<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
s<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
30 mg powder for concentrate for solution for infusion, 140 mg\u00a0powder for concentrate for solution for\u00a0infusion\u00a0elotuzumab
vedotin<\/p>\n\n\n\n
What Polivy is<\/strong><\/p>\n\n\n\n Polivy is a cancer medicine that contains the active substance polatuzumab vedotin.<\/p>\n\n\n\n What is Polivy used for<\/strong><\/p>\n\n\n\n Polivy is used to treat “diffuse large-cell B-cell lymphoma” that has returned or has not improved with at least one previous treatment and when you cannot have a\u00a0stem cell transplant.<\/p>\n\n\n\n Diffuse large-cell B-cell lymphoma is cancer that develops from\u00a0B-lymphocytes, also called\u00a0B-cells.\u00a0These are a type of blood cells.<\/p>\n\n\n\n How does Polivy work?<\/strong><\/p>\n\n\n\n The active substance in Polivy is made from a monoclonal\u00a0antibody\u00a0bound to MMAE which is a substance that can kill cancer cells.\u00a0The monoclonal antibody portion of the drug attaches to a target on the\u00a0B cells.\u00a0Once attached to the\u00a0B cells, the drug MMAE is released into the\u00a0B cells\u00a0and kills them.<\/p>\n\n\n\n What other medicines is Polivy given with<\/strong><\/p>\n\n\n\n Polivy is given in combination with two other anticancer medicines called rituximab and bendamustine.<\/p>\n\n\n\n If you are not sure, talk to your doctor or nurse before receiving Polivy.<\/p>\n\n\n\n Talk to your doctor or nurse before using Polivy if any of the following apply to you (or you are not sure):<\/p>\n\n\n\n If any of the above apply to you (or you are not sure), talk to your doctor or nurse before getting Polivy.<\/p>\n\n\n\n Be aware of the following side effects<\/strong><\/p>\n\n\n\n Polivy can cause serious side effects that you need to tell your doctor or nurse immediately. These include:<\/p>\n\n\n\n Myelosuppression<\/strong><\/p>\n\n\n\n Myelosuppression is a condition in which the production of blood cells decreases, leading to fewer\u00a0red blood cells,\u00a0white blood cells,\u00a0and\u00a0platelets.\u00a0Your doctor will take blood samples to check the number of\u00a0blood cells.<\/p>\n\n\n\n Tell your doctor or nurse immediately if you:<\/p>\n\n\n\n Peripheral neuropathy<\/strong><\/p>\n\n\n\n Tell your doctor or nurse immediately if you have problems with altered sensation in the skin, especially in the hands or feet, for example:<\/p>\n\n\n\n If you have had any of these symptoms before treatment with Polivy, contact your doctor immediately if you notice any changes in your symptoms.<\/p>\n\n\n\n If you have symptoms of\u00a0peripheral\u00a0neuropathy, your doctor may lower your\u00a0dose.<\/p>\n\n\n\n Infection is<\/strong><\/p>\n\n\n\n Signs and symptoms of infection vary between individuals. Tell your doctor or nurse immediately if you develop symptoms of infection such as:<\/p>\n\n\n\n Progressive multifocal leukoencephalopathy (PML)<\/strong><\/p>\n\n\n\n PML is a very rare and life-threatening infection of the brain, which has occurred in a patient treated with Polivy together with bendamustine and another medicine called obinutuzumab.<\/p>\n\n\n\n Tell your doctor or nurse immediately if you get:<\/p>\n\n\n\n If you have had any of these symptoms before treatment with Polivy, contact your doctor immediately if you notice any changes in your symptoms. You may need medical treatment.<\/p>\n\n\n\n Tumor light syndrome<\/strong><\/p>\n\n\n\n Some people may develop abnormal levels of certain substances (such as\u00a0potassium\u00a0and\u00a0uric acid\u00a0) in the blood caused by the rapid breakdown of cancer cells during treatment.\u00a0This is called tumor light syndrome. Your doctor or nurse will take blood samples to check the risk of this condition.<\/p>\n\n\n\n Infusion-related reactions<\/strong><\/p>\n\n\n\n Infusion-related reactions and allergic or anaphylactic (more severe allergic) reactions may occur.\u00a0Your doctor or nurse will observe if you get any\u00a0side effects\u00a0during the\u00a0infusion\u00a0and for 30 to 90 minutes after the end of the\u00a0infusion.\u00a0If you get a severe reaction, your doctor may stop taking Polivy.<\/p>\n\n\n\n Liver damage<\/strong><\/p>\n\n\n\n This medicine can cause inflammation or damage the cells in the liver that affect the normal functioning of the liver. Damaged liver cells can leak large amounts of certain substances (liver enzymes and bilirubin ) into the bloodstream, which can be detected with blood tests.