{"id":20736,"date":"2022-04-11T10:31:21","date_gmt":"2022-04-11T10:31:21","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20736"},"modified":"2022-04-13T14:41:04","modified_gmt":"2022-04-13T14:41:04","slug":"penthrox","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/penthrox\/","title":{"rendered":"Penthrox &#8211; Methoxyflurane uses, dose and side effects"},"content":{"rendered":"\n<p>99.9%, 3 ml\u00a0inhalation\u00a0vapor, liquid<br>methoxyflurane<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Penthrox is and what it is used for<\/h2>\n\n\n\n<p>Penthrox contains an active substance called methoxyflurane.&nbsp;It is a drug used to reduce pain.&nbsp;It is inhaled through the specially designed Penthrox inhaler.<\/p>\n\n\n\n<p>Penthrox is intended to reduce the severity of the pain, rather than stop it completely.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Penthrox<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Penthrox<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to methoxyflurane, inhaled anesthetics (inhalation anesthetics), or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you or someone in your family has had\u00a0malignant\u00a0hyperthermia;\u00a0Malignant\u00a0hyperthermia\u00a0is a condition in which symptoms such as very high fever, rapid and irregular heartbeat, muscle spasms, and breathing problems have occurred after you or a family member, have been given anesthetic<\/li><li>if you or a family member have previously had severe\u00a0side effects\u00a0from inhaled anesthetics<\/li><li>if you have a history of liver damage after using methoxyflurane or any inhaled anesthetic<\/li><li>if you have impaired kidney function and your doctor thinks that Penthrox is not suitable.<\/li><li>if you have altered consciousness for any reason including head injury, drugs, or alcohol<\/li><li>if you have heart or circulation problems<\/li><li>if you have shallow breathing or difficulty breathing.<\/li><\/ul>\n\n\n\n<p>This medicine must not be used as an anesthetic.<\/p>\n\n\n\n<p>If you are not sure if you should get this medicine, talk to your healthcare provider.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your healthcare provider before using Penthrox if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have liver or kidney problems<\/li><li>have a medical condition that can cause kidney problems<\/li><li>is older.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Do not give this medicine to children.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Penthrox<\/h2>\n\n\n\n<p>Tell your healthcare provider if you are taking or have recently taken any other medicines.&nbsp;In particular, tell your healthcare provider if you are taking any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Isoniazid\u00a0to treat\u00a0tuberculosis<\/li><li>Phenobarbital or carbamazepine to treat\u00a0epilepsy<\/li><li>Rifampicin or other\u00a0antibiotics\u00a0to treat\u00a0infection<\/li><li>Drugs or illicit drugs that have a calming effect on the nervous system such as strong painkillers (\u00a0opioids\u00a0), sleeping pills, anesthetics (general\u00a0anesthesia\u00a0), phenothiazines, sedatives, muscle relaxants, and\u00a0sedative\u00a0antihistamines<\/li><li>Antibiotics\u00a0and other drugs that can damage the kidneys, such as\u00a0tetracycline, gentamicin, colistin, polymyxin B, amphotericin B, and contrast agents<\/li><li>Efavirenz or nevirapine for the treatment of\u00a0HIV<\/li><\/ul>\n\n\n\n<p>Ask your healthcare provider if you are unsure.<\/p>\n\n\n\n<p>If you need treatment in a hospital that requires general\u00a0anesthesia, tell the doctor treating you that you have used this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Penthrox with food, drink, and alcohol<\/h2>\n\n\n\n<p>Do not drink alcohol while taking this medicine as it may increase its effect.<\/p>\n\n\n\n<p>You can eat and drink as usual while taking this medicine unless your healthcare provider has given you other instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Tell your healthcare provider before taking this medicine if you are pregnant, planning to have a baby, breastfeeding, or planning to breastfeed.\u00a0Healthcare professionals will discuss the possible risks and benefits of receiving this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Penthrox can cause drowsiness or dizziness.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Penthrox contains butylhydroxytoluene (E321)<\/h2>\n\n\n\n<p>This medicine contains a stabilizing agent called butylhydroxytoluene (E321).&nbsp;Butylhydroxytoluene may cause local skin reactions (eg&nbsp;contact dermatitis&nbsp;), or irritation of the eyes and mucous membranes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Penthrox<\/h2>\n\n\n\n<p>Always take this medicine exactly as your healthcare professional has told you.&nbsp;If you are unsure, consult your healthcare provider.<\/p>\n\n\n\n<p>Adults:<\/p>\n\n\n\n<p>One or two bottles containing 3 ml of Penthrox can be used per\u00a0administration.\u00a0The maximum\u00a0dose\u00a0is two bottles of 3 ml per\u00a0administration.\u00a0Do not inhale more than the maximum\u00a0dose.<\/p>\n\n\n\n<p><strong>How to use Penthrox<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>1.<\/td><td>Healthcare professionals prepare the inhaler and place the wrist strap over your wrist.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161129000105#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>2.<\/td><td>Inhale through the mouthpiece of the inhaler to relieve pain.&nbsp;The healthcare staff will show you if you are unsure.&nbsp;Get used to the fruity smell of the medicine by inhaling gently during the first breaths.&nbsp;Exhale through the inhaler.&nbsp;After the first breaths, you can breathe normally through the inhaler.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161129000105#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>3.<\/td><td>If you need stronger pain relief, cover the hole in the clear container, filled with charcoal, with your finger during use.&nbsp;The healthcare staff will show you where the hole is.