{"id":20563,"date":"2022-04-06T11:27:10","date_gmt":"2022-04-06T11:27:10","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20563"},"modified":"2023-01-07T10:40:59","modified_gmt":"2023-01-07T10:40:59","slug":"pelgraz","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/pelgraz\/","title":{"rendered":"Pelgraz &#8211; Pegfilgrastim Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>Pelgraz 6 mg&nbsp;Pegfilgrastim Solution for injection&nbsp;in the pre-filled injector<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Pelgraz Is And What It Is Used For<\/h2>\n\n\n\n<p>Pelgraz contains the active substance pegfilgrastim.\u00a0Pegfilgrastim is a\u00a0protein\u00a0produced using biotechnology in a\u00a0bacterium\u00a0called\u00a0<em>E. coli<\/em>.\u00a0It belongs to a group of\u00a0proteins\u00a0called\u00a0cytokines\u00a0and is very similar to a natural\u00a0protein\u00a0(granulocyte colony-stimulating factor) produced in the body.<\/p>\n\n\n\n<p>Pelgraz is used to reduce the duration of\u00a0neutropenia\u00a0(low\u00a0white blood cell count\u00a0) and the occurrence of febrile\u00a0neutropenia\u00a0(low\u00a0white blood cell count\u00a0with concomitant <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a>), which may be due to the use of\u00a0cytotoxic\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/treatment-of-cancer-in-children\/\">chemotherapy<\/a>\u00a0(drugs that destroy fast-growing cells).\u00a0The white\u00a0blood cells\u00a0are important because they help your body fight infections.\u00a0These\u00a0blood cells\u00a0are very sensitive to\u00a0chemotherapy; this treatment can decrease their number in the body.\u00a0About the number of\u00a0white blood cells drops to a low level, there may not be enough left in the body to fight bacteria, and you may become more susceptible to\u00a0infection.<\/p>\n\n\n\n<p>Your doctor has given you Pelgraz to help your&nbsp;bone marrow&nbsp;(the part of the skeleton where&nbsp;blood cells&nbsp;are formed) form more&nbsp;white blood cells&nbsp;that help your body fight&nbsp;infection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before Using Pelgraz<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Pelgraz<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to pegfilgrastim, filgrastim, or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Pelgraz if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>An allergic reaction can result in weakness<\/li><li>A drop in blood pressure<\/li><li>Difficulty breathing<\/li><li>Swelling of the face ( anaphylaxis )<\/li><li>Redness and swelling<\/li><li>Rash<\/li><li>Skin with\u00a0itching<\/li><li>If allergic to latex.\u00a0The grey needle sleeve on the pre-filled syringe contains a latex derivative and may cause severe allergic reactions.<\/li><li>Have a <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a>, fever, and difficulty breathing.\u00a0This may be a sign of\u00a0acute\u00a0respiratory distress syndrome.<\/li><li>Suffer from one or more of the following side effects:<ul><li>Swelling or fluid retention may occur while urinating less frequently than usual;\u00a0breathing difficulties;\u00a0swollen abdomen and a feeling of satiety;\u00a0general feeling of tiredness. This can be a symptom of a condition called capillary leakage syndrome, which causes blood to leak from the small blood vessels.\u00a0See section 4.<\/li><\/ul><\/li><li>Suffer from pain in the upper abdomen on the left side of the tip of the left shoulder blade.\u00a0This may be a sign of\u00a0splenomegaly.<\/li><li>Recently had a severe lung infection (\u00a0pneumonia\u00a0)<ul><li>Fluid in the lungs (\u00a0pulmonary edema\u00a0)<\/li><li>Inflammation\u00a0of the lungs (interstitial lung disease) or abnormal results on chest X-ray (lung infiltration).<\/li><\/ul><\/li><li>Know that you have changed the number of\u00a0blood cells\u00a0(e.g. increased number of\u00a0white blood cells\u00a0or\u00a0anemia) or decreased the number of\u00a0platelets, which reduces the blood&#8217;s ability to clot (\u00a0thrombocytopenia\u00a0).\u00a0Your doctor may want to check this more often than usual.<\/li><li>Have\u00a0sickle cell anemia.\u00a0Your doctor may want to check this more often than usual.<\/li><li>If a patient with breast or lung <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a>, as Pelgraz in combination with\u00a0chemotherapy\u00a0and radiation therapy may increase the risk of a cancerous stage called\u00a0myelodysplastic syndrome\u00a0(MDS) or a blood cancer called\u00a0acute myeloid leukemia\u00a0(AML).