{"id":20559,"date":"2022-04-06T11:24:15","date_gmt":"2022-04-06T11:24:15","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20559"},"modified":"2022-04-07T10:05:35","modified_gmt":"2022-04-07T10:05:35","slug":"pedea","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/pedea\/","title":{"rendered":"Pedea &#8211; Ibuprofen uses, dose and side effects"},"content":{"rendered":"\n<p>5 mg \/ ml\u00a0solution\u00a0for injection<br>Ibuprofen<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Read all of this leaflet carefully before your child starts taking this medicine. <\/strong>Save this information, you may need to read it again. If you have any further questions, ask your doctor or pharmacist. This medicine has been prescribed for your child.\u00a0Do not give it to others.\u00a0It may harm them, even if they show symptoms similar to your child&#8217;s. If any of the\u00a0side effects\u00a0gets serious, or if you notice any\u00a0side effects\u00a0not listed in this leaflet, please tell your doctor or pharmacist.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">What Pedea is and what it is used for<\/h2>\n\n\n\n<p>As long as the baby remains in the womb, the baby does not need to use its lungs.&nbsp;An unborn baby has a blood vessel called the&nbsp;<em>ductus arteriosus<\/em>&nbsp;near the heart that allows the baby&#8217;s blood to pass past the lungs and circulate to the rest of the body.<\/p>\n\n\n\n<p>When the baby is born and begins to use its lungs, the&nbsp;<em>ductus arteriosus<\/em>&nbsp;usually closes .&nbsp;However, this does not always happen.&nbsp;The medical term for this condition is open&nbsp;<em>ductus arteriosus<\/em>&nbsp;.&nbsp;This can cause heart problems in your baby.&nbsp;This condition is much more common in premature infants than in full-term infants.<\/p>\n\n\n\n<p>Pedea, when given to your baby, can help close the&nbsp;<em>ductus arteriosus<\/em>&nbsp;.<\/p>\n\n\n\n<p>The active substance in Pedea is&nbsp;ibuprofen&nbsp;.&nbsp;Pedea closes the&nbsp;<em>ductus arteriosus<\/em>&nbsp;by preventing the production of&nbsp;prostaglandin&nbsp;, a naturally occurring substance in the body that keeps the&nbsp;<em>ductus arteriosus<\/em>&nbsp;open.<em><\/em><em><\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Before Pedea is given to your child<\/h2>\n\n\n\n<p>Pedea should only be given to your child by a qualified healthcare professional in an intensive care unit for infant care.<\/p>\n\n\n\n<p><strong>Do not use Pedea<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If your child is allergic (hypersensitive) to&nbsp;ibuprofen&nbsp;or any of the other ingredients of Pedea;<\/li><li>if your child has a life-threatening&nbsp;infection&nbsp;that has not been treated;<\/li><li>if your baby is bleeding, especially if the bleeding is in the skull or intestines;<\/li><li>if your child has a decrease in the number of blood cells called&nbsp;platelets&nbsp;(&nbsp;thrombocytopenia&nbsp;) or other problems with blood coagulation;<\/li><li>if your child has kidney problems;<\/li><li>if your child has other heart problems that require the&nbsp;ductus arteriosus&nbsp;to remain open so that adequate blood circulation is maintained;<\/li><li>if your child has or is suspected of having special bowel problems (a condition called&nbsp;necrotizing&nbsp;enterocolitis).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Take special care with Pedea<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Before treatment with Pedea, the baby&#8217;s heart must be examined to confirm that the&nbsp;ductus arteriosus&nbsp;is open.<\/li><li>Pedea should not be given during the first 6 hours after birth.<\/li><li>If your child is suspected of having liver disease.&nbsp;Signs and symptoms of this include yellowing of the skin and eyes.