{"id":20613,"date":"2022-04-07T10:37:09","date_gmt":"2022-04-07T10:37:09","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20613"},"modified":"2022-04-08T11:15:57","modified_gmt":"2022-04-08T11:15:57","slug":"pemetrexed-hexal","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/pemetrexed-hexal\/","title":{"rendered":"Pemetrexed Hexal &#8211; Pemetrexed uses, dose and side effects"},"content":{"rendered":"\n<p>25 mg \/ ml&nbsp;concentrate for&nbsp;solution for&nbsp;infusion<br>pemetrexed<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Pemetrexed Hexal is and what it is used for<\/h2>\n\n\n\n<p>Pemetrexed Hexal is a medicine used to treat cancer.<\/p>\n\n\n\n<p>Pemetrexed Hexal is given together with cisplatin, another anti-cancer medicine, for the treatment of malignant pleural mesothelioma, a form of lung cancer, to patients who have not previously received anticancer medicine (&nbsp;chemotherapy&nbsp;).<\/p>\n\n\n\n<p>Pemetrexed Hexal is also used with cisplatin in the initial treatment of advanced lung cancer.<\/p>\n\n\n\n<p>Pemetrexed Hexal can be prescribed to you if you have advanced lung cancer and your disease has responded to treatment or if it is largely unchanged after initial&nbsp;chemotherapy&nbsp;.<\/p>\n\n\n\n<p>In addition, Pemetrexed Hexal is used to treat advanced lung cancer in patients whose disease has progressed after the use of other initial&nbsp;chemotherapy drugs&nbsp;.<\/p>\n\n\n\n<p>This medicine is for the treatment of adults only.<\/p>\n\n\n\n<p>Pemetrexed contained in Pemetrexed Hexal may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Pemetrexed Hexal<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Pemetrexed Hexal<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to pemetrexed or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are breastfeeding.&nbsp;You should stop breastfeeding during treatment with Pemetrexed Hexal.<\/li><li>if you have recently been vaccinated or are just about to be vaccinated against yellow fever.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or other healthcare professional before receiving Pemetrexed Hexal.<\/p>\n\n\n\n<p>Talk to your doctor or another healthcare professional if you have or have had kidney problems, as you may not be able to get Pemetrexed Hexal.<\/p>\n\n\n\n<p>Before each&nbsp;infusion&nbsp;, blood samples will be taken to determine if the function of the kidneys and liver is sufficient and to check that the amount of&nbsp;blood cells&nbsp;is sufficient to obtain Pemetrexed Hexal.&nbsp;Your doctor may choose to change the&nbsp;dose&nbsp;or postpone your treatment depending on your general condition and if your blood levels are too low.&nbsp;If you are also taking cisplatin, your doctor will make sure that you have been given enough fluids and that you will receive appropriate treatment before and after the cisplatin treatment to prevent vomiting.<\/p>\n\n\n\n<p>If you have received radiation therapy or if such treatment is planned, tell your doctor, like radiation therapy and Pemetrexed Hexal may cause immediate or late\u00a0side effects\u00a0.<\/p>\n\n\n\n<p>If you have recently been vaccinated, you should tell your doctor, as Pemetrexed Hexal in connection with vaccination may cause unwanted reactions.<\/p>\n\n\n\n<p>Tell your doctor if you have or have had heart disease in the past.