{"id":20565,"date":"2022-04-06T11:28:45","date_gmt":"2022-04-06T11:28:45","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20565"},"modified":"2022-04-07T10:05:06","modified_gmt":"2022-04-07T10:05:06","slug":"pemazyre","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/pemazyre\/","title":{"rendered":"Pemazyre &#8211; Pemigatinib uses, dose and side effects"},"content":{"rendered":"\n<p>4.5 mg, 9 mg, 13.5 mg&nbsp;tablets<br>pemigatinib<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Pemazyre is and what it is used for<\/h2>\n\n\n\n<p>Pemazyre contains the active substance pemigatinib, which belongs to a group of cancer medicines called tyrosine kinase inhibitors.\u00a0It blocks the effect of\u00a0protein\u00a0in the cell called fibroblast growth factor receptor types 1, 2, and 3 (FGFR1, FGFR2, and FGFR3) which helps regulate cell growth.\u00a0Cancer cells may have an abnormal form of this\u00a0protein.\u00a0By blocking FGFR, pemigatinib can prevent the growth of such cancer cells.<\/p>\n\n\n\n<p>Pemazyre is used:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>to treat adults with bile duct cancer (also called cholangiocarcinoma) whose cancer cells have an abnormal form of FGFR2\u2011\u00a0protein, and<\/li><li>when cancer has spread to other parts of the body or cannot be removed by surgery, and<\/li><li>when treatment with other drugs no longer works.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Pemazyre<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Pemazyre<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to pemigatinib or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you use\u00a0St. John&#8217;s wort, a traditional herbal remedy for treating mild depression<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Pemazyre if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>been told that you have an increase or decrease in a mineral in the blood called phosphorus<\/li><li>vision or eye problems<\/li><li>severely impaired liver function.&nbsp;Your treatment may need to be adjusted.<\/li><li>severely impaired renal function.&nbsp;Your treatment may need to be adjusted.<\/li><li>cancer cells that have spread to the brain or spinal cord.<\/li><\/ul>\n\n\n\n<p>Eye examinations are recommended:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>before starting treatment with Pemazyre<\/li><li>every two months during the first six months of treatment<\/li><li>every three months thereafter or immediately if any visual symptoms occur, including flashes of light, visual disturbances, or dark spots.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you get any vision-related symptoms.<\/p>\n\n\n\n<p>You should also use lubricating or moisturizing&nbsp;eye drops&nbsp;or&nbsp;gels&nbsp;to prevent or treat dry eyes.<\/p>\n\n\n\n<p>Pemacic acid can harm a fetus.\u00a0An effective contraceptive must be used during treatment and for at least one week after the last\u00a0dose\u00a0of Pemazyre infertile women and in men with female fertile partners.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Pemazyre should not be given to children or adolescents under 18 years of age.&nbsp;It is not known if it is safe and effective in this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Pemazyre<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>In particular, you should tell your doctor if you are taking any of the following medicines so that your doctor can decide if your treatment needs to be changed:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>St. John&#8217;s wort<\/strong>: a traditional herbal remedy for treating mild depression.\u00a0You\u00a0must not\u00a0take\u00a0St. John&#8217;s wort\u00a0during treatment with Pemazyre.<\/li><li>drugs with names of active substances ending in &#8221;\u00a0azole\u00a0&#8220;: they are used to reduce\u00a0the release\u00a0of gastric acid.\u00a0Avoid using these medicines during treatment with Pemazyre.