\u00a0Symptoms may include fatigue, fever, and easy bruising and bleeding.<\/li><li>Suffer from sudden signs of\u00a0allergy, such as rash,\u00a0itching\u00a0or\u00a0hives, swelling of the face, lips, tongue, or other parts of the body, shortness of breath, wheezing, or difficulty breathing.\u00a0These may be signs of a severe\u00a0allergic reaction.<\/li><\/ul>\n\n\n\n<p>You will have regular blood, and urine tests as Pelgraz can damage the small filters in your kidneys (\u00a0glomerulonephritis\u00a0).<\/p>\n\n\n\n<p>Severe skin reactions (Stevens-Johnson syndrome) have been reported using Pelgraz.\u00a0Stop using Pelgraz and seek medical attention immediately if you experience any symptoms described in section 4.<\/p>\n\n\n\n<p>Talk to your doctor about the risk of developing blood cancer.&nbsp;If you develop or are at high risk of developing blood cancer, do not use Pelgraz unless your doctor tells you to.<\/p>\n\n\n\n<p>If you have symptoms that indicate\u00a0inflammation\u00a0of the\u00a0aorta\u00a0(the large blood vessel that carries blood from the heart to the body), this has been reported rarely in cancer patients and healthy donors.\u00a0Symptoms may include fever, abdominal pain, malaise, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/back-hurts\/\">back pain<\/a>, and elevated markers of inflammation (e.g. C-reactive\u00a0protein\u00a0and\u00a0white blood cells\u00a0).\u00a0Tell your doctor if you notice these symptoms.<\/p>\n\n\n\n<p><strong>Impaired treatment response to pegfilgrastim<\/strong><\/p>\n\n\n\n<p>If you stop responding to treatment with pegfilgrastim or if the response to treatment decreases, your doctor will investigate why.\u00a0Your doctor will, among other things, check if you have developed\u00a0antibodies\u00a0that neutralize the activity of pegfilgrastim.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children And Young People<\/h2>\n\n\n\n<p>The safety and efficacy of Pelgraz in children have not yet been established.&nbsp;Talk to your doctor or pharmacist before taking any medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Drugs And Pelgraz<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy And Breastfeeding<\/h2>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.\u00a0Pregnant women have not tried Pelgraz.\u00a0You must tell your doctor if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Is pregnant<\/li><li>Think you are pregnant<\/li><li>Plans to have children<\/li><\/ul>\n\n\n\n<p>If you become pregnant during treatment with Pelgraz, talk to your doctor.<\/p>\n\n\n\n<p>If you do not receive any other instructions from your doctor, you must stop breastfeeding if you use Pelgraz.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>Pelgraz has no or negligible effect on the ability to drive and use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pelgraz Contains Sorbitol (E420) And Sodium<\/h2>\n\n\n\n<p>This medicine contains 30 mg sorbitol in each pre-filled injector, equivalent to 50 mg\/ml.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per 6 mg\u00a0dose, i.e. essentially &#8216;sodium-free.&#8217;\u00a0It is next to &#8220;sodium-free.&#8221;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Use Pelgraz<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Pelgraz is intended for use by adults from 18 years of age.<\/li><li>Always use Pelgraz exactly as your doctor has told you.\u00a0Ask your doctor or pharmacist if you are unsure.\u00a0The usual\u00a0dose\u00a0is a 6 mg\u00a0subcutaneous\u00a0injection\u00a0(\u00a0injection\u00a0under the skin) with a pre-filled injector.\u00a0Dose\u00a0one should give at least 24 hours after your last\u00a0dose\u00a0of\u00a0chemotherapy\u00a0at the end of each chemotherapy cycle.<\/li><li>Avoid vigorous shaking of Pelgraz as this may affect the effect.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How\u00a0To Inject Yourself With\u00a0Pelgraz<\/h2>\n\n\n\n<p>Your doctor may decide that you should inject Pelgraz yourself.&nbsp;Your doctor or nurse will show you how to&nbsp;inject&nbsp;yourself.&nbsp;Do not try to inject yourself if your doctor or nurse has not shown you what to do.<\/p>\n\n\n\n<p>Below are instructions on how\u00a0to inject yourself with Pelgraz.\u00a0For your illness to be treated, however, close and\u00a0continuous\u00a0contact with a doctor is required.\u00a0If you are unsure how to inject one or have any questions, ask your doctor or nurse for help.