{"id":20884,"date":"2022-04-15T15:50:24","date_gmt":"2022-04-15T15:50:24","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20884"},"modified":"2022-04-18T17:05:53","modified_gmt":"2022-04-18T17:05:53","slug":"piperacillin-tazobactam-sandoz","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/piperacillin-tazobactam-sandoz\/","title":{"rendered":"Piperacillin \/ Tazobactam Sandoz &#8211; Tazobactam uses, dose and side effects"},"content":{"rendered":"\n<p>2 g \/ 0.25 g and 4 g \/ 0.5 g&nbsp;powder for solution for&nbsp;infusion&nbsp;piperacillin<br>\/ tazobactam<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Piperacillin \/ Tazobactam Sandoz is and what it is used for<\/h2>\n\n\n\n<p>Piperacillin belongs to a group of medicines called &#8216;broad-spectrum penicillin antibiotics&#8217;.&nbsp;It can kill many types of bacteria.&nbsp;Tazobactam may prevent certain resistant bacteria from surviving the effects of piperacillin.&nbsp;This means that more types of bacteria are killed when piperacillin and tazobactam are given together.<\/p>\n\n\n\n<p>Piperacillin \/ Tazobactam Sandoz is used in adults and adolescents to treat bacterial infections, such as those affecting the lower respiratory tract (lungs), urinary tract (kidneys and bladder), abdomen, skin, or blood.\u00a0Piperacillin \/ Tazobactam Sandoz can be used to treat bacterial infections in patients with low\u00a0white blood cell count\u00a0(reduced resistance to\u00a0infections\u00a0).<\/p>\n\n\n\n<p>Piperacillin \/ Tazobactam Sandoz is used in children aged 2-12 years to treat\u00a0infections\u00a0in the abdomen, such as appendicitis,\u00a0peritonitis\u00a0(\u00a0infection\u00a0of the fluid and the lining of the abdominal organs), an\u00a0infection\u00a0of the gallbladder.\u00a0Piperacillin \/ Tazobactam Sandoz can be used to treat bacterial infections in patients with low\u00a0white blood cell count\u00a0(reduced resistance to\u00a0infections\u00a0).<\/p>\n\n\n\n<p>In case of some serious\u00a0infection, your doctor may consider using Piperacillin \/ Tazobactam Sandoz in combination with other\u00a0antibiotics.<\/p>\n\n\n\n<p>Piperacillin and tazobactam contained in Piperacillin \/ Tazobactam Sandoz may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Piperacillin \/ Tazobactam Sandoz<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Piperacillin \/ Tazobactam Sandoz<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to piperacillin or tazobactam or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are allergic to\u00a0antibiotics\u00a0called\u00a0penicillins,\u00a0cephalosporins,\u00a0or other beta-lactamase inhibitors, you may be allergic to Piperacillin \/ Tazobactam Sandoz.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Piperacillin \/ Tazobactam Sandoz:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have\u00a0allergies\u00a0is.\u00a0If you have multiple\u00a0allergies, be sure to tell your doctor or another healthcare provider before receiving this product.<\/li><li>if you have diarrhea before, or if you get diarrhea during or after treatment.\u00a0In this case, be sure to tell your doctor or another healthcare professional immediately.\u00a0Do not take any medicine for diarrhea without first checking with your doctor.<\/li><li>if you have low potassium levels in your blood.\u00a0Your doctor may want to check your kidneys before you receive this medicine and he\/she may perform regular blood tests during treatment.<\/li><li>if you have any kidney or liver problems or receive\u00a0hemodialysis.\u00a0Your doctor may want to check your kidneys before you receive this medicine and he\/she may perform regular blood tests during treatment.<\/li><li>if you are taking certain medicines (called anticoagulants) to avoid excessive blood clotting (see also &#8220;Other medicines and Piperacillin \/ Tazobactam Sandoz&#8221; in this information) or if any unexpected bleeding occurs during treatment.\u00a0In this case, tell your doctor or another healthcare professional immediately.<\/li><li>if you get cramps during treatment.\u00a0In this case, tell your doctor or other healthcare professional about it.<\/li><li>if you think you have a new or worsening\u00a0infection.\u00a0In this case, tell your doctor or other healthcare professional about it.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children under 2 years<\/h2>\n\n\n\n<p>The use of piperacillin\/tazobactam is not recommended for use in children below 2 years of age due to insufficient data on safety and efficacy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Piperacillin \/ Tazobactam Sandoz<\/h2>\n\n\n\n<p>Tell your doctor or another healthcare professional if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.