{"id":20940,"date":"2022-04-18T18:24:25","date_gmt":"2022-04-18T18:24:25","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20940"},"modified":"2022-04-22T16:40:38","modified_gmt":"2022-04-22T16:40:38","slug":"plegridy","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/plegridy\/","title":{"rendered":"Plegridy &#8211; Peginterferon beta 1a uses, dose and side effects"},"content":{"rendered":"\n<p>63\/94\/125 micrograms&nbsp;solution for injection&nbsp;in a pre-filled pen&nbsp;peginterferon<br>beta 1a<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Plegridy is and what it is used for<\/h2>\n\n\n\n<p><strong>What Plegridy is<\/strong><\/p>\n\n\n\n<p>The active substance in Plegridy is peginterferon beta-1a.&nbsp;Peginterferon beta-1a is a modified form of&nbsp;interferon&nbsp;that is long-acting.&nbsp;Interferons&nbsp;are natural substances that are produced in the body to help protect against&nbsp;infections&nbsp;and diseases.<\/p>\n\n\n\n<p><strong>What Plegridy is used for<\/strong><\/p>\n\n\n\n<p><strong>This medicine is used to treat relapsing-remitting&nbsp;multiple sclerosis&nbsp;(MS) in adults 18 years of age and older.<\/strong><\/p>\n\n\n\n<p>MS is a long-term disease that affects the&nbsp;central nervous system&nbsp;(&nbsp;CNS&nbsp;), including the brain and spinal cord, where the body&#8217;s immune system (its natural defenses) damages the protective substance (myelin) that surrounds the nerves in the brain and spinal cord.&nbsp;This disrupts the signals between the brain and other parts of the body and causes the symptoms of MS.&nbsp;Patients with relapsing-remitting MS may have periods when the disease is not active (&nbsp;remission&nbsp;) between flare-up symptoms (&nbsp;relapses&nbsp;).<\/p>\n\n\n\n<p><strong>Everyone has their variants of MS symptoms.\u00a0These may include:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Feeling of poor balance or dizziness, difficulty walking, stiffness and muscle spasms, fatigue, numbness of the face, arms, or legs<\/li><li>Acute\u00a0or\u00a0chronic\u00a0pain, bladder and bowel problems, sexual problems, and vision problems<\/li><li>Hard to think and concentrate, depression.<\/li><\/ul>\n\n\n\n<p><strong>How Plegridy works<\/strong><\/p>\n\n\n\n<p><strong>It seems that Plegridy prevents the body&#8217;s immune system from damaging the brain and spinal cord<\/strong>.\u00a0This can help reduce the number of\u00a0relapses\u00a0you have and slow down the disabling effects of MS.\u00a0Treatment with Plegridy can help prevent you from getting worse, but it does not cure MS.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Plegridy<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Plegridy<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are allergic<\/strong>\u00a0to peginterferon beta-1a,\u00a0interferon\u00a0beta-1a, or any of the other ingredients of this medicine (listed in section 6).\u00a0See section 4 for symptoms of an\u00a0allergic reaction.<\/li><li><strong>If you have severe depression<\/strong>\u00a0or have suicidal thoughts.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>Talk to a doctor if you have ever had:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Depression<\/strong>\u00a0or problems that affect your mood<\/li><li><strong>Suicidal thoughts<\/strong><ul><li>Your doctor may still prescribe Plegridy to you, but you must tell your doctor if you have ever had depression or similar problems that affected your mood.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>If you have any of the conditions listed below<\/strong>, talk to your\u00a0doctor, pharmacist, or nurse\u00a0before injecting Plegridy.\u00a0They may get worse when you use Plegridy:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Serious liver or kidney problems<\/strong><\/li><li><strong>Irritation at the injection site<\/strong> may lead to skin or\u00a0tissue\u00a0damage (\u00a0necrosis\u00a0at the injection site).