<\/p>\n\n\n\n<p><strong>How Do I Take Pelgraz\u00a0Injections\u00a0myself?<\/strong><\/p>\n\n\n\n<p>Injection&nbsp;should be made into the&nbsp;tissue&nbsp;just under the skin, a so-called&nbsp;subcutaneous&nbsp;injection.<\/p>\n\n\n\n<p><strong>Equipment<\/strong><\/p>\n\n\n\n<p>To give yourself a\u00a0subcutaneous\u00a0injection,\u00a0you need the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A pre-filled injector with Pelgraz;<\/li><li>An alcohol compress.<\/li><\/ul>\n\n\n\n<p><strong>What should I do before giving myself a&nbsp;subcutaneous&nbsp;injection&nbsp;of Pelgraz?<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Take the pre-filled injector out of the refrigerator.<\/li><li>Check the expiration date on the pre-filled injector label (EXP).\u00a0Do not use it if the date has passed on the last day of the month indicated if it has been stored outside the refrigerator for more than 72 hours or is otherwise unusable.<\/li><li>Check the appearance of Pelgraz.\u00a0It must be a clear and colourless liquid.\u00a0If the liquid contains particles, do not use it.<\/li><li>Injection\u00a0one feels more comfortable if you let the pre-filled injector lie for 30 minutes to reach room temperature or warm it gently in your hand for a few minutes.\u00a0Do not heat Pelgraz in any other way (e.g. do not heat the syringe in the microwave or hot water).<\/li><li>Wash your hands thoroughly.<\/li><li>Find a comfortable, clean place with good lighting, and ensure you have everything you need (pre-filled injector and alcohol compress) within reach.<\/li><\/ol>\n\n\n\n<p><strong>How do I prepare my&nbsp;injection&nbsp;with Pelgraz?<\/strong><\/p>\n\n\n\n<p>Before injecting Pelgraz, do the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Choose a clean place with good lighting to&nbsp;administer&nbsp;the drug.<\/li><li>Check the expiration date on the packaging.&nbsp;Do not use it if the expiration date has passed.<\/li><li>Develop a spirit compress and a container for stabbing and cutting objects.<\/li><\/ul>\n\n\n\n<p><strong>Preparation<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20190226000039#\" rel=\"noopener\"><\/a><\/td><td>Wash your hands with soap under running warm water.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20190226000039#\" rel=\"noopener\"><\/a><\/td><td>Choose an injection site (abdomen or thigh if the patient injects himself, with the addition of the alternative back of the arm with the help of health care professionals or caregivers).<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20190226000039#\" rel=\"noopener\"><\/a><\/td><td>Clean the injection site: use an alcohol swab to clean the area.&nbsp;Allow airing dry.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>1. Before&nbsp;injection<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20190226000039#\" rel=\"noopener\"><\/a><\/td><td>Inspect the liquid in the window.\u00a0Check for colour changes, turbidity, or large particles.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20190226000039#\" rel=\"noopener\"><\/a><\/td><td>Remove the bottom cover: turn and pull the bottom cover to remove it.&nbsp;Keep your hands away from the needle cover after removing the cover.&nbsp;Do not replace the cover.&nbsp;Discard the bottom lid immediately.&nbsp;Do not inject if you drop the pre-filled injector after removing the cap. Inject within 5 minutes after removing the bottom cover.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>2.&nbsp;Injection<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20190226000039#\" rel=\"noopener\"><\/a><\/td><td>Place the injector directly against the skin (approximately 90 degrees).<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20190226000039#\" rel=\"noopener\"><\/a><\/td><td>Push the handle straight down.&nbsp;The medicine is injected when you press.&nbsp;Do this at a speed that is comfortable for you. Do not lift the injector during&nbsp;the injection.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20190226000039#\" rel=\"noopener\"><\/a><\/td><td>Injection\u00a0one is completed when you have pressed down the handle as far as possible, you hear a clicking sound, and the orange body is no longer visible.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20190226000039#\" rel=\"noopener\"><\/a><\/td><td>Lift straight up.&nbsp;The yellow ribbon indicates that the needle cover is locked.