<\/li><li>itraconazole: a medicine used to treat fungal infections<\/li><li>rifampicin: a medicine for\u00a0tuberculosis\u00a0or some\u00a0other\u00a0infection<\/li><li>carbamazepine\u00a0,\u00a0phenytoin\u00a0,\u00a0phenobarbital\u00a0,\u00a0primidone\u00a0: antiepileptic\u00a0drugs<\/li><li>efavirenz: anti\u00a0&#8211;\u00a0HIV\u00a0drug<\/li><li>cyclophosphamide,\u00a0ifosfamide\u00a0: other anticancer medicines<\/li><li>methadone: a drug for the treatment of severe pain or to manage addiction<\/li><li>digoxin: a drug used to treat heart disease<\/li><li>dabigatran: a medicine to prevent blood clots<\/li><li>colchicine: a drug used to treat gout attacks.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pemazyre with food and drink<\/h2>\n\n\n\n<p>Avoid eating grapefruit and drinking grapefruit juice while using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Pregnancy<\/strong><br>Pemazyre can harm the unborn baby and should not be used during pregnancy unless your doctor tells you otherwise.\u00a0A pregnancy test should be performed before starting treatment.<\/li><li><strong>Contraceptive advise<\/strong> for men and women<br>Women treated with Pemazyre should not become pregnant.\u00a0Therefore, women who may become pregnant must use effective contraception during treatment and for at least one week after the last\u00a0dose\u00a0of Pemazyre.\u00a0Talk to your doctor about the most suitable contraceptive for you.<br>Men should avoid getting a woman pregnant.\u00a0They must use effective contraception during treatment and for at least one week after the last\u00a0dose\u00a0of Pemazyre.<\/li><li>Breast-feeding<br>Do not breastfeed during treatment with Pemazyre and for at least one week after the last\u00a0dose.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Pemacic acid can cause&nbsp;side effects&nbsp;such as fatigue or visual disturbances.&nbsp;Do not drive or use machines if this happens.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Pemazyre<\/h2>\n\n\n\n<p>Treatment with Pemazyre should be initiated by a physician experienced in the diagnosis and treatment of bile duct cancer.&nbsp;Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;is<\/strong><\/p>\n\n\n\n<p>1 tablet of Pemazyre 13.5 mg was taken once daily for 14 days, followed by 7 days without taking Pemazyre.<\/p>\n\n\n\n<p>Treatment continues with the same 14-day pattern of Pemazyre once daily, followed by a 7-day treatment interruption.&nbsp;Do not take Pemazyre for the 7 days without treatment.&nbsp;Your doctor will adjust the&nbsp;dose&nbsp;one or discontinue treatment if necessary.<\/p>\n\n\n\n<p><strong>Use<\/strong><\/p>\n\n\n\n<p>Swallow the tablet whole with a glass of water at the same time each day.&nbsp;Pemazyre can be taken with or without food.<\/p>\n\n\n\n<p>The tablets should not be crushed, chewed, divided, or dissolved.<\/p>\n\n\n\n<p><strong>Usage time<\/strong><\/p>\n\n\n\n<p>Take Pemazyre for as long as your doctor prescribes it.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Pemazyre than you should<\/h2>\n\n\n\n<p>Tell your doctor if you have taken more Pemazyre than you should.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Pemazyre<\/h2>\n\n\n\n<p>If you miss a\u00a0dose\u00a0of Pemazyre by 4 hours or more, or if you vomit after taking Pemazyre, do not take a double\u00a0dose\u00a0of Pemazyre tablets to make up for a forgotten\u00a0dose.\u00a0Take the next\u00a0dose\u00a0of Pemazyre at the scheduled time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Pemazyre<\/h2>\n\n\n\n<p>Do not stop taking Pemazyre without discussing it with your doctor, as this may reduce the success of your treatment.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately if<\/strong>&nbsp;you experience any of the serious&nbsp;side effects&nbsp;below.&nbsp;These&nbsp;side effects&nbsp;can occur with the following frequency:<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low sodium levels in the blood;\u00a0symptoms include decreased ability to think, headache, nausea, poor balance, confusion, seizures,\u00a0coma<\/li><li>blood tests show an increase in\u00a0creatinine, which may indicate kidney problems;\u00a0Elevated creatinine\u00a0does not usually cause\u00a0symptoms, but symptoms of kidney problems may include nausea and changes in urination.