5 mg, 20 mg\u00a0modified-release tablets
hydrocortisone<\/p>\n\n\n\n
Plenadren contains a substance called\u00a0hydrocortisone\u00a0(sometimes called\u00a0cortisol\u00a0).\u00a0Hydrocortisone\u00a0is a\u00a0glucocorticoid.\u00a0Plenadren belongs to a group of medicines called\u00a0corticosteroids.\u00a0Glucocorticoids\u00a0are found naturally in the body and help keep you in good health.<\/p>\n\n\n\n
Plenadren is used in adults to treat a condition called adrenal insufficiency, or cortisol deficiency.\u00a0Adrenal insufficiency occurs when the adrenal glands (located just above the kidneys) do not produce enough of the\u00a0hormone\u00a0et\u00a0cortisol.\u00a0Patients who have long-term (\u00a0chronic\u00a0) adrenal insufficiency need replacement therapy to survive.<\/p>\n\n\n\n
Plenadren replaces the natural\u00a0cortisol\u00a0that is lacking in adrenal insufficiency.\u00a0The drug gives hydrocortisone to the body during the day.\u00a0The level of\u00a0cortisol\u00a0in the blood increases rapidly and reaches a maximum level about 1 hour after you take the tablet in the morning.\u00a0Then the cortisol level gradually decreases during the day until it is almost zero late in the evening and at night when it should be low.<\/p>\n\n\n\n
Talk to your doctor or pharmacist before taking Plenadren<\/p>\n\n\n\n
The use of Plenadren is not recommended in children and adolescents under 18 years of age as it has not been studied in these patients.<\/p>\n\n\n\n
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0For long-term treatment with anti-infective\u00a0drugs (\u00a0antibiotics\u00a0), the\u00a0dose\u00a0of one of Plenadren may need to be adjusted.\u00a0If Plenadren is used at the same time as mifepristone, an abortion treatment, the effect of Plenadren may be reduced.<\/p>\n\n\n\n
You should also tell your doctor or pharmacist if you are taking any of the following medicines, as one dose of Plenadren may need to be changed:<\/p>\n\n\n\n
Do not take this medicine with grapefruit juice as the juice may affect the way the medicine works.<\/p>\n\n\n\n
If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n
You must continue to take Plenadren during pregnancy.\u00a0It is unlikely that the treatment will harm the mother or child when treating pregnant women.\u00a0You should tell your doctor if you become pregnant as the\u00a0dose\u00a0of one of Plenadren may need to be adjusted.<\/p>\n\n\n\n
You can breastfeed while taking Plenadren.\u00a0Hydrocortisone\u00a0is excreted in breast milk.\u00a0The dose of\u00a0hydrocortisone\u00a0used in replacement therapy is unlikely to have any effect on the\u00a0child.\u00a0However, you should still consult your doctor if you plan to breastfeed your baby.<\/p>\n\n\n\n
Fertility\u00a0can be reduced in women with adrenal insufficiency or cortisol deficiency.\u00a0There are no indications that Plenadren, in\u00a0doses\u00a0used for\u00a0substitution\u00a0treatment, affects\u00a0fertility.<\/p>\n\n\n\n
This medicine has a minor effect on the ability to drive and use machines.\u00a0Severe fatigue and short-term dizziness have been reported.\u00a0Inadequately treated, or untreated, adrenal insufficiency reduces the ability to concentrate and affects the ability to drive and use machines.\u00a0Therefore, you must take Plenadren according to your doctor’s instructions when driving or using machines.\u00a0If you are affected, do not drive or use machines until you have consulted your doctor.<\/p>\n\n\n\n
Always take this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure. Dose one is specially tailored for you by your doctor.<\/p>\n\n\n\n
In case of a short-term or temporary illness such as\u00a0infection\u00a0or fever and in case of physical stress, e.g.\u00a0In connection with surgery, you need more\u00a0hydrocortisone\u00a0because the body can not produce the extra\u00a0cortisol\u00a0needed in these situations.\u00a0Therefore, the\u00a0dose\u00a0should be increased temporarily.\u00a0Your doctor may\u00a0prescribe\u00a0other hydrocortisone tablets instead of Plenadren or as a supplement to Plenadren.\u00a0Consult your doctor and follow the instructions on what to do in these situations.<\/p>\n\n\n\n You may need to take twice or three times as much Plenadren per day for milder illnesses as mild infections and moderate stress. Then you should take the second dose of this medicine 6-10 hours after the morning dose. If it is not enough to double the daily dose, take a third dose 6-10 hours after the second dose (wait 6-10 hours between each dose ). Once the temporary illness has passed, you should return to your usual maintenance dose of this medicine.<\/p>\n\n\n\n The following signs and symptoms may indicate that you need to take additional\u00a0doses\u00a0of Plenadren or other forms of hydrocortisone: fatigue, weight loss, stomach upset, dizziness when getting up from a sitting to standing position, darker skin, especially in folds of skin or exposed areas.\u00a0Contact a doctor immediately for advice if you notice any of this.<\/p>\n\n\n\n However, see\u00a0a doctor immediately<\/strong>\u00a0if you notice any of the following: severe weakness, fainting, abdominal pain, nausea, vomiting, back pain, confusion, decreased consciousness,\u00a0and delirium\u00a0(very confused condition).<\/p>\n\n\n\n Too high a dose of this drug for a period longer than a few days can be detrimental to health. Blood pressure may increase, you may gain weight and your blood sugar may become too high. A higher dose may sometimes be needed for the body to cope with increased stress, e.g. fever. If an extra dose is needed often and regularly, contact your doctor for a new assessment of your normal maintenance dose.