trastuzumab<\/a> and medicines called cytotoxic\u00a0drugs.\u00a0Information on these medicines can be found in separate package leaflets.\u00a0Ask your doctor or nurse for information about these medicines.<\/p>\n\n\n\nHow Perjeta works<\/strong><\/p>\n\n\n\nPerjeta belongs to a group of medicines called monoclonal\u00a0antibodies, which attach to a specific type of\u00a0receptor\u00a0on cancer cells.<\/p>\n\n\n\n
Perjeta recognizes and binds to a receptor called “human epidermal growth factor receptor 2” ( HER2 ).
What you need to know before you get Perjeta<\/h2>\n\n\n\nDo not use Perjeta<\/h2>\n\n\n\nIf you are allergic to pertuzumab or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\nIf you are not sure, ask your doctor or nurse.<\/p>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n Treatment with Perjeta may affect the functions of the heart. Talk to a doctor or nurse before receiving Perjeta:<\/p>\n\n\n\n
If you have previously had heart problems (such as\u00a0heart failure, treatment for severe irregular heartbeat, uncontrolled high\u00a0blood pressure, recent heart attack), your heart function will be checked before and during treatment with Perjeta and your doctor will check that your heart is functioning properly.<\/li> if you have had heart problems with trastuzumab before.<\/li> if you have previously been treated with\u00a0cytotoxic drugs\u00a0from the group of\u00a0anthracyclines, such as doxorubicin or epirubicin – these medicines can damage the heart muscle and increase the risk of heart problems during treatment with Perjeta.<\/li><\/ul>\n\n\n\nIf any of the above apply to you (or you are not sure), talk to your doctor or nurse before taking Perjeta. See section 4 \u201cSerious side effects\u201d for more information on signs of heart problems.<\/p>\n\n\n\n
Infusion<\/strong>Febrile\u00a0neutropenia\u00a0(Small number of\u00a0white blood cells\u00a0and fever)<\/strong>Diarrhea<\/strong><\/p>\n\n\n\nTreatment with Perjeta can cause severe diarrhea. Patients over the age of 65 have a higher risk of diarrhea compared with patients younger than the age of 65. Diarrhea is a condition in which your body produces more watery stools than normal. If you experience severe diarrhea during your cancer treatment, your doctor may start treatment for diarrhea and possibly discontinue your treatment with Perjeta until the diarrhea is under control.<\/p>\n\n\n\n
Children and young people<\/h2>\n\n\n\n Perjeta should not be used in patients under 18 years of age as there is insufficient information for the treatment of this age group.<\/p>\n\n\n\n
Use in the elderly<\/strong><\/p>\n\n\n\nPatients over the age of 65 who are treated with Perjeta more often experience\u00a0side effects\u00a0such as decreased appetite, decreased\u00a0red blood cell count, weight loss, feeling tired, loss or changed taste, weakness, numbness, tingling or tingling sensation mainly in feet and legs and diarrhea, compared to patients younger than 65 years of age.<\/p>\n\n\n\n
Other medicines and Perjeta<\/h2>\n\n\n\n Tell your doctor or nurse if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n Before starting treatment, you must tell your doctor or nurse if you are pregnant or breastfeeding, or if you think you may be pregnant or are planning to have a baby.