\u00a0Some medicines may affect or be affected by piperacillin and tazobactam.\u00a0This applies:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines for\u00a0gout\u00a0(probenecid).\u00a0This can increase the time it takes for piperacillin and tazobactam to leave the body.<\/li><li>drugs that thin the blood or treat blood clots (eg\u00a0heparin,\u00a0warfarin,\u00a0or\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiplo-citrus\/\">acetylsalicylic acid<\/a>\u00a0).<\/li><li>medicines used to relax your muscles during surgery.\u00a0Tell your doctor if you are going to be anesthetized<\/li><li>with methotrexate (a medicine used to treat cancer,\u00a0arthritis,\u00a0or\u00a0psoriasis\u00a0).\u00a0Piperacillin and tazobactam may increase the time it takes for methotrexate to leave the body.<\/li><li>medicines that lower the level of potassium in the blood (eg tablets that increase urination or certain medicines for cancer).<\/li><li>medicines containing the other antibiotics <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tobi\/\">tobramycin<\/a>, gentamycin, or vancomycin.\u00a0Tell your doctor if you have kidney problems.<\/li><\/ul>\n\n\n\n<p><strong>Effects on laboratory tests<\/strong><\/p>\n\n\n\n<p>Tell your doctor or laboratory staff that you are taking Piperacillin \/ Tazobactam Sandoz if you have to take a blood or urine sample.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or healthcare professional for advice before taking this medicine.<\/p>\n\n\n\n<p>Your doctor will decide if Piperacillin \/ Tazobactam Sandoz is right for you.<\/p>\n\n\n\n<p>Piperacillin and tazobactam can pass to the baby in the womb or pass to breast milk.\u00a0If you are breastfeeding, your doctor will decide if Piperacillin \/ Tazobactam Sandoz is right for you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>The use of Piperacillin \/ Tazobactam Sandoz is not expected to affect the ability to drive or use machines.&nbsp;<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Piperacillin \/ Tazobactam Sandoz contains excipients<\/h2>\n\n\n\n<p><strong>Piperacillin \/ Tazobactam Sandoz 2&nbsp;<\/strong>&nbsp;<strong>g \/ 0.25 g contains<\/strong>&nbsp;109 mg&nbsp;sodium&nbsp;(the main ingredient in table salt \/ table salt) per unit dose.&nbsp;This corresponds to 6% of the maximum recommended daily intake of&nbsp;sodium&nbsp;for adults.<\/p>\n\n\n\n<p><strong>Piperacillin \/ Tazobactam Sandoz 4&nbsp;<\/strong>&nbsp;<strong>g \/ 0.5 g contains<\/strong>&nbsp;217 mg&nbsp;sodium&nbsp;(the main ingredient in table salt \/ table salt) per unit dose.&nbsp;This corresponds to 11% of the maximum recommended daily&nbsp;sodium&nbsp;intake for adults.<\/p>\n\n\n\n<p>This should be taken into account if you have been prescribed a low-salt diet.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Piperacillin \/ Tazobactam Sandoz<\/h2>\n\n\n\n<p>Your doctor or other healthcare professional will give you this medicine by&nbsp;infusion&nbsp;(a 30-minute drip) into one of your veins.<\/p>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>The dose of medicine you are given depends on what you are being treated for, your age, and whether you have kidney problems or not.<\/p>\n\n\n\n<p><strong>Adults and adolescents over 12 years<\/strong><\/p>\n\n\n\n<p>The usual\u00a0dose\u00a0is 4 g \/ 0.5 g piperacillin\/tazobactam given every 6-8 hours as\u00a0an infusion\u00a0into one of your veins (directly into the bloodstream).<\/p>\n\n\n\n<p><strong>Patients with kidney problems<\/strong><\/p>\n\n\n\n<p>Your doctor may need to reduce the\u00a0dose\u00a0of Piperacillin \/ Tazobactam Sandoz or how often you get it.\u00a0Your doctor may also want to test your blood to ensure that the treatment is given at the right\u00a0dose, especially if you have to take the medicine for a long time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children aged 2 to 12 years<\/h2>\n\n\n\n<p>The usual\u00a0dose\u00a0for children with abdominal infections is 100 mg \/ 12.5 mg piperacillin\/tazobactam per kg body weight given every 8 hours in a vein (directly in the bloodstream).\u00a0The usual\u00a0dose\u00a0for children with low\u00a0white blood cell count\u00a0is 80 mg \/ 10 mg piperacillin\/tazobactam per kg body weight given every 6 hours in a vein (directly in the bloodstream).