\u00a0When you are ready to inject, carefully follow the instructions in section 7, \u201c\u00a0Instructions on how to inject Plegridy pre-filled pen\u00a0\u201d, at the end of this leaflet.\u00a0This is to reduce the risk of injection site reactions.<\/li><li>Epilepsy\u00a0or other types of seizures where medication has not given sufficient results.<\/li><li>Heart problems can cause symptoms such as\u00a0chest pain (angina), especially after an activity;\u00a0swollen ankles, shortness of breath (\u00a0chronic\u00a0heart failure\u00a0);\u00a0or irregular heartbeat (\u00a0arrhythmia\u00a0).<\/li><li>Thyroid problems<\/li><li>A low number of\u00a0white blood cells\u00a0or\u00a0platelets, may increase the risk of\u00a0infection, or bleeding<\/li><\/ul>\n\n\n\n<p><strong>Additional things to consider when using Plegridy<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You will need to take blood samples to determine the number of your\u00a0blood cells, blood status, and levels of liver enzymes.\u00a0These will be performed before you start using Plegridy, regularly after you start treatment with Plegridy, and then for periods during treatment, even if you do not have any special symptoms.\u00a0These blood tests are done in addition to the tests that are normally taken to check your MS.<\/li><li>The function of your\u00a0thyroid gland\u00a0will be checked regularly or when your doctor deems it necessary for other reasons.<\/li><li>Blood clots in the small blood vessels can occur during treatment.\u00a0These blood clots can affect your kidneys.\u00a0This can occur after several weeks of treatment up to several years after you start taking Plegridy.\u00a0Your doctor may want to check your\u00a0blood pressure, blood (\u00a0platelet count\u00a0), and how your kidneys are working.<\/li><\/ul>\n\n\n\n<p>Should you accidentally sting yourself or anyone else with the needle in Plegridy, wash the affected area\u00a0<strong>immediately<\/strong>\u00a0with soap and water and\u00a0<strong>contact a doctor or nurse as soon as possible<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Plegridy must&nbsp;<strong>not be used<\/strong>&nbsp;in children and adolescents under 18 years of age.&nbsp;The safety and efficacy of Plegridy in this age group are unknown.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Plegridy<\/h2>\n\n\n\n<p>Plegridy should be used with caution in combination with medicines that are broken down in the body by a group of&nbsp;proteins&nbsp;called \u201ccytochrome P450\u201d (eg some medicines used to&nbsp;treat epilepsy&nbsp;or depression).<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, especially those used to treat\u00a0epilepsy\u00a0or depression.\u00a0This also applies to over-the-counter medicines.<\/p>\n\n\n\n<p>Sometimes you need to remind other healthcare professionals that you are being treated with Plegridy.&nbsp;For example, if you are being prescribed other medicines or if you are going to have a blood test.&nbsp;Plegridy may affect other medicines or the test result.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>No adverse effects are expected on breast-fed infants\/infants.\u00a0Plegridy can be used during breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Plegridy has no or negligible effect on the ability to drive and use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Plegridy contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg), ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Plegridy<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Usual dose:<\/strong><\/p>\n\n\n\n<p>One&nbsp;injection&nbsp;of Plegridy 125 micrograms every 14 days (every two weeks).&nbsp;Try to use Plegridy at the same time on the same day of the week each time you inject.<\/p>\n\n\n\n<p><strong>To begin with Plegridy<\/strong><\/p>\n\n\n\n<p>If Plegridy is new to you, your doctor may advise you to increase the\u00a0dose\u00a0gradually so that you can adjust to the effects of Plegridy before you reach the full\u00a0dose.