{"id":20734,"date":"2022-04-11T10:29:56","date_gmt":"2022-04-11T10:29:56","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20734"},"modified":"2022-04-13T14:41:10","modified_gmt":"2022-04-13T14:41:10","slug":"pentavac","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/pentavac\/","title":{"rendered":"Pentavac uses, dose and side effects"},"content":{"rendered":"\n<p>Powder and solvent for\u00a0suspension for\u00a0injection\u00a0of Diphtheria,\u00a0tetanus, pertussis (acellular, component), polio (inactivated), and\u00a0Haemophilus influenzae\u00a0type b conjugated vaccine (\u00a0adsorbed\u00a0)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Pentavac is and what it is used for<\/h2>\n\n\n\n<p>Pentavac is a vaccine.&nbsp;Vaccines are used to protect against infectious diseases.<\/p>\n\n\n\n<p>This vaccine helps protect your child against\u00a0diphtheria, tetanus, pertussis, polio (poliomyelitis), and serious diseases caused by\u00a0<em>Haemophilus influenzae<\/em>\u00a0type b (often just called Hib\u00a0infections\u00a0).<\/p>\n\n\n\n<p>It is given as a series of primary vaccinations to infants and as a booster vaccination for children who received this vaccine or a similar vaccine when they were younger.<\/p>\n\n\n\n<p>When an&nbsp;injection&nbsp;of Pentavac is given, the body&#8217;s natural defenses will produce protection against the following diseases.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diphtheria\u00a0is a contagious disease that usually first affects the throat.\u00a0In the throat,\u00a0infection\u00a0causes pain and swelling, which can lead to suffocation.\u00a0The\u00a0bacterium\u00a0that causes the disease also gives rise to a\u00a0toxin\u00a0(poison) that can damage the heart, kidneys, and nerves.<\/li><li>Tetanus is caused by tetanus bacteria that enter through a deep wound.\u00a0The bacterium produces a\u00a0toxin\u00a0(poison) that causes muscle spasms, leading to an inability to breathe and the risk of suffocation.<\/li><li>Whooping cough (pertussis) is an\u00a0infection\u00a0of the respiratory tract, which can occur at any time in life, but most often affects infants and children.\u00a0Increasingly severe cough attacks, which can last for several weeks, are characteristic of the disease.\u00a0The cough attacks can be followed by a choking sound.<\/li><li>Poliomyelitis (often just called polio) is caused by a\u00a0virus\u00a0that affects the nerves.\u00a0It can lead to paralysis or muscle weakness, most commonly in the legs.\u00a0Paralysis of the muscle that controls breathing and swallowing can be fatal.<\/li><li>Haemophilus influenzae\u00a0type b\u00a0infections\u00a0(often just called Hib\u00a0infections\u00a0) are serious and invasive\u00a0infections\u00a0of the meninges (\u00a0membranes\u00a0that surround the brain), lungs, throat, blood, skin, joints, and bones.<\/li><\/ul>\n\n\n\n<p><strong>Important<\/strong><\/p>\n\n\n\n<p>Pentavac only helps prevent diseases caused by the same bacteria and\u00a0viruses\u00a0used to make the vaccine.\u00a0Your child may still get infectious diseases caused by other bacteria or\u00a0viruses.<\/p>\n\n\n\n<p>Pentavac does not protect against infectious diseases caused by other types of&nbsp;<em>Haemophilus influenzae<\/em>&nbsp;or against&nbsp;inflammation&nbsp;of the outer membranes of the brain (&nbsp;meningitis&nbsp;) that have other origins.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before your child receives Pentavac<\/h2>\n\n\n\n<p>It is important to inform your doctor, pharmacist, or nurse if any of the points below apply to your child so that they can ensure that Pentavac is suitable for your child.<\/p>\n\n\n\n<p><strong>Do not use Pentavac if your child<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>is allergic to:<ul><li>the active substances in Pentavac or any of the other ingredients of Pentavac (see section 6)<\/li><li>other vaccines containing any of the substances listed in section 6<\/li><li>any vaccine that protects against pertussis<\/li><\/ul><\/li><li>have a high fever or an\u00a0acute\u00a0illness (eg fever, sore throat, cough, cold, or\u00a0flu\u00a0).\u00a0Vaccination with Pentavac may need to be postponed until your child gets better<\/li><li>have an active disease of the brain (\u00a0encephalopathy\u00a0)<\/li><li>have had a severe reaction to any pertussis vaccine that affected the brain.