{"id":20890,"date":"2022-04-15T15:56:18","date_gmt":"2022-04-15T15:56:18","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20890"},"modified":"2022-04-18T17:05:25","modified_gmt":"2022-04-18T17:05:25","slug":"pixuvri","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/pixuvri\/","title":{"rendered":"Pixuvri &#8211; Pixantron uses, dose and side effects"},"content":{"rendered":"\n<p>29 mg\u00a0powder for concentrate for\u00a0solution for\u00a0infusion<br>pixantrone<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Pixuvri is and what it is used for<\/h2>\n\n\n\n<p>Pixuvri belongs to a group of pharmacotherapeutic agents called &#8216;antineoplastic agents&#8217;.&nbsp;These are used as a treatment for cancer.<\/p>\n\n\n\n<p>Pixuvri is used to treat adult patients who have had multiple relapses or have refractory aggressive non-Hodgkin&#8217;s lymphoma.\u00a0Pixuvri kills cancer cells by binding to\u00a0DNA, leading to cell death.\u00a0It is used for patients in cases where their cancer does not respond to or has recurred after other chemotherapy treatments.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Pixuvri<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Pixuvri<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to pixantrone dimaleate or any of the other ingredients of this medicine (listed in section 6),<\/li><li>if you have recently been vaccinated,<\/li><li>if you have been told that you have a persistent, persistently low number of\u00a0red blood cells,\u00a0white blood cells,\u00a0and\u00a0platelets,<\/li><li>if you have very serious liver problems.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before using Pixuvri<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have been told that you have a very low\u00a0white blood cell count,<\/li><li>if you suffer from heart disease or uncontrolled high\u00a0blood pressure, especially if you have ever been told that you have had\u00a0heart failure\u00a0or if you have had a heart attack in the last six months,<\/li><li>if you have an\u00a0infection,<\/li><li>if you have ever been treated for cancer,<\/li><li>if you are on a special sodium-poor diet,<\/li><li>if you are taking other medicines that may interact with Pixuvri (see &#8220;Other medicines and Pixuvri&#8221; below).<\/li><\/ul>\n\n\n\n<p><strong>Sensitivity of the skin to sunlight<\/strong><\/p>\n\n\n\n<p>During your treatment with pixantrone,\u00a0expose\u00a0yourself as little as possible or completely avoid natural and artificial sunlight (tanning beds or UVA \/ B treatment).\u00a0If you are exposed to sunlight, wear sunscreen and use sunscreen that is highly UV-A absorbent.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine should not be given to children under the age of 18 as there is no information on the treatment of children and adolescents with Pixuvri.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Pixuvri<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.\u00a0This is extremely important as concomitant use of more than one drug may enhance or weaken their effect.\u00a0Pixuvri should not be used with other medicines unless your doctor tells you to.\u00a0Be especially careful to tell your doctor if you are currently taking, or have recently taken, any of the following medicines:<\/p>\n\n\n\n<p>Tell your doctor if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Warfarin&nbsp;to prevent the formation of blood clots<\/li><li>Theophylline for the treatment of lung diseases such as&nbsp;emphysema&nbsp;or&nbsp;asthma<\/li><li>Amitriptyline for the treatment of depression<\/li><li>Olanzapine, clozapine for the treatment of schizophrenia or manic depression<\/li><li>Haloperidol&nbsp;for the treatment of anxiety and insomnia<\/li><li>Ondansetron to prevent nausea and vomiting during&nbsp;chemotherapy<\/li><li>Propranolol for the treatment of high&nbsp;blood pressure<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pixuvri with food and drink<\/h2>\n\n\n\n<p>You do not need to change your diet after treatment with Pixuvri unless your doctor tells you to.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Pixuvri should not be given to pregnant women as it may harm the unborn baby.\u00a0If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p>Appropriate contraceptives must be used during treatment with Pixuvri and for a maximum of 6 months after treatment.