{"id":20609,"date":"2022-04-07T10:33:24","date_gmt":"2022-04-07T10:33:24","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20609"},"modified":"2022-04-08T11:16:11","modified_gmt":"2022-04-08T11:16:11","slug":"pemetrexed-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/pemetrexed-accord\/","title":{"rendered":"Pemetrexed Accord &#8211; Pemetrexed uses, dose and side effects"},"content":{"rendered":"\n<p>25 mg \/ ml&nbsp;concentrate for&nbsp;solution for&nbsp;infusion<br>pemetrexed<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Pemetrexed Accord is and what it is used for<\/h2>\n\n\n\n<p>Pemetrexed Accord is a medicine used to treat cancer.<\/p>\n\n\n\n<p>Pemetrexed Accord is co-administered with cisplatin, another anti-cancer drug, for the treatment of malignant pleural mesothelioma, a form of lung cancer, in patients who have not previously received anti-cancer drug therapy.<\/p>\n\n\n\n<p>Pemetrexed Accord is also used with cisplatin in the initial treatment of advanced lung cancer.<\/p>\n\n\n\n<p>Pemetrexed Accord can be prescribed to you if you have advanced lung cancer and your disease has responded to treatment or if it is largely unchanged after initial drug treatment.<\/p>\n\n\n\n<p>In addition, Pemetrexed Accord is used to treat advanced lung cancer whose disease has progressed, after other previous drug treatments have been used.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Pemetrexed Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Pemetrexed Accord<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to pemetrexed or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are breast-feeding.&nbsp;You should stop breast-feeding during treatment with Pemetrexed Accord.<\/li><li>if you have recently been vaccinated or are just about to be vaccinated against yellow fever.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist or nurse before using Pemetrexed Accord.<\/p>\n\n\n\n<p>Talk to your doctor or pharmacist if you have or have had kidney problems, as you may not be able to get Pemetrexed Accord.<\/p>\n\n\n\n<p>Before each&nbsp;infusion&nbsp;, blood samples will be taken to determine if the function of the kidneys and liver is sufficient and to check that the amount of&nbsp;blood cells&nbsp;is sufficient to obtain Pemetrexed Accord.&nbsp;Your doctor may choose to change the&nbsp;dose&nbsp;or postpone your treatment depending on your general condition and if your blood levels are too low.&nbsp;If you are also taking cisplatin, your doctor will make sure that you have been given enough fluids and that you will receive appropriate treatment before and after the cisplatin treatment to prevent vomiting.<\/p>\n\n\n\n<p>If you have received radiation therapy or if such treatment is planned, tell your doctor, as radiation therapy and Pemetrexed Accord may cause immediate or late&nbsp;side effects&nbsp;.<\/p>\n\n\n\n<p>If you have recently been vaccinated, you should tell your doctor, as Pemetrexed Accord in connection with vaccination may cause unwanted reactions.<\/p>\n\n\n\n<p>Tell your doctor if you have, or have previously had, heart disease.<\/p>\n\n\n\n<p>If you have fluid accumulation around your lung, your doctor may decide to remove the fluid before treatment with Pemetrexed Accord.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine should not be given to children and adolescents as there is no experience with the medicine in children and adolescents under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Pemetrexed Accord<\/h2>\n\n\n\n<p>Tell your doctor if you are taking any medicine for pain or&nbsp;inflammation&nbsp;(swelling), such as&nbsp;so-called non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs&nbsp;), including over-the-counter drugs (such as&nbsp;ibuprofen&nbsp;).&nbsp;There are many different types of these drugs with varying duration of action.