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to a doctor or nurse before vaccination if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>your child is allergic (hypersensitive) to glutaraldehyde,\u00a0neomycin, streptomycin, or polymyxin B. These substances are used in the manufacture of Pentavac, and there may be very small amounts of these substances left in the vaccine;<\/li><li>your child has a problem with the immune system or is receiving treatment that lowers the immune system.\u00a0In such cases, it is recommended that vaccination be postponed until such illness or treatment is completed.\u00a0Giving Pentavac to children with\u00a0chronic\u00a0immune system\u00a0problems (including\u00a0HIV\u00a0infection\u00a0) is recommended, but protection against\u00a0infection\u00a0after vaccination may not be as good as in children with good immunity to\u00a0infection.<\/li><li>your child had a temporary loss of mobility and feeling (\u00a0Guillain-Barr\u00e9 syndrome\u00a0) or loss of mobility, pain, and numbness in the arm and shoulder (brachial\u00a0neuritis\u00a0) after a previous\u00a0injection\u00a0of vaccine containing\u00a0tetanus.\u00a0Your doctor or nurse will decide whether to give Pentavac to your child<\/li><li>your child has\u00a0thrombocytopenia\u00a0(low\u00a0platelet count\u00a0) or a bleeding disorder (such as\u00a0hemophilia) because he or she may be bleeding at the injection site<\/li><li>your child has previously received a pertussis vaccine, and one of the following occurred shortly afterward:<ul><li>fever of 40 \u00b0 C or more within 48 hours, which was not caused by any other identifiable cause<\/li><li>episodes with a shock-like condition or pallor, lethargy, and incontestability or fainting (hypotonic-hyporesponsive episodes or collapse,) within 48 hours after vaccination<\/li><li>persistent and inconsolable crying for more than 3 hours within 48 hours after vaccination<\/li><li>seizures, with or without fever, within 3 days after vaccination.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Pentavac<\/h2>\n\n\n\n<p>Pentavac can be given at the same time as the measles-mumps-rubella vaccine.\u00a0Your doctor or nurse will give the two\u00a0injections\u00a0at different injection sites and will use separate syringes for each\u00a0injection.<\/p>\n\n\n\n<p>Tell your doctor, nurse, or pharmacist if your child is taking, has recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Ask your doctor, pharmacist, or nurse to explain if there is something you do not understand.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Not relevant.&nbsp;This vaccine is for use in children only<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pentavac contains phenylalanine, ethanol, and sodium<\/h2>\n\n\n\n<p>Pentavac contains 12.5 micrograms of phenylalanine per 0.5 ml\u00a0dose.\u00a0Phenylalanine can be harmful to people with phenylketonuria (PKU), a rare, inherited disease that leads to the accumulation of high levels of phenylalanine in the body.<\/p>\n\n\n\n<p>Pentavac contains 2 mg alcohol (&nbsp;ethanol&nbsp;) per 0.5 ml&nbsp;dose&nbsp;.&nbsp;The small amount of alcohol in this medicine does not produce any noticeable effects.<\/p>\n\n\n\n<p>Pentavac contains less than 1 mmol\u00a0sodium\u00a0per\u00a0dose, ie it is essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Pentavac<\/h2>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>For the vaccine to be effective, your child must receive several\u00a0doses\u00a0of the vaccine at different times before he\/she becomes 2 years old.\u00a0Two alternative schedules for when these\u00a0doses\u00a0can be given are shown in the table below.\u00a0Your doctor will decide what schedule your child will receive.<br><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19971114000041#\" rel=\"noopener\">Show larger<\/a><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&nbsp;<\/td><td>Age at first&nbsp;dose&nbsp;one<\/td><td>Age at second&nbsp;dose&nbsp;one<\/td><td>Age at third&nbsp;dose&nbsp;one<\/td><td>Amplifying dose<\/td><\/tr><tr><td>Scheme 1 (Booster dose required)<\/td><td>2 or 3 months<\/td><td>3 to 5 months<\/td><td>4 to 7 months<\/td><td>12 to 24 months<\/td><\/tr><tr><td>Scheme 2(Booster dose not required)<\/td><td>3 months<\/td><td>5 months<\/td><td>12 months<\/td><td>(No booster dose)<\/td><\/tr><tr><td>Injections\u00a0according to schedule 1 are given at 1-2 month intervals between each of the first three\u00a0doses.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>If your child misses a&nbsp;dose&nbsp;of Pentavac<\/strong><\/p>\n\n\n\n<p>If your child misses a scheduled\u00a0injection, your doctor will decide when\u00a0to give the current\u00a0dose.<\/p>\n\n\n\n<p><strong>Method of administration<\/strong><\/p>\n\n\n\n<p>Vaccination should be given by healthcare professionals who are trained in the use of vaccines, and who can handle any unusually severe\u00a0allergic reaction\u00a0to the\u00a0injection.