\u00a0You will receive a\u00a0starter\u00a0pack containing your first 2 injections: an orange\u00a0pen\u00a0with Plegridy 63 micrograms (for day 0) and a blue pen with\u00a0Plegridy\u00a094 micrograms (for day 14).<\/p>\n\n\n\n<p>After that, you will receive a maintenance pack of gray pencils with Plegridy 125 micrograms (for day 28 and then every other week).<\/p>\n\n\n\n<p>Read the instructions in section 7, \u201c&nbsp;<em>Instructions on how to inject Plegridy pre-filled pen<\/em>&nbsp;\u201d, at the end of the package leaflet before you start using Plegridy.<\/p>\n\n\n\n<p>Use the list printed on the inside of the starter pack cover to&nbsp;keep&nbsp;track of your injection dates.<\/p>\n\n\n\n<p><strong>Inject yourself<\/strong><\/p>\n\n\n\n<p>Plegridy should be injected under the skin (\u00a0<em>subcutaneous\u00a0injection<\/em>\u00a0).\u00a0Change the injection site. Do not use the same injection site for subsequent\u00a0injections.<\/p>\n\n\n\n<p>You can inject Plegridy yourself without the help of your doctor if you have been taught how to do it.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Read and follow the instructions given in the instructions in section 7, &#8221;&nbsp;<em>Instructions on how to inject Plegridy&nbsp;<\/em><em>pre-filled&nbsp;pen<\/em>&nbsp;&#8220;, before you start.<\/li><li><strong>If you have problems<\/strong>&nbsp;handling the pen, ask your doctor or nurse for help.<\/li><\/ul>\n\n\n\n<p><strong>How long to use Plegridy<\/strong><\/p>\n\n\n\n<p>Your doctor will tell you how long you must continue to use Plegridy.\u00a0You must continue to use Plegridy regularly.\u00a0Do not make any changes unless your doctor tells you to.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Plegridy than you should&nbsp;<\/h2>\n\n\n\n<p>You should only inject Plegridy once every two weeks.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have used more than one\u00a0injection\u00a0of Plegridy over 7 days,\u00a0<strong>contact your doctor or nurse immediately.<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Plegridy<\/h2>\n\n\n\n<p>You must inject Plegridy once every two weeks.&nbsp;This regular schedule helps to ensure that the treatment is delivered as evenly as possible.<\/p>\n\n\n\n<p>If you miss your normal day, inject as soon as you can and then continue as usual.\u00a0However, you should not inject more than once during 7 days.\u00a0Do not use two\u00a0injections\u00a0to compensate for a missed\u00a0injection.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Liver problem<\/strong><\/li><\/ul>\n\n\n\n<p><em>(common &#8211; may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<p>If you get any of these symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The skin or whites of the eyes turn yellow<\/li><li>Itching&nbsp;all over the body<\/li><li>Nausea, vomiting<\/li><li>Easy to get bruises<ul><li><strong>Contact a doctor immediately.&nbsp;<\/strong>This may be a sign of a possible liver problem.<\/li><\/ul><\/li><li><strong>Depression<\/strong><\/li><\/ul>\n\n\n\n<p><em>(common &#8211; may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<p>If you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Feeling abnormally sad, anxious or worthless or<\/li><li>Have suicidal thoughts<ul><li><strong>Contact a doctor immediately<\/strong>.<\/li><\/ul><\/li><li><strong>Severe\u00a0allergic reaction<\/strong><\/li><\/ul>\n\n\n\n<p><em>(uncommon &#8211; may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<p>If you get any of this:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hard to breathe<\/li><li>Swelling of the face (lips, tongue, or throat)<\/li><li>Rash or\u00a0redness\u00a0of the skin<ul><li>Contact a doctor immediately.<\/li><\/ul><\/li><li><strong>Seizures<\/strong><\/li><\/ul>\n\n\n\n<p><em>(uncommon &#8211; may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<p>If you have a seizure<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li><strong>Contact a doctor immediately.