<\/p>\n\n\n\n In most cases, you do not get any symptoms, but tell your doctor or nurse immediately if you get:<\/p>\n\n\n\n Your doctor will take blood samples to check your liver function before and regularly during treatment.<\/p>\n\n\n\n This medicine should not be used in children or adolescents under 18 years of age. This is because there is no information about its use in this age group.<\/p>\n\n\n\n Tell your doctor or nurse if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n This also applies to over-the-counter medicines and herbal medicines.<\/p>\n\n\n\n Contraceptives (women and men)<\/strong><\/p>\n\n\n\n If you are a woman of\u00a0childbearing potential, you must use effective contraception during treatment and for 9 months after the last\u00a0dose\u00a0of one of Polivy.<\/p>\n\n\n\n Men must use contraception during treatment and for 6 months after the last dose of one of Polivy.<\/p>\n\n\n\n Pregnancy<\/strong><\/p>\n\n\n\n It is important to tell your doctor before and during treatment, if you are pregnant, think you may be pregnant, or are planning to have a baby. This is because Polivy may affect your baby’s health.\u00a0You should not use this medicine if you are pregnant unless you and your doctor consider it necessary and the benefit to you outweighs the potential risk to the unborn baby.\u00a0<\/p>\n\n\n\n Breast-feeding<\/strong><\/p>\n\n\n\n Do not breastfeed when you receive Polivy and for at least 3 months after the last\u00a0dose, as small amounts of Polivy may pass into your breast milk.<\/p>\n\n\n\n Fertility<\/strong><\/p>\n\n\n\n Men who are to be treated with this medicine should be advised to take sperm samples for storage before starting treatment.<\/p>\n\n\n\n Polivy has little effect on your ability to drive, cycle, and use tools or machines.\u00a0If you experience infusion-related reactions or nerve damage, or if you feel tired, weak, or dizzy (see section 4), do not drive, cycle or use any tools or machines until the reaction has disappeared.<\/p>\n\n\n\n See section 4 for more information on\u00a0side effects.<\/p>\n\n\n\n This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose, ie essentially ‘sodium-free’.<\/p>\n\n\n\n Polivy is given under the supervision of a doctor who has experience in administering these treatments.\u00a0It is given to a friend as an\u00a0infusion\u00a0(drip) for 90 minutes.<\/p>\n\n\n\n How much Polivy is given<\/strong><\/p>\n\n\n\n The dose of one of these drugs depends on your body weight.<\/p>\n\n\n\n You will be given 6 treatment cycles of Polivy in combination with two other medicines called rituximab and bendamustine.<\/p>\n\n\n\n Each cycle lasts for 21 days.<\/p>\n\n\n\n If you miss a booked time, book a new time immediately.\u00a0For the treatment to have full effect, it is very important not to miss a\u00a0dose.<\/p>\n\n\n\n Do not stop treatment with Polivy unless you have discussed it with your doctor. Discontinuation of treatment may worsen your illness.<\/p>\n\n\n\n If you have any further questions on the use of this product, ask your doctor or nurse. Possible side effects<\/p>\n\n\n\n Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n The following side effects have been reported with this medicine:<\/p>\n\n\n\n Serious side effects are<\/strong><\/p>\n\n\n\n Tell your doctor or nurse if you notice any of the following serious side effects – you may need urgent medical attention. It may be new symptoms or a change in your current symptoms.<\/p>\n\n\n\n Other side effects:<\/strong><\/p>\n\n\n\n Tell your doctor or nurse if you experience any of the following side effects:<\/p>\n\n\n\n Very common (may affect more than 1 in 10 people)<\/strong><\/p>\n\n\n\n Common <\/strong>(may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n Polivy will be stored by healthcare professionals at the hospital or clinic. The storage conditions and handling are as follows:<\/p>\n\n\n\n Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n Polivy powder for concentrate for solution for\u00a0infusion\u00a0is a white to slightly off-white powder (powder cake) in a\u00a0glass\u00a0vial.<\/p>\n\n\n\n Each pack of Polivy consists of one\u00a0vial.