{"id":20744,"date":"2022-04-11T10:37:45","date_gmt":"2022-04-11T10:37:45","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20744"},"modified":"2022-12-30T10:43:55","modified_gmt":"2022-12-30T10:43:55","slug":"pergoveris","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/pergoveris\/","title":{"rendered":"Pergoveris &#8211; Follitropin Alfa \/ Lutropin Alfa Uses, Dose, And Side Effects"},"content":{"rendered":"\n<p><strong>Pergoveris (300 IU + 150 IU) \/ 0.48 ml solution for injection in a pre-filled pen<br>follitropin alfa \/ lutropin alfa<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Pergoveris Is And What It Is Used For<\/h2>\n\n\n\n<p><strong>What Pergoveris is<\/strong><\/p>\n\n\n\n<p>Pergoveris&nbsp;solution for injection&nbsp;contains two different active substances called &#8220;follitropin alfa&#8221; and &#8220;lutropin alfa&#8221;.&nbsp;Both belong to a family of&nbsp;hormones&nbsp;called&nbsp;gonadotropins, which are involved in reproduction and&nbsp;fertility.<\/p>\n\n\n\n<p><strong>What Pergoveris is used for<\/strong><\/p>\n\n\n\n<p>This medicine stimulates the development of the follicles (each containing an egg) in your ovaries (ovaries).\u00a0This is to help you get pregnant.\u00a0It should be used by adult women (18 years or older) who have low levels (severe deficiency) of &#8220;follicle-stimulating hormone&#8221; (\u00a0FSH\u00a0) and &#8220;luteinizing hormone&#8221; (\u00a0LH\u00a0).\u00a0These women are usually infertile.<\/p>\n\n\n\n<p><strong>How Pergoveris works<\/strong><\/p>\n\n\n\n<p>The active substances in Pergoveris are copies of the natural&nbsp;hormones&nbsp;FSH&nbsp;and&nbsp;LH.&nbsp;In your body:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stimulates\u00a0FSH\u00a0egg production<\/li><li>LH\u00a0stimulates the\u00a0release\u00a0of one of the eggs.<\/li><\/ul>\n\n\n\n<p>By replacing the missing\u00a0hormones, Pergoveris enables women with low levels of\u00a0FSH\u00a0and\u00a0LH\u00a0to develop a\u00a0follicle.\u00a0This will then release an egg after injection\u00a0of the\u00a0hormone\u00a0&#8220;human chorionic gonadotropin (\u00a0hCG\u00a0).&#8221;\u00a0This helps the woman to get pregnant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before Using Pergoveris<\/h2>\n\n\n\n<p>Before starting treatment, your and your partner&#8217;s fertility should be evaluated by a doctor with experience treating fertility disorders.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Pergoveris<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to follicle-stimulating\u00a0hormone\u00a0(\u00a0FSH\u00a0),\u00a0luteinizing hormone\u00a0(\u00a0LH\u00a0), or any of the other ingredients of this medicine (listed in section 6)<\/li><li>If you have a brain tumor (in your\u00a0hypothalamus\u00a0or\u00a0pituitary gland\u00a0)<\/li><li>If you have large ovaries or fluid-filled blisters in the ovaries (ovarian cysts) of unknown origin<\/li><li>if you have unexplained\u00a0vaginal\u00a0bleeding<\/li><li>If you have ovarian, uterine, or breast <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a><\/li><li>If you have a condition that would make a normal pregnancy impossible, such as\u00a0menopause, malformed genitals, or benign\u00a0tumours\u00a0in your uterus.<\/li><\/ul>\n\n\n\n<p>Do not use this medicine if any of the above apply to you.\u00a0If unsure, talk to your doctor, pharmacist, or nurse before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Pergoveris.<\/p>\n\n\n\n<p>Porphyry<\/p>\n\n\n\n<p>Talk to your doctor before starting treatment if you or someone in your family has&nbsp;porphyria&nbsp;(an inability to break down porphyrins that can be transmitted from parents to children).<\/p>\n\n\n\n<p>Tell your doctor immediately if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your skin becomes brittle and easily gets blisters, especially skin that has often been exposed to the sun,<\/li><li>If you get <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a> in the abdomen, arms, or legs.<\/li><\/ul>\n\n\n\n<p>In the above events, your doctor may recommend that you stop treatment.<\/p>\n\n\n\n<p>Ovarian hyperstimulation syndrome (OHSS)<\/p>\n\n\n\n<p>This drug stimulates the ovaries.\u00a0This increases the risk of developing ovarian hyperstimulation syndrome (OHSS).\u00a0This is when your\u00a0follicles\u00a0develop too much and become large cysts.