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>3. Disposal<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20190226000039#\" rel=\"noopener\"><\/a><\/td><td>Discard the used Pelgraz pre-filled injector.&nbsp;Place the injector in an approved container for stabbing and cutting objects.&nbsp;The regulations vary depending on the region.&nbsp;Ask your doctor or pharmacist how to dispose of the injector properly.&nbsp;Do not dispose of the injector in household waste.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Remember<\/strong><\/p>\n\n\n\n<p>Ask your doctor or nurse for help and advice if you have problems.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Use More Pelgraz Than You Should\u00a0<\/h2>\n\n\n\n<p>If you take more Pelgraz, you should contact a doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Take Pelgraz<\/h2>\n\n\n\n<p>If you inject Pelgraz yourself and have missed your\u00a0dose, you should contact your doctor to discuss when you should inject the next\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Stop Taking Pelgraz<\/h2>\n\n\n\n<p>Your doctor will tell you when to stop taking Pelgraz.&nbsp;It is perfectly normal to receive several treatments with Pelgraz.<\/p>\n\n\n\n<p>If you have any further questions about the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible Pelgraz Side Effects<\/h2>\n\n\n\n<p>This medicine can cause side effects like all medicines, although not everybody gets them.<\/p>\n\n\n\n<p>If you get any of the following&nbsp;side effects, talk to your doctor straight away:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling or fluid retention may occur while urinating less frequently than usual;\u00a0breathing difficulties;\u00a0swollen abdomen and a feeling of satiety;\u00a0and a general feeling of tiredness.\u00a0These symptoms often develop rapidly.<\/li><\/ul>\n\n\n\n<p>These symptoms may signify a less common condition (which may affect up to 1 in 100 people) called &#8220;capillary leakage syndrome,&#8221; which causes blood to leak from small blood vessels into the body.\u00a0This condition must treat immediately.<\/p>\n\n\n\n<p><strong>Very common\u00a0pelgraz injection side effects\u00a0(<\/strong>\u00a0may affect more than 1 user in 10)\u00a0<strong>:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Skeletal pain.\u00a0Your doctor may recommend what you can take to relieve skeletal pain.<\/li><li>Headache and nausea.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10 people)&nbsp;<strong>:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Injection site pain.<\/li><li>General joint and muscle pain.<\/li><li>Chest pain that is not due to heart disease or heart attack.<\/li><li>Some changes in blood values \u200b\u200bmay occur, but these are detected during routine blood tests.\u00a0Your\u00a0white blood cells\u00a0may increase over a limited period.\u00a0The number of\u00a0platelets\u00a0can decrease, which can lead to bruising.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon\u00a0pelgraz injection side effects(<\/strong>\u00a0may affect up to 1 in 100 people)\u00a0<strong>:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergy-like reactions, including\u00a0redness\u00a0and swelling, rash, and raised itchy skin areas.<\/li><li>Severe allergic reactions, including\u00a0anaphylaxis\u00a0(weakness, drop in blood pressure, difficulty breathing, swelling of the face).<\/li><li>Increased spleen size.<\/li><li>Anthrax.\u00a0Some cases of anthrax were fatal.\u00a0You must contact your doctor immediately if you experience pain in the upper left side of the abdomen or up against the left shoulder, as this may indicate problems with the spleen.<\/li><li>Breathing problems.\u00a0If you have a cough, fever, and difficulty breathing, consult a doctor.<\/li><li>Sweets syndrome (plum-coloured, raised, painful skin changes on the arms and legs and sometimes on the face and neck with fever) has occurred, but other factors may be important.<\/li><li>Cutaneous\u00a0vasculitis\u00a0(\u00a0inflammation\u00a0of the blood vessels of the skin).<\/li><li>Damage to the small filters in the kidneys (\u00a0glomerulonephritis\u00a0).<\/li><li>Redness\u00a0at the injection site.<\/li><li>Abnormal blood samples (\u00a0lactate dehydrogenase,\u00a0uric acid,\u00a0and alkaline phosphatase).<\/li><li>Abnormal blood tests for liver function (\u00a0alanine aminotransferase\u00a0and\u00a0aspartate aminotransferase\u00a0).<\/li><li>Bloody cough (hemoptysis).