<\/p>\n\n\n\n<p>If you have fluid accumulation around your lungs, your doctor may decide to remove the fluid before treatment with Pemetrexed Hexal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine should not be used by children or adolescents as there is no experience with the medicine in children and adolescents under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Pemetrexed Hexal<\/h2>\n\n\n\n<p>Tell your doctor if you are taking any medicine for pain or&nbsp;inflammation&nbsp;(swelling), such as&nbsp;so-called non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs&nbsp;), including over-the-counter ones (such as&nbsp;ibuprofen&nbsp;).&nbsp;There are many different types of these drugs with varying duration of action.&nbsp;Knowing the date of the planned&nbsp;infusion&nbsp;of Pemetrexed Hexal and \/ or renal function status, your doctor must advise you on which medicines you can take and when you can take them.&nbsp;If you are not sure, ask your doctor or&nbsp;pharmacist&nbsp;if any of your medicines are&nbsp;NSAIDs&nbsp;.<\/p>\n\n\n\n<p>Tell your doctor or another healthcare professional if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby,\u00a0<strong>tell your doctor.\u00a0<\/strong>Treatment with Pemetrexed Hexal should be avoided during pregnancy.\u00a0Your doctor will discuss any possible risks of Pemetrexed Hexal during pregnancy.<\/p>\n\n\n\n<p>Women should use effective contraception during treatment with Pemetrexed Hexal.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Tell your doctor if you are breastfeeding.<\/p>\n\n\n\n<p>Breast-feeding should be discontinued during treatment with Pemetrexed Hexal.<\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>Men are advised not to have children during and up to 6 months after Pemetrexed Hexal treatment and should therefore use an effective method of contraception during Pemetrexed Hexal treatment and up to 6 months after stopping treatment.&nbsp;If you plan to have children during treatment or the following 6 months after treatment, consult your doctor or&nbsp;pharmacist&nbsp;.&nbsp;You may want to seek advice on sperm preservation before starting treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Treatment with Pemetrexed Hexal may make you feel tired.&nbsp;Be careful when driving or using machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and \/ or&nbsp;side effects&nbsp;.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pemetrexed Hexal contains sodium and propylene glycol<\/h2>\n\n\n\n<p><strong>Pemetrexed Hexal 100 mg (4 ml&nbsp;vial&nbsp;)<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per&nbsp;vial&nbsp;, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<p>This medicine contains 200 mg of propylene glycol per&nbsp;vial&nbsp;.<\/p>\n\n\n\n<p><strong>Pemetrexed Hexal 500 mg (20 ml&nbsp;vial&nbsp;)<\/strong><\/p>\n\n\n\n<p>This medicine contains 55.6 mg&nbsp;sodium&nbsp;(the main ingredient in table salt \/ table salt) per&nbsp;vial&nbsp;.&nbsp;This corresponds to 3% of the maximum recommended daily&nbsp;sodium&nbsp;intake for adults.<\/p>\n\n\n\n<p>This medicine contains 1000 mg of propylene glycol per&nbsp;vial&nbsp;.<\/p>\n\n\n\n<p><strong>Pemetrexed Hexal 1000 mg (40 ml&nbsp;vial&nbsp;)<\/strong><\/p>\n\n\n\n<p>This medicine contains 111.2 mg&nbsp;sodium&nbsp;(the main ingredient in table salt \/ table salt) per&nbsp;vial&nbsp;.&nbsp;This corresponds to 6% of the maximum recommended daily intake of&nbsp;sodium&nbsp;for adults.<\/p>\n\n\n\n<p>This medicine contains 2000 mg of propylene glycol per\u00a0vial\u00a0.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Pemetrexed Hexal<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Pemetrexed Hexal<\/h2>\n\n\n\n<p>Pemetrexed Hexal should only be given under the supervision of a doctor who has experience in the treatment of anti-cancer drugs (&nbsp;cytostatics&nbsp;).<\/p>\n\n\n\n<p>Pemetrexed Hexal is given in a\u00a0dose\u00a0of 500 mg per square meter of body surface area.