\u00a0Talk to a doctor immediately if you experience <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Pain in the lower abdomen<\/li><li>Rapid weight gain<\/li><li>Nausea or <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/stomach-disease-diarrhea-and-vomiting\/\">vomiting<\/a><\/li><li>Difficulty breathing<\/li><\/ul>\n\n\n\n<p>Your doctor may ask you to stop using this medicine (see section 4, under \u201cMost serious side effects\u201d).<\/p>\n\n\n\n<p>If you are not ovulating and the recommended\u00a0<strong>Pergoveris dose<\/strong>\u00a0and administration schedules are followed, OHSS is less likely.\u00a0Treatment with this medicine rarely causes severe OHSS.\u00a0This becomes more likely if the medicine used for final follicular maturation (containing\u00a0human chorionic gonadotropin,\u00a0hCG\u00a0) is given (see section 3, under \u201cHow much to use\u201d for information).\u00a0If you develop OHSS, your doctor may not give you any\u00a0hCG\u00a0during this treatment cycle, and you may be told not to have intercourse or to use barrier contraceptives for at least four days.<\/p>\n\n\n\n<p>Your doctor will ensure that the ovarian response is carefully monitored using ultrasound and blood tests (estradiol measurements) before and during treatment.<\/p>\n\n\n\n<p>Multiple pregnancies<\/p>\n\n\n\n<p>When you use Pergoveris, there is a greater risk that you will become pregnant with more than one child at a time (&#8220;multiple births&#8221;, usually twins) than if you become pregnant naturally.&nbsp;Multiple pregnancies can cause medical complications for you and your children.&nbsp;You can reduce the risk of multiple pregnancies by using the right&nbsp;dose&nbsp;of Pergoveris at the right times.<\/p>\n\n\n\n<p>To minimize the risk of multiple pregnancies, ultrasound examinations and blood tests are recommended.<\/p>\n\n\n\n<p>Miscarriage<\/p>\n\n\n\n<p>When your ovaries are stimulated to produce eggs, you are at greater risk of miscarriage than the average woman.<\/p>\n\n\n\n<p>Ectopic pregnancy<\/p>\n\n\n\n<p>For women who have or have had a blocked or damaged fallopian tube, there is a risk of pregnancy where the embryo attaches outside the uterus (ectopic pregnancy).&nbsp;This is regardless of whether the pregnancy came about through spontaneous conception or fertility treatment.<\/p>\n\n\n\n<p>Problems with blood clots (thromboembolic events)<\/p>\n\n\n\n<p>Talk to your doctor before using Pergoveris if you or a family member have ever had blood clots in your legs or lungs or a heart attack or\u00a0stroke.\u00a0You may be at increased risk of having severe blood clots or worsening existing ones during treatment with Pergoveris.<\/p>\n\n\n\n<p>The tumour\u00a0is on the genitals.<\/p>\n\n\n\n<p>There have been reports of\u00a0benign and malignant tumours in the ovaries and other reproductive organs in women who have undergone several courses of fertility treatments.<\/p>\n\n\n\n<p>Allergic reactions<\/p>\n\n\n\n<p>There have been isolated reports of non-severe allergic reactions to Pergoveris.\u00a0Tell your doctor if you have had these reactions to a similar medicine before using Pergoveris.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children And Young People<\/h2>\n\n\n\n<p>Pergoveris should not be used in children or adolescents under 18.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Pergoveris<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Pergoveris should not be used with other medicines in the same&nbsp;syringe.&nbsp;You can use Pergoveris at the same time as an approved preparation containing follitropin alfa as a separate&nbsp;injection&nbsp;if your doctor prescribes it.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy And Breastfeeding<\/h2>\n\n\n\n<p>Do not use Pergoveris if you are pregnant or breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>This medicine is not expected to affect your ability to drive, cycle or use tools and machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pergoveris Contains Sodium<\/h2>\n\n\n\n<p>Pergoveris contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per&nbsp;dose, ie it is essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Use Pergoveris<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use Of This Medicine<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Pergoveris is intended to be injected\u00a0just under the skin (\u00a0subcutaneously\u00a0).\u00a0Choose a new injection site every day to minimize skin irritation.<\/li><li>Your doctor or nurse will show you how to use the Pergoveris pre-filled pen\u00a0to\u00a0inject the medicine.<\/li><li>If they think you can safely\u00a0administer\u00a0Pergoveris, you can prepare and inject the medicine yourself at home.