<\/strong><\/li><\/ol>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Injury at the injection site<\/strong><\/li><\/ul>\n\n\n\n<p><em>(rare &#8211; may affect up to 1 in 1,000 people)<\/em><\/p>\n\n\n\n<p>If you get any of these symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A wound on the skin along with swelling,\u00a0inflammation,\u00a0or fluid leaking around the injection site<ul><li><strong>Contact a doctor for advice.<\/strong><\/li><\/ul><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Kidney problems including scarring that can impair kidney function<\/strong><\/li><\/ul>\n\n\n\n<p><em>(rare &#8211; may affect up to 1 in 1,000 people)<\/em><\/p>\n\n\n\n<p>If you get any or all of these symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Frothy urine<\/li><li>Fatigue<\/li><li>Swelling, especially in the ankles and eyelids, and weight gain.<ul><li><strong>Contact a doctor as this may be a sign of a possible kidney problem.<\/strong><\/li><\/ul><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Blood problem<\/strong><\/li><\/ul>\n\n\n\n<p><em>(rare &#8211; may affect up to 1 in 1,000 people)<\/em><\/p>\n\n\n\n<p>The following may happen Blood clots in the small blood vessels that can affect your kidneys (thrombotic thrombocytopenic purpura or\u00a0hemolytic uremic syndrome\u00a0).\u00a0Symptoms may include increased bruising, bleeding, fever, extreme weakness, headache, dizziness, or fainting.\u00a0Your doctor may notice changes in your blood and kidney function.<\/p>\n\n\n\n<p>If you get any or all of these symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Increased number of bruises or bleeding<\/li><li>Extreme weakness<\/li><li>Headache, dizziness, or dizziness<ul><li><strong>Contact a doctor immediately.<\/strong><\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may affect more than 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Flu-like symptoms.\u00a0These symptoms are not flu, see below.\u00a0You can not infect others.<\/li><li>Headache<\/li><li>Muscle pain (\u00a0myalgia\u00a0)<\/li><li>Pain in the joints, arms, legs, or neck (\u00a0arthralgia\u00a0)<\/li><li>Overindulge<\/li><li>Fever<\/li><li>A feeling of weakness and tiredness (\u00a0asthenia\u00a0)<\/li><li>Redness,\u00a0itching,\u00a0or pain around the injection site<ul><li><strong>Contact a doctor if any of these effects bother you.<\/strong><\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Flu-like symptoms<\/strong><\/p>\n\n\n\n<p>Flu-like symptoms\u00a0are more common when you have just started using Plegridy.\u00a0They gradually diminish as you continue your\u00a0injections.\u00a0See below for easy ways to deal with these\u00a0flu-like symptoms\u00a0if you get them.<\/p>\n\n\n\n<p>Three simple ways to help reduce the impact of flu-like symptoms:<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Consider the time of your Plegridy injection.\u00a0When the\u00a0flu-like symptoms\u00a0begin and end are different for each patient.\u00a0The\u00a0flu-like symptoms\u00a0begin on average about 10 hours after\u00a0injection\u00a0and last between 12 and 24 hours.<\/li><li>Take\u00a0paracetamol\u00a0or\u00a0ibuprofen\u00a0half an hour before Plegridy\u00a0injection\u00a0and continue to take\u00a0paracetamol\u00a0or\u00a0ibuprofen\u00a0for as long as you have\u00a0flu-like symptoms.\u00a0Talk to your doctor or pharmacist about how much to take and for how long.<\/li><li>If you have a fever, drink plenty of water to avoid dehydration.<\/li><\/ol>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea or vomiting<\/li><li>Hair loss (\u00a0alopecia\u00a0)<\/li><li>Itching\u00a0of the skin<\/li><li>Elevated body temperature<\/li><li>Changes around the place where you injected, e.g.