\u00a0Your height and weight are used to calculate the body surface area.\u00a0Your doctor will use the measurement of your body surface area to calculate the correct\u00a0dose\u00a0for you.\u00a0This\u00a0dose\u00a0can be adjusted or the treatment can be postponed depending on your blood levels and your general condition.\u00a0A hospital pharmacist, nurse, or doctor will have mixed the Pemetrexed Hexal \u2011 concentrate in\u00a0sterile\u00a09 mg \/ ml (0.9%) sodium chloride solution or 50 mg \/ ml (5%)\u00a0sterile\u00a0glucose solution before giving it to you.<\/p>\n\n\n\n<p>Pemetrexed Hexal is always given as&nbsp;an infusion&nbsp;into a friend.&nbsp;Infusion&nbsp;one lasts for about 10 minutes.<\/p>\n\n\n\n<p><strong>When Pemetrexed Hexal is given in combination with cisplatin:<\/strong><\/p>\n\n\n\n<p>Your doctor or hospital pharmacist will have calculated the required&nbsp;dose&nbsp;using your height and weight.<\/p>\n\n\n\n<p>Cisplatin is also given as&nbsp;an infusion&nbsp;into a vein and is given approximately 30 minutes after the end of the Pemetrexed Hexal infusion.&nbsp;Infusion&nbsp;one of cisplatin lasts for about 2 hours.<\/p>\n\n\n\n<p>You usually receive&nbsp;an infusion&nbsp;once every three weeks.<\/p>\n\n\n\n<p><strong>Other medicines:<\/strong><\/p>\n\n\n\n<p>Corticosteroids: Your doctor will prescribe steroid tablets (equivalent to 4 milligrams of <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toflacort\/\">dexamethasone<\/a> twice daily).\u00a0You should take these tablets the day before, on the day of treatment, and the day after treatment with Pemetrexed Hexal.\u00a0The tablets are given to reduce the frequency and severity of the skin reactions that may occur during treatment for cancer.<\/p>\n\n\n\n<p>Vitamin supplement: Your doctor will prescribe a&nbsp;preparation&nbsp;of&nbsp;folic acid&nbsp;(&nbsp;vitamin&nbsp;) to be taken by mouth or a multivitamin preparation containing&nbsp;folic acid&nbsp;(350 to 1000 micrograms) that you should take once a day during treatment with Pemetrexed Hexal.&nbsp;You should take at least 5&nbsp;doses&nbsp;during the seven days preceding the first&nbsp;dose&nbsp;of one of Pemetrexed Hexal.&nbsp;You should continue to take&nbsp;folic acid&nbsp;for 21 days after the last dose of Pemetrexed&nbsp;Hexal\u2011&nbsp;.&nbsp;You will also receive a B&nbsp;<sub>12<\/sub>&nbsp;Vitamin Injection (1000 micrograms) the week before Pemetrexed Hexal&nbsp;Infusionone and then approximately every 9 weeks (equivalent to 3 treatments with Pemetrexed Hexal).&nbsp;Vitamin&nbsp;B&nbsp;<sub>12<\/sub>&nbsp;and&nbsp;folic acid&nbsp;are&nbsp;given to reduce the possible harmful effects of cancer treatment.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<\/p>\n\n\n\n<p><strong>You should contact your doctor immediately if you notice any of the following side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Fever or\u00a0infection<\/strong>\u00a0(common and very common): if you have a temperature of 38 \u00b0 C or more, sweating, or other signs of an\u00a0infection\u00a0(because you may have lower than normal\u00a0white blood cell count\u00a0, which is very common).\u00a0Infection\u00a0one (blood poisoning) can be serious and lead to death.<\/li><li>If you start to feel\u00a0chest pain\u00a0(common) or have a fast heart rate (less common).<\/li><li>If you feel\u00a0pain,\u00a0redness\u00a0, swelling, or soreness in your mouth\u00a0(very common).<\/li><li>Allergic reaction: if you get a\u00a0rash\u00a0(very common),\u00a0burning or stinging sensation\u00a0(common), or\u00a0fever\u00a0(common).