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;may<\/strong>&nbsp;occur with the following frequencies&nbsp;<strong>:<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high or low phosphate levels in blood samples<\/li><li>taste disorders<\/li><li>dry eyes<\/li><li>nausea<\/li><li>inflammation\u00a0of the oral mucosa<\/li><li>diarrhea<\/li><li>constipation<\/li><li>dry mouth<\/li><li>skin reactions with\u00a0redness, swelling, and pain on palms and soles of the feet, so-called hand-foot syndrome<\/li><li>nail toxicity, including nails coming off the\u00a0nail bed, nail paint, nail bleeding, nails breaking, discoloration or structural changes in the nails, infected skin around the nail<\/li><li>hair loss<\/li><li>dry skin<\/li><li>joint pain<\/li><li>fatigue<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fluid accumulation under the retina (the photosensitive layer on the back of the eye)<\/li><li>inflammation\u00a0of the cornea (the transparent outer layer of the eye)<\/li><li>impaired vision<\/li><li>eyelash\u00a0changes including abnormally long\u00a0eyelashes, ingrown\u00a0eyelashes<\/li><li>abnormal hair growth<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Pemazyre<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister and after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>This medicine does not require any special storage conditions.<\/p>\n\n\n\n<p>The medicine should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is pemigatinib.<br>Each 4.5 mg tablet contains 4.5 mg of pemigatinib.<br>Each 9 mg tablet contains 9 mg of pemigatinib.<br>Each 13.5 mg tablet contains 13.5 mg of pemigatinib.<\/li><li>The other ingredients are microcrystalline cellulose, sodium starch glycolate (type A), and magnesium stearate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Pemazyre 4.5 mg tablets are round, white to off-white, debossed with \u201cI\u201d on one side and \u201c4.5\u201d on the other.<\/p>\n\n\n\n<p>Pemazyre 9 mg tablets are oval, white to off-white, debossed with \u201cI\u201d on one side and \u201c9\u201d on the other.<\/p>\n\n\n\n<p>Pemazyre 13.5 mg tablets are round, white to off-white, debossed with \u201cI\u201d on one side and \u201c13.5\u201d on the other.<\/p>\n\n\n\n<p>The tablets are supplied in blister cards containing 14 tablets.&nbsp;Carton containing 14 or 28 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Incyte Biosciences Distribution BV<\/p>\n\n\n\n<p>Paasheuvelweg 25<\/p>\n\n\n\n<p>1105 BP Amsterdam<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Incyte Biosciences Distribution BV<\/p>\n\n\n\n<p>Paasheuvelweg 25<\/p>\n\n\n\n<p>1105 BP Amsterdam<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Tjoapack Netherlands BV<\/p>\n\n\n\n<p>New Donk 9<\/p>\n\n\n\n<p>4879 AC Etten \u2011 Leur<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pemazyre contains the active substance pemigatinib, which belongs to a group of cancer medicines called tyrosine kinase inhibitors. It blocks the effect of protein in the cell called fibroblast growth factor receptor type 1, 2 and 3 (FGFR1, FGFR2 and FGFR3) which helps regulate cell growth. Cancer cells may have an abnormal form of this protein . By blocking FGFR, pemigatinib can prevent the growth of such cancer cells.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[20983,20987,20986,20978,20982,20981,20984,20979,20985,20980],"class_list":["post-20565","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-pemazyre","tag-pemazyre-side-effects","tag-pemazyre-tablet","tag-pemigatinib","tag-pemigatinib-side-effects","tag-pemigatinib-tabelt","tag-what-is-pemazyre","tag-what-is-pemigatinib","tag-what-pemazyre-is-used-for","tag-what-pemigatinib-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20565"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20565\/revisions"}],"predecessor-version":[{"id":20592,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20565\/revisions\/20592"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20565"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20565"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}