<\/li><li>Blood disorders (\u00a0myelodysplastic syndrome\u00a0[MDS] or\u00a0acute myeloid leukemia\u00a0[AML].<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation\u00a0of the\u00a0aorta\u00a0(the large blood vessel that carries blood from the heart to the body), see section 2.<\/li><li>Bleeding in the lung.<\/li><li>Stevens-Johnson syndrome can start as reddish, target-like, or round spots on the torso, often with blisters in the middle.\u00a0Skin peeling and sores in the mouth, throat, nose, genitals, and eyes may also occur.\u00a0These reactions are often preceded by fever and\u00a0flu-like symptoms.\u00a0If you develop any of these symptoms, stop using Pelgraz and contact your doctor immediately or seek medical attention.\u00a0See also section 2<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How To Store Pelgraz<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of sight and reach of children.<\/li><li>Do not use this medicine after the expiry date stated on the carton and the pre-filled injector label (EXP).\u00a0The expiration date is the last day of the specified month.<\/li><li>Store in a refrigerator (2 \u00b0 C \u2011 8 \u00b0 C).<\/li><li>Pelgraz can be stored at room temperature (maximum 25 \u00b1 2 \u00b0 C) for 72 hours.\u00a0Pelgraz stored at room temperature for more than 72 hours should be discarded.\u00a0If you have questions about storage, talk to a doctor, nurse, or pharmacist.<\/li><li>Do not freeze.\u00a0Accidental freezing for a maximum of 24 hours does not impair the stability of Pelgraz.<\/li><li>The pre-filled injector must be stored in the carton.\u00a0Sensitive to light.<\/li><li>Do not use this medicine if it is cloudy or contains particles.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.\u00a0Ask your pharmacist how to dispose of medicines that are no longer required.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Of The Pack And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is pegfilgrastim.&nbsp;Each pre-filled injector contains 6 mg of pegfilgrastim in a 0.6 ml solution.<\/li><li>The other ingredients are sodium acetate, sorbitol (E420), polysorbate 20, and water for injections (see section 2).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And The Contents Of The Pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Pelgraz is a clear, colourless\u00a0solution for injection\u00a0in a pre-filled injector with a needle.\u00a0A pre-filled injector contains 0.6 ml of solution.<\/li><li>Pelgraz is supplied in packs of 1 pre-filled injector in a mono carton with alcohol compress.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorization&nbsp;<\/strong><strong>Holder<\/strong><\/p>\n\n\n\n<p>Accord Healthcare SLU<\/p>\n\n\n\n<p>World Trade Center, Moll de Barcelona, \u200b\u200bs \/ n,<\/p>\n\n\n\n<p>Edifici Est 6\u00aa planta,<\/p>\n\n\n\n<p>08039 Barcelona,<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Accord Healthcare Limited<\/p>\n\n\n\n<p>Sage House, 319 Pinner Road<\/p>\n\n\n\n<p>North Harrow<\/p>\n\n\n\n<p>Middlesex<\/p>\n\n\n\n<p>HA1 4HF<\/p>\n\n\n\n<p>UK<\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomierska 50,95-200 Pabianice, Poland<\/p>\n\n\n\n<p>Accord Healthcare BV,<\/p>\n\n\n\n<p>Winthontlaan 200,<\/p>\n\n\n\n<p>3526 kV Utrecht,<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pelgraz is used in cancer patients to help with neutropenia (low levels of neutrophils, a type of white blood cell), a common side effect of cancer treatment, and can leave patients vulnerable to infections.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[2393,20988,2396,20989,20992,20993,18708,20990,18709,20991],"class_list":["post-20563","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-pegfilgrastim","tag-pegfilgrastim-injection","tag-pegfilgrastim-side-effects","tag-pelgraz","tag-pelgraz-injection","tag-pelgraz-side-effects","tag-what-is-pegfilgrastim","tag-what-is-pelgraz","tag-what-pegfilgrastim-is-used-for","tag-what-pelgraz-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20563","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20563"}],"version-history":[{"count":44,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20563\/revisions"}],"predecessor-version":[{"id":43960,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20563\/revisions\/43960"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20563"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20563"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20563"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}