<\/p>\n\n\n\n<p>Pentavac is given as an&nbsp;injection&nbsp;into a muscle in your child&#8217;s thigh or upper arm.&nbsp;Your doctor or nurse will avoid giving this&nbsp;injection&nbsp;into a blood vessel.<\/p>\n\n\n\n<p>Your doctor or nurse will give your child the vaccine immediately after mixing the two components of Pentavac.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, nurse, or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all vaccines and medicines, Pentavac can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Severe allergic reactions are always a rare possibility after receiving a vaccine.<\/p>\n\n\n\n<p>These reactions may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty breathing, blue discoloration of the tongue or lips, low\u00a0blood pressure\u00a0(causing dizziness), and fainting (collapse).<\/li><li>sudden signs of\u00a0allergy\u00a0such as swelling of the face, lips, tongue, or other parts of the body (\u00a0edema, Quincke&#8217;s\u00a0edema\u00a0).<\/li><\/ul>\n\n\n\n<p>When such signs or symptoms occur, they usually develop very quickly after an&nbsp;injection&nbsp;has been given, and while the affected person is still in the clinic or doctor&#8217;s office.<\/p>\n\n\n\n<p><strong>If any of these symptoms occur after you have left the place where your child received an\u00a0injection, you must contact a doctor IMMEDIATELY.<\/strong><\/p>\n\n\n\n<p>Very common reactions (affects more than 1 child in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>reduced appetite<\/li><li>nervousness or irritability<\/li><li>abnormal crying<\/li><li>drowsiness<\/li><li>vomiting (nausea)<\/li><li>redness&nbsp;at the injection site<\/li><li>fever of 38 \u00b0 C or more<\/li><li>swelling at the injection site<\/li><li>injection site pain<\/li><\/ul>\n\n\n\n<p>After the basic vaccination, the frequency of injection site reactions tends to increase with booster&nbsp;dose&nbsp;one.<\/p>\n\n\n\n<p>Common reactions (affects less than 1 in 10 children):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea<\/li><li>reduced appetite<\/li><li>hardness (hardening) at the injection site<\/li><li>restless sleep<\/li><\/ul>\n\n\n\n<p>Uncommon reactions (affects less than 1 in 100 children):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>redness&nbsp;and swelling of 5 cm or more around the injection site<\/li><li>fever of 39 \u00b0 C or more<\/li><li>prolonged inconsolable crying (inconsolable crying lasting more than 3 hours)<\/li><\/ul>\n\n\n\n<p>Rare reactions (affects less than 1 in 1,000 children):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high fever above 40 \u00b0 C<\/li><li>swelling of one or both legs.\u00a0This can occur along with blue discoloration of the skin (cyanosis),\u00a0redness, bleeding in small areas under the skin (transient purpura), and heavy crying.\u00a0If this reaction occurs, it occurs mainly after the first (primary)\u00a0injections\u00a0and can be seen within the first hours after vaccination.\u00a0All symptoms disappear completely within 24 hours without any need for treatment.<\/li><\/ul>\n\n\n\n<p>Reactions with unknown frequency (frequency can not be calculated from available data) are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cramps with or without fever<\/li><li>episodes where your child ends up in a shock-like state or is pale, limp, and uncontactable for some time (hypotonic hyporesponsive episodes)<\/li><li>skin rash,\u00a0redness,\u00a0and itching (\u00a0erythema, hives)<\/li><li>major reactions at the injection site (greater than 5 cm), including extensive swelling of the limb where the\u00a0injection\u00a0was given, from the injection site past one or both joints.\u00a0These reactions begin within 24-72 hours after vaccination, may be associated with\u00a0redness, heat, tenderness, or pain at the injection site, and improve within 3-5 days without the need for treatment.<\/li><\/ul>\n\n\n\n<p>Other reactions observed with vaccines containing the same active substances as this vaccine:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>temporary loss of mobility or feeling (\u00a0Guillain-Barr\u00e9 syndrome\u00a0) and loss of mobility, pain, and numbness (brachial neuritis) in the arm and shoulder.<\/li><\/ul>\n\n\n\n<p>In very premature infants (born at or before 28 weeks of gestation), longer-than-normal breaks between breaths may occur for 2-3 days after vaccination.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Pentavac<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C).