{"id":20738,"date":"2022-04-11T10:32:51","date_gmt":"2022-04-11T10:32:51","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20738"},"modified":"2022-04-13T14:40:56","modified_gmt":"2022-04-13T14:40:56","slug":"pentocur","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/pentocur\/","title":{"rendered":"Pentocur &#8211; Thiopental sodium uses, dose and side effects"},"content":{"rendered":"\n<p>Powder for solution for&nbsp;injection&nbsp;thiopental<br>sodium<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Pentocur is and what it is used for<\/h2>\n\n\n\n<p>Pentocur contains the active substance thiopental sodium.&nbsp;It is a fast-acting thiobarbiturate given&nbsp;intravenously&nbsp;(&nbsp;injection&nbsp;into a vein).<\/p>\n\n\n\n<p>Pentocur is used:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>to initiate general&nbsp;anesthesia&nbsp;(a condition of deep sleep during, for example,&nbsp;surgery&nbsp;)<\/li><li>for hypnosis (you are sleepy but not completely asleep) during&nbsp;anesthesia&nbsp;with other anesthetics<\/li><li>as part of the treatment for seizures (including those caused by local anesthetics)<\/li><li>to lower the pressure in the skull (&nbsp;intracranial pressure&nbsp;) in patients where the pressure is elevated (if controlled ventilation is given)<\/li><\/ul>\n\n\n\n<p>Thiopental sodium contained in Pentocur may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Pentocur<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Pentocur<\/h2>\n\n\n\n<p>You should not receive Pentocur&nbsp;<strong>:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to thiopental,\u00a0barbiturates,\u00a0or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have airway obstruction which prevents airflow (\u00a0respiratory\u00a0obstruction\u00a0)<\/li><li>if you have\u00a0acute\u00a0asthma\u00a0(severe asthma attack)<\/li><li>if you suffer from hereditary muscle disease that breaks down the muscles (myotonic dystrophy)<\/li><li>if you are in severe\u00a0shock<\/li><li>if you have\u00a0porphyria<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>If possible, talk to your doctor or nurse before receiving Pentocur.\u00a0The healthcare professional must take extra care and may need to adjust your\u00a0dose\u00a0if you have\/are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>elevated pressure in your skull<\/li><li>asthma\u00a0or another serious respiratory disease<\/li><li>inflammation\u00a0of the mouth, jaw, or throat &#8211; this can lead to breathing problems during the use of Pentocur<\/li><li>any cardiovascular disease or high\u00a0blood pressure<\/li><li>inflammation\u00a0of the pericardium<\/li><li>low fluid volume in the body (\u00a0hypovolemia\u00a0) or if you are dehydrated<\/li><li>severe bleeding or burns<\/li><li>myasthenia gravis\u00a0(a disease that weakens muscles)<\/li><li>impaired function of the\u00a0adrenal cortex, even if treated with\u00a0cortisone<\/li><li>general malaise, malnutrition, or weight loss<\/li><li>high levels of\u00a0urea,\u00a0toxins,\u00a0or\u00a0potassium\u00a0in the blood<\/li><li>severe\u00a0anemia\u00a0(\u00a0anemia\u00a0)<\/li><li>shock<\/li><li>impaired liver or kidney function<\/li><li>any metabolic disease (such as\u00a0thyrotoxicosis,\u00a0myxedema,\u00a0and\u00a0diabetes\u00a0)<\/li><li>alcohol dependence or drug abuse<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Pentocur<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>The following medicines may affect or be affected by this&nbsp;injection&nbsp;and may need to be adjusted before or after you receive this injection:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>aminophylline and theophylline (for the treatment of\u00a0asthma\u00a0)<\/li><li>midazolam (a sedative)<\/li><li>opioid analgesics (strong painkillers)<\/li><li>probenecid (anti-gout\u00a0medicine )<\/li><li>sufentanil (painkiller)<\/li><li>chloral hydrate (sleeping pills)<\/li><li>muscle relaxants<\/li><li>MAO inhibitors\u00a0and\u00a0tricyclic antidepressants\u00a0(for the treatment of depression) eg\u00a0citalopram, amitriptyline<\/li><li>drugs that suppress the activity of the\u00a0central nervous system<\/li><li>metoclopramide and droperidol (medicines for nausea and vomiting)<\/li><li>an herbal medicine containing\u00a0St. John&#8217;s wort\u00a0(\u00a0Hypericum perforatum\u00a0)<\/li><li>androgen\u00a0er (for the treatment of