&nbsp;Knowing the date of the planned&nbsp;infusion&nbsp;of Pemetrexed Accord and \/ or renal function status, your doctor must advise you on which medicines you can take and when you can take them.&nbsp;If you are not sure, ask your doctor or&nbsp;pharmacist&nbsp;if any of your medicines are&nbsp;NSAIDs&nbsp;.<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.&nbsp;Pemetrexed Accord treatment should be avoided during pregnancy.&nbsp;Your doctor will discuss any possible risks of Pemetrexed Accord during pregnancy.&nbsp;Women should use effective contraception during treatment with Pemetrexed Accord.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Tell your doctor if you are breast-feeding.<\/p>\n\n\n\n<p>Breast-feeding should be discontinued during treatment with Pemetrexed Accord.<\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>Men are advised not to have children during and up to 6 months after Pemetrexed Accord treatment and should therefore use an effective method of contraception during Pemetrexed Accord treatment and up to 6 months after stopping treatment.&nbsp;If you plan to have children during treatment or the following 6 months after treatment, consult your doctor or&nbsp;pharmacist&nbsp;.&nbsp;You may want to seek advice on sperm preservation before starting treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Treatment with Pemetrexed Accord may make you feel tired.&nbsp;Be careful when driving or using machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pemetrexed Accord contains sodium<\/h2>\n\n\n\n<p>The maximum recommended daily&nbsp;dose&nbsp;of one of these medicines contains 304 mg of&nbsp;sodium&nbsp;(the main ingredient in table salt \/ table salt) per&nbsp;dose&nbsp;.&nbsp;This corresponds to 15.2% of the highest recommended daily intake of&nbsp;sodium&nbsp;for adults.<\/p>\n\n\n\n<p>Talk to your pharmacist or doctor about your need for Pemetrexed Accord daily for a long period of time, especially if you have been prescribed a low-salt diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Pemetrexed Accord<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;of Pemetrexed Accord is 500 mg per square meter of body surface area.&nbsp;Your height and weight are used to calculate the body surface area.&nbsp;Your doctor will use the measurement of your body surface area to calculate the correct&nbsp;dose&nbsp;for you.&nbsp;This&nbsp;dose&nbsp;can be adjusted or the treatment can be postponed depending on blood levels and your general condition.<\/p>\n\n\n\n<p>Pemetrexed Accord is always given as&nbsp;an infusion&nbsp;into a friend.&nbsp;Infusion&nbsp;one lasts for about 10 minutes.<\/p>\n\n\n\n<p>When Pemetrexed Accord is given in combination with cisplatin:<\/p>\n\n\n\n<p>Your doctor or hospital pharmacist will have calculated the required&nbsp;dose&nbsp;using your height and weight.&nbsp;Cisplatin is also given as&nbsp;an infusion&nbsp;into a vein and is given approximately 30 minutes after the end of the Pemetrexed Accord infusion.&nbsp;Infusion&nbsp;one of cisplatin lasts for about 2 hours.<\/p>\n\n\n\n<p>You usually receive&nbsp;an infusion&nbsp;once every three weeks.<\/p>\n\n\n\n<p>Other medicines:<\/p>\n\n\n\n<p>Corticosteroids: Your doctor will prescribe steroid tablets (equivalent to 4 milligrams of <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toflacort\/\">dexamethasone<\/a> twice daily).&nbsp;You should take these tablets the day before, on the day of treatment and the day after treatment with Pemetrexed Accord.&nbsp;The tablets are given to reduce the frequency and severity of the skin reactions that may occur during treatment for cancer.<\/p>\n\n\n\n<p>Vitamin supplement: Your doctor will prescribe a&nbsp;preparation&nbsp;of&nbsp;folic acid&nbsp;(&nbsp;vitamin&nbsp;) to be taken by mouth or a multivitamin preparation containing&nbsp;folic acid&nbsp;(350 to 1,000 micrograms) that you should take once a day during treatment with Pemetrexed Accord.