<\/p>\n\n\n\n Roche Registration GmbH<\/p>\n\n\n\n Emil-Barell-Strasse 1<\/p>\n\n\n\n 79639 Grenzach-Wyhlen<\/p>\n\n\n\n Germany<\/p>\n\n\n\n Manufacturer<\/strong><\/p>\n\n\n\n Roche Registration AG<\/p>\n\n\n\n Emil-Barell-Strasse 1<\/p>\n\n\n\n 79639 Grenzach-Wyhlen<\/p>\n\n\n\n Germany<\/p>\n\n\n\n Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n This medicine has received a “conditional marketing authorization”. This means that more information about the drug is expected.<\/p>\n\n\n\n The European Medicines Agency reviews new information on this medicine at least every year and updates this leaflet as needed.<\/p>\n","protected":false},"excerpt":{"rendered":" s 30 mg powder for concentrate for solution for infusion, 140 mg\u00a0powder for concentrate for solution for\u00a0infusion\u00a0elotuzumabvedotin What Polivy is and what it is used for What Polivy is Polivy is a cancer medicine that contains the active substance polatuzumab vedotin. What is Polivy used for Polivy is used to treat “diffuse large-cell B-cell lymphoma” […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21461,21456,21457,21460,21452,21455,21458,21453,21459,21454],"class_list":["post-20949","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-polivy","tag-benefits-of-vedotin","tag-polivy","tag-polivy-side-effects","tag-vedotin","tag-vedotin-side-effects","tag-what-is-polivy","tag-what-is-vedotin","tag-what-polivy-is-used-for","tag-what-vedotin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20949","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20949"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20949\/revisions"}],"predecessor-version":[{"id":20993,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20949\/revisions\/20993"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20949"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}What you need to know before using Polivy<\/h2>\n\n\n\n
Do not use Polivy<\/h2>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
Children and young people<\/h2>\n\n\n\n
Other medicines and Polivy<\/h2>\n\n\n\n
Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Polivy contains sodium<\/h2>\n\n\n\n
How to use Polivy<\/h2>\n\n\n\n
If you forget a dose of Polivy<\/h2>\n\n\n\n
If you stop using Polivy<\/h2>\n\n\n\n
How to store Polivy<\/h2>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Belgium \/ Belgique \/ Belgien<\/strong>NV Roche SATel: +32 (0) 25 25 82 11<\/td> Lithuania<\/strong>UAB \u201cRoche Lietuva\u201dTel: +370 5 2546799<\/td><\/tr> Bulgaria<\/strong>Russia BULGARIA LOODTel: +359 2 818 44 44<\/td> Luxembourg \/ Luxemburg<\/strong>(See \/ See Belgium \/ Belgium)<\/td><\/tr> Czech Republic<\/strong>Roche sroTel: +420 – 2 20382111<\/td> Hungary<\/strong>Roche (Magyarorsz\u00e1g) Kft.Tel: +36 – 23 446 800<\/td><\/tr> Denmark<\/strong>Roche a \/ sTel: +45 – 36 39 99 99<\/td> Malta<\/strong>Irreferi g\u0127all-Irlanda<\/td><\/tr> Germany<\/strong>Roche Pharma AGTel: +49 (0) 7624 140<\/td> The Netherlands<\/strong>Roche Nederland BVTel: +31 (0) 348 438050<\/td><\/tr> Eesti<\/strong>Roche Eesti O\u00dcTel: + 372 – 6 177 380<\/td> Norway<\/strong>Roche Norge ASTel: +47 – 22 78 90 00<\/td><\/tr> Greece<\/strong>Roche (Hellas) AE:\u0397\u03bb: +30 210 61 66 100<\/td> Austria<\/strong>Roche Austria GmbHTel: +43 (0) 1 27739<\/td><\/tr> Spain<\/strong>Roche Farma SATel: +34 – 91 324 81 00<\/td> Poland<\/strong>Roche Polska Sp.z ooTel: +48 – 22 345 18 88<\/td><\/tr> France<\/strong>RocheTel: +33 (0) 1 47 61 40 00<\/td> Portugal<\/strong>Roche Pharmac\u00eautica Chemica, LdaTel: +351 – 21 425 70 00<\/td><\/tr> Croatia<\/strong>Roche dooTel: + 385 1 47 22 333<\/td> Romania<\/strong>Roche Rom\u00e2nia SRLTel: +40 21 206 47 01<\/td><\/tr> Ireland<\/strong>Roche Products (Ireland) Ltd.Tel: +353 (0) 1 469 0700<\/td> Slovenia<\/strong>Roche pharmacevtska dru\u017eba dooTel: +386 – 1 360 26 00<\/td><\/tr> Iceland<\/strong>Roche a \/ sc \/ o Icepharma hfPhone: +354 540 8000<\/td> Slovak Republic<\/strong>Roche Slovensko, sroTel: +421 – 2 52638201<\/td><\/tr> Italy<\/strong>Roche SpATel: +39 – 039 2471<\/td> Finland \/ Finland<\/strong>Roche Oy Puh \/ Tel: +358 (0) 10 554 500<\/td><\/tr> K <\/strong>\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>\u0393.\u0391.\u03a3\u03c4\u03b1\u03bc\u03ac\u03c4\u03b7\u03c2 & \u03a3\u03b9\u03b1 \u039b\u03c4\u03b4.:\u0397\u03bb: +357 – 22 76 62 76<\/td> Sweden<\/strong>Roche ABTel: +46 (0) 8 726 1200<\/td><\/tr> Latvia<\/strong>Roche Latvija SIATel: +371 – 6 7039831<\/td> United Kingdom (Northern Ireland)<\/strong>Roche Products (Ireland) Ltd.Tel: +44 (0) 1707 366000<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n