\u00a0Skin reactions can be serious and lead to death (rare).<\/li><li>Contact your doctor if you get\u00a0severe skin rash,\u00a0itching,\u00a0or blisters\u00a0(\u00a0Stevens-Johnson syndrome\u00a0or\u00a0toxic epidermal necrolysis\u00a0).<\/li><li>If you get\u00a0tired\u00a0, feel\u00a0weak\u00a0, get short of\u00a0breath\u00a0easily, or if you look pale (because you may have less\u00a0hemoglobin\u00a0than normal, which is very common).<\/li><li>If it\u00a0bleeds from the gums, nose, or mouth\u00a0or you get any bleeding that does not want to stop, reddish or pinkish urine, unexpected bruising (because you may have fewer\u00a0platelets\u00a0than normal, which is common).<\/li><li>If you experience sudden shortness of breath, intense\u00a0chest pain,\u00a0or cough with bloody cough (less common) (may indicate a blood clot in the blood vessels of the lungs).<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;of Pemetrexed Hexal may occur:<\/strong><\/p>\n\n\n\n<p><strong><em>Very common<\/em><\/strong>&nbsp;(may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Infection<\/li><li>Sore throat<\/li><li>Low\u00a0neutrophil count\u00a0(\u00a0white blood cell\u00a0type )<\/li><li>Low\u00a0white blood cell count<\/li><li>Low hemoglobin (\u00a0anemia\u00a0)<\/li><li>Pain,\u00a0redness\u00a0, swelling, or soreness in the mouth<\/li><li>Decreased appetite<\/li><li>Vomiting<\/li><li>Diarrhea<\/li><li>Nausea<\/li><li>Rash<\/li><li>Flaking skin<\/li><li>Abnormal blood counts showing\u00a0reduced\u00a0kidney function<\/li><li>Fatigue (fatigue).<\/li><\/ul>\n\n\n\n<p><strong><em>Common<\/em><\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blood infection<\/li><li>Fever with low\u00a0neutrophil count\u00a0(\u00a0white blood cell\u00a0type )<\/li><li>Reduced\u00a0platelet count<\/li><li>Allergic reaction<\/li><li>Dehydration<\/li><li>Taste changes<\/li><li>Muscle weakness and muscle wasting due to damage to motor nerves, especially in the arms and legs<\/li><li>Loss of sensation, burning pain, and unsteady gait due to damage to sensory nerves<\/li><li>Dizziness<\/li><li>Inflammation\u00a0or swelling of the conjunctiva (a\u00a0membrane\u00a0that lies at the far end of the eyelids and covers the whites of the eyes)<\/li><li>Dry eyes<\/li><li>Tear-filled eyes<\/li><li>Dried\u00a0conjunctiva\u00a0( the\u00a0membrane\u00a0that lies at the far end of the eyelids and covers the white of the eyes) and the\u00a0cornea\u00a0(the clear layer that protects the\u00a0iris\u00a0and\u00a0pupil\u00a0)<\/li><li>Swollen eyelids<\/li><li>Eye problems, such as dryness, tearing, irritation, and \/ or pain.<\/li><li>Heart failure\u00a0(a condition that affects the pumping power of your heart muscle)<\/li><li>Irregular heartbeat<\/li><li>Indigestion<\/li><li>Constipation<\/li><li>Abdominal pain<\/li><li>Liver: increase in the substances in the blood produced by the liver<\/li><li>Increased skin pigmentation<\/li><li>Itching<\/li><li>Rash on the body with circular marks<\/li><li>Hair loss<\/li><li>Hives<\/li><li>Kidney failure<\/li><li>Decreased renal function<\/li><li>Fever<\/li><li>Pain<\/li><li>Excess fluid in body tissue, which causes swelling<\/li><li>Chest pain<\/li><li>Inflammation\u00a0and ulceration of the mucous membranes that line the digestive tract.