&nbsp;You must take at least 5&nbsp;doses&nbsp;during the seven days preceding the first&nbsp;dose&nbsp;of one of Pemetrexed Accord.&nbsp;You should continue to take&nbsp;folic acid&nbsp;for 21 days after the last Pemetrexed Accord&nbsp;dose&nbsp;.&nbsp;You will also receive a&nbsp;vitamin&nbsp;B&nbsp;<sub>12<\/sub>&nbsp;injection&nbsp;(&nbsp;1,000 micrograms) the week before the Pemetrexed Accord&nbsp;infusion .one and then approximately every 9 weeks (equivalent to 3 treatment regimens with Pemetrexed Accord).&nbsp;Vitamin&nbsp;B&nbsp;<sub>12<\/sub>&nbsp;and&nbsp;folic acid&nbsp;are given to reduce the possible harmful effects of cancer treatment.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<\/p>\n\n\n\n<p>You should contact your doctor immediately if you notice any of the following side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fever or&nbsp;infection&nbsp;(common or very common): if you have a temperature of 38 \u00b0 C or more, sweating or other signs of an&nbsp;infection&nbsp;(because you may have a lower&nbsp;white blood cell count&nbsp;than normal, which is very common).&nbsp;Infection&nbsp;one (blood poisoning) can be serious and lead to death.<\/li><li>If you start to feel chest pain (common) or have a fast heart rate (less common).<\/li><li>If you feel pain,&nbsp;redness&nbsp;, swelling or soreness in your mouth (very common).<\/li><li>Allergic reaction: if you get a rash (very common) \/ burning or stinging sensation (common) or fever (common).&nbsp;Skin reactions can be serious and lead to death (rare).&nbsp;Contact your doctor if you get a lot of rash,&nbsp;itching&nbsp;or blisters (&nbsp;Stevens-Johnson&nbsp;syndrome or&nbsp;toxic epidermal necrolysis&nbsp;).<\/li><li>If you get tired, feel weak, get short of breath easily or if you look pale (because you may have less&nbsp;hemoglobin&nbsp;than normal, which is very common).<\/li><li>If there is bleeding from the gums, nose or mouth or you get any bleeding that does not want to stop, reddish or pinkish urine, unexpected bruising (because you may have fewer&nbsp;platelets&nbsp;than normal, which is common).<\/li><li>If you experience sudden shortness of breath, intense chest pain or cough with bloody cough (less common) (may indicate a blockage in the blood vessels of the lungs).<\/li><\/ul>\n\n\n\n<p>Other&nbsp;side effects&nbsp;of Pemetrexed Accord that may occur:<\/p>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10)<\/em><\/p>\n\n\n\n<p>Infection<\/p>\n\n\n\n<p>Sore throat<\/p>\n\n\n\n<p>Low&nbsp;neutrophil count&nbsp;(&nbsp;white blood cell&nbsp;type )<\/p>\n\n\n\n<p>Low&nbsp;white blood cell count<\/p>\n\n\n\n<p>Low hemoglobin (&nbsp;anemia&nbsp;)<\/p>\n\n\n\n<p>Pain,&nbsp;redness&nbsp;, swelling or soreness in the mouth<\/p>\n\n\n\n<p>Decreased appetite<\/p>\n\n\n\n<p>Vomiting<\/p>\n\n\n\n<p>Diarrhea<\/p>\n\n\n\n<p>Nausea<\/p>\n\n\n\n<p>Rash<\/p>\n\n\n\n<p>Flaking skin<\/p>\n\n\n\n<p>Abnormal blood counts showing&nbsp;reduced&nbsp;kidney function<\/p>\n\n\n\n<p>Fatigue (fatigue)<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<p>Blood infection<\/p>\n\n\n\n<p>Fever with low&nbsp;neutrophil count&nbsp;(&nbsp;white blood cell&nbsp;type )<\/p>\n\n\n\n<p>Reduced&nbsp;platelet count<\/p>\n\n\n\n<p>Allergic reaction<\/p>\n\n\n\n<p>Dehydration<\/p>\n\n\n\n<p>Taste changes<\/p>\n\n\n\n<p>Muscle weakness due to damage to motor nerves, especially in the arms and legs<\/p>\n\n\n\n<p>Loss of sensation, burning pain and unsteady gait due to damage to sensory nerves<\/p>\n\n\n\n<p>Dizziness<\/p>\n\n\n\n<p>Inflammation&nbsp;or swelling of the conjunctiva (&nbsp;membrane&nbsp;at the end of the eyelids and covering the whites of the eyes<\/p>\n\n\n\n<p>Dry eyes<\/p>\n\n\n\n<p>Tear-filled eyes<\/p>\n\n\n\n<p>Dried&nbsp;conjunctiva&nbsp;(&nbsp;membrane&nbsp;on the outer part of the eyelids and covering the eyes white and&nbsp;cornea&nbsp;(the clear layer that protects the&nbsp;iris&nbsp;and&nbsp;pupil&nbsp;)<\/p>\n\n\n\n<p>Swollen eyelids<\/p>\n\n\n\n<p>Eye problems, such as dryness, tearing, irritation, and \/ or pain.