Tell your doctor immediately if you become pregnant during treatment with Perjeta or for 6 months after stopping treatment.<\/li> Ask your doctor if you can breastfeed during or after treatment with Perjeta.<\/li><\/ul>\n\n\n\nPerjeta can harm the fetus. You should use effective contraception during treatment with Perjeta and for at least 6 months after stopping treatment. Talk to your doctor about which contraceptive is best for you.<\/p>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n Perjeta may have a minor effect on your ability to drive or use machines. However, if you experience dizziness, infusion reactions, allergic or anaphylactic reactions, do not drive or use machines until these symptoms have disappeared.<\/p>\n\n\n\n
Perjeta contains excipients<\/h2>\n\n\n\n Sodium<\/strong> :<\/p>\n\n\n\nPerjeta contains less than 1 mmol\u00a0sodium\u00a0per\u00a0dose, ie it is essentially ‘sodium-free’.<\/p>\n\n\n\n
How to get Perjeta<\/h2>\n\n\n\n Getting this medicine<\/strong>The drug is given as an\u00a0intravenous\u00a0infusion\u00a0(“drip”) directly into a blood vessel every 3 weeks.<\/li> Dosage\u00a0one and the duration of\u00a0infusion\u00a0one will vary between the first\u00a0infusion\u00a0one and the subsequent\u00a0infusions.<\/li> The number of\u00a0infusions\u00a0you will receive depends on how you respond to the treatment and whether you receive treatment before or after\u00a0surgery\u00a0(\u00a0neoadjuvant\u00a0or adjuvant treatment) or for a disease that has spread.<\/li> Perjeta is given with other cancer medicines (trastuzumab and\u00a0chemotherapy\u00a0).<\/li><\/ul>\n\n\n\nAt first infusion one<\/strong><\/p>\n\n\n\nYou will receive 840 mg Perjeta for 60 minutes.\u00a0Your doctor or nurse will observe whether you experience any\u00a0side effects\u00a0during\u00a0infusion\u00a0one or within 60 minutes after the end of the\u00a0infusion.<\/li> You will also receive trastuzumab and\u00a0chemotherapy.<\/li><\/ul>\n\n\n\nFor all of the following\u00a0infusions,<\/strong>\u00a0if the first\u00a0infusion\u00a0was well tolerated:<\/p>\n\n\n\nYou will receive 420 mg Perjeta as an infusion over 30-60 minutes.\u00a0Your doctor or nurse will observe you if you get any\u00a0side effects\u00a0during\u00a0infusion\u00a0one or within 30 to 60 minutes after the end of the\u00a0infusion.<\/li> You will also receive trastuzumab and\u00a0chemotherapy.<\/li><\/ul>\n\n\n\nFor more information on trastuzumab dosage and cytotoxic drugs (which may also cause side effects ), see the Package Leaflet for these products. Ask your doctor or nurse if you have any questions about these medicines.<\/p>\n\n\n\n
If you forget to use Perjeta<\/h2>\n\n\n\n If you have forgotten or missed a treatment visit to get Perjeta, make an appointment as soon as possible. If more than 6 weeks have passed since your last visit, you will receive a higher dose of Perjeta of 840 mg.<\/p>\n\n\n\n
If you stop using Perjeta<\/h2>\n\n\n\n Do not stop treatment without consulting your doctor first.\u00a0You must get all the\u00a0infusions\u00a0that have been recommended.<\/p>\n\n\n\n
If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n
Serious side effects are<\/strong><\/p>\n\n\n\nTell your doctor or nurse immediately if you notice any of the following side effects:<\/strong><\/p>\n\n\n\nVery severe or persistent diarrhea (stools 7 or more times a day).<\/li> Decreased number of\u00a0white blood cells\u00a0(shown in a blood test), together with or without fever, may increase the risk of\u00a0infection.<\/li> Infusion reactions with symptoms that can be either mild or more severe and may include nausea, fever, chills, fatigue, headache, loss of appetite, joint, and muscle aches, and hot flashes.<\/li> Allergic and anaphylactic (more severe allergic) reactions with symptoms that may include swelling of the face and respiratory tract, with difficulty breathing.\u00a0In very rare cases, patients have died due to anaphylactic reactions during\u00a0infusion\u00a0with Perjeta.<\/li> Heart problems (\u00a0heart failure\u00a0) with symptoms that may include coughing, shortness of breath, and swelling (fluid accumulation) in the arms or legs.<\/li> Tumor light syndrome (a condition that can occur when cancer cells die quickly, causing changes in the levels of minerals and residues in the blood, which can be seen with blood tests).\u00a0Symptoms may include kidney problems (weakness, shortness of breath, fatigue, and confusion), heart problems (heart flutter with a faster or slower heartbeat), cramps, vomiting or diarrhea, and tingling in the mouth, hands, or feet.<\/li><\/ul>\n\n\n\nTell your doctor or nurse immediately if you notice any of the above side effects:<\/p>\n\n\n\n