<\/li><\/ul>\n\n\n\n<p><strong><em>Uncommon<\/em><\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduction in the number of red and\u00a0white blood cells\u00a0and\u00a0platelets<\/li><li>Stroke<\/li><li>Type of\u00a0stroke\u00a0in which an\u00a0artery\u00a0to the brain is blocked<\/li><li>Bleeding inside the skull<\/li><li>Angina (chest pain caused by decreased blood flow to the heart)<\/li><li>Myocardial infarction<\/li><li>Narrowing or blockage of the coronary arteries<\/li><li>Elevated heart rate<\/li><li>Reduced blood distribution to arms and legs<\/li><li>Blood clots in the pulmonary blood vessels (\u00a0pulmonary embolism\u00a0)<\/li><li>Inflammation\u00a0and scarring of the lungs with respiratory problems<\/li><li>Passage of bright red blood from the anus<\/li><li>Bleeding in the gastrointestinal tract<\/li><li>Broken intestine<\/li><li>Inflammation\u00a0of the esophageal\u00a0mucosa\u00a0(esophagus)<\/li><li>Colitis\u00a0(\u00a0inflammation\u00a0of the wall of the colon, which may be accompanied by bleeding from the intestines or\u00a0rectum\u00a0(seen only in combination with cisplatin)<\/li><li>Inflammation\u00a0,\u00a0edema\u00a0,\u00a0erythema,\u00a0and\u00a0erosion\u00a0of the mucosal surface of the esophagus caused by radiation therapy<\/li><li>Inflammation\u00a0of the lung caused by radiation therapy.<\/li><\/ul>\n\n\n\n<p><strong><em>Rare<\/em><\/strong>&nbsp;(may affect up to 1 in 1,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Destruction of&nbsp;red blood cells<\/li><li>Anaphylactic&nbsp;shock&nbsp;(severe&nbsp;allergic reaction&nbsp;)<\/li><li>Inflammatory conditions of the liver<\/li><li>Redness of the skin<\/li><li>Skin rash that may occur on skin that has previously been exposed to radiation therapy.<\/li><\/ul>\n\n\n\n<p><strong><em>Very rare<\/em><\/strong>&nbsp;(may affect up to 1 in 10,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Infection\u00a0of skin and soft tissue<\/li><li>Stevens-Johnson syndrome (a type of severe reaction in the skin and mucous membranes that can be life-threatening)<\/li><li>Toxic epidermal necrolysis\u00a0(a type of severe skin reaction that can be life-threatening)<\/li><li>An autoimmune\u00a0condition that results in skin rashes and blisters on legs, arms, and abdomen<\/li><li>Inflammation\u00a0of the skin is characterized by the presence of bullous conditions with fluid-filled blisters<\/li><li>Fragile skin, blisters, and\u00a0erosion\u00a0as well as scarring of the skin<\/li><li>Redness\u00a0, pain, and swelling mainly in the lower legs<\/li><li>Inflammation\u00a0of the skin and fat under the skin (pseudocellulitis)<\/li><li>Inflammation\u00a0of the skin (\u00a0dermatitis\u00a0)<\/li><li>Skin that becomes inflamed, itchy, red, cracked and rough<\/li><li>Intense itchy spots.<\/li><\/ul>\n\n\n\n<p><strong><em>Has been reported<\/em><\/strong>&nbsp;(occurs in unknown number of users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A form of&nbsp;diabetes&nbsp;that is primarily based on kidney&nbsp;pathology<\/li><li>Kidney disorder involving tubular epithelial cells (which form renal tubules) death.<\/li><\/ul>\n\n\n\n<p>You may get any of these symptoms and \/ or ailments.&nbsp;If you start to experience any of these&nbsp;side effects&nbsp;, talk to your doctor as soon as possible.<\/p>\n\n\n\n<p>If you have any&nbsp;side effects&nbsp;, talk to your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Pemetrexed Hexal<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><strong>Unopened&nbsp;vial<\/strong><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.&nbsp;Store in the original package.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p><strong>After the first opening<\/strong><\/p>\n\n\n\n<p>The medicine should be used immediately.&nbsp;Any unused product should be discarded.<\/p>\n\n\n\n<p><strong>After dilution<\/strong><\/p>\n\n\n\n<p><em>100 mg&nbsp;vial<\/em><\/p>\n\n\n\n<p>Stability of the reconstituted infusion solution has been demonstrated for 3 days in a refrigerator at 2-8 \u00b0 C, protected from light.