<\/p>\n\n\n\n<p>Heart failure&nbsp;(a condition that affects the pumping power of your heart muscle)<\/p>\n\n\n\n<p>Irregular heartbeat<\/p>\n\n\n\n<p>Indigestion<\/p>\n\n\n\n<p>Constipation<\/p>\n\n\n\n<p>Abdominal pain<\/p>\n\n\n\n<p>Liver: increase in the substances in the blood produced by the liver<\/p>\n\n\n\n<p>Increased skin pigmentation<\/p>\n\n\n\n<p>Itching<\/p>\n\n\n\n<p>Rash on the body there with red marks<\/p>\n\n\n\n<p>Hair loss<\/p>\n\n\n\n<p>Hives<\/p>\n\n\n\n<p>Kidney failure<\/p>\n\n\n\n<p>Decreased renal function<\/p>\n\n\n\n<p>Fever<\/p>\n\n\n\n<p>Pain<\/p>\n\n\n\n<p>Excess fluid in body tissue, which causes swelling<\/p>\n\n\n\n<p>Chest pain<\/p>\n\n\n\n<p>Inflammation&nbsp;and ulceration of the mucous membranes that line the digestive tract<\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<p>Reduction in the number of red and&nbsp;white blood cells&nbsp;and&nbsp;platelets<\/p>\n\n\n\n<p>Stroke<\/p>\n\n\n\n<p>Type of&nbsp;stroke&nbsp;when an&nbsp;artery&nbsp;to the brain is blocked<\/p>\n\n\n\n<p>Bleeding inside the skull<\/p>\n\n\n\n<p>Angina (Chest pain caused by decreased blood flow to the heart)<\/p>\n\n\n\n<p>Myocardial infarction<\/p>\n\n\n\n<p>Narrowing or blockage of the coronary arteries<\/p>\n\n\n\n<p>Elevated heart rate<\/p>\n\n\n\n<p>Reduced blood distribution to the limbs<\/p>\n\n\n\n<p>Blood clots in the pulmonary blood vessels (&nbsp;pulmonary embolism&nbsp;)<\/p>\n\n\n\n<p>Inflammation&nbsp;and scarring of the lungs with respiratory problems<\/p>\n\n\n\n<p>Passage of bright red blood from the anus<\/p>\n\n\n\n<p>Bleeding in the gastrointestinal tract<\/p>\n\n\n\n<p>Broken intestine<\/p>\n\n\n\n<p>Inflammation&nbsp;of the esophageal&nbsp;mucosa&nbsp;(esophagus)<\/p>\n\n\n\n<p>Colitis&nbsp;(&nbsp;inflammation&nbsp;of the wall of the colon, which may be accompanied by bleeding from the intestines or&nbsp;rectum&nbsp;(seen only in combination with cisplatin)<\/p>\n\n\n\n<p>Inflammation&nbsp;,&nbsp;edema&nbsp;,&nbsp;erythema&nbsp;and&nbsp;erosion&nbsp;of the mucosal surface of the esophagus caused by radiation therapy<\/p>\n\n\n\n<p>Inflammation&nbsp;of the lung caused by radiation therapy<\/p>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people)<\/em><\/p>\n\n\n\n<p>Destruction of&nbsp;red blood cells<\/p>\n\n\n\n<p>Anaphylactic&nbsp;shock&nbsp;(severe&nbsp;allergic reaction&nbsp;)<\/p>\n\n\n\n<p>Inflammatory conditions of the liver<\/p>\n\n\n\n<p>Redness of the skin<\/p>\n\n\n\n<p>Skin rash that may occur on skin that has previously been exposed to radiation therapy.<\/p>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 people)<\/em><\/p>\n\n\n\n<p>Infection&nbsp;of skin and&nbsp;soft&nbsp;tissue<\/p>\n\n\n\n<p>Stevens-Johnson syndrome (a type of severe reaction to skin and mucous membranes that can be life-threatening)<\/p>\n\n\n\n<p>Toxic epidermal necrolysis&nbsp;(a type of severe skin reaction that can be life-threatening)<\/p>\n\n\n\n<p>Autoimmune&nbsp;condition that results in skin rashes and blisters on legs, arms and abdomen<\/p>\n\n\n\n<p>Inflammation&nbsp;of the skin characterized by the presence of bullous conditions with fluid-filled blistering)<\/p>\n\n\n\n<p>Fragile skin, blisters and&nbsp;erosion&nbsp;as well as scarring of the skin<\/p>\n\n\n\n<p>Redness&nbsp;, pain and swelling mainly in the lower legs<\/p>\n\n\n\n<p>Inflammation&nbsp;of the skin and fat under the skin (pseudocellulitis)<\/p>\n\n\n\n<p>Inflammation&nbsp;of the skin (&nbsp;dermatitis&nbsp;)<\/p>\n\n\n\n<p>Skin that becomes inflamed, itchy, red, cracked and rough<\/p>\n\n\n\n<p>Intense itchy spots<\/p>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<p>A form of&nbsp;diabetes&nbsp;that is primarily based on kidney&nbsp;pathology<\/p>\n\n\n\n<p>Kidney disorder involving tubular epithelial cells (which form renal tubules) death.