<\/li><li>If you inject Pergoveris yourself, read it carefully and follow the &#8220;Instructions for Use&#8221;.<\/li><\/ul>\n\n\n\n<p><strong>How much to use<\/strong><\/p>\n\n\n\n<p>Treatment is initiated at the recommended&nbsp;dose&nbsp;of one of Pergoveris containing 150 International Units (IU) follitropin alfa and 75 IU lutropin alfa daily.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Depending on how you respond to treatment, your doctor may decide to add a&nbsp;dose&nbsp;of an approved preparation containing follitropin alfa to your Pergoveris&nbsp;injection&nbsp;every day.&nbsp;In this case, one&nbsp;dose&nbsp;of follitropin alfa is usually increased every 7 or 14 days by 37.5 to 75 IU.<\/li><li>The treatment continues until you get the desired answer.&nbsp;This is when you have developed a suitable&nbsp;follicle&nbsp;as assessed by ultrasound scan and blood tests.<\/li><li>This can take up to 5 weeks.<\/li><\/ul>\n\n\n\n<p>Once you have received the desired response, you will receive an&nbsp;injection&nbsp;of&nbsp;human chorionic gonadotropin&nbsp;(&nbsp;hCG&nbsp;) 24 to 48 hours after your last Pergoveris&nbsp;injection.&nbsp;The best time to have intercourse is the same day as&nbsp;the hCG&nbsp;injection&nbsp;one&nbsp;and the day after.&nbsp;Alternatively, intrauterine insemination or any other medically assisted reproductive technology may be performed based on the physician&#8217;s judgment.<\/p>\n\n\n\n<p>If your body responds too strongly, your treatment will be stopped, and you will not receive any\u00a0hCG\u00a0(see section 2, under \u201cOvarian hyperstimulation syndrome (OHSS)\u201d).\u00a0In that case, your doctor will give you a lower\u00a0dose\u00a0of follitropin alfa during the following cycle.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Use More Pergoveris Than You Should\u00a0<\/h2>\n\n\n\n<p>The effects of an overdose of Pergoveris are unknown, but OHSS may occur.&nbsp;However, this only occurs if&nbsp;hCG&nbsp;has been administered (see section 2, under \u201cOvarian hyperstimulation syndrome (OHSS)\u201d).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Use Pergoveris<\/h2>\n\n\n\n<p>Do not use a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.&nbsp;Contact your doctor.<\/p>\n\n\n\n<p>If you have any further questions about the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible Pergoveris Effects<\/h2>\n\n\n\n<p>This medicine can cause side effects like all medicines, although not everybody gets them.<\/p>\n\n\n\n<p><strong>The most serious&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p><strong>Contact your doctor immediately if you get any of the&nbsp;side effects&nbsp;listed below.&nbsp;Your doctor may ask you to stop using Pergoveris.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reactions such as <ul><li>Skin rash<\/li><li>Reddening skin<\/li><\/ul><\/li><li>Hives<\/li><li>Swelling of the face with difficulty breathing can sometimes be serious.\u00a0<\/li><\/ul>\n\n\n\n<p>These Pergoveris side effects are very rare.<\/p>\n\n\n\n<p>Ovarian hyperstimulation syndrome (OHSS)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Pain in the lower abdomen, along with nausea or vomiting.\u00a0These are symptoms of ovarian hyperstimulation syndrome (OHSS).\u00a0This may indicate that the ovaries are overreacting to the treatment and that large ovarian cysts have developed (see section 2, under \u201cOvarian hyperstimulation syndrome (OHSS)\u201d).\u00a0This\u00a0side effect\u00a0is common.\u00a0If this happens, your doctor must examine you as soon as possible.<\/li><li>OHSS can become difficult with clearly enlarged ovaries, decreased urine production, weight gain, difficulty breathing, and possible fluid accumulation in the abdominal cavity or chest.\u00a0This\u00a0side effect\u00a0is less common (it may affect up to 1 in 100 people).<\/li><li>Complications of OHSS, such as ovarian torsion or blood clots, can occur in rare cases (may affect up to 1 in 1,000 people).<\/li><li>Severe thrombotic complications (thromboembolic events) with severe OHSS can occur in rare cases.\u00a0This can cause chest pain, shortness of breath,\u00a0stroke,\u00a0or heart attack.\u00a0In rare cases, this can also occur independently of OHSS (see section 2, under \u201cProblems with blood clots (thromboembolic events)\u201d).