<\/p>\n\n\n\n If you forget to take the tablet in the morning, take it as soon as possible afterward.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.\u00a0If you experience any of the signs and symptoms listed in the section \u201cNeed an extra\u00a0dose\u00a0of Plenadren\u201d, contact your doctor immediately.<\/p>\n\n\n\n It can be life-threatening to stop taking Plenadren.\u00a0Therefore, you must continue to take this medicine exactly as your doctor has told you.\u00a0Do not stop taking it without consulting your doctor.<\/p>\n\n\n\n If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n If you switch from other hydrocortisone tablets to Plenadren, you may experience\u00a0side effects\u00a0during the first few weeks.\u00a0These\u00a0side effects\u00a0can include stomach pain, nausea, and fatigue.\u00a0Normally, they disappear over time.\u00a0If they do not, contact your doctor.<\/p>\n\n\n\n The side effects\u00a0of this drug are as follows:<\/p>\n\n\n\n Very common (may affect more than 1 user in 10)<\/p>\n\n\n\n Common (may affect up to 1 in 10 of 100 users)<\/p>\n\n\n\n Additional\u00a0side effects\u00a0have been reported with other drugs containing\u00a0hydrocortisone.\u00a0These drugs have also been given for indications other than as replacement therapy for adrenal insufficiency, often in higher\u00a0doses.\u00a0The frequency of these possible\u00a0side effects\u00a0is unknown (it can not be calculated from the available data).\u00a0Tell your doctor if you experience any of these\u00a0side effects.<\/p>\n\n\n\n Keep out of sight and reach of children.<\/p>\n\n\n\n Do not use this medicine after the expiry date which is stated on the can label after \u201cEXP\u201d. The expiration date is the last day of the specified month.<\/p>\n\n\n\n No special storage instructions.<\/p>\n\n\n\n Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n Plenadren 5 mg: Each modified-release tablet\u00a0contains 5 mg of\u00a0hydrocortisone.<\/p>\n\n\n\n Plenadren 20 mg: Each modified-release tablet\u00a0contains 20 mg\u00a0of hydrocortisone.<\/p>\n\n\n\n The other ingredients are hypromellose (E464), microcrystalline cellulose (E460), pregelatinized\u00a0starch\u00a0(maize),\u00a0colloidal\u00a0anhydrous silicon (E551), and magnesium stearate.\u00a0The casing system is a\u00a0mixture\u00a0of macrogol (3350), polyvinyl alcohol, talc (E553b), and titanium oxide (E171).\u00a0The tablets containing 5 mg\u00a0hydrocortisone\u00a0also contain iron oxide red (E172), iron oxide yellow (E172), and iron oxide black (E172).<\/p>\n\n\n\n The tablets are round (diameter 8 mm) and convex.<\/p>\n\n\n\n The 5 mg tablets are pink. The 20 mg tablets are white.<\/p>\n\n\n\n Plenadren is sold in jars with screw caps. One jar contains 50 tablets.<\/p>\n\n\n\n Pack sizes:<\/p>\n\n\n\n Carton containing a jar of 50 modified-release\u00a0tablets.<\/p>\n\n\n\n Carton containing 2 cans of 50 modified-release\u00a0tablets (100 tablets).<\/p>\n\n\n\n Not all pack sizes may be available in your country.<\/p>\n\n\n\n Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n Takeda Pharmaceuticals International AG Ireland Branch<\/p>\n\n\n\n Block 3 Miesian Plaza<\/p>\n\n\n\n 50-58 Baggot Street Lower<\/p>\n\n\n\n Dublin 2<\/p>\n\n\n\n Ireland<\/p>\n\n\n\n Manufacturer<\/strong><\/p>\n\n\n\n Takeda Pharmaceuticals International AG Ireland Branch<\/p>\n\n\n\n Block 3 Miesian Plaza<\/p>\n\n\n\n 50-58 Baggot Street Lower<\/p>\n\n\n\n Dublin 2<\/p>\n\n\n\n Ireland<\/p>\n\n\n\n Shire Pharmaceuticals Ireland Limited<\/p>\n\n\n\n Block 2 & 3 Miesian Plaza<\/p>\n\n\n\n 50 – 58 Baggot Street Lower<\/p>\n\n\n\n Dublin 2<\/p>\n\n\n\n Ireland<\/p>\n","protected":false},"excerpt":{"rendered":" 5 mg, 20 mg\u00a0modified-release tabletshydrocortisone What Plenadren is and what it is used for Plenadren contains a substance called\u00a0hydrocortisone\u00a0(sometimes called\u00a0cortisol\u00a0).\u00a0Hydrocortisone\u00a0is a\u00a0glucocorticoid.\u00a0Plenadren belongs to a group of medicines called\u00a0corticosteroids.\u00a0Glucocorticoids\u00a0are found naturally in the body and help keep you in good health. Plenadren is used in adults to treat a condition called adrenal insufficiency, or cortisol deficiency.\u00a0Adrenal […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[2406,2409,13531,21479,21482,21483,10946,10945,21480,21481],"class_list":["post-20942","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-hydrocortisone","tag-hydrocortisone-side-effects","tag-hydrocortisone-tablet","tag-plenadren","tag-plenadren-side-effects","tag-plenadren-tablet","tag-what-hydrocortisone-is-used-for","tag-what-is-hydrocortisone","tag-what-is-plenadren","tag-what-plenadren-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20942","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20942"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20942\/revisions"}],"predecessor-version":[{"id":20996,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20942\/revisions\/20996"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20942"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
The need for extra\u00a0dose\u00a0is of Plenadren<\/strong><\/p>\n\n\n\nIf you take more Plenadren than you should<\/h2>\n\n\n\n
If you forget to take Plenadren<\/h2>\n\n\n\n
If you stop taking Plenadren<\/h2>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
How to store Plenadren<\/h2>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n