<\/p>\n\n\n\n<p>You may get some of these symptoms and \/ or ailments.&nbsp;If you start to experience any of these&nbsp;side effects&nbsp;, talk to your doctor as soon as possible.<\/p>\n\n\n\n<p>If you have any&nbsp;side effects&nbsp;, talk to your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Pemetrexed Accord<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Infusion solutions: The medicine should be used immediately.&nbsp;Chemical and physical shelf life for 72 hours at room temperature has been demonstrated for the infusion solution of pemetrexed, if&nbsp;reconstituted&nbsp;as directed.<\/p>\n\n\n\n<p>Do not use this medicine for visible signs of deterioration.<\/p>\n\n\n\n<p>This medicine is for single use only.&nbsp;Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is pemetrexed.&nbsp;One ml of concentrate contains pemetrexed disodium hemipentahydrate equivalent to 25 mg pemetrexed.<\/p>\n\n\n\n<p>One&nbsp;vial&nbsp;of 4 ml concentrate contains pemetrexed disodium hemipentahydrate equivalent to 100 mg pemetrexed.<\/p>\n\n\n\n<p>One&nbsp;vial&nbsp;of 20 ml concentrate contains pemetrexed disodium hemipentahydrate equivalent to 500 mg pemetrexed.<\/p>\n\n\n\n<p>One&nbsp;vial&nbsp;of 34 ml concentrate contains pemetrexed disodium hemipentahydrate equivalent to 850 mg.<\/p>\n\n\n\n<p>One&nbsp;vial&nbsp;of 40 ml concentrate contains pemetrexed disodium hemipentahydrate equivalent to 1,000 mg.<\/p>\n\n\n\n<p>The other ingredients are citric acid, L \u2011 methionine, monothiolglycerol, sodium hydroxide, concentrated&nbsp;hydrochloric acid&nbsp;and water for injections (see section 2 \u201cPemetrexed Accord contains sodium\u201d).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Pemetrexed Accord is a concentrate for solution for&nbsp;infusion&nbsp;packaged in a&nbsp;glass&nbsp;vial .&nbsp;It is a clear, colorless to light yellow solution.<\/p>\n\n\n\n<p>The pack contains a&nbsp;vial&nbsp;containing either 4 ml, 20 ml, 34 ml or 40 ml of concentrate.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Accord Healthcare SLU<\/p>\n\n\n\n<p>World Trade Center, Moll de Barcelona, \u200b\u200bs \/ n<\/p>\n\n\n\n<p>Edifici Est 6\u00aa planta<\/p>\n\n\n\n<p>08039 Barcelona<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomierska 50,95-200 Pabianice, Poland<\/p>\n\n\n\n<p>LABORATORI FUNDACI\u00d3 DAU<\/p>\n\n\n\n<p>C \/ C, 12-14 Pol.&nbsp;Ind.&nbsp;Zona Franca, Barcelona, \u200b\u200b08040, Spain<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pemetrexed Accord is co-administered with cisplatin, another anti-cancer drug, for the treatment of malignant pleural mesothelioma, a form of lung cancer, in patients who have not previously received anti-cancer drug therapy.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[21095,21135,10012,21131,21134,10015,10013,21132,21133,10014],"class_list":["post-20609","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-pemetrexed","tag-benefits-of-pemetrexed-accord","tag-pemetrexed","tag-pemetrexed-accord","tag-pemetrexed-accord-side-effects","tag-pemetrexed-side-effects","tag-what-is-pemetrexed","tag-what-is-pemetrexed-accord","tag-what-pemetrexed-accord-is-used-for","tag-what-pemetrexed-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20609"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20609\/revisions"}],"predecessor-version":[{"id":20672,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20609\/revisions\/20672"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20609"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20609"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}