\u00a0This applies to women who may become pregnant and men who receive Pixuvri and can have children.<\/p>\n\n\n\n<p>Do not breastfeed while you are being treated with Pixuvri.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>It is not known if Pixuvri affects the ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pixuvri contains sodium<\/h2>\n\n\n\n<p>After\u00a0reconstitution\u00a0and dilution, this medicinal product contains approximately 1 g (43 mmol) of\u00a0sodium\u00a0(the main ingredient in table salt\/table salt) per\u00a0dose.\u00a0This corresponds to 50% of the maximum recommended daily intake of\u00a0sodium\u00a0for adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Pixuvri<\/h2>\n\n\n\n<p><strong>How much Pixuvri will be given<\/strong><\/p>\n\n\n\n<p>The amount (&nbsp;dose&nbsp;) of Pixuvri you will receive depends on your body surface area in square meters (m&nbsp;<sup>2<\/sup>&nbsp;).&nbsp;This is determined by your height and weight.&nbsp;Your blood test results and your state of health will also be taken into account.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 50 mg \/ m&nbsp;<sup>2<\/sup>&nbsp;.&nbsp;If necessary, your doctor will adjust&nbsp;dose&nbsp;one during treatment.<\/p>\n\n\n\n<p>Your doctor will perform some tests before you receive Pixuvri.<\/p>\n\n\n\n<p><strong>How often Pixuvri will be given<\/strong><\/p>\n\n\n\n<p>Pixuvri is given on days 1, 8, and 15 of each 28-day cycle for up to 6 cycles.<\/p>\n\n\n\n<p>Before\u00a0infusion, you may be given medicines to prevent or reduce any reactions to Pixuvri, such as medicines for nausea.<\/p>\n\n\n\n<p><strong>How Pixuvri will be given<\/strong><\/p>\n\n\n\n<p>Pixuvri will be given as a drip into a vein (by&nbsp;intravenous&nbsp;infusion&nbsp;).&nbsp;This will be performed by a nurse or doctor.<\/p>\n\n\n\n<p><strong>How long&nbsp;an infusion&nbsp;one will take<\/strong><\/p>\n\n\n\n<p>It will take about an hour unless otherwise stated.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Infusion reactions<\/strong><\/p>\n\n\n\n<p>Pain\/redness at the injection site may in rare cases occur during\u00a0the infusion\u00a0of Pixuvri.\u00a0Tell the person giving you the\u00a0infusion\u00a0immediately if it hurts or if the injection site turns red.\u00a0Infusion\u00a0one may need to be slowed down or discontinued.\u00a0When these symptoms disappear or improve, the\u00a0infusion\u00a0can be resumed.<\/p>\n\n\n\n<p>Pixuvri has a deep blue color and for several days after receiving Pixuvri, your skin and eyes may get a bluish discoloration, just as your urine may discolor in blue.\u00a0The discoloration of the skin usually disappears after a few days or weeks as the drug is eliminated.<\/p>\n\n\n\n<p><strong>Infection&nbsp;is<\/strong><\/p>\n\n\n\n<p>Tell your doctor if you get any symptoms of infection (such as fever, chills, difficulty breathing, cough, mouth ulcers, difficulty swallowing, or severe diarrhea) after treatment with Pixuvri.\u00a0You may get an\u00a0infection\u00a0more easily after receiving Pixuvri.<\/p>\n\n\n\n<p><strong>Heart<\/strong><\/p>\n\n\n\n<p>There is a risk that your heart&#8217;s pumping function may be impaired as a result of treatment or that you may develop a serious condition called\u00a0heart failure, especially if you already had impaired heart function at the start of Pixuvri treatment.\u00a0Your doctor will monitor your heart function to see if there are any signs or symptoms that your heart may be affected.<\/p>\n\n\n\n<p><strong>Tell your doctor if you think you have any of the following reactions<\/strong><\/p>\n\n\n\n<p>Very common: may affect more than 1 in 10 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea, vomiting<\/li><li>skin discoloration<\/li><li>thinning or loss of hair<\/li><li>abnormal staining of the urine<\/li><li>physical weakness<\/li><li>low\u00a0white blood cell count, low red blood cell count (\u00a0anemia\u00a0), and low\u00a0platelet count\u00a0(may require\u00a0transfusion\u00a0).