<\/li><li>If your child has an&nbsp;infection&nbsp;for which the child is being treated, the doctor will only treat your child with Pedea after careful consideration of your child&#8217;s condition.<\/li><li>To avoid damage to the skin and surrounding&nbsp;tissue&nbsp;, healthcare professionals should carefully&nbsp;administer&nbsp;Pedea to the child.<\/li><li>Ibuprofen&nbsp;may affect your baby&#8217;s blood ability to coagulate.&nbsp;Your child should therefore be monitored for the risk of bleeding.<\/li><li>Your baby may develop some bleeding from the intestines and kidneys.&nbsp;To detect this, your baby&#8217;s feces and urine should be tested to determine if there is any blood present.<\/li><li>Pedea can reduce the amount of urine your baby excretes.&nbsp;If this is&nbsp;significant&nbsp;, your child&#8217;s treatment may be stopped until the amount of urine returns to normal.<\/li><li>Pedea may be less effective in very premature babies who have a gestational age of 27 weeks.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Using Pedea with other medicines:<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if your child is taking or has recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<p>Some medicines, if given together with Pedea, can cause\u00a0side effects.\u00a0These are described below:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>your child may have problems with urinary excretion and may thus have been prescribed diuretics.&nbsp;Ibuprofen&nbsp;may reduce the effect of these medicines.<\/li><li>your child may be given&nbsp;anticoagulants&nbsp;(medicines that inhibit blood clotting).&nbsp;Ibuprofen&nbsp;may increase the&nbsp;anticoagulant&nbsp;effect of this preparation.<\/li><li>your child may receive nitric oxide to improve blood oxygenation.&nbsp;Ibuprofen&nbsp;may increase the risk of bleeding.<\/li><li>Your child may be given&nbsp;cortisone&nbsp;to prevent&nbsp;inflammation&nbsp;.&nbsp;Ibuprofen&nbsp;may increase the risk of bleeding in the stomach and intestines.<\/li><li>Your child may be given amino acids (a family of&nbsp;antibiotics&nbsp;) to treat an&nbsp;infection&nbsp;.&nbsp;Ibuprofen&nbsp;may increase blood levels and increase the risk of&nbsp;side effects&nbsp;on the kidneys and ears.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Important information about some of the ingredients of Pedea<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(15 mg) per 2 ml, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Pedea is used<\/h2>\n\n\n\n<p>Pedea should only be given by qualified healthcare professionals to your child in an intensive care unit for infant care.<\/p>\n\n\n\n<p>One treatment is defined as three intravenous&nbsp;injections&nbsp;of Pedea given at 24 hour intervals.&nbsp;The dose&nbsp;administered is calculated based on your child&#8217;s weight.&nbsp;First&nbsp;dose&nbsp;one is 10 mg \/ kg and second and third&nbsp;dose&nbsp;one is 5 mg \/ kg.<\/p>\n\n\n\n<p>This calculated amount is given as an&nbsp;infusion&nbsp;into a vein over a 15-minute period.<\/p>\n\n\n\n<p>If the&nbsp;<em>ductus arteriosus&nbsp;<\/em>does not close or reopens after the first treatment, your child&#8217;s doctor may decide to give you another treatment.<\/p>\n\n\n\n<p>If the&nbsp;<em>ductus arteriosus&nbsp;<\/em>does not close after the second treatment, surgery may be suggested.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Pedea can cause&nbsp;side effects&nbsp;, although not everybody gets them.&nbsp;However, it is difficult to distinguish them from recurrent complications that occur in premature infants and complications caused by the disease.