag-ponvory-side-effects","tag-ponvory-tablet","tag-what-is-ponesimod","tag-what-is-ponvory","tag-what-ponesimod-is-used-for","tag-what-ponvory-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20951","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20951"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20951\/revisions"}],"predecessor-version":[{"id":20992,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20951\/revisions\/20992"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20951"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20951"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20951"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}What you need to know before taking Ponvory<\/h2>\n\n\n\n
Do not take Ponvory<\/h2>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
Children and young people<\/h2>\n\n\n\n
Other medicines and Ponvory<\/h2>\n\n\n\n
Pregnancy, contraception, and breastfeeding<\/h2>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Ponvory contains lactose<\/h2>\n\n\n\n
How to take Ponvory<\/h2>\n\n\n\n
Deposit packaging day<\/strong><\/td> Daily dose<\/strong><\/td><\/tr> Day 1<\/td> 2 mg<\/td><\/tr> Day 2<\/td> 2 mg<\/td><\/tr> Day 3<\/td> 3 mg<\/td><\/tr> Day 4<\/td> 3 mg<\/td><\/tr> Day 5<\/td> 4 mg<\/td><\/tr> Day 6<\/td> 4 mg<\/td><\/tr> Day 7<\/td> 5 mg<\/td><\/tr> Day 8<\/td> 6 mg<\/td><\/tr> Day 9<\/td> 7 mg<\/td><\/tr> Day 10<\/td> 8 mg<\/td><\/tr> Day 11<\/td> 9 mg<\/td><\/tr> Day 12<\/td> 10 mg<\/td><\/tr> Day 13<\/td> 10 mg<\/td><\/tr> Day 14<\/td> 10 mg<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n If you take more Ponvory than you should<\/h2>\n\n\n\n
If you forget to take Ponvory<\/h2>\n\n\n\n
Do not stop taking Ponvory without talking to your doctor.<\/h2>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
How to store Ponvory<\/h2>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
sodium,\u00a0lactose monohydrate\u00a0(see ‘Ponvory contains lactose’), magnesium stearate, microcrystalline cellulose, Povidone K30,\u00a0colloidal\u00a0anhydrous silica, and sodium lauryl sulfate.\u00a0Tablet\u00a0coating Hypromellose,\u00a0lactose monohydrate, macrogol, titanium dioxide, and triacetin.\u00a0Ponvory 3 mg film-coated tablets<\/em>\u00a0Red iron oxide (E172) and yellow iron oxide (E172)\u00a0Ponvory 4 mg film-coated tablets<\/em>\u00a0Red iron oxide (E172) and black iron oxide (E172)\u00a0Ponvory 5 mg film-coated tablets<\/em>\u00a0Black iron oxide (E172) and yellow iron oxide (E172\u00a0) mg film-coated tablets<\/em>\u00a0Red iron oxide (E172) and yellow iron oxide (E172)
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<\/em>
Ponvory 8 mg film-coated tablets<\/em>
Red iron oxide (E172) and black iron oxide (E172)\u00a0Ponvory 9 mg film-coated tablets<\/em>\u00a0Red iron oxide (E172) and black iron oxide (E172), yellow iron oxide (E172)\u00a0Ponvory 10 mg film-coated tablets<\/em>\u00a0Red iron oxide (E172) iron oxide (E172)\u00a0Ponvory 20 mg film-coated tablets<\/em>\u00a0Yellow iron oxide (E172)
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<\/em><\/li><\/ul>\n\n\n\nWhat the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n