<\/p>\n\n\n\n<p>Your doctor will calculate a\u00a0dose\u00a0depending on your child&#8217;s body weight, but each dose\u00a0should not exceed 4 g \/ 0.5 g Piperacillin \/ Tazobactam Sandoz.<\/p>\n\n\n\n<p>You will be given Piperacillin \/ Tazobactam Sandoz until the signs of&nbsp;infection&nbsp;have completely disappeared (5 to 14 days).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Piperacillin \/ Tazobactam Sandoz than you should<\/h2>\n\n\n\n<p>Because you are being given Piperacillin \/ Tazobactam Sandoz by a doctor or other healthcare professional, it is unlikely that you will be given the wrong\u00a0dose.\u00a0However, if you experience\u00a0side effects\u00a0such as\u00a0cramps or if you think you have had too much, tell your doctor immediately.<\/p>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0If a child has ingested the medicine by mistake, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you miss a dose of Piperacillin \/ Tazobactam Sandoz<\/h2>\n\n\n\n<p>If you think you have not received a\u00a0dose\u00a0of Piperacillin \/ Tazobactam Sandoz tell your doctor or another healthcare professional immediately.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Contact your doctor immediately<\/strong>&nbsp;if you experience any of these potentially serious&nbsp;side effects&nbsp;for Piperacillin \/ Tazobactam Sandoz:<\/p>\n\n\n\n<p><strong>The serious&nbsp;side effects&nbsp;(&nbsp;<\/strong><strong>frequency in brackets)&nbsp;<\/strong><strong>of Piperacillin \/ Tazobactam Sandoz are:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe skin rash (\u00a0Stevens-Johnson syndrome, bullous\u00a0dermatitis\u00a0(reported), exfoliative\u00a0dermatitis\u00a0(reported),\u00a0toxic epidermal necrolysis\u00a0(rare)), which initially appear as reddish target-like dots or round spots, often with blisters in the middle, on the bonfire.\u00a0Additional signs are sores in the mouth, throat, nose, arms, legs, and genitals as well as eye inflammation (red and swollen eyes).\u00a0The skin rash can worsen to widespread blistering or flaking of the skin and can be life-threatening.<\/li><li>severe allergic condition with potentially fatal outcome (drug reaction with\u00a0eosinophilia\u00a0and systemic symptoms) that can affect the skin but especially internal organs, such as kidneys and liver (has been reported)<\/li><li>a skin condition (\u00a0acute\u00a0generalized exanthematous\u00a0pustulosis\u00a0) followed by fever consisting of a large number of very small fluid-filled blisters on large parts of the skin, which become swollen and red (have been reported)<\/li><li>swelling of the face, lips, tongue, or other parts of the body (has been reported)<\/li><li>shortness of breath, wheezing, or difficulty breathing (has been reported)<\/li><li>severe skin rash or\u00a0hives\u00a0(uncommon),\u00a0itching\u00a0or rash (common)<\/li><li>whites of the eyes or skin yellow (has been reported)<\/li><li>damage to blood cells (signs of this may be shortness of breath for no reason, urine turning red or brown (has been reported), nosebleeds (rare), or bruises in the form of small dots (purpura) (has been reported)), greatly reduced number of\u00a0whites blood cells\u00a0(rare)<\/li><li>severe or persistent diarrhea followed by fever or weakness (rare)<\/li><\/ul>\n\n\n\n<p><strong>Very&nbsp;<\/strong><strong>common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect more than 1 user in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fungal infection<\/li><li>decreased\u00a0platelet count, decreased\u00a0red blood cell count\u00a0or blood pigment\/hemoglobin, abnormal laboratory test results (positive direct Coombs), prolonged coagulation time (prolonged activated\u00a0partial\u00a0thromboplastin time)<\/li><li>decreased protein content in the blood<\/li><li>headache, insomnia<\/li><li>stomach pain, vomiting, nausea, constipation, upset stomach<\/li><li>increased levels of liver enzymes in the blood<\/li><li>abnormal blood tests for kidney function<\/li><li>fever, injection site reaction<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decrease in\u00a0white blood cell count\u00a0(\u00a0leukopenia\u00a0), prolonged coagulation time (prolonged prothrombin time)<\/li><li>decrease in potassium levels in the blood (\u00a0hypokalaemia\u00a0), decreased blood sugar (blood glucose)<\/li><li>low\u00a0blood pressure,\u00a0inflammation\u00a0of the veins (feels like tenderness or\u00a0redness\u00a0in the affected area)<\/li><li>reddening of the skin<\/li><li>increased content of