male\u00a0infertility\u00a0)<\/li><li>antiepileptic\u00a0drugs<\/li><li>glucocorticoids\u00a0(anti-inflammatory drugs)<\/li><li>drugs for the treatment of bacterial\u00a0infections\u00a0such as metronidazole, sulfafurazole,\u00a0isoniazid, vancomycin<\/li><li>estrogen\u00a0(for the treatment of menopause)<\/li><li>drugs for the treatment of\u00a0diabetes\u00a0taken by mouth<\/li><li>drugs for the treatment of high\u00a0blood pressure\u00a0eg\u00a0captopril,\u00a0enalapril, terazosin, felodipine,\u00a0hydralazine,\u00a0losartan, methyldopa,\u00a0moxonidine,\u00a0and\u00a0diuretics\u00a0(\u00a0diuretics\u00a0)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiplo-citrus\/\">acetylsalicylic acid<\/a>\u00a0and other painkillers<\/li><li>antipsychotic drugs such as promethazine or quetiapine;\u00a0lithium<\/li><li>diazoxide (for the treatment of hypoglycemia)<\/li><li>tablets or sprays used to treat\u00a0angina pectoris\u00a0(angina)<\/li><li>blood thinners (\u00a0oral anticoagulants\u00a0)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pentocur with alcohol<\/h2>\n\n\n\n<p>Dose&nbsp;one of Pentocur may need to be increased if you are addicted to or regularly consume large amounts of alcohol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p>Pentocur should only be given to pregnant women if your doctor thinks it is necessary.<\/p>\n\n\n\n<p>Thiopental is excreted in breast milk.\u00a0Breast-feeding should be temporarily discontinued (for at least 12 hours after thiopental use) or breast milk should be pumped out before using Pentocur.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Pentocur has a significant effect on the ability to drive and use machines.\u00a0Even if waking up is relatively fast, you may experience dizziness (feeling dizzy), confusion, and dullness.\u00a0Therefore, patients should not drive or use machines 24-36 hours after using Pentocur.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are in a position to perform or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pentocur contains sodium<\/h2>\n\n\n\n<p>One&nbsp;vial&nbsp;Pentocur 500 mg contains 51-56 mg (or 2.2 &#8211; 2.4 mmol)&nbsp;sodium&nbsp;, one vial Pentocur 1000 mg contains 102-112 mg (4.4-4.9 mmol)&nbsp;sodium&nbsp;(the main ingredient in table salt \/ table salt ).&nbsp;This corresponds to 2.8% (500 mg&nbsp;vial&nbsp;) and 5.6% (1000 mg&nbsp;vial&nbsp;) of the highest recommended daily intake of&nbsp;sodium&nbsp;for adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Pentocur<\/h2>\n\n\n\n<p>Pentocur will be given to you by anesthesiologists who will be available at all times when you receive Pentocur.&nbsp;Resuscitation equipment will also be available.<\/p>\n\n\n\n<p>Pentocur will be given directly into one of your blood vessels, a vein (&nbsp;intravenously&nbsp;).<\/p>\n\n\n\n<p>A test dose will be given to adjusting the\u00a0dose\u00a0to your needs.<\/p>\n\n\n\n<p>Anesthesia<\/p>\n\n\n\n<p>Your doctor will determine your dose\u00a0and it will be based on your age, gender, body weight, and general health.\u00a0You will be given a\u00a0dose\u00a0to initiate anesthesia and additional\u00a0injections\u00a0to maintain anesthesia.<\/p>\n\n\n\n<p>Cramps<\/p>\n\n\n\n<p>Injection&nbsp;of Pentocur should be given as soon as possible after the onset of seizures.&nbsp;An additional&nbsp;dose&nbsp;may be needed to keep the seizures under control.<\/p>\n\n\n\n<p>Elevated pressure in the skull<\/p>\n\n\n\n<p>You will be given a\u00a0dose, based on your body weight, to lower the pressure in your head (controlled ventilation is given at the same time).<\/p>\n\n\n\n<p>Impaired liver and kidney function<\/p>\n\n\n\n<p>Your doctor will reduce the&nbsp;dose&nbsp;one if you have impaired liver or kidney function.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you are given too much Pentocur<\/h2>\n\n\n\n<p>It is unlikely that you will receive an\u00a0overdose, as healthcare professionals will take care of\u00a0administering\u00a0one of Pentocur.<\/p>\n\n\n\n<p>Overdose may occur with too many\u00a0injections\u00a0or if Pentocur is administered too quickly.\u00a0In case of suspected or obvious overdose, the drug should be discontinued.\u00a0Symptoms of overdose include an alarming drop in blood pressure and medical\u00a0shock.\u00a0In addition, respiratory arrest, coughing, and other breathing difficulties may occur (however, this may also be a sign of underdosing).