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161129000105#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>4.<\/td><td>You do not have to breathe in and out through the inhaler all the time.\u00a0The healthcare professional will encourage you to take a break from the inhaler as it will make the pain relief lasts longer.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161129000105#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>5.<\/td><td>Continue to use the inhaler until your healthcare provider tells you to stop, or until you have inhaled the maximum recommended\u00a0dose.<\/td><td>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Do not give this medicine to anyone else, even if they show signs of illness similar to yours.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Penthrox than you should&nbsp;<\/h2>\n\n\n\n<p>The healthcare professionals who give the medicine have experience with its use, so it is very unlikely that you will get too much of it.&nbsp;You should not use more than 2 bottles at the same time.&nbsp;If the maximum&nbsp;dose&nbsp;is exceeded, Penthrox can cause kidney damage.&nbsp;Tell your healthcare provider immediately if you think you have been given too much of this medicine.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your healthcare professional.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>If you have any of the following, tell your healthcare provider immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe allergic reactions with symptoms such as difficulty breathing and\/or swelling of the face.<\/li><li>Liver problems, such as decreased appetite, nausea, vomiting, jaundice (yellowing of the skin and\/or eyes), dark urine, pale stools, pain\/aches, or tenderness when touching the right abdomen (below the ribs).<\/li><li>Kidney problems such as decreased or heavy urination or swelling of the feet or lower legs.<\/li><\/ul>\n\n\n\n<p><strong>The above\u00a0side effects\u00a0can be life-threatening, so talk to your healthcare provider immediately.<\/strong><\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dizziness<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drowsiness<\/li><li>Headache or nausea<\/li><li>The feeling of extreme happiness<\/li><li>Feeling of drunkenness<\/li><li>Taste disorders<\/li><li>Cough<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anxiety or depression<\/li><li>Attention Deficit Hyperactivity Disorder<\/li><li>Inappropriate feelings or actions<\/li><li>Repetition of words or speech difficulties<\/li><li>Memory loss<\/li><li>Tingling in the skin of hands and feet<\/li><li>Numbness<\/li><li>Impaired vision<\/li><li>Redness&nbsp;of the skin<\/li><li>Low or high&nbsp;blood pressure<\/li><li>Dry mouth<\/li><li>Discomfort or itchy feeling in the mouth<\/li><li>Increased salivation<\/li><li>Increased appetite<\/li><li>Vomiting<\/li><li>Sweating<\/li><li>Fatigue<\/li><li>Feeling of abnormality<\/li><li>Overindulge<\/li><li>Relaxed feeling<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurs in an unknown number of users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hypersensitivity<\/li><li>Mood swings<\/li><li>Restlessness or anxiety<\/li><li>Feeling we have &#8216;Run out of gas&#8217; emotionally<\/li><li>Confusion<\/li><li>Changed level of consciousness<\/li><li>Feeling of suffocation<\/li><li>Respiratory distress<\/li><li>Uncontrolled eye movements<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Penthrox<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special temperature instructions.<\/p>\n\n\n\n<p>The healthcare professional disposes of any remaining liquid of the Penthrox\u00a0<strong>inhaler<\/strong>\u00a0appropriately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is methoxyflurane.&nbsp;Each sealed bottle contains 3 ml of 99.9% methoxyflurane.&nbsp;The other ingredients are butylhydroxytoluene (E321).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Penthrox is a clear, almost colorless, volatile liquid, with a characteristic fruity odor that becomes a vapor or gas when used with the Penthrox inhaler.<\/p>\n\n\n\n<p>Penthrox is available in the following packages:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A bottle of Penthrox 3 ml with a tear-off safety seal (packs of 10 x 3 ml), or<\/li><li>Combination pack with a bottle of Penthrox 3 ml, a Penthrox\u2011\u00a0inhaler,\u00a0and a container of activated carbon (pack of 1 x 3 ml or 10 x 3 ml)<\/li><\/ul>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Medical Developments NED BV<\/p>\n\n\n\n<p>411 Strawinskylaan, WTC Tower A<\/p>\n\n\n\n<p>1077 XX Amsterdam<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>MIAS Pharma Limited<\/p>\n\n\n\n<p>Suite 2, Stafford House<\/p>\n\n\n\n<p>Strand Road<\/p>\n\n\n\n<p>Portmarnock, Co.&nbsp;Dublin<\/p>\n\n\n\n<p>Ireland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>99.9%, 3 ml\u00a0inhalation\u00a0vapor, liquidmethoxyflurane What Penthrox is and what it is used for Penthrox contains an active substance called methoxyflurane.&nbsp;It is a drug used to reduce pain.&nbsp;It is inhaled through the specially designed Penthrox inhaler. Penthrox is intended to reduce the severity of the pain, rather than stop it completely. What you need to know [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21223,21228,21219,21222,21224,21227,21220,21225,21221,21226],"class_list":["post-20736","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-methoxyflurane","tag-benefits-of-penthrox","tag-methoxyflurane","tag-methoxyflurane-side-effects","tag-penthrox","tag-penthrox-side-effects","tag-what-is-methoxyflurane","tag-what-is-penthrox","tag-what-methoxyflurane-is-used-for","tag-what-penthrox-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20736","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20736"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20736\/revisions"}],"predecessor-version":[{"id":20798,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20736\/revisions\/20798"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20736"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20736"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20736"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}