<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;include<\/strong><\/p>\n\n\n\n<p>Very common side effects of Pergoveris\u00a0(may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fluid-filled blisters in the ovaries (ovarian cysts)<\/li><li>Headache<\/li><li>Local reactions at the injection site include <ul><li>Pain<\/li><li>Itching<\/li><li>Bruising<\/li><li>Swelling<\/li><li>Irritation<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Common&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhoea<\/li><li>Chest pain<\/li><li>Nausea or vomiting<\/li><li>Abdominal and pelvic pain<\/li><li>Abdominal cramps and <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/flatulence\/\">flatulence<\/a><\/li><\/ul>\n\n\n\n<p>Very rare&nbsp;(may affect up to 1 in 10,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your&nbsp;asthma&nbsp;can get worse.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How To Store Pergoveris<\/h2>\n\n\n\n<p><strong>Pergoveris storage<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of sight and reach of children.<\/li><li>Do not use this medicine after the expiry date stated on the label and carton after EXP or EXP.\u00a0The expiration date is the last day of the specified month.<\/li><li>Store in a refrigerator (2 \u00b0 C \u2011 8 \u00b0 C).\u00a0Do not freeze.<\/li><li>Store in the original package.\u00a0Sensitive to light.<\/li><li>Once the package has been opened, the pre-filled pen can be stored for 28 days outside the refrigerator (at 25 \u00b0 C).\u00a0Do not use medicines left in the pre-filled pen after 28 days.<\/li><li>Do not use Pergoveris if you notice signs of the deteriorating product, if the liquid contains particles or is unclear.<\/li><li>Dispose of the used needle safely after\u00a0injection.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.\u00a0Ask your pharmacist how to dispose of medicines that are no longer required.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Of The Pack And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<p>The active substances are follitropin alfa and lutropin alfa.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>1 Pergoveris (300 IU + 150 IU) \/ 0.48 ml pre-filled&nbsp;pen&nbsp;contains 300 IU (international units) follitropin alfa and 150 IU lutropin alfa in 0.48 ml and can deliver two&nbsp;doses&nbsp;of Pergoveris 150 IU \/ 75 IU.<\/li><\/ul>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sucrose, arginine monohydrochloride, poloxamer 188, methionine, phenol, disodium phosphate dihydrate, sodium dihydrogen phosphate monohydrate, and water for injections.&nbsp;Very small amounts of concentrated&nbsp;phosphoric acid&nbsp;and sodium hydroxide are added to keep the acidity (&nbsp;pH&nbsp;value) normal.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And The Contents Of The Pack<\/h2>\n\n\n\n<p>Pergoveris is supplied as a clear, colourless to pale yellow\u00a0solution for injection\u00a0in a pre-filled multi-dose pen:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Pergoveris (300 IU + 150 IU) \/ 0.48 ml is supplied in packs of 1 pre-filled multi-dose pen&nbsp;and 5 disposable injection needles.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Merck Europe BV, Gustav Mahlerplein 102, 1082 MA Amsterdam, The Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Merck Serono SpA, Via delle Magnolie 15 (Industrial Zone), I-70026 Modugno (Bari), Italy<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pergoveris is a fertility medicine used in women to stimulate the development of follicles, the structures inside the ovaries that contain an egg. Pergoveris is for adult women with low levels of two hormones stimulating the ovaries &#8211; follicle-stimulating hormone (FSH) and luteinizing hormone (LH).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[20462,21190,13703,20458,20461,16655,16658,21186,21189,20460,20459,16656,21187,16657,21188],"class_list":["post-20744","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-follitropin-alfa","tag-benefits-of-pergoveris","tag-benefits-of-v","tag-follitropin-alfa","tag-follitropin-alfa-side-effects","tag-lutropin-alfa","tag-lutropin-alfa-side-effects","tag-pergoveris","tag-pergoveris-side-effects","tag-what-follitropin-alfa-is-used-for","tag-what-is-follitropin-alfa","tag-what-is-lutropin-alfa","tag-what-is-pergoveris","tag-what-lutropin-alfa-is-used-for","tag-what-pergoveris-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20744","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20744"}],"version-history":[{"count":37,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20744\/revisions"}],"predecessor-version":[{"id":42145,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20744\/revisions\/42145"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}