<\/p>\n\n\n\n<p>The frequency of possible&nbsp;side effects&nbsp;listed below is defined according to the following system:<\/p>\n\n\n\n<p>Very common (affects more than 1 user in 10)<\/p>\n\n\n\n<p>Common (affects 1 to 10 users in 100)<\/p>\n\n\n\n<p>Uncommon (affects 1 to 10 users in 1000)<\/p>\n\n\n\n<p>Very rare (affects less than 1 user in 10,000)<\/p>\n\n\n\n<p>Has been reported (occurs in an unknown number of users)<\/p>\n\n\n\n<p><strong>Very common:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased\u00a0platelet count\u00a0(\u00a0thrombocytopenia\u00a0),<\/li><li>Reduction of\u00a0white blood cells, so-called\u00a0neutrophils\u00a0(\u00a0neutropenia\u00a0)<\/li><li>Elevated creatinine level in the blood,<\/li><li>The decreased sodium level in the blood,<\/li><li>Respiratory problems (bronchopulmonary dysplasia)<\/li><\/ul>\n\n\n\n<p><strong>Usual:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Intracranial hemorrhage (\u00a0intraventricular\u00a0hemorrhage) and brain damage (periventricular leukomalacia)<\/li><li>Bleeding in the lung<\/li><li>Perforation of the intestine and damage to the intestinal tissue (\u00a0necrotizing\u00a0enterocolitis),<\/li><li>Decreased volume of excreted urine, blood in the urine,\u00a0fluid retention<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Acute&nbsp;deterioration of renal function<\/li><li>Bleeding in the intestines<\/li><li>The oxygen level in the arterial blood is below normal (&nbsp;hypoxemia&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Has been reported:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Holes in the stomach<\/li><\/ul>\n\n\n\n<p>If any of the&nbsp;side effects&nbsp;gets serious, or if you notice any&nbsp;side effects&nbsp;not listed in this leaflet, please tell your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Pedea<\/h2>\n\n\n\n<p>Keep out of sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and on the label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Pedea should be used immediately after opening.<\/p>\n\n\n\n<p>The medicine should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is&nbsp;ibuprofen&nbsp;.&nbsp;Each ml contains 5 mg of&nbsp;ibuprofen&nbsp;.&nbsp;Each&nbsp;2 ml&nbsp;ampoule contains 10 mg&nbsp;of ibuprofen&nbsp;.<\/li><li>The other ingredients are <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tribonate\/\">trometamol<\/a>, sodium chloride, sodium hydroxide (for&nbsp;pH&nbsp;correction ),&nbsp;hydrochloric acid&nbsp;25% (for&nbsp;pH&nbsp;correction ) and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Pedea 5 mg \/ ml&nbsp;solution for injection&nbsp;is a clear, colorless to slightly yellowish solution.<\/p>\n\n\n\n<p>Pedea 5 mg \/ ml&nbsp;solution for injection&nbsp;is supplied in cartons of four 2&nbsp;ml&nbsp;ampoules.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Record Rare Diseases<\/p>\n\n\n\n<p>Real Estate &#8220;Le Wilson&#8221;<\/p>\n\n\n\n<p>70, avenue du G\u00e9n\u00e9ral de Gaulle<\/p>\n\n\n\n<p>F- 92800 Puteaux<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Record Rare Diseases<\/p>\n\n\n\n<p>Real Estate &#8220;Le Wilson&#8221;<\/p>\n\n\n\n<p>70, avenue du G\u00e9n\u00e9ral de Gaulle<\/p>\n\n\n\n<p>F-92800 Puteaux<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Record Rare Diseases<\/p>\n\n\n\n<p>Eco River Parc<\/p>\n\n\n\n<p>30, rue des Peupliers<\/p>\n\n\n\n<p>F-92000 Nanterre<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>For any information about this medicine, please contact the local representative of the Marketing Authorization Holder.