Other side effects:<\/strong><\/p>\n\n\n\nVery common (more than 1 in 10 patients):<\/strong><\/p>\n\n\n\nDiarrhea<\/li> Hair loss<\/li> Nausea or fatigue<\/li> Rash<\/li> Inflammation\u00a0of the digestive tract (eg sore mouth)<\/li> Reduced number of\u00a0red blood cells\u00a0– detected by blood tests<\/li> Joint or muscle pain, muscle weakness<\/li> Constipation<\/li> Decreased appetite<\/li> Altered or loss of taste<\/li> Fever<\/li> Swollen ankles or other parts of the body due to water accumulation in the body<\/li> Insomnia<\/li> Pastures<\/li> The feeling of weakness, numbness, tingling, or stinging sensation, especially in the feet and legs<\/li> Nasal blood<\/li> Cough<\/li> Heartburn<\/li> Dry, itchy, or acne-like skin<\/li> Nail problems<\/li> Sore throat, red, sore or runny nose,\u00a0flu-like symptoms,\u00a0and fever<\/li> Increased tear production<\/li> Fever is associated with dangerously low levels of a type of\u00a0white blood cell\u00a0(\u00a0neutrophils\u00a0)<\/li> Pain in the body, arms, legs, and abdomen<\/li> Respiratory distress<\/li> Dizziness<\/li><\/ul>\n\n\n\nCommon side effects (up to 1 in 10 patients)<\/strong><\/p>\n\n\n\nFeeling of numbness, tingling, or tingling in feet or hands;\u00a0sharp stabbing, throbbing, icy, or burning pain;\u00a0feelings of pain for something that should not be painful such as light touch;\u00a0decreased ability to feel changes in heat or cold;\u00a0impaired balance or coordination.<\/li> Inflammation\u00a0of the cuticles<\/li> Infection\u00a0of the ears, nose, or throat<\/li> Decreased function of the left ventricle of the heart, with or without symptoms<\/li><\/ul>\n\n\n\nUncommon (up to 1 in 100 patients)<\/strong><\/p>\n\n\n\nChest symptoms such as dry cough or shortness of breath (possible symptoms of interstitial lung disease, a condition with tissue damage around the air sacs in the lungs)<\/li> Fluid around the lungs that causes difficulty breathing<\/li><\/ul>\n\n\n\nIf you experience any of the above symptoms after stopping treatment with Perjeta, contact your doctor immediately and tell them that you have been treated with Perjeta before.<\/p>\n\n\n\n
Some of the\u00a0side effects\u00a0may be due to your breast cancer.\u00a0If you are taking Perjeta at the same time as trastuzumab and\u00a0chemotherapy, some of the\u00a0side effects\u00a0may be caused by the other medicines.<\/p>\n\n\n\n
How to store Perjeta<\/h2>\n\n\n\n Perjeta will be stored by medical staff at the hospital or clinic. The medicinal product must be stored as follows:<\/p>\n\n\n\n
Keep this medicine out of the sight and reach of children.<\/li> Do not use this medicine after the expiry date which is stated on the carton after EXP.\u00a0day.\u00a0The expiration date is the last day of the specified month.<\/li> Store in a refrigerator (2 \u00b0 C – 8 \u00b0 C).<\/li> Do not freeze.<\/li> Keep the vial in the outer carton.\u00a0Sensitive to light.<\/li> Do not use this medicine if you notice particles in the solution or if the color is incorrect (see section 6).<\/li> Medicines should not be disposed of via wastewater or household waste.\u00a0Ask your pharmacist how to dispose of medicines no longer required.\u00a0These measures will help to protect the environment.<\/li><\/ul>\n\n\n\nContents of the pack and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\nThe active substance is pertuzumab.\u00a0Each\u00a0vial\u00a0contains 420 mg of pertuzumab at a concentration of 30 mg\/ml.<\/li> The other ingredients are concentrated acetic acid, L-Histidine, sucrose, polysorbate, and water for injections.<\/li><\/ul>\n\n\n\nWhat the medicine looks like and the contents of the pack<\/h2>\n\n\n\n Perjeta is a concentrated solution for\u00a0infusion.\u00a0It is a clear to slightly opalescent, colorless to pale yellow solution.\u00a0Perjeta is supplied as a glass\u00a0vial\u00a0containing 14 ml of concentrate.