<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Tell your doctor&nbsp;<strong>immediately<\/strong>&nbsp;if you experience any of the following symptoms &#8211; you may need&nbsp;urgent&nbsp;medical attention:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Difficulty breathing, wheezing, rash,\u00a0itching,\u00a0hives,\u00a0and dizziness.\u00a0This can be a severe\u00a0allergic reaction\u00a0(has been reported, occurs in an unknown number of users).<\/li><li>Swelling of the face, tongue, or throat;\u00a0difficulty swallowing, and drops in blood pressure (\u00a0angioedema\u00a0and anaphylactoid reactions) are rare\u00a0side effects\u00a0and may affect up to 1 in 1,000 people.<\/li><\/ul>\n\n\n\n<p>Other&nbsp;side effects&nbsp;that may occur:<\/p>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart rhythm disorders<\/li><li>heart disease<\/li><li>low&nbsp;blood pressure<\/li><li>somnolence<\/li><li>prolonged awakening from&nbsp;anesthesia<\/li><li>breathing difficulties<\/li><li>hyperventilation&nbsp;(rapid breathing)<\/li><li>difficulty swallowing<\/li><li>cough<\/li><li>snoring<\/li><li>overindulge<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurs in an unknown number of users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the increased amount of\u00a0potassium\u00a0in the blood (hyperkalemia)<\/li><li>decreased amount of\u00a0potassium\u00a0in the blood (\u00a0hypokalaemia\u00a0)<\/li><li>loss of appetite<\/li><li>general malaise, weakness<\/li><li>fatigue (exhaustion)<\/li><li>headache<\/li><li>dizziness<\/li><li>allergic reactions, skin reactions, hypersensitivity<\/li><\/ul>\n\n\n\n<p>When Pentocur is given, there may initially be cramps in the larynx, cough, or sneezing.\u00a0Vomiting after surgery and use of Pentocur is less common but persistent drowsiness, confusion, memory loss, and chills may occur.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Pentocur<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Unopened vial:<\/td><td>No special storage instructions.<\/td><\/tr><tr><td>After reconstitution:<\/td><td>Store in a refrigerator (2-8 \u00b0 C) for a maximum of 24 hours.Store at room temperature for a maximum of 6 hours.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is thiopental sodium.<\/li><li>Each&nbsp;vial&nbsp;of Pentocur 0.5 g powder for solution for&nbsp;injection&nbsp;contains 500 mg of thiopental sodium (as thiopental sodium and sodium carbonate).<\/li><li>Each&nbsp;vial&nbsp;of Pentocur 1 g powder for solution for&nbsp;injection&nbsp;contains 1000 mg of thiopental sodium (as thiopental sodium and sodium carbonate).<\/li><li>The other ingredient is sodium carbonate<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Glass vial&nbsp;with bromobutyl rubber cap, aluminum seal, in cardboard.<\/p>\n\n\n\n<p><em>Pack sizes:<\/em><\/p>\n\n\n\n<p>Pentocur powder for solution for&nbsp;injection&nbsp;0.5 g: 1 x 1&nbsp;vial&nbsp;,<br>10 x 1&nbsp;vial&nbsp;, 20 x 1&nbsp;vial&nbsp;or 50 x 1&nbsp;vial&nbsp;.<\/p>\n\n\n\n<p>Pentocur powder for solution for\u00a0injection\u00a01 g: 1 x 1\u00a0vial,<br>10 x 1\u00a0vial\u00a0, 20 x 1\u00a0vial\u00a0or 50 x 1\u00a0vial\u00a0.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>VUAB Pharma as, Vltavska 53, 25263 Roztoky, Czech Republic.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pentocur contains the active substance thiopental sodium. It is a fast-acting thiobarbiturate given intravenously ( injection into a vein).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21218,21213,21214,21217,21209,21212,21215,21210,21216,21211],"class_list":["post-20738","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-pentocur","tag-benefits-of-thiopental-sodium","tag-pentocur","tag-pentocur-side-effects","tag-thiopental-sodium","tag-thiopental-sodium-side-effects","tag-what-is-pentocur","tag-what-is-thiopental-sodium","tag-what-pentocur-is-used-for","tag-what-thiopental-sodium-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20738","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20738"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20738\/revisions"}],"predecessor-version":[{"id":20797,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20738\/revisions\/20797"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20738"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20738"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20738"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}