<\/li><\/ul>\n\n\n\n<p>Common: may affect up to 1 in 10 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection\u00a0such as lung infection, skin infections,\u00a0infections\u00a0is with low\u00a0white blood cell count, cod<\/li><li>fever<\/li><li>blood poisoning (\u00a0sepsis\u00a0)<\/li><li>changed taste experience<\/li><li>abnormal skin sensations such as numbness, and crawling or tingling (\u00a0paresthesia\u00a0)<\/li><li>headache<\/li><li>somnolence<\/li><li>fatigue<\/li><li>inflammation\u00a0of the eyes (\u00a0conjunctivitis\u00a0)<\/li><li>diarrhea<\/li><li>abdominal pain<\/li><li>inflammation\u00a0and\/or ulceration of the throat and mouth<\/li><li>dry mouth, constipation, indigestion, loss of appetite<\/li><li>skin changes such as\u00a0redness\u00a0and\u00a0itching\u00a0of the skin, nail changes<\/li><li>heart damage, decrease in the heart&#8217;s ability to pump blood, blocking of electrical signals in the heart, uneven or fast heart rate<\/li><li>low\u00a0blood pressure<\/li><li>vascular discoloration, pale skin<\/li><li>shortness of breath, cough<\/li><li>blood in the urine<\/li><li>excess\u00a0protein\u00a0is in the urine<\/li><li>swollen legs or calves or other parts of the body<\/li><li>pain in the skeleton<\/li><li>chest pain<\/li><li>low levels of\u00a0phosphate\u00a0in the blood<\/li><li>an abnormal blood test of liver or kidney function.<\/li><\/ul>\n\n\n\n<p>Uncommon: may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe\u00a0infections\u00a0such as\u00a0septic\u00a0shock,\u00a0inflammation\u00a0of the lungs&#8217; airways,\u00a0pneumonia, fungal infection,\u00a0inflammation\u00a0of the skin (\u00a0cellulite\u00a0),\u00a0meningitis,\u00a0infection\u00a0of the gastrointestinal tract<\/li><li>viral infections such as\u00a0shingles\u00a0or reactivation of another\u00a0virus\u00a0such as\u00a0oral\u00a0herpes<\/li><li>nervousness, insomnia<\/li><li>reduced energy<\/li><li>dizziness, fraud<\/li><li>dry eyes<\/li><li>numbness in the mouth<\/li><li>corneal\u00a0infection<\/li><li>allergy\u00a0to the drug<\/li><li>decreased\u00a0calcium\u00a0and sodium levels in the blood, increased uric acid levels in the blood<\/li><li>inflammation\u00a0or accumulation of fluid around the lungs<\/li><li>Suva<\/li><li>bleeding such as bleeding in the intestine, purple spots on the body due to broken blood vessels<\/li><li>vascular irritation<\/li><li>night sweats<\/li><li>irregular heartbeats<\/li><li>spontaneous\u00a0erection<\/li><li>skin rash and\/or ulceration<\/li><li>pain, swelling, weakness, stiffness in joints or muscles<\/li><li>reduced urine production<\/li><li>weight loss<\/li><li>elevated\u00a0bilirubin\u00a0in the blood or urine<\/li><li>inflammation\u00a0of the esophagus<\/li><li>pain in the neck, back,\u00a0extremities\u00a0er<\/li><li>nail infection<\/li><li>development of a neoplasm (\u00a0tumor\u00a0)<\/li><li>new\u00a0bone marrow\u00a0or blood cancer, such as\u00a0acute myeloid leukemia\u00a0(AML) or myelodysplastic syndrome (MDS)<\/li><li>liver damage<\/li><li>bone marrow failure<\/li><li>increased\u00a0eosinophils\u00a0in the blood<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Pixuvri<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the vial label and the carton after \u201cEXP\u201d.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C to 8 \u00b0 C).<\/p>\n\n\n\n<p>Keep the vial in the outer carton.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Pixuvri contains nothing that prevents the growth of bacteria and should therefore be used immediately after\u00a0reconstitution.\u00a0If not used immediately, in-use storage times and conditions before use should not be allowed to exceed 24 hours from 2 \u00b0 C to 8 \u00b0 C.<\/p>\n\n\n\n<p>Reconstituted pixantrone solution is stable for up to 24 hours at room temperature (15 \u00b0 C to 25 \u00b0 C) in standard infusion bags.<\/p>\n\n\n\n<p>Pixuvri is for single use only.\u00a0Any unused product\u00a0or\u00a0waste material\u00a0should\u00a0be disposed of by local requirements.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is pixantrone.\u00a0Each\u00a0vial\u00a0contains 50 mg of pixantron dimaleate (equivalent to 29 mg of pixantron).\u00a0The other ingredients are\u00a0lactose monohydrate, sodium hydroxide,\u00a0hydrochloric acid,\u00a0and sodium chloride.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Pixuvri is a powder for concentrate for solution for\u00a0infusion.\u00a0It is a dark blue powder that is supplied in vials containing 29 mg pixantrone.\u00a0Pack size: 1 vial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Servier Laborierires Servier<\/p>\n\n\n\n<p>50, rue Carnot<\/p>\n\n\n\n<p>92284 Suresnes Cedex<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>The Laboratory Servier Industrie<\/p>\n\n\n\n<p>905 Route de Saran<\/p>\n\n\n\n<p>45520 Judy<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>SA Servier Benelux NVTel: +32 (0) 2 529 43 11<\/td><td><strong>Lithuania<\/strong>UAB \u201cSERVIER PHARMA\u201dTel: +370 (5) 2 63 86 28<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Medical LODG serviceTel: +359 2 921 57 00<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>SA Servier Benelux NVTel: +32 (0) 2 529 43 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Servier sroTel: +420 222 118 111<\/td><td><strong>Hungary<\/strong>Servier Hungaria Kft.Tel: +36 1 238 7799<\/td><\/tr><tr><td><strong>Denmark<\/strong>Servier Danmark A \/ STel: +45 36 44 22 60<\/td><td><strong>Malta<\/strong>VJ Salomone Pharma Ltd&nbsp;Tel: + 356 21 22 01 74<\/td><\/tr><tr><td><strong>Germany<\/strong>Servier Deutschland GmbHTel: +49 (0) 89 57095 01<\/td><td><strong>The Netherlands<\/strong>Servier Nederland Farma BVTel: + 31 (0) 71 5246700<\/td><\/tr><tr><td><strong>Eesti<\/strong>Servier Laboratories O\u00dcTel: + 372 664 5040<\/td><td><strong>Norway<\/strong>Servier Danmark A \/ STel: +45 36 44 22 60<\/td><\/tr><tr><td><strong>E&nbsp;<\/strong><strong>\u03bb\u03bb\u03ac\u03b4\u03b1<\/strong>&nbsp;\u0395\u03a0\u0395 \u0395\u039b\u039b\u0391\u03a3 \u03a6\u0391\u03a1\u039c\u0391\u039a\u0395\u03a5\u03a4\u0399\u039a\u0397 \u0395\u03a0\u0395&nbsp;:\u0397\u03bb: + 30 210 939 1000<\/td><td><strong>Austria<\/strong>Servier Austria GmbHTel: +43 (1) 524 39 99<\/td><\/tr><tr><td><strong>Spain<\/strong>Servierios Servier SLTel: + 34 91 748 96 30<\/td><td><strong>Poland<\/strong>Servier Polska Sp.&nbsp;z ooTel: + 48 (0) 22 594 90 00<\/td><\/tr><tr><td><strong>France<\/strong>Servier Laborierires ServierTel: + 33 (0) 1 55 72 60 00<\/td><td><strong>Portugal<\/strong>Servier Portugal, LdaTel: + 351 21 312 20 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>Servier Pharma, dooTel: + 385 (0) 1 3016 222<\/td><td><strong>Romania<\/strong>Servier Pharma SRLTel: + 4 021 528 52 80<\/td><\/tr><tr><td><strong>Ireland<\/strong>Servier Laboratories (Ireland) Ltd.Tel: + 353 (0) 1 663 8110<\/td><td><strong>Slovenia<\/strong>Servier Pharma dooTel: + 386 (0) 1 563 48 11<\/td><\/tr><tr><td><strong>Iceland<\/strong>Servier Laboratoriesc \/ o Icepharma hfPhone: + 354 540 8000<\/td><td><strong>Slovak Republic<\/strong>Servier Slovensko spol.&nbsp;s roTel: + 421 2 5920 41 11<\/td><\/tr><tr><td><strong>Italy<\/strong>Servier Italia SpATel: + 39 (06) 669081<\/td><td><strong>Finland \/ Finland<\/strong>Servier Finland OyP. \/ Tel: +358 (0) 9 279 80 80<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>CA Papaellinas Ltd.:\u0397\u03bb: + 357 22 741 741<\/td><td><strong>Sweden<\/strong>Servier Sverige ABTel: +46 (0) 8 522 508 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Servier LatviaTel: + 371 67502039<\/td><td><strong>United Kingdom<\/strong>Servier Laboratories LtdTel: +44 (0) 1753 666409<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Pixuvri belongs to a group of pharmacotherapeutic agents called &#8216;antineoplastic agents&#8217;. These are used as a treatment for cancer.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21339,21344,21335,21338,21340,21343,21336,21341,21337,21342],"class_list":["post-20890","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-pixantron","tag-benefits-of-pixuvri","tag-pixantron","tag-pixantron-side-effects","tag-pixuvri","tag-pixuvri-side-effects","tag-what-is-pixantron","tag-what-is-pixuvri","tag-what-pixantron-is-used-for","tag-what-pixuvri-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20890","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20890"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20890\/revisions"}],"predecessor-version":[{"id":20921,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20890\/revisions\/20921"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20890"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20890"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20890"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}