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n Roche Registration GmbH<\/p>\n\n\n\n
Emil-Barell-Strasse 1<\/p>\n\n\n\n
D-79639 Grenzach-Wyhlen<\/p>\n\n\n\n
Germany<\/p>\n\n\n\n
Manufacturer<\/strong>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\nBelgium \/ Belgique \/ Belgien<\/strong>NV Roche SATel: +32 (0) 2 525 82 11<\/td>Lithuania<\/strong>UAB \u201cRoche Lietuva\u201dTel: +370 5 2546799<\/td><\/tr>Bulgaria<\/strong>Russia BULGARIA LOODTel: +359 2 818 44 44<\/td>Luxembourg \/ Luxemburg<\/strong>(See \/ See Belgium \/ Belgium)<\/td><\/tr>Czech Republic<\/strong>Roche sroTel: +420 – 2 20382111<\/td>Hungary<\/strong>Roche (Magyarorsz\u00e1g) Kft.Tel: +36 – 1 279 4500<\/td><\/tr>Denmark<\/strong>Roche a \/ sTel: +45 – 36 39 99 99<\/td>Malta<\/strong>(See Ireland)<\/td><\/tr>Germany<\/strong>Roche Pharma AGTel: +49 (0) 7624 140<\/td>The Netherlands<\/strong>Roche Nederland BVTel: +31 (0) 348 438050<\/td><\/tr>Eesti<\/strong>Roche Eesti O\u00dcTel: + 372 – 6 177 380<\/td>Norway<\/strong>Roche Norge ASTel: +47 – 22 78 90 00<\/td><\/tr>Greece<\/strong>Roche (Hellas) AE:\u0397\u03bb: +30 210 61 66 100<\/td>Austria<\/strong>Roche Austria GmbHTel: +43 (0) 1 27739<\/td><\/tr>Spain<\/strong>Roche Farma SATel: +34 – 91 324 81 00<\/td>Poland<\/strong>Roche Polska Sp.z ooTel: +48 – 22 345 18 88<\/td><\/tr>France<\/strong>RocheTel: +33 (0) 1 47 61 40 00<\/td>Portugal<\/strong>Roche Pharmac\u00eautica Chemica, LdaTel: +351 – 21 425 70 00<\/td><\/tr>Croatia<\/strong>Roche dooTel: + 385 1 47 22 333<\/td>Romania<\/strong>Roche Rom\u00e2nia SRLTel: +40 21 206 47 01<\/td><\/tr>Ireland<\/strong>Roche Products (Ireland) Ltd.Tel: +353 (0) 1 469 0700<\/td>Slovenia<\/strong>Roche pharmacevtska dru\u017eba dooTel: +386 – 1 360 26 00<\/td><\/tr>Iceland<\/strong>Roche a \/ sc \/ o Icepharma hfPhone: +354 540 8000<\/td>Slovak Republic<\/strong>Roche Slovensko, sroTel: +421 – 2 52638201<\/td><\/tr>Italy<\/strong>Roche SpATel: +39 – 039 2471<\/td>Finland \/ Finland<\/strong>Roche OyPuh \/ Tel: +358 (0) 10 554 500<\/td><\/tr>\u038e\u03c0\u03c1\u03bf\u03c2<\/strong>\u0393.\u0391.\u03a3\u03c4\u03b1\u03bc\u03ac\u03c4\u03b7\u03c2 & \u03a3\u03b9\u03b1 \u039b\u03c4\u03b4.:\u0397\u03bb: +357 – 22 76 62 76<\/td>Sweden<\/strong>Roche ABTel: +46 (0) 8 726 1200<\/td><\/tr>Latvia<\/strong>Roche Latvija SIATel: +371 – 6 7039831<\/td>United Kingdom (Northern Ireland)<\/strong>Roche Products (Ireland) Ltd.Tel: +44 (0) 1707 366000<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"Perjeta contains the active substance pertuzumab and is used to treat adult patients with breast cancer when:<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21185,21180,21181,21184,21176,21179,21182,21177,21183,21178],"class_list":["post-20746","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-perjeta","tag-benefits-of-pertuzumab","tag-perjeta","tag-perjeta-side-effects","tag-pertuzumab","tag-pertuzumab-side-effects","tag-what-is-perjeta","tag-what-is-pertuzumab","tag-what-perjeta-is-used-for","tag-what-pertuzumab-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20746","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20746"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20746\/revisions"}],"predecessor-version":[{"id":20793,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20746\/revisions\/20793"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20746"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20746"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20746"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}