\u00a0swelling,\u00a0inflammation, bruising, heat, rash, or discoloration<\/li><li>Changes in the blood may cause fatigue or decrease the ability to fight\u00a0infection<\/li><li>An increased amount of liver enzymes in the blood (shows up in blood tests)<ul><li><strong>Contact a doctor if any of these effects bother you.<\/strong><\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hives<\/li><li>Changes in the blood may cause unexplained bruising or bleeding.<ul><li><strong>Contact a doctor if any of these effects bother you.<\/strong><\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong><\/p>\n\n\n\n<p><em>&nbsp;(&nbsp;<\/em><em>occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Pulmonary\u00a0arterial\u00a0hypertension: A disease with severe narrowing of the blood vessels of the lungs that leads to high\u00a0blood pressure\u00a0in the blood vessels that carry blood from the heart to the lungs.\u00a0Pulmonary\u00a0arterial\u00a0hypertension\u00a0has been observed at different times during treatment, even up to several years after initiating\u00a0interferon-beta treatment.<br><br>To facilitate the traceability of this medicine, your doctor or pharmacist should document the product name and batch number in your patient record.\u00a0Note these details in case you are asked about this information in the future.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Plegridy<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Store in the original package.\u00a0Sensitive to light.\u00a0Only open the package when you need a new\u00a0pen.<\/li><li>Store in a refrigerator\u00a02 &#8211; 8 \u00baC.<ul><li>Do not freeze.\u00a0Throw away Plegridy who has been frozen.<\/li><\/ul><\/li><li>Plegridy can be stored outside the refrigerator at room temperature (up to 25 \u00b0 C) for up to 30 days but must be\u00a0protected from light.<ul><li>Plegridy can be taken out of the refrigerator and put back more than once if needed.<\/li><li>Check that the time that the pens are outside the refrigerator does not\u00a0exceed 30 days in total.<\/li><li>Dispose of pens stored outside the refrigerator for more than 30 days.<\/li><li>If you are unsure how many days you have kept a\u00a0pen\u00a0outside the refrigerator, throw away the pen.<\/li><\/ul><\/li><li>Do not use this medicine if you notice any of the following:<ul><li>If the pen is broken.<\/li><li>If the solution is colored, cloudy, or contains liquid particles.<\/li><\/ul><\/li><li>Medicines should not be disposed of via wastewater or household waste.\u00a0Ask your pharmacist how to dispose of medicines no longer required.\u00a0These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is peginterferon beta 1a.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>One 63 micrograms pre-filled\u00a0pen\u00a0contains 63 micrograms of peginterferon beta 1a in a 0.5 ml solution.<\/li><li>A 94 microgram pre-filled\u00a0pen\u00a0contains 94 micrograms of peginterferon beta 1a in a 0.5 ml solution.<\/li><li>One 125 micrograms pre-filled\u00a0pen\u00a0contains 125 micrograms of peginterferon beta 1a in a 0.5 ml solution.<\/li><\/ul>\n\n\n\n<p>The other ingredients are Sodium acetate trihydrate, glacial acetic acid, L arginine hydrochloride, polysorbate 20, and water for injections (see section 2 \u201cPlegridy contains sodium\u201d).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Plegridy is a clear and colorless&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;glass&nbsp;pen with an attached needle.<\/p>\n\n\n\n<p>Pack sizes:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Plegridy starter pack&nbsp;contains&nbsp;an orange pre-filled&nbsp;pen&nbsp;with 63 micrograms and a blue pre-filled&nbsp;pen&nbsp;with 94 micrograms.<\/li><li>The 125 microgram gray pens are supplied in packs containing two or six pre-filled pens.