&nbsp;Do not freeze.&nbsp;If the vaccine has been frozen, it must be discarded.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>Each 0.5 ml\u00a0dose\u00a0of reconstituted vaccine contains: <a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19971114000041#\" rel=\"noopener\">Show larger<\/a><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>The active substances are:<\/td><td><\/td><\/tr><tr><td>Purified&nbsp;diphtheria&nbsp;-toxoid<\/td><td>not less than 30 IU&nbsp;<sup>2 3<\/sup><\/td><\/tr><tr><td>Purified tetanus toxoid&nbsp;<sup>1<\/sup><\/td><td>not less than 40 IU&nbsp;<sup>2 3<\/sup><\/td><\/tr><tr><td>Purified pertussis toxoid (PTxd)<\/td><td>25 micrograms<\/td><\/tr><tr><td>Purified filamentous hemagglutinin (FHA)<\/td><td>25 micrograms<\/td><\/tr><tr><td>Inactivated poliovirus type 1&nbsp;<sup>4<\/sup><\/td><td>D-&nbsp;antigen&nbsp;<sup>5<\/sup>&nbsp;.&nbsp;40 units<\/td><\/tr><tr><td>Inactivated poliovirus type 2&nbsp;<sup>4<\/sup><\/td><td>D-&nbsp;antigen&nbsp;<sup>5<\/sup>&nbsp;.&nbsp;8 units<\/td><\/tr><tr><td>Inactivated poliovirus type 3&nbsp;<sup>4<\/sup><\/td><td>D-antigen&nbsp;<sup>5<\/sup>&nbsp;.&nbsp;32 units<\/td><\/tr><tr><td><em>Haemophilus influenzae<\/em>&nbsp;type b polysaccharide conjugated to tetanus protein<\/td><td>10 micrograms<\/td><\/tr><tr><td>* IE: International devices** Amount of&nbsp;antigen&nbsp;in the vaccine<\/td><\/tr><tr><td><\/td><\/tr><tr><td><sup>1<\/sup>\u00a0Adsorbed on aluminum hydroxide, hydrated (0.3 mg Al\u00a0<sup>3+<\/sup>\u00a0)<sup>2<\/sup>\u00a0IU: International units<sup>3<\/sup>\u00a0Or equivalent activity determined by an immunogenicity evaluation<sup>4<\/sup>\u00a0Made from Vero cells<sup>5<\/sup>\u00a0Or the equivalent amount of antigen in the vaccine<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Aluminum hydroxide is included in the vaccine as an adsorbent.&nbsp;Adsorbents are substances that are included in certain vaccines to accelerate, improve and \/ or prolong the protective effects of the vaccine.<\/p>\n\n\n\n<p>The other ingredients are formaldehyde, phenoxyethanol,&nbsp;ethanol&nbsp;anhydrous, Medium 199 Hanks without pheno-red, concentrated acetic acid and \/ or sodium hydroxide (for&nbsp;pH&nbsp;adjustment), <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tribonate\/\">trometamol<\/a>, sucrose, concentrated&nbsp;hydrochloric acid&nbsp;(for&nbsp;pH&nbsp;adjustment), water for injections.&nbsp;Medium 199 is a complex&nbsp;mixture&nbsp;of&nbsp;amino acids&nbsp;(including phenylalanine), mineral salts,&nbsp;vitamins&nbsp;and other components (such as&nbsp;glucose&nbsp;) diluted in water for injections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Pentavac, powder and&nbsp;suspension for&nbsp;injection&nbsp;,&nbsp;are available as a single dose (0.5 ml) pre-filled&nbsp;syringe&nbsp;with a single-dose vial of&nbsp;<em>Haemophilus influenzae<\/em>&nbsp;type b vaccine (freeze-dried vaccine) in the same package.<em><\/em><\/p>\n\n\n\n<p>Pack sizes of 1 or 10 without needle, with mounted needle, with 1 separate needle or with 2 separate needles.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Sanofi Pasteur Europe<\/p>\n\n\n\n<p>14 Henry Vall\u00e9e Space<\/p>\n\n\n\n<p>69007 Lyon<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Sanofi Pasteur, 14 Espace Henry Vall\u00e9e, 69007 Lyon, France<\/p>\n\n\n\n<p><strong>Local representative:<\/strong><\/p>\n\n\n\n<p>Sanofi AB<\/p>\n\n\n\n<p>Box 30052<\/p>\n\n\n\n<p>104 25 Stockholm<\/p>\n\n\n\n<p>Tel: +46 8-634 50 00<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Pentavac<\/td><td>Belgium, Denmark, Finland, Greece, Iceland, Luxembourg, Portugal, Sweden<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Pentavac is a vaccine. Vaccines are used to protect against infectious diseases.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21233,21229,21234,21235,21232,21230,21231],"class_list":["post-20734","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-pentavac","tag-pentavac","tag-pentavac-injection","tag-pentavac-powder","tag-pentavac-side-effects","tag-what-is-pentavac","tag-what-pentavac-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20734","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20734"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20734\/revisions"}],"predecessor-version":[{"id":20799,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20734\/revisions\/20799"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20734"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20734"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}