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgique \/ Belgi\u00eb \/ Belgien<\/strong>RecordatiTel: +32 2 46101 36<\/td><td><strong>Lithuania<\/strong>Recordati AB.Tel: + 46 8 545 80 230Sweden<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Record Rare DiseasesTel: +33 (0) 1 47 73 64 58France<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>RecordatiTel: +32 2 46101 36Belgium \/ Belgium<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Record Rare DiseasesTel: +33 (0) 1 47 73 64 58France<\/td><td><strong>Hungary<\/strong>Record Rare DiseasesTel: +33 (0) 1 47 73 64 58Franciaorsz\u00e1g<\/td><\/tr><tr><td><strong>Denmark<\/strong>Recordati AB.Tel: +46 8 545 80 230Sweden<\/td><td><strong>Malta<\/strong>Record Rare DiseasesTel: +33 1 47 73 64 58Franza<\/td><\/tr><tr><td><strong>Germany<\/strong>Recordati Rare Diseases Germany GmbH&nbsp;Tel: +49 731 140 554 0<\/td><td><strong>The Netherlands<\/strong>RecordatiTel: +32 2 46101 36Belgium<\/td><\/tr><tr><td><strong>Eesti<\/strong>Recordati AB.Tel: + 46 8 545 80 230Rootsi<\/td><td><strong>Norway<\/strong>Recordati AB.Tel: +46 8 545 80 230Sweden<\/td><\/tr><tr><td><strong>Greece<\/strong>Record Rare DiseasesT\u03b7\u03bb: +33 (0) 1 47 73 64 58.\u0391\u03bb\u03bb\u03af\u03b1<\/td><td><strong>Austria<\/strong>Recordati Rare Diseases Germany GmbHTel: +49 731 140 554 0Germany<\/td><\/tr><tr><td><strong>Spain<\/strong>Recordati Rare Diseases Spain SLUTel: +34 91 659 28 90<\/td><td><strong>Poland<\/strong>Record Rare DiseasesTel: +33 (0) 1 47 73 64 58France<\/td><\/tr><tr><td><strong>France<\/strong>Record Rare DiseasesTel: +33 (0) 1 47 73 64 58<\/td><td><strong>Portugal<\/strong>Jaba Recordati SATel: +351 21 432 95 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>Record Rare DiseasesTel: +33 (0) 1 47 73 64 58French<\/td><td><strong>Romania<\/strong>Record Rare DiseasesTel: +33 (0) 1 47 73 64 58France<\/td><\/tr><tr><td><strong>Ireland<\/strong>Record Rare DiseasesTel: +33 (0) 1 47 73 64 58France<\/td><td><strong>Slovenia<\/strong>Record Rare DiseasesTel: +33 (0) 1 47 73 64 58France<\/td><\/tr><tr><td><strong>Iceland<\/strong>Recordati AB.Phone: +46 8 545 80 230Sweden<\/td><td><strong>Slovak Republic<\/strong>Record Rare DiseasesTel: +33 (0) 1 47 73 64 58France<\/td><\/tr><tr><td><strong>Italy<\/strong>Recordati Rare Diseases Italy SrlTel: +39 02 487 87 173<\/td><td><strong>Finland \/ Finland<\/strong>Recordati AB.Puh \/ Tel: +46 8 545 80 230Sweden<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>Record Rare Diseases:\u0397\u03bb: +33 1 47 73 64 58.\u0391\u03bb\u03bb\u03af\u03b1<\/td><td><strong>Sweden<\/strong>Recordati AB.Tel: + 46 8 545 80 230<\/td><\/tr><tr><td><strong>Latvia<\/strong>Recordati AB.Tel: + 46 8 545 80 230Sweden<\/td><td><strong>United Kingdom<\/strong>Recordati Rare Diseases UK Ltd.Tel: +44 (0) 1491 414333<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>As long as the baby remains in the womb, the baby does not need to use its lungs. An unborn baby has a blood vessel called the ductus arteriosus near the heart that allows the baby&#8217;s blood to pass past the lungs and circulate to the rest of the body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[5320,21001,5322,21002,21005,21006,8318,5321,21003,21004],"class_list":["post-20559","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-ibuprofen","tag-ibuprofen-injection","tag-ibuprofen-side-effects","tag-pedea","tag-pedea-injection","tag-pedea-side-effects","tag-what-ibuprofen-is-used-for","tag-what-is-ibuprofen","tag-what-is-pedea","tag-what-pedea-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20559","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20559"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20559\/revisions"}],"predecessor-version":[{"id":20596,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20559\/revisions\/20596"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20559"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20559"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20559"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}