<\/li><\/ul>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Biogen Netherlands BV<\/p>\n\n\n\n<p>Prins Mauritslaan 13<\/p>\n\n\n\n<p>1171 LP Badhoevedorp<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>FUJIFILM Diosynth Biotechnologies Denmark ApS<\/p>\n\n\n\n<p>Biotek All\u00e9 1<\/p>\n\n\n\n<p>DK-3400 Hiller\u00f8d<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Biogen Netherlands BV<\/p>\n\n\n\n<p>Prins Mauritslaan 13<\/p>\n\n\n\n<p>1171 LP Badhoevedorp<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Biogen Belgium NV \/ SATel: +32 2 2191218<\/td><td><strong>Lithuania<\/strong>UAB &#8220;JOHNSON &amp; JOHNSON&#8221;Tel: +370 5 278 68 88<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>TP WATERMARMATel: +359 2 962 12 00<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Biogen Belgium NV \/ SATel: +32 2 2191218<\/td><\/tr><tr><td><strong>Czech Republic&nbsp;<\/strong><strong>a<\/strong>Biogen (Czech Republic) sroTel: +420 255 706 200<\/td><td><strong>Hungary<\/strong>Biogen Hungary Kft.Tel: +36 1 899 9883<\/td><\/tr><tr><td><strong>Denmark<\/strong>Biogen Denmark A \/ STel: +45 77 41 57 57<\/td><td><strong>Malta<\/strong>Pharma.&nbsp;MT Ltd.Tel: +356 21337008<\/td><\/tr><tr><td><strong>Germany<\/strong>Biogen GmbHTel: +49 (0) 89 99 6170<\/td><td><strong>The Netherlands<\/strong>Biogen Netherlands BVTel: +31 20 542 2000<\/td><\/tr><tr><td><strong>Eesti<\/strong>UAB &#8220;JOHNSON &amp; JOHNSON&#8221; Eesti subsidiaryTel: +372 617 7410<\/td><td><strong>Norway<\/strong>Biogen Norway ASTel: +47 23 40 01 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Genesis Pharma SATel: +30 210 8771500<\/td><td><strong>Austria<\/strong>Biogen Austria GmbH.Tel: +43 1 484 46 13<\/td><\/tr><tr><td><strong>Spain<\/strong>Biogen Spain SLTel: +34 91 310 7110<\/td><td><strong>Poland<\/strong>Biogen Poland Sp.&nbsp;z ooTel: +48 22 351 51 00<\/td><\/tr><tr><td><strong>France<\/strong>Biogen France SASTel: +33 (0) 1 41 37 9595<\/td><td><strong>Portugal<\/strong>Biogen Portugal,Sociedade Pharmac\u00eautica Unipessoal, Lda.Tel: +351 21 318 8450<\/td><\/tr><tr><td><strong>Croatia<\/strong>Medis Adria dooTel: +385 1 230 34 46<\/td><td><strong>Romania<\/strong>Johnson &amp; Johnson Romania SRLTel: +40 21 207 18 00<\/td><\/tr><tr><td><strong>Ireland<\/strong>Biogen Idec (Ireland) Ltd.Tel: +353 (0) 1 463 7799<\/td><td><strong>Slovenia<\/strong>Biogen Pharma dooTel: +386 1 511 02 90<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hfTel: +354 540 8000<\/td><td><strong>Slovak Republic<\/strong>Biogen Slovakia sroTel: +421 2 323 34 008<\/td><\/tr><tr><td><strong>Italy<\/strong>Biogen Italia srlTel: +39 02 584 9901<\/td><td><strong>Finland \/ Finland<\/strong>Biogen Finland OyTel: +358 207 401 200<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>Genesis Pharma Cyprus LtdTel: +3572 2 769946<\/td><td><strong>Sweden<\/strong>Biogen Sweden ABTel: +46 8 594 113 60<\/td><\/tr><tr><td><strong>Latvia<\/strong>UAB &#8220;JOHNSON &amp; JOHNSON&#8221; fili\u0101le Latvij\u0101Tel: +371 678 93561<\/td><td><strong>United Kingdom&nbsp;<\/strong><strong>(Northern Ireland)<\/strong>Biogen Idec (Ireland) LimitedTel: +44 (0) 1628 50 1000<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>The active substance in Plegridy is peginterferon beta-1a. Peginterferon beta-1a is a modified form of interferon that is long-acting. Interferons are natural substances that are produced in the body to help protect against infections and diseases.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21488,21493,21484,21487,21489,21492,21485,21490,21486,21491],"class_list":["post-20940","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-peginterferon-beta-1a","tag-benefits-of-plegridy","tag-peginterferon-beta-1a","tag-peginterferon-beta-1a-side-effects","tag-plegridy","tag-plegridy-side-effects","tag-what-is-peginterferon-beta-1a","tag-what-is-plegridy","tag-what-peginterferon-beta-1a-is-used-for","tag-what-plegridy-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20940"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20940\/revisions"}],"predecessor-version":[{"id":20997,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20940\/revisions\/20997"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}