<\/p>\n\n\n\n<p><em>500 mg&nbsp;vial&nbsp;and 1000 mg&nbsp;vial<\/em><\/p>\n\n\n\n<p>Stability of the reconstituted infusion solution has been demonstrated for 7 days at room temperature, protected from light, and for 14 days in a refrigerator at 2\u20138 \u00b0 C, protected from light.<\/p>\n\n\n\n<p>From a microbiological perspective, the drug should be used immediately.&nbsp;If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and the reconstituted solution should not normally be stored for longer than 24 hours at 2-8 \u00b0 C, unless diluted under controlled and validated aseptic (sterile) conditions.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is pemetrexed (as pemetrexed disodium hemipentahydrate).<\/p>\n\n\n\n<p>Each ml of concentrate for solution for&nbsp;infusion&nbsp;contains 25 mg of pemetrexed (as pemetrexed disodium hemipentahydrate).<\/p>\n\n\n\n<p>Each 4 ml&nbsp;vial&nbsp;contains 100 mg of pemetrexed (as pemetrexed disodium hemipentahydrate).<\/p>\n\n\n\n<p>Each 20 ml&nbsp;vial&nbsp;contains 500 mg of pemetrexed (as pemetrexed disodium hemipentahydrate).<\/p>\n\n\n\n<p>Each 40 ml&nbsp;vial&nbsp;contains 1000 mg of pemetrexed (as pemetrexed disodium hemipentahydrate).<\/p>\n\n\n\n<p>The other ingredients are sodium thiosulphate pentahydrate (E539), propylene glycol (E1520),&nbsp;hydrochloric acid&nbsp;(for&nbsp;pH&nbsp;adjustment), sodium hydroxide (E524) (for&nbsp;pH&nbsp;adjustment), water for injections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Pemetrexed Hexal is a concentrate for solution for&nbsp;infusion&nbsp;.&nbsp;It is a clear, colorless to yellow or greenish yellow solution.&nbsp;The solution is virtually particle-free.<\/p>\n\n\n\n<p>Pemetrexed Hexal is packaged in a type I glass&nbsp;vial&nbsp;with a bromobutyl rubber stopper and an aluminum cap with a light blue plastic snap cap.<\/p>\n\n\n\n<p>Each&nbsp;vial&nbsp;contains 4 ml, 20 ml or 40 ml concentrate for solution for&nbsp;infusion&nbsp;.<\/p>\n\n\n\n<p>Each pack contains 1&nbsp;vial&nbsp;(with or without protective plastic cover).<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Hexal A \/ S, Edvard Thomsens Vej 14, 2300 Copenhagen S, Denmark<\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>EBEWE Pharma Ges.mH Nfg.KG, Mondseestrasse 11, 4866 Unterach am Attersee, Austria<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Fareva Unterach GmbH, Mondseestrasse 11, 4866 Unterach am Attersee, Austria<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pemetrexed Hexal is given together with cisplatin, another anticancer medicine, for the treatment of malignant pleural mesothelioma, a form of lung cancer, to patients who have not previously received anticancer medicine ( chemotherapy ).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21095,21125,10012,21121,21124,10015,10013,21122,21123,10014],"class_list":["post-20613","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-pemetrexed","tag-benefits-of-pemetrexed-hexal","tag-pemetrexed","tag-pemetrexed-hexal","tag-pemetrexed-hexal-side-effects","tag-pemetrexed-side-effects","tag-what-is-pemetrexed","tag-what-is-pemetrexed-hexal","tag-what-pemetrexed-hexal-is-used-for","tag-what-pemetrexed-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20613","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20613"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20613\/revisions"}],"predecessor-version":[{"id":20670,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20613\/revisions\/20670"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20613"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}