a degradation product from blood pigments (\u00a0bilirubin\u00a0)<\/li><li>skin reactions with\u00a0redness, skin changes,\u00a0hives<\/li><li>joint and muscle pain<\/li><li>frostbite<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation&nbsp;of the mucous membranes of the mouth<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>\u00a0(occurs in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sharply reduced number of\u00a0red blood cells,\u00a0white blood cells,\u00a0and\u00a0platelets\u00a0(pancytopenia), decreased number of\u00a0white blood cells\u00a0(\u00a0neutropenia\u00a0), decreased number of\u00a0red blood cells\u00a0due to premature degradation, prolonged bleeding time, increased number of\u00a0platelets, increased number of certain types of\u00a0white blood cells\u00a0(\u00a0eosinophilia)\u00a0)<\/li><li>allergic reaction\u00a0and severe\u00a0allergic reaction<\/li><li>hepatitis, renal impairment, and kidney problems<\/li><li>a type of lung disease with an increased number of\u00a0eosinophils\u00a0(a type of\u00a0white blood cell\u00a0) in the lungs<\/li><\/ul>\n\n\n\n<p>Treatment with piperacillin has been associated with an increased incidence of fever and rash in patients with\u00a0cystic fibrosis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Piperacillin \/ Tazobactam Sandoz<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and label after EXP.&nbsp;or EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Unopened vials\/glass vials<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>For storage instructions for reconstituted\/diluted solution, see the end of the package leaflet under &#8220;The following information is intended for medical or healthcare professionals only&#8221;.<\/p>\n\n\n\n<p>For single use only.&nbsp;Discard any unused solution.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are piperacillin and tazobactam.One\u00a0vial\u00a0contains 2 g piperacillin (as piperacillin sodium) and 0.25 g tazobactam (as tazobactam sodium).One\u00a0vial\u00a0or glass vial contains 4 g piperacillin (as piperacillin sodium) and 0.5 g tazobactam (as tazobactam sodium).\u00a0<\/li><li>Other ingredients: This medicine does not contain any other ingredients other than the active substances.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Piperacillin \/ Tazobactam Sandoz 2 g \/ 0.25 g is a white to off-white powder for solution for\u00a0infusion, packaged in\u00a0a vial\u00a0a glass vials are packaged in cartons<\/p>\n\n\n\n<p>Pack sizes: 1, 5, 10, 12 and 50 vials.<\/p>\n\n\n\n<p>Piperacillin \/ Tazobactam Sandoz 4 g \/ 0.5 g is a white to off-white powder for solution for\u00a0infusion, packaged in vials or vials.\u00a0The vials or glass bottles are packed in cartons.<\/p>\n\n\n\n<p>Pack sizes: 1, 5, 10, 12 and 50 vials \/ vials.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.&nbsp;&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder:<\/em><\/p>\n\n\n\n<p>Sandoz A \/ S, Edvard Thomsens Vej 14, 2300 Copenhagen S, Denmark<\/p>\n\n\n\n<p><em>Manufacturer:<\/em><\/p>\n\n\n\n<p>Sandoz GmbH, Biochemiestrasse 10, 6250 Kundl, Austria<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Piperacillin belongs to a group of medicines called &#8216;broad-spectrum penicillin antibiotics&#8217;. It can kill many types of bacteria. Tazobactam may prevent certain resistant bacteria from surviving the effects of piperacillin. This means that more types of bacteria are killed when piperacillin and tazobactam are given together.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21362,21365,21371,21374,21377,21378,21363,21372,21375,21364,21373,21376],"class_list":["post-20884","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-piperacillin","tag-piperacillin-side-effects","tag-tazobactam","tag-tazobactam-sandoz","tag-tazobactam-sandoz-side-effects","tag-tazobactam-side-effects","tag-what-is-piperacillin","tag-what-is-tazobactam","tag-what-is-tazobactam-sandoz","tag-what-piperacillin-is-used-for","tag-what-tazobactam-is-used-for","tag-what-tazobactam-sandoz-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20884","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20884"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20884\/revisions"}